An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Far less well-known is a much greater catastrophe that took place at the end of the Permian period 251 million years ago: 90 percent of life was destroyed, including saber-toothed reptiles and their rhinoceros-sized prey on land, as well as vast numbers of fish and other species in the sea.This book documents not only what happened during this gigantic mass extinction but also the recent rekindling of the idea of catastrophism. Was the end-Permian event caused by the impact of a huge meteorite or comet, or by prolonged volcanic eruption in Siberia? The evidence has been accumulating through the 1990s and into the new millennium, and Michael Benton gives his verdict at the very end. From field camps in Greenland and Russia to the laboratory bench, When Life Nearly Died involves geologists, paleontologists, environmental modelers, geochemists, astronomers, and experts on biodiversity and conservation. Their working methods are vividly described and explained, and the current disputes are revealed. The implications of our understanding of crises in the past for the current biodiversity crisis are also presented in detail. 46 b/w illustrations.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Antonio Damasio makes clear that we descend biologically, psychologically, and even socially from a long lineage that begins with single living cells; that our minds and cultures are linked by an invisible thread to the ways and means of ancient unicellular life and other primitive life-forms; and that inherent in our very chemistry is a powerful force, a striving toward life maintenance that governs life in all its guises, including the development of genes that help regulate and transmit life. In The Strange Order of Things, Damasio gives us a new way of comprehending the world and our place in it.www.antoniodamasio.com

    But how does virality actually work? In The Rules of Contagion, epidemiologist Adam Kucharski explores topics including gun violence, online manipulation, and, of course, outbreaks of disease to show how much we get wrong about contagion, and how astonishing the real science is.Why did the president retweet a Mussolini quote as his own? Why do financial bubbles take off so quickly? And why are disinformation campaigns so effective? By uncovering the crucial factors driving outbreaks, we can see how things really spread -- and what we can do about it.Whether you are an author seeking an audience, a defender of truth, or simply someone interested in human social behavior, The Rules of Contagion is an essential guide to modern life.

    You experience it passing every day when you watch clocks tick, bread toast, and children grow. But most physicists see things differently, from Newton to Einstein to today’s quantum theorists. For them, time isn’t real. You may think you experience time passing, but they say it’s just an illusion.Lee Smolin, author of the controversial bestseller The Trouble with Physics, argues this limited notion of time is holding physics back. It’s time for a major revolution in scientific thought. The reality of time could be the key to the next big breakthrough in theoretical physics.What if the laws of physics themselves were not timeless? What if they could evolve? Time Reborn offers a radical new approach to cosmology that embraces the reality of time and opens up a whole new universe of possibilties. There are few ideas that, like our notion of time, shape our thinking about literally everything, with major implications for physics and beyond—from climate change to the economic crisis. Smolin explains in lively and lucid prose how the true nature of time impacts our world.

    For among the finches of Daphne Major, natural selection is neither rare nor slow: it is taking place by the hour, and we can watch.In this dramatic story of groundbreaking scientific research, Jonathan Weiner follows these scientists as they watch Darwin's finches and come up with a new understanding of life itself. The Beak of the Finch is an elegantly written and compelling masterpiece of theory and explication in the tradition of Stephen Jay Gould.With a new preface.

    She explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story.

    With the Big Bang, it went from a state of unimaginable density to an all-encompassing cosmic fireball to a simmering fluid of matter and energy, laying down the seeds for everything from dark matter to black holes to one rocky planet orbiting a star near the edge of a spiral galaxy that happened to develop life. But what happens at the end of the story? In billions of years, humanity could still exist in some unrecognizable form, venturing out to distant space, finding new homes and building new civilizations. But the death of the universe is final. What might such a cataclysm look like? And what does it mean for us? Dr. Katie Mack has been contemplating these questions since she was eighteen, when her astronomy professor first informed her the universe could end at any moment, setting her on the path toward theoretical astrophysics. Now, with lively wit and humor, she unpacks them in The End of Everything, taking us on a mind-bending tour through each of the cosmos’ possible finales: the Big Crunch; the Heat Death; Vacuum Decay; the Big Rip; and the Bounce. In the tradition of Neil DeGrasse’s bestseller Astrophysics for People in a Hurry, Mack guides us through major concepts in quantum mechanics, cosmology, string theory, and much more, in a wildly fun, surprisingly upbeat ride to the farthest reaches of everything we know.

    It is so important that it provides the fundamental underpinning of all modern sciences. Without it, we'd have no nuclear power or nuclear bombs, no lasers, no TV, no computers, no science of molecular biology, no understanding of DNA, no genetic engineering—at all. John Gribbin tells the complete story of quantum mechanics, a truth far stranger than any fiction. He takes us step-by-step into an ever more bizarre and fascinating place—requiring only that we approach it with an open mind. He introduces the scientists who developed quantum theory. He investigates the atom, radiation, time travel, the birth of the universe, superconductors and life itself. And in a world full of its own delights, mysteries and surprises, he searches for Schrödinger's Cat—a search for quantum reality—as he brings every reader to a clear understanding of the most important area of scientific study today—quantum physics.

