Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, sleep apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep--and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while "sleep-eating." The teenager prone to the serious, yet unfortunately nicknamed "Sleeping Beauty Syndrome" stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hyper-sexuality while awake.With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    Contrary to what the glossy magazines would have us believe, we do not enjoy potato chips because they crunch just like the insects our forebears snacked on. As Zuk argues, such beliefs incorrectly assume that we’re stuck—finished evolving—and have been for tens of thousands of years. She draws on fascinating evidence that examines everything from adults’ ability to drink milk to the texture of our ear wax to show that we’ve actually never stopped evolving. Our nostalgic visions of an ideal evolutionary past in which we ate, lived, and reproduced as we were “meant to” fail to recognize that we were never perfectly suited to our environment. Evolution is about change, and every organism is full of trade-offs.From debunking the caveman diet to unraveling gender stereotypes, Zuk gives an analysis of widespread paleofantasies and the scientific evidence that undermines them, all the while broadening our understanding of our origins and what they can really tell us about our present and our future.

    Although there are more than thirty thousand species of fish—more than all mammals, birds, reptiles, and amphibians combined—we rarely consider how individual fishes think, feel, and behave. Balcombe upends our assumptions about fishes, portraying them not as unfeeling, dead-eyed feeding machines but as sentient, aware, social, and even Machiavellian—in other words, much like us. What a Fish Knows draws on the latest science to present a fresh look at these remarkable creatures in all their breathtaking diversity and beauty. Fishes conduct elaborate courtship rituals and develop lifelong bonds with shoalmates. They also plan, hunt cooperatively, use tools, curry favor, deceive one another, and punish wrongdoers. We may imagine that fishes lead simple, fleeting lives—a mode of existence that boils down to a place on the food chain, rote spawning, and lots of aimless swimming. But, as Balcombe demonstrates, the truth is far richer and more complex, worthy of the grandest social novel. Highlighting breakthrough discoveries from fish enthusiasts and scientists around the world and pondering his own encounters with fishes, Balcombe examines the fascinating means by which fishes gain knowledge of the places they inhabit, from shallow tide pools to the deepest reaches of the ocean. Teeming with insights and exciting discoveries, What a Fish Knows offers a thoughtful appraisal of our relationships with fishes and inspires us to take a more enlightened view of the planet’s increasingly imperiled marine life. What a Fish Knows will forever change how we see our aquatic cousins—the pet goldfish included.

    To the right listener, they tell us all about themselves: where they came from, how they lived, how they died - and who killed them. Forensic scientists can unlock the mysteries of the past and help justice to be done using the messages left by a corpse, a crime scene or the faintest of human traces. Forensics uncovers the secrets of forensic medicine, drawing on interviews with top-level professionals, ground-breaking research and Val McDermid's own experience to lay bare the secrets of this fascinating science. And, along the way, she wonders at how maggots collected from a corpse can help determine time of death, how a DNA trace a millionth the size of a grain of salt can be used to convict a killer and how a team of young Argentine scientists led by a maverick American anthropologist uncovered the victims of a genocide.In her crime novels, Val McDermid has been solving complex crimes and confronting unimaginable evil for years. Now, she's looking at the people who do it for real, and real crime scenes. It's a journey that will take her to war zones, fire scenes and autopsy suites, and bring her into contact with extraordinary bravery and wickedness, as she traces the history of forensics from its earliest beginnings to the cutting-edge science of the modern day.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    Gut, an international bestseller, gives the alimentary canal its long-overdue moment in the spotlight. With quirky charm, rising science star Giulia Enders explains the gut’s magic, answering questions like: Why does acid reflux happen? What’s really up with gluten and lactose intolerance? How does the gut affect obesity and mood? Communication between the gut and the brain is one of the fastest-growing areas of medical research—on par with stem-cell research. Our gut reactions, we learn, are intimately connected with our physical and mental well-being. Enders’s beguiling manifesto will make you finally listen to those butterflies in your stomach: they’re trying to tell you something important.

    Yet The Origin of Species (1859) is also a humane and inspirational vision of ecological interrelatedness, revealing the complex mutual interdependencies between animal and plant life, climate and physical environment, and—by implication—within the human world. Written for the general reader, in a style which combines the rigour of science with the subtlety of literature, The Origin of Species remains one of the founding documents of the modern age.

