This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    In this biography, Laura Thompson describes the Edwardian world in which she grew up, explores the relationships she had, including those with her two husbands and daughter, and investigates the mysteries still surrounding Christie's life - including her disappearance in 1926. Agatha Christie is a mystery and writing about her is a detection job in itself. But, with access to all of Christie's letters, papers and writing notebooks, as well as interviews with her grandson, daughter, son-in-law, and their living relations, Thompson is able to unravel not only the detailed workings of Christie's detective fiction but the truth behind her private life as well.

    Her father, Maharajah Duleep Singh, was heir to the Kingdom of the Sikhs, one of the greatest empires of the Indian subcontinent, a realm that stretched from the lush Kashmir Valley to the craggy foothills of the Khyber Pass and included the mighty cities of Lahore and Peshawar. It was a territory irresistible to the British, who plundered everything, including the fabled Koh-I-Noor diamond. Exiled to England, the dispossessed Maharajah transformed his estate at Elveden in Suffolk into a Moghul palace, its grounds stocked with leopards, monkeys and exotic birds. Sophia, god-daughter of Queen Victoria, was raised a genteel aristocratic Englishwoman: presented at court, afforded grace and favor lodgings at Hampton Court Palace and photographed wearing the latest fashions for the society pages. But when, in secret defiance of the British government, she travelled to India, she returned a revolutionary. Sophia transcended her heritage to devote herself to battling injustice and inequality, a far cry from the life to which she was born. Her causes were the struggle for Indian Independence, the fate of the lascars, the welfare of Indian soldiers in the First World War – and, above all, the fight for female suffrage. She was bold and fearless, attacking politicians, putting herself in the front line and swapping her silks for a nurse's uniform to tend wounded soldiers evacuated from the battlefields. Meticulously researched and passionately written, this enthralling story of the rise of women and the fall of empire introduces an extraordinary individual and her part in the defining moments of recent British and Indian history.

    The Butcher tells the riveting true story of a hit man who loved his work too much—a maniac believed responsible for more than sixty remarkably brutal murders—whom even organized crime’s most cold-blooded assassins feared. Another riveting journey into the darkest corners of the underworld, Carlo’s The Butcher is destined to be a true crime classic alongside Wiseguys by Nicholas Pileggi and Underboss by Peter Maas.

    In some ways the model for the new wave of adventure books, Adrift is an undeniable seafaring classic, a riveting firsthand account by the only man known to have survived more than a month alone at sea, fighting for his life in an inflatable raft after his small sloop capsized only six days out. Adrift is a must-have for any adventure library.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write an exploration of family, history, and love.

    When famed archaeologist Arthur Evans unearthed the ruins of a sophisticated Bronze Age civilization that flowered on Crete 1,000 years before Greece's Classical Age, he discovered a cache of ancient tablets, Europe's earliest written records. For half a century, the meaning of the inscriptions, and even the language in which they were written, would remain a mystery. Award-winning New York Times journalist Margalit Fox's riveting real-life intellectual detective story travels from the Bronze Age Aegean--the era of Odysseus, Agamemnon, and Helen--to the turn of the 20th century and the work of charismatic English archeologist Arthur Evans, to the colorful personal stories of the decipherers. These include Michael Ventris, the brilliant amateur who deciphered the script but met with a sudden, mysterious death that may have been a direct consequence of the decipherment; and Alice Kober, the unsung heroine of the story whose painstaking work allowed Ventris to crack the code.

     Trust.  Triumph.I trust Roselle with my life, every day. She trusts me to direct her. And today is no different, except the stakes are higher. Michael HingsonFirst came the boom the loud, deep, unapologetic bellow that seemed to erupt from the very core of the earth. Eerily, the majestic high-rise slowly leaned to the south. On the seventy-eighth floor of the World Trade Center's north tower, no alarms sounded, and no one had information about what had happened at 8:46 a.m. on September 11, 2001. What should have been a normal workday for thousands of people. All that was known to the people inside was what they could see out the windows: smoke and fire and millions of pieces of burning paper and other debris falling through the air.Blind since birth, Michael couldn't see a thing, but he could hear the sounds of shattering glass, falling debris, and terrified people flooding around him and his guide dog, Roselle. However, Roselle sat calmly beside him. In that moment, Michael chose to trust Roselle's judgment and not to panic. They are a team.Thunder Dog allows you entry into the isolated, fume-filled chamber of stairwell B to experience survival through the eyes of a blind man and his beloved guide dog. Live each moment from the second a Boeing 767 hits the north tower, to the harrowing stairwell escape, to dodging death a second time as both towers fold into the earth.It's the 9/11 story that will forever change your spirit and your perspective. Thunder Dog illuminates Hingson's lifelong determination to achieve parity in a sighted world, and how the rare trust between a man and his guide dog can inspire an unshakable faith in each one of us.