    They distill more than 20 years of research and first-hand accounts from the most biodiverse ecosystems on Earth into straightforward principles and guidance for confronting our culture of hyper-novelty.For evolutionary biologists Heather Heying and Bret Weinstein, the cause of our woes is clear: the modern world is out of sync with our ancient brains and bodies. We evolved to live in clans, but today most people don't even know their neighbors' names. Differences between the sexes once served a necessary evolutionary purpose, but today many dismiss the concept of biological sex as offensive. The cognitive dissonance spawned by trying to live in a society we're not built for is killing us.

      In the past few years, a handful of scientists have been in a race to explain a disturbing aspect of our universe: only 4 percent of it consists of the matter that makes up you, me, our books, and every planet, star, and galaxy. The rest—96 percent of the universe—is completely unknown.   Richard Panek tells the dramatic story of how scientists reached this conclusion, and what they’re doing to find this "dark" matter and an even more bizarre substance called dark energy. Based on in-depth, on-site reporting and hundreds of interviews—with everyone from Berkeley’s feisty Saul Perlmutter and Johns Hopkins’s meticulous Adam Riess to the quietly revolutionary Vera Rubin—the book offers an intimate portrait of the bitter rivalries and fruitful collaborations, the eureka moments and blind alleys, that have fueled their search, redefined science, and reinvented the universe.

    Can our world support that? What kind of world will it be? Those answering these questions generally fall into two deeply divided groups--Wizards and Prophets, as Charles Mann calls them in this balanced, authoritative, nonpolemical new book. The Prophets, he explains, follow William Vogt, a founding environmentalist who believed that in using more than our planet has to give, our prosperity will lead us to ruin. Cut back! was his mantra. Otherwise everyone will lose! The Wizards are the heirs of Norman Borlaug, whose research, in effect, wrangled the world in service to our species to produce modern high-yield crops that then saved millions from starvation. Innovate! was Borlaug's cry. Only in that way can everyone win! Mann delves into these diverging viewpoints to assess the four great challenges humanity faces--food, water, energy, climate change--grounding each in historical context and weighing the options for the future. With our civilization on the line, the author's insightful analysis is an essential addition to the urgent conversation about how our children will fare on an increasingly crowded Earth.

    Now comes a gripping account of the doctors and scientists fighting to protect us, an urgent wake-up call about the future of emerging viruses—from the #1 bestselling author of The Hot Zone, soon to be a National Geographic original miniseries.This time, Ebola started with a two-year-old child who likely had contact with a wild creature and whose entire family quickly fell ill and died. The ensuing global drama activated health professionals in North America, Europe, and Africa in a desperate race against time to contain the viral wildfire. By the end—as the virus mutated into its deadliest form, and spread farther and faster than ever before—30,000 people would be infected, and the dead would be spread across eight countries on three continents.In this taut and suspenseful medical drama, Richard Preston deeply chronicles the outbreak, in which we saw for the first time the specter of Ebola jumping continents, crossing the Atlantic, and infecting people in America. Rich in characters and conflict—physical, emotional, and ethical—Crisis in the Red Zone is an immersion in one of the great public health calamities of our time.Preston writes of doctors and nurses in the field putting their own lives on the line, of government bureaucrats and NGO administrators moving, often fitfully, to try to contain the outbreak, and of pharmaceutical companies racing to develop drugs to combat the virus. He also explores the charged ethical dilemma over who should and did receive the rare doses of an experimental treatment when they became available at the peak of the disaster. Crisis in the Red Zone makes clear that the outbreak of 2013–2014 is a harbinger of further, more severe outbreaks, and of emerging viruses heretofore unimagined—in any country, on any continent. In our ever more interconnected world, with roads and towns cut deep into the jungles of equatorial Africa, viruses both familiar and undiscovered are being unleashed into more densely populated areas than ever before.The more we discover about the virosphere, the more we realize its deadly potential. Crisis in the Red Zone is an exquisitely timely book, a stark warning of viral outbreaks to come.

    . . . Wonderland inspires grins and well-what-d'ya-knows" —The New York Times Book Review From the New York Times-bestselling author of How We Got to Now and Where Good Ideas Come From, a look at the world-changing innovations we made while keeping ourselves entertained. This lushly illustrated history of popular entertainment takes a long-zoom approach, contending that the pursuit of novelty and wonder is a powerful driver of world-shaping technological change. Steven Johnson argues that, throughout history, the cutting edge of innovation lies wherever people are working the hardest to keep themselves and others amused.Johnson's storytelling is just as delightful as the inventions he describes, full of surprising stops along the journey from simple concepts to complex modern systems. He introduces us to the colorful innovators of leisure: the explorers, proprietors, showmen, and artists who changed the trajectory of history with their luxurious wares, exotic meals, taverns, gambling tables, and magic shows.In Wonderland, Johnson compellingly argues that observers of technological and social trends should be looking for clues in novel amusements. You'll find the future wherever people are having the most fun.