Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities. . . .But, Zimmer writes, "Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are--our appearance, our height, our penchants--in inconceivably subtle ways." Heredity isn't just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors--using a word that once referred to kingdoms and estates--but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world's best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.

    Now, in The New Science of the Human Past, Reich describes just how the human genome provides not only all the information that a fertilized human egg needs to develop but also contains within it the history of our species. He delineates how the Genomic Revolution and ancient DNA are transforming our understanding of our own lineage as modern humans; how genomics deconstructs the idea that there are no biologically meaningful differences among human populations (though without adherence to pernicious racist hierarchies); and how DNA studies reveal the deep history of human inequality--among different populations, between the sexes, and among individuals within a population.

    Evo Devo Evolutionary Developmental Biology is the new science that has finally cracked open the box. Within the pages of his rich and riveting book, Sean B. Carroll explains how we are discovering that complex life is ironically much simpler than anyone ever expected.

    Darwin was only too aware of the storm his theory of evolution would provoke but he would surely have raised an incredulous eyebrow at the controversy still raging a century and a half later. Evolution is accepted as scientific fact by all reputable scientists and indeed theologians, yet millions of people continue to question its veracity.In The Greatest Show on Earth Richard Dawkins takes on creationists, including followers of ‘Intelligent Design’ and all those who question the fact of evolution through natural selection. Like a detective arriving on the scene of a crime, he sifts through fascinating layers of scientific facts and disciplines to build a cast-iron case: from the living examples of natural selection in birds and insects; the ‘time clocks’ of trees and radioactive dating that calibrate a timescale for evolution; the fossil record and the traces of our earliest ancestors; to confirmation from molecular biology and genetics. All of this, and much more, bears witness to the truth of evolution.The Greatest Show on Earth comes at a critical time: systematic opposition to the fact of evolution is now flourishing as never before, especially in America. In Britain and elsewhere in the world, teachers witness insidious attempts to undermine the status of science in their classrooms. Richard Dawkins provides unequivocal evidence that boldly and comprehensively rebuts such nonsense. At the same time he shares with us his palpable love of the natural world and the essential role that science plays in its interpretation. Written with elegance, wit and passion, it is hard-hitting, absorbing and totally convincing.

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    In 1887, 23-year-old reporter Nellie Bly had herself committed to a New York City asylum for 10 days to expose the horrific conditions for 19th-century century mental patients.

    Yet despite advanced training in cancer genetics and years of practicing medicine, Dr. Theo Ross was never certain whether the history of cancers in her family was simple bad luck or a sign that they were carriers of a cancer-causing genetic mutation. Then she was diagnosed with melanoma, and for someone with a dark complexion, melanoma made no sense. It turned out there was a genetic factor at work.   Using her own family’s story, the latest science of cancer genetics, and her experience as a practicing physician, Ross shows readers how to spot the patterns of inherited cancer, how to get tested for cancer-causing genes, and what to do if you have one. With a foreword by Siddartha Mukherjee, prize winning author of The Emperor of All Maladies, this will be the first authoritative, go-to for people facing inherited cancer, this book empowers readers to face their genetic heritage without fear and to make decisions that will keep them and their families healthy.

    Today, it is the most common form of officially classified mental illness. Scott Stossel gracefully guides us across the terrain of an affliction that is pervasive yet too often misunderstood. Drawing on his own long-standing battle with anxiety, Stossel presents an astonishing history, at once intimate and authoritative, of the efforts to understand the condition from medical, cultural, philosophical, and experiential perspectives. He ranges from the earliest medical reports of Galen and Hippocrates, through later observations by Robert Burton and Søren Kierkegaard, to the investigations by great nineteenth-century scientists, such as Charles Darwin, William James, and Sigmund Freud, as they began to explore its sources and causes, to the latest research by neuroscientists and geneticists. Stossel reports on famous individuals who struggled with anxiety, as well as on the afflicted generations of his own family. His portrait of anxiety reveals not only the emotion’s myriad manifestations and the anguish anxiety produces but also the countless psychotherapies, medications, and other (often outlandish) treatments that have been developed to counteract it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze—while at the same time exploring how those who suffer from it find ways to manage and control it. My Age of Anxiety is learned and empathetic, humorous and inspirational, offering the reader great insight into the biological, cultural, and environmental factors that contribute to the affliction.