    Her first book is a revelatory treatise on plant life—but it is also so much more. Lab Girl is a book about work, love, and the mountains that can be moved when those two things come together. It is told through Jahren’s stories: about her childhood in rural Minnesota with an uncompromising mother and a father who encouraged hours of play in his classroom’s labs; about how she found a sanctuary in science, and learned to perform lab work done “with both the heart and the hands”; and about the inevitable disappointments, but also the triumphs and exhilarating discoveries, of scientific work.Yet at the core of this book is the story of a relationship Jahren forged with a brilliant, wounded man named Bill, who becomes her lab partner and best friend. Their sometimes rogue adventures in science take them from the Midwest across the United States and back again, over the Atlantic to the ever-light skies of the North Pole and to tropical Hawaii, where she and her lab currently make their home.

    Scientists are confident that there is alien life across the universe yet we have not moved beyond our perception of 'aliens' as Hollywood stereotypes. The time has come to abandon our fixation on alien monsters and place our expectations on solid scientific footing.Using his own expert understanding of life on Earth and Darwin's theory of evolution - which applies throughout the universe - Cambridge zoologist Dr Arik Kershenbaum explains what alien life must be like: how these creatures will move, socialise and communicate.For example, by observing fishes whose electrical pulses indicate social status, we can see that other planets might allow for communication by electricity. As there was evolutionary pressure to wriggle along a sea floor, Earthling animals tend to have left/right symmetry; on planets where creatures evolved mid-air or in soupy tar they might be lacking any symmetry at all.Might there be an alien planet with supersonic animals? Will they scream with fear, act honestly, or have technology? Is the universe swarming with robots? Dr Kershenbaum uses cutting-edge science to paint an entertaining and compelling picture of extra-terrestrial life.The Zoologist's Guide to the Galaxy is the story of how life really works, on Earth and in space.***'If you don't want to be surprised by extraterrestrial life, look no further than this lively overview of the laws of evolution that have produced life on earth' - Frans de Waal, author of Mama's Last Hug - Animal Emotions and What They Tell Us about Ourselves'A fun, and thoroughly biological, exploration of possible and impossible alien beings. If you'd love to know what real aliens from other planets might really be like, this is the book for you' - Susan Blackmore, author of Seeing Myself'Surveying the deep-time of evolution on Earth and his own cutting-edge research into animal communication, Kershenbaum provides a fascinating insight into the deepest of questions: what might an alien actually look like'- Lewis Dartnell, author of Origins'Arik Kershenbaum takes us on a joyous voyage of animal diversity and illustrates the singular importance of natural selection in explaining life - here on Earth - and what will likely be discovered throughout the galaxy. A stimulating read!' - Daniel T. Blumstein, Professor of Ecology and Evolutionary Biology, University of California Los Angeles

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Today there is just one. Us. Homo sapiens. How did our species succeed in the battle for dominance? Why did our foraging ancestors come together to create cities and kingdoms? How did we come to believe in gods, nations and human rights; to trust money, books and laws; and to be enslaved by bureaucracy, timetables and consumerism? And what will our world be like in the millennia to come? In Sapiens, Dr Yuval Noah Harari spans the whole of human history, from the very first humans to walk the earth to the radical – and sometimes devastating – breakthroughs of the Cognitive, Agricultural and Scientific Revolutions. Drawing on insights from biology, anthropology, paleontology and economics, he explores how the currents of history have shaped our human societies, the animals and plants around us, and even our personalities. Have we become happier as history has unfolded? Can we ever free our behaviour from the heritage of our ancestors? And what, if anything, can we do to influence the course of the centuries to come? Bold, wide-ranging and provocative, Sapiens challenges everything we thought we knew about being human: our thoughts, our actions, our power ... and our future.

    In this book, he expands the points he has made, and claims that this debate is not so much about religion versus science, as about the nature of science itself. With infectious enthusiasm, he reveals the mechanics of evolutionary theory, explains how it is rooted in the testable and verifiable scientific method, and why it is therefore a sound explanation of our beginning. He argues passionately that to continue to assert otherwise, to continue to insist that creationism has a place in the science classroom is harmful not only to our children, but to the future of the greater world as well.

    Why does music evoke such powerful moods? The answers are at last be- coming clear, thanks to revolutionary neuroscience and the emerging field of evolutionary psychology. Both a cutting-edge study and a tribute to the beauty of music itself, This Is Your Brain on Music unravels a host of mysteries that affect everything from pop culture to our understanding of human nature, including: • Are our musical preferences shaped in utero? • Is there a cutoff point for acquiring new tastes in music? • What do PET scans and MRIs reveal about the brain’s response to music? • Is musical pleasure different from other kinds of pleasure?This Is Your Brain on Music explores cultures in which singing is considered an essential human function, patients who have a rare disorder that prevents them from making sense of music, and scientists studying why two people may not have the same definition of pitch. At every turn, this provocative work unlocks deep secrets about how nature and nurture forge a uniquely human obsession.