It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital in the Bronx, New York.

    If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting fifty years of false starts, abysmal failures and miraculous triumphs, as experienced by one the world’s foremost heart surgeons, O.H. “Bud” Frazier, who has given his life to saving the un-savable. His journey takes him from a small town in west Texas to one of the country’s most prestigious medical institutions, The Texas Heart Institute, from the halls of Congress to the animal laboratories where calves are fitted with new heart designs. The roadblocks to success —medical setbacks, technological shortcomings, government regulations – are immense. Still, Bud and his associates persist, finding inspiration in the unlikeliest of places. A field beside the Nile irrigated by an Archimedes screw. A hardware store in Brisbane, Australia. A seedy bar on the wrong side of Houston. Until post WWII, heart surgery did not exist. Ticker provides a riveting history of the pioneers who gave their all to the courageous process of cutting into the only organ humans cannot live without. Heart surgeons Michael DeBakey and Denton Cooley, whose feud dominated the dramatic beginnings of heart surgery. Christian Barnaard, who changed the world overnight by performing the first heart transplant. Inventor Robert Jarvik, whose artificial heart made patient Barney Clark a worldwide symbol of both the brilliant promise of technology and the devastating evils of experimentation run amuck. Rich in supporting players, Ticker introduces us to Bud’s brilliant colleagues in his quixotic quest to develop an artificial heart: Billy Cohn, the heart surgeon and inventor who devotes his spare time to the pursuit of magic and music; Daniel Timms, the Brisbane biomedical engineer whose design of a lightweight, pulseless heart with but a single moving part offers a new way forward. And, as government money dries up, the unlikeliest of backers, Houston’s furniture king, Mattress Mack. In a sweeping narrative of one man’s obsession, Swartz raises some of the hardest questions of the human condition. What are the tradeoffs of medical progress? What is the cost, in suffering and resources, of offering patients a few more months, or years of life? Must science do harm to do good? Ticker takes us on an unforgettable journey into the power and mystery of the human heart.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    He regales us with stories of spontaneous human combustion; vicious tribes of tailed men; the Two-Headed Boy of Bengal; Mary Toft, who allegedly gave birth to seventeen rabbits; and Julia Pastrana, exhibited around the world as the Ape Woman. Bondeson combines an historian's skill in showing us our timeless fascination with the grotesque with a physician's diagnostic abilities, as he examines the evidence and provides likely explanations for these peculiar events.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    Sparked by her unexpected encounter with the surviving roses he planted in 1936, Solnit’s account of this understudied aspect of Orwell’s life explores his writing and his actions—from going deep into the coal mines of England, fighting in the Spanish Civil War, critiquing Stalin when much of the international left still supported him (and then critiquing that left), to his analysis of the relationship between lies and authoritarianism. Through Solnit’s celebrated ability to draw unexpected connections, readers encounter the photographer Tina Modotti’s roses and her Stalinism, Stalin’s obsession with forcing lemons to grow in impossibly cold conditions, Orwell’s slave-owning ancestors in Jamaica, Jamaica Kincaid’s critique of colonialism and imperialism in the flower garden, and the brutal rose industry in Colombia that supplies the American market. The book draws to a close with a rereading of Nineteen Eighty-Four that completes her portrait of a more hopeful Orwell, as well as a reflection on pleasure, beauty, and joy as acts of resistance.

    From the fourteenth-century plague to HIV/AIDS today, diseases have fundamentally altered the shape of society, politics, and culture. In a sweeping, thoughtful account, "Twelve Diseases That Changed Our World" considers the history of twelve important diseases: their impact, their consequences, their costs, and the lessons learned. Examining hemophilia, blight, tuberculosis, cholera, smallpox, bubonic plague, influenza, malaria, yellow fever, and syphilis, this book not only covers the diseases' histories but also addresses public health responses and societal upheavals. Historical perspectives on these diseases will be indispensable for a better understanding of how we and our forbearers survived the onslaught of "plagues" and how we might avoid their devastating consequences in the future. Crucial to this examination is exploring how past experience can help us to deal effectively with "coming plagues." Whether attempts to control outbreaks were successful or not, lessons can be learned that are crucial for disease containment today. Most significantly, this book explains the lessons learned from attempts to contain past disease outbreaks and how that knowledge can be utilized in the future. Despite the challenges that a major epidemic presents, "Twelve Diseases That Changed Our World" also details various past successes in which diseases were brought under control and social disorder was minimized.