    Connor's the star of the track team, the valedictorian, a demigod living among the students at Rose Hill High School. But Kyle is more of a loner who's most comfortable playing video games in the basement. Also, these twins were born two years apart.Conceived in vitro at the Genesis Innovations Laboratory after their parents struggled to have children, the boys were carried separately; they thought it'd be safer that way. And it was, until Connor suddenly dies of a heart attack on his eighteenth birthday. Soon Kyle learns of other kids conceived in the Genesis lab who've died the exact same way. It turns out the doctor their parents enlisted to help them may not have been everything he seemed. He gave them perfect children, but with one fatal flaw.Just as he's falling in love, Kyle's caught in a race against time to unlock the secrets hidden in his DNA. A thrilling adventure that will keep readers guessing at every turn, Deadly Design is packed with adrenaline and heart.

    Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences.In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility.A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.

    I was mentally and physically broken. So fractured, I hadn't eaten properly or slept well, or even changed my expression for months. I sat in a cubicle, behind paper-thin curtains, listening to the rest of the hospital happen around me, and I shook with the effort of not crying. I was an inch away from defeat, from the acceptance of a failure I assumed would be inevitable, but I knew I had to carry on. I had to somehow walk through it.Because I wasn't the patient. I was the doctor."A frank account of mental health from both sides of the doctor-patient divide, from the bestselling author of The Trouble with Goats and Sheep and Three Things About Elsie, based on her own experience as a doctor working on a psychiatric ward.

    Six years later she made her first suicide attempt, then wandered the streets of New York City dressed in ragged clothes, tormenting voices crying out in her mind. Lori Schiller had entered the horrifying world of full-blown schizophrenia. She began an ordeal of hospitalizations, halfway houses, relapses, more suicide attempts, and constant, withering despair. But against all odds, she survived. Now in this personal account, she tells how she did it, taking us not only into her own shattered world, but drawing on the words of the doctors who treated her and family members who suffered with her.In this new edition, Lori Schiller recounts the dramatic years following the original publication -- a period involving addiction, relapse, and ultimately, love and recovery.Moving, harrowing, and ultimately uplifting, THE QUIET ROOM is a classic testimony to the ravages of mental illness and the power of perseverance and courage.

