But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    The human system for processing sound is a biological marvel, an intricate assembly of delicate membranes, bones, receptor cells, and neurons. Yet many people take their ears for granted, abusing them with loud restaurants, rock concerts, and Q-tips. And then, eventually, most of us start to go deaf.Millions of Americans suffer from hearing loss. Faced with the cost and stigma of hearing aids, the natural human tendency is to do nothing and hope for the best, usually while pretending that nothing is wrong. In Volume Control, David Owen argues this inaction comes with a huge social cost. He demystifies the science of hearing while encouraging readers to get the treatment they need for hearing loss and protect the hearing they still have.Hearing aids are rapidly improving and becoming more versatile. Inexpensive high-tech substitutes are increasingly available, making it possible for more of us to boost our weakening ears without bankrupting ourselves. Relatively soon, physicians may be able to reverse losses that have always been considered irreversible. Even the insistent buzz of tinnitus may soon yield to relatively simple treatments and techniques. With wit and clarity, Owen explores the incredible possibilities of technologically assisted hearing. And he proves that ears, whether they're working or not, are endlessly interesting.

    In the same period it also produced treatments to control the progress of Parkinson's, rheumatoid arthritis, and schizophrenia. It made realities of open-heart surgery, organ transplants, test-tube babies. Unquestionably, the medical accomplishments of the postwar years stand at the forefront of human endeavor, yet progress in recent decades has slowed nearly to a halt. In this winner of the Los Angeles Times Book Prize, medical doctor and columnist James Le Fanu both surveys the glories of medicine in the postwar years and analyzes the factors that for the past twenty-five years have increasingly widened the gulf between achievement and advancement: the social theories of medicine, ethical issues, and political debates over health care that have hobbled the development of vaccines and discovery of new "miracle" cures. While fully demonstrating the extraordinary progress effected by medical research in the latter half of the twentieth century, Le Fanu also identifies the perils that confront medicine in the twenty-first. 16 pages of black-and-white photographs add to what the Los Angeles Times cited as "a sobering, contrarian challenge" to the "nostrum of medicine as a never-ending font of ‘miracle cures'." "[From] a respected science writer ... important information that ... has been overlooked or ignored by many physicians." —New Republic "Provocative and engrossing and informative." —Houston Chronicle "Marvelously written, meticulously researched ... one of the most thought-provoking and important works to appear in recent years." —Choice

    This practical text reviews basic microbiology and how to approach the pharmacotherapy of a patient with a presumed infection. It also contains concise Drug Class Reviews with an explanation of the characteristics of various classes of antibacterial drugs and antifungal drugs. Antibiotics Simplified, Third Edition simplifies learning infectious disease pharmacotherapy and condenses the many facts that are taught about antibiotics into one quick reference guide. This guide will help students learn the characteristics of antibiotics and why an antibiotic is useful for an indication. With an understanding of the characteristics of the antibiotics, students will be able to make a logical choice to treat an infection more easily. With helpful figures and flow charts, Drug Class Reviews, a Spectra of Activity chart, and an index for reference, this is an ideal handbook for students as well as practicing pharmacists, physicians, and other clinicians!

    . . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    In addition to the dozens of medications we take to treat serious illnesses, we take drugs to help us sleep, to keep us awake, to keep our noses from running, our backs from aching, and our minds from racing. Name a symptom, there's a pill to suppress it.Modern drugs can be miraculously life-saving, and many illnesses demand their use. But what happens when our reliance on powerful pharmaceuticals blinds us to their risks? Painful side effects and dependency are common, and adverse drug reactions are America's fourth leading cause of death.In Mind Over Meds, bestselling author Dr. Andrew Weil alerts readers to the problem of overmedication, and outlines when medicine is necessary, and when it is not. Dr. Weil examines how we came to be so drastically overmedicated, presents science that proves drugs aren't always the best option, and provides reliable integrative medicine approaches to treating common ailments like high blood pressure, allergies, depression, and even the common cold. With case histories, healthy alternative treatments, and input from other leading physicians, Mind Over Meds is the go-to resource for anyone who is sick and tired of being sick and tired.

    In What Is Life?, he takes up the challenge of describing what it means to be alive in a way that every reader can understand.It is a shared journey of discovery; step-by-step Nurse illuminates five great ideas that underpin biology—the Cell, the Gene, Evolution by Natural Selection, Life as Chemistry, and Life as Information. He introduces the scientists who made the most important advances, and, using his personal experiences in and out of the lab, he shares with us the challenges, the lucky breaks, and the thrilling eureka moments of discovery.Nurse writes with delight at life’s richness and with a sense of the urgent role of biology in our time. To survive the challenges that face us all today—climate change, pandemic, loss of biodiversity and food security—it is vital that we all understand what life is.