    Some even call him the Grandfather of Goth.But who was this man, who lived with over twenty thousand books and six cats, who roomed with Frank O'Hara at Harvard, and was known--in the late 1940s, no less--to traipse around in full-length fur coats, clanking bracelets, and an Edwardian beard? An eccentric, a gregarious recluse, an enigmatic auteur of whimsically morbid masterpieces, yes but who was the real Edward Gorey behind the Oscar Wildean pose?He published over a hundred books and illustrated works by Samuel Beckett, T.S. Eliot, Edward Lear, John Updike, Charles Dickens, Hilaire Belloc, Muriel Spark, Bram Stoker, Gilbert & Sullivan, and others. At the same time, he was a deeply complicated and conflicted individual, a man whose art reflected his obsessions with the disquieting and the darkly hilarious.Based on newly uncovered correspondence and interviews with personalities as diverse as John Ashbery, Donald Hall, Lemony Snicket, Neil Gaiman, and Anna Sui, Born to be Posthumous draws back the curtain on the eccentric genius and mysterious life of Edward Gorey.

    As body armor and advanced trauma care helped save the lives—if not the limbs—of American soldiers fighting in Afghanistan and Iraq, Walter Reed quickly became the world leader in amputee rehabilitation. But no matter the injury, physical therapy began the moment the soldiers emerged from surgery. Days at Walter Reed were intense, chaotic, consuming, and heartbreaking, but they were also filled with camaraderie and humor. Working in a glassed-in fishbowl gymnasium, Levine, her colleagues, and their combat-injured patients were on display at every moment to tour groups, politicians, and celebrities. Some would shudder openly at the sight—but inside the glass and out of earshot, the PTs and the patients cracked jokes, played pranks, and compared stumps. With dazzling storytelling, Run, Don’t Walk introduces a motley array of oddball characters including:  Jim, a retired lieutenant-colonel who stays up late at night baking cake after cake, and the militant dietitian who is always after him; a surgeon who only speaks in farm analogies; a therapy dog gone rogue; —and Levine’s toughest patient, the wild, defiant Cosmo, who comes in with one leg amputated and his other leg shattered. Entertaining, engrossing, and ultimately inspiring, Run, Don’t Walk is a fascinating look into a hidden world.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.

    McGregor, and many other Beatrix Potter characters remain in the hearts of millions. However, though Potter is a household name around the world, few know the woman behind the illustrations. Her personal life, including a romantic relationship with her publisher, Norman Warne, and her significant achievements outside of children's literature remain largely unknown. In Linda Lear's enchanting new biography, we get the life story of this incredible, funny, and independent woman. As one of the first female naturalists in the world, Potter brought the beauty and importance of nature back into the imagination at a time when plunder was more popular than preservation. Through her art she sought to encourage conservation and change the world. With never before seen illustrations and intimate detail, Lear goes beyond our perrenial fascination with Potter as a writer and illustrator of children's books, and delves deeply into the life of a most unusual and gifted woman--one whose art was timeless, and whose generosity left an indelible imprint on the countryside.

    A lyrical journey from hope to despair and back again, The First Cell explores cancer from every angle: medical, scientific, cultural, and personal. Indeed, Raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. Like When Breath Becomes Air, The First Cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear.

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    Often they seem aloof, uncaring, and hurried. Of course, they’re not all like that, and most didn’t start out that way. Here are voices of third-year students just as they begin to take on clinical responsibilities. Their words focus on the odd transition students face when they must deal with real people in real time and in real crises and when they must learn to put aside their emotions to make quick, accurate, and sensitive decisions. Their decisions aren’t always right, and the consequences can be life-altering—for all involved. Moving, disturbing, and candid, their true stories show us a side of the profession that few ever see, or could even imagine. They show, often painfully, how medical students grow up, right at the bedside.

    Her beloved Little House series tells a classic coming-of-age story based on Wilder’s own family life and is a reflection of the pioneer spirit of the time. They are also deeply rooted in the natural world. The plants, animals, and landscapes are so integral to the stories, they are practically their own characters. The World of Laura Ingalls Wilder, by New York Times bestselling author Marta McDowell, explores Wilder’s deep relationship to the landscape. Follow the wagon trail of the series, starting in the Wisconsin setting of Little House in the Big Woods to the Dakotas and finally to Missouri. Throughout, you’ll learn details about Wilder’s life and inspirations, discover how to visit the real places today, and even learn to grow the plants and vegetables featured in the stories.  The artful package includes original illustrations by Helen Sewell and Garth Williams, along with historical and contemporary photographs. The World of Laura Ingalls Wilder is a must-have treasure for the millions of readers enchanted by Laura’s wild and beautiful life.