    He "did," however, admit to dismembering her, boiling her bones, and hiding them in the Port Authority locker." At the heart of countless crimes lies the mystery of the human mind. In this eye-opening book, Dr. Cheryl Paradis draws back the curtain on the fascinating world of forensic psychology and revisits the most notorious and puzzling cases she has handled in her multifaceted career."Out it all came, a slew of bizarre comments about the electronic chips implanted in his brain."Her riveting, sometimes shocking stories reveal the crucial and often surprising role forensic psychology plays in the pursuit of justice. Sometimes the accused believe their own bizarre lies, creating a world that pushes them into frightening, violent crimes."My client is charged with murder and tells me he is a descendent of kings. He says he is of royal blood. Can you evaluate him for an insanity defense?"Join Dr. Paradis in a stark concrete cell, with the accused handcuffed to a chair opposite her, as she takes on the daunting task of mapping the suspect's madness--or exposing it as fakery. Have a front-row seat in a tense, packed courtroom, where her testimony can determine an individual's fate. The criminal mind has never been so intimately revealed--or so darkly compelling."A forensic psychologist reveals the dark and troubling human mind. Fascinating."--Robert K. Tanenbaum The Experts PraiseThe Measure of Madness"Fascinating . . . A forensic psychologist reveals the dark and powerful motives that challenge our justice system and opens up the troubling workings of the human mind."--Robert K. Tanenbaum, author of "Capture""Compelling . . . Dr. Cheryl Paradis offers a window into the world of a clinical psychologist who has made many assessments for the courts."--Katherine Ramsland, author of "The Criminal Mind""Eloquent . . . Anyone concerned with the relationship between deviance and mental illness will find this excellent book to be of great value."--Simon Baatz, author of "For the Thrill of It: Leopold, Loeb and the Murder that Shocked Chicago""Clearly written and comprehensive . . . Dr. Paradis skillfully leads the reader through the labyrinth of the psychotic criminal mind and the maze of the judicial system."--Barbara Kirwin, author of "The Mad, the Bad, and the Innocent""Insightful, remarkable . . . not to be missed if you want to understand the real-world dramas that underlie criminal justice."--Barbara Oakley, author of "Evil Genes""Informative, discussion-provoking . . . a much needed, intriguing collection of personal reflections as well as fascinating cases."--Thomas M. O'Rourke, Director of Forensic Psychiatry, Kings County Hospital Center"Riveting . . .Cheryl Paradis shows us a world rarely seen and one full of mystery."--John Coston, author of "To Kill and Kill Again" and "Sleep My Child Forever""Lucid, intelligent, provocative . . . Cheryl Paradis is an articulate expert guide to the bizarre and routinely baffling world of irrational and aberrant crime."--Stephen G. Michaud, author of "The Only Living Witness" and "Whisper of Fear""A marvelous book . . . a masterpiece that not only beautifully describes the people she examines but, just as importantly, fills in the dialogues between herself and others and includes her own thoughts and feelings. This book stands out."--Daniel W. Schwartz, M.D., Director (Ret.) of Forensic Psychiatry Service, Kings County Hospital"Written with clarity, objectivity, and expertise . . . Cheryl Paradis draws you into the fascinating world of the forensic psychologist and into the minds and often disturbing motives of the defendants she has examined."--Robert H. Berger, M.D., Clinical Professor of Psychiatry, New York University School of Medicine"Chilling . . . "The Measure of Madness" is an insider's view of a world few of us really know. Dr. Paradis makes clear that the reality of criminal forensic psychology is far different -- and far more fascinating -- than that portrayed in TV and movies. Fans of 'CSI' and 'Law and Order' as well as criminal law practitioners will find this book hard to resist."--Robert Reuland, criminal defense attorney and author of "Hollowpoint" and "Semiautomatic""A down-to-earth, tell-all case book . . . an unvarnished insider's view into the fascinating world of forensic psychology and the minds of mentally ill criminal offenders. This book will be of interest not only to forensic specialists, but to all those who have ever thought of entering this vexing but richly rewarding profession or wondered what it might be like to take an intimate look at the criminally insane."--Sanford L. Drob, Ph.D., former Director of Psychological Assessment at Bellevue Hospital, New York"Engaging, vivid, invaluable . . . a fascinating look at real-life case materials from the author's own practice as a forensic psychologist. The accounts of criminal defendants whose minds are on trial and the issues that Paradis must determine in making her evaluations make this book a must-read for anyone interested in the intersection of psychology and criminal law."--Patricia E. Erickson, J.D., Ph.D., co-author of "Crime, Punishment, and Mental Illness: Law and the Behavioral Sciences in Conflict" "The criminal justice system fascinates most of us but too often the violence seems incomprehensible. Cheryl Paradis' intriguing account of a number of her cases from the viewpoint of a forensic psychologist is informative and provides an inside look at crime and mental illness, something we all need to know a lot more about."--Leslie Crocker Snyder, former New York state Supreme Court Judge, author of "25 to Life

    They were hunter-gatherers, consummate foraging experts, but taking the world as they found it. Then a revolution occurred – our ancestors’ interaction with other species changed. They began to tame them. The human population boomed; civilization began.In her new book, Tamed, Alice Roberts uncovers the amazing deep history of ten familiar species with incredible wild pasts: dogs, apples and wheat; cattle; potatoes and chickens; rice, maize, and horses – and, finally, humans. Alice Roberts not only reveals how becoming part of our world changed these animals and plants, but shows how they became our allies, essential to the survival and success of our own species – and to our future.Enlightening, wide-ranging and endlessly fascinating, Tamed is an epic story, encompassing hundreds of thousands of years of history and archaeology alongside cutting-edge genetics and anthropology. Yet it is also a deeply personal journey that will change how we see ourselves and the species on which we have left our mark.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.