    She also lectures widely on autism—because Temple Grandin is autistic, a woman who thinks, feels, and experiences the world in ways that are incomprehensible to the rest of us. In this unprecedented book, Grandin delivers a report from the country of autism. Writing from the dual perspectives of a scientist and an autistic person, she tells us how that country is experienced by its inhabitants and how she managed to breach its boundaries to function in the outside world. What emerges in Thinking in Pictures is the document of an extraordinary human being, one who, in gracefully and lucidly bridging the gulf between her condition and our own, sheds light on the riddle of our common identity.

    His life and this book remind us that America remains the land of the brave and generous.” — Tom Brokaw Like many young idealists, Eric Greitens wanted to make a difference, so he traveled to the world’s trouble spots to work in refugee camps and serve the sick and the poor. Yet when innocent civilians were threatened with harm, there was nothing he could do but step in afterward and try to ease the suffering. In studying humanitarianism, he realized a fundamental truth: when an army invades, the weak need protection. So he joined the Navy SEALs and became one of the world’s elite warriors. Greitens led his men through the unforgettable soul-testing of SEAL training and went on to deployments in Kenya, Afghanistan, and Iraq, where he faced harrowing encounters and brutal attacks. Yet even in the deadliest combat situations, the lessons of his humanitarian work bore fruit. At the heart of this powerful story lies a paradox: sometimes you have to be strong to do good, but you also have to do good to be strong. The heart and the fist together are more powerful than either one alone. “If you're restless or itching for some calling you can't name, read this book. Give it to your son and daughter. The Heart and the Fist epitomizes — as does Mr. Greitens's life, present and future — all that is best in this country, and what we need desperately right now.” — Steven Pressfield, author of Gates of Fire “Vivid and compelling . . . a great read.” — Washington Times A Hudson Booksellers Top Ten Nonfiction Book of the Year A USA Today and Publishers Weekly Bestseller WITH A NEW AFTERWORD

    Through the eyes of this black woman, we see a wide range of historical figures and events of the antebellum South, the Washington of the Civil War years, and the final stages of the war.

    Drawing on a rich store of materials from the archives of Highclere Castle, including diaries, letters, and photographs, the current Lady Carnarvon has written a transporting story of this fabled home on the brink of war.    Much like her Masterpiece Classic counterpart, Lady Cora Crawley, Lady Almina was the daughter of a wealthy industrialist, Alfred de Rothschild, who married his daughter off at a young age, her dowry serving as the crucial link in the effort to preserve the Earl of Carnarvon's ancestral home.  Throwing open the doors of Highclere Castle to tend to the wounded of World War I, Lady Almina distinguished herself as a brave and remarkable woman.    This rich tale contrasts the splendor of Edwardian life in a great house against the backdrop of the First World War and offers an inspiring and revealing picture of the woman at the center of the history of Highclere Castle.

    But after three divorces, she ran away to make a life for herself in one of the largest cities in the world: Edo.In the book we experience the drama and excitement of Edo just prior to the arrival of American Commodore Perry’s fleet, which transformed Japan. During this pivotal moment in Japanese history, Tsuneno bounces from tenement to tenement, marries a masterless samurai, and eventually enters the service of a famous city magistrate. Tsuneno’s life provides a window into 19th-century Japanese culture—and a rare view of an extraordinary woman who sacrificed her family and her reputation to make a new life for herself, in defiance of social conventions.

    A prize-winning, successful novelist in her 30s, McCracken was happy to be an itinerant writer and self-proclaimed spinster. But suddenly she fell in love, got married, and two years ago was living in a remote part of France, working on her novel, and waiting for the birth of her first child.This book is about what happened next. In her ninth month of pregnancy, she learned that her baby boy had died. How do you deal with and recover from this kind of loss? Of course you don't--but you go on. And if you have ever experienced loss or love someone who has, the company of this remarkable book will help you go on.