In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn’t everything, it’s the only thing—no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process.The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra’s dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison’s mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren’t all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong.Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    On the eve of this centenary, journalist Johann Hari set off on an epic three-year, thirty-thousand-mile journey into the war on drugs. What he found is that more and more people all over the world have begun to recognize three startling truths: Drugs are not what we think they are. Addiction is not what we think it is. And the drug war has very different motives to the ones we have seen on our TV screens for so long.In Chasing the Scream, Hari reveals his discoveries entirely through the stories of people across the world whose lives have been transformed by this war. They range from a transsexual crack dealer in Brooklyn searching for her mother, to a teenage hit-man in Mexico searching for a way out. It begins with Hari's discovery that at the birth of the drug war, Billie Holiday was stalked and killed by the man who launched this crusade--and it ends with the story of a brave doctor who has led his country to decriminalize every drug, from cannabis to crack, with remarkable results.Chasing the Scream lays bare what we really have been chasing in our century of drug war--in our hunger for drugs, and in our attempt to destroy them. This book will challenge and change how you think about one of the most controversial--and consequential--questions of our time.

    But this is not the whole story.Shedding light on controversial research and investigating the ferocious gender wars in biology, psychology and anthropology, Angela Saini takes readers on an eye-opening journey to uncover how women are being rediscovered. She explores what these revelations mean for us as individuals and as a society, revealing an alternative view of science in which women are included, rather than excluded.

    His congregation was racially integrated, and he was a much-lauded leader in the contemporary civil rights movement. Eventually, Jones moved his church, Peoples Temple, to northern California. He became involved in electoral politics, and soon was a prominent Bay Area leader.In this riveting narrative, Jeff Guinn examines Jones’s life, from his extramarital affairs, drug use, and fraudulent faith healing to the fraught decision to move almost a thousand of his followers to a settlement in the jungles of Guyana in South America. Guinn provides stunning new details of the events leading to the fatal day in November, 1978 when more than nine hundred people died—including almost three hundred infants and children—after being ordered to swallow a cyanide-laced drink.Guinn examined thousands of pages of FBI files on the case, including material released during the course of his research. He traveled to Jones’s Indiana hometown, where he spoke to people never previously interviewed, and uncovered fresh information from Jonestown survivors. He even visited the Jonestown site with the same pilot who flew there the day that Congressman Leo Ryan was murdered on Jones’s orders. The Road to Jonestown is the definitive book about Jim Jones and the events that led to the tragedy at Jonestown.

    secretary of stateA Fascist, observes Madeleine Albright, “is someone who claims to speak for a whole nation or group, is utterly unconcerned with the rights of others, and is willing to use violence and whatever other means are necessary to achieve the goals he or she might have.” The twentieth century was defined by the clash between democracy and Fascism, a struggle that created uncertainty about the survival of human freedom and left millions dead. Given the horrors of that experience, one might expect the world to reject the spiritual successors to Hitler and Mussolini should they arise in our era. In Fascism: A Warning, Madeleine Albright draws on her experiences as a child in war-torn Europe and her distinguished career as a diplomat to question that assumption.Fascism, as she shows, not only endured through the twentieth century but now presents a more virulent threat to peace and justice than at any time since the end of World War II.  The momentum toward democracy that swept the world when the Berlin Wall fell has gone into reverse.  The United States, which historically championed the free world, is led by a president who exacerbates division and heaps scorn on democratic institutions.  In many countries, economic, technological, and cultural factors are weakening the political center and empowering the extremes of right and left.  Contemporary leaders such as Vladimir Putin and Kim Jong-un are employing many of the tactics used by Fascists in the 1920s and 30s.Fascism: A Warning is a book for our times that is relevant to all times.  Written  by someone who has not only studied history but helped to shape it, this call to arms teaches us the lessons we must understand and the questions we must answer if we are to save ourselves from repeating the tragic errors of the past.