    It has found adherents in Silicon Valley billionaires Ray Kurzweil and Peter Diamandis. Google has entered the picture, establishing a bio-tech subsidiary aimed at solving the problem of aging.In To Be a Machine, journalist Mark O'Connell takes a headlong dive into this burgeoning movement. He travels to the laboratories, conferences, and basements of today's foremost transhumanists, where he's presented with the staggering possibilities and moral quandaries of new technologies like mind uploading, artificial superintelligence, cryonics, and device implants.A contributor to Slate, The New Yorker, and The New York Times Magazine, O'Connell serves as a sharp and lively guide to the outer limits of technology in the twenty first century. In investigating what it means to be a machine, he offers a surprising, singular meditation on what it means to be human."

    While it is an account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life.The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.

    Clegg—who studied physics at Cambridge University and specializes in making the strangest aspects of the universe accessible to the general reader —explores the Quantum Age, the revolution led by our understanding of the very, very small.Atoms, electrons, and photons of light are all quantum particles, acting totally unlike the objects we experience. This weird quantum behavior lies at the heart of every electronic device and powers lasers in everything from DVDs to eye correction. It is also behind quantum biology, the astonishing new realization that biological functions, from our ability to see and photosynthesis in plants to the amazing ability of birds to navigate, rely directly on quantum effects.We've all heard about how odd quantum theory is. But in this book, for the first time, Clegg reveals to a popular science audience precisely how useful it is. Incredible revelations along the way will thrill popular science fans and general readers alike.Brian Clegg is an acclaimed science writer published by Icon Books and St. Martin's Press. His books include Inflight Science, Dice World (forthcoming), The Universe Inside You, Gravity, and Extra-Sensory.

    We all have one, but most of us will never see one. The heart surgeon now has that privilege but, for centuries, the heart was out of reach even for surgeons. So when a surgeon nowadays opens up a ribcage and mends a heart, it remains something of a miracle, even if, to some, it is merely plumbing. As with plumbers, the quality of surgeons’ work varies. As with plumbers, surgeons’ opinion of their own prowess and their own attitude to risk are not always reliable. Measurement is key. We’ve had a century of effective evidence-based medicine. We’ve had barely a decade of thorough monitoring of clinical outcomes. Thanks to the ground-breaking risk modelling of pioneering surgeons like Samer Nashef, we at last know how to judge whether an operation is in a patient’s best interest, which hospital and surgeon would be best for that operation, when it might best be performed and what the exact level of risk is. We have at last made what is important in surgery measurable. But how should surgeons, and their patients, use these newfound insights? Ever since his days as a medical student, Samer Nashef has challenged the medical profession to be more open and more accurate about the success of surgical procedures, for the sake of the patients. In The Naked Surgeon, he unclothes his own profession to demonstrate to his reader (and prospective patient) many revelations, such as the paradox at the heart of the cardiac surgeon’s craft: the more an operation is likely to kill you, the better it is for you. And he does so with absolute clarity, fluency and not a little wit.

    Yet a real definition of “now” has eluded even the great Einstein. We know that time stretches and is affected by gravity and velocity. Yet, as eminent physicist Richard A. Muller points out, it is only today that we have all the physics at hand—relativity, entropy, entanglement, antimatter, and the Big Bang—to explain the flow of time. With these building blocks in place, Muller reaches a startling conclusion: our expanding universe is continuously creating not only new space but also new time. The front edge of this new time is what we call “now,” and this moment is truly unique—it is the only moment in which we can exercise our free will. Muller’s thought-provoking vision is a powerful counter to established theories in science and philosophy, and his arguments will spark major debate about the most fundamental assumptions of our universe.

    These assorted merchants, gardeners, barber-surgeons, midwives, instrument makers, mathematics teachers, engineers, alchemists, and other experimenters, she contends, formed a patchwork scientific community whose practices set the stage for the Scientific Revolution. While Francis Bacon has been widely regarded as the father of modern science, scores of his London contemporaries also deserve a share in this distinction. It was their collaborative, yet often contentious, ethos that helped to develop the ideals of modern scientific research.The book examines six particularly fascinating episodes of scientific inquiry and dispute in sixteenth-century London, bringing to life the individuals involved and the challenges they faced. These men and women experimented and invented, argued and competed, waged wars in the press, and struggled to understand the complexities of the natural world. Together their stories illuminate the blind alleys and surprising twists and turns taken as medieval philosophy gave way to the empirical, experimental culture that became a hallmark of the Scientific Revolution.

    In The Forgetting Machine, neuroscientist Rodrigo Quiroga explains how the mechanics of memory illuminates these discussions, with implications for everything from understanding Alzheimer's disease to the technology of Artificial Intelligence. You'll also learn about the research behind what Quiroga coined -Jennifer Aniston Neurons---cells in the human brain that are responsible for representing specific concepts, such as recognizing a certain celebrity's face. The discovery of these neurons opens new windows into the workings of human memory. In this accessible, fascinating look at the science of remembering, you'll learn how we turn perceptions into memories, how language shapes our experiences, and the crucial role forgetting plays in human recollection. You'll see how electricity, chemistry, and abstraction combine to form something more than the human brain--the human mind. And you'll gain surprising insight into what our brains can tell us about who we are. The Forgetting Machine takes us on a journey through science and science fiction, philosophy and identity, using what we know about how we remember (and forget) to explore the very roots of what makes us human.

    Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s.One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline.In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.