    There they discover a city in the midst of revolution, bustling with gay men in search of liberation—few of whom are raising a child.Steve throws himself into San Francisco’s vibrant cultural scene. He takes Alysia to raucous parties, pushes her in front of the microphone at poetry readings, and introduces her to a world of artists, thinkers, and writers. But the pair live like nomads, moving from apartment to apartment, with a revolving cast of roommates and little structure. As a child Alysia views her father as a loving playmate who can transform the ordinary into magic, but as she gets older Alysia wants more than anything to fit in. The world, she learns, is hostile to difference.In Alysia’s teens, Steve’s friends—several of whom she has befriended—fall ill as AIDS starts its rampage through their community. While Alysia is studying in New York and then in France, her father tells her it’s time to come home; he’s sick with AIDS. Alysia must choose whether to take on the responsibility of caring for her father or continue the independent life she has worked so hard to create.Reconstructing their life together from a remarkable cache of her father’s journals, letters, and writings, Alysia Abbott gives us an unforgettable portrait of a tumultuous, historic time in San Francisco as well as an exquisitely moving account of a father’s legacy and a daughter’s love.It has been named a Stonewall Book Award-Israel Fishman Non-Fiction Award Honor Book for 2014.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    Now a major motion picture starring Nicole Kidman, Russell Crowe, and Lucas Hedges, directed by Joel Edgerton.. The son of a Baptist pastor and deeply embedded in church life in small town Arkansas, as a young man Garrard Conley was terrified and conflicted about his sexuality. When Garrard was a nineteen-year-old college student, he was outed to his parents, and was forced to make a life-changing decision: either agree to attend a church-supported conversion therapy program that promised to “cure” him of homosexuality; or risk losing family, friends, and the God he had prayed to every day of his life. Through an institutionalized Twelve-Step Program heavy on Bible study, he was supposed to emerge heterosexual, ex-gay, cleansed of impure urges and stronger in his faith in God for his brush with sin. Instead, even when faced with a harrowing and brutal journey, Garrard found the strength and understanding to break out in search of his true self and forgiveness. By confronting his buried past and the burden of a life lived in shadow, Garrard traces the complex relationships among family, faith, and community. At times heart-breaking, at times triumphant, this memoir is a testament to love that survives despite all odds.

    Even before its usage to mean a female canine, bitch didn’t refer to gender at all—it originated as a gender-neutral word meaning genitalia. A perfectly innocuous word devolving into a female insult is the case for tons more terms, including hussy, which simply meant “housewife,” or slut, which meant “untidy” and was also used to describe men. These words are just a few among history’s many English slurs hurled at women. Amanda Montell, feminist linguist and staff features editor at online beauty and health magazine Byrdie.com, deconstructs language—from insults and cursing to grammar and pronunciation patterns—to reveal the ways it has been used for centuries to keep women form gaining equality. Ever wonder why so many people are annoyed when women use the word “like” as a filler? Or why certain gender neutral terms stick and others don’t? Or even how linguists have historically discussed women’s speech patterns? Wordslut is no stuffy academic study; Montell’s irresistible humor shines through, making linguistics not only approachable but both downright hilarious and profound.

    About one-quarter of the children on Kristof's old school bus died in adulthood from drugs, alcohol, suicide, or reckless accidents. And while these particular stories unfolded in one corner of the country, they are representative of many places the authors write about, ranging from the Dakotas and Oklahoma to New York and Virginia. But here too are stories about resurgence, among them: Annette Dove, who has devoted her life to helping the teenagers of Pine Bluff, Arkansas, as they navigate the chaotic reality of growing up poor; Daniel McDowell, of Baltimore, whose tale of opioid addiction and recovery suggests that there are viable ways to solve our nation's drug epidemic. Taken together, these accounts provide a picture of working-class families needlessly but profoundly damaged as a result of decades of policy mistakes. With their superb, nuanced reportage, Kristof and WuDunn have given us a book that is both riveting and impossible to ignore.

    What does it take to run the American supermarket? How do products get to shelves? Who sets the price? And who suffers the consequences of increased convenience and efficiency? In this exposé, author Benjamin Lorr pulls back the curtain on this highly secretive industry. Combining deep sourcing and immersive reporting, Lorr leads a wild investigation in which we learn the secrets of Trader Joe's success from Trader Joe himself, why truckers call their job "sharecropping on wheels," what it takes for a product to earn certification labels like "organic" and "fair trade," the struggles entrepreneurs face as they fight for shelf space, including essential tips, tricks, and traps for any new food business, the truth behind the alarming slave trade in the shrimp industry and much more.

    Space to think. Space to connect. Space to be yourself. And this is your invitation to join us. In The New Queer Conscience, LGBTQIA+ activist Adam Eli argues the urgent need for queer responsibility -- that queers anywhere are responsible for queers everywhere.Pocket Change Collective is a series of small books with big ideas from today's leading activists and artists. In this installment, The New Queer Conscience, Voices4 Founder and LGBTQIA+ activist Adam Eli offers a candid and compassionate introduction to queer responsibility. Eli calls on his Jewish faith to underline how kindness and support within the queer community can lead to a stronger global consciousness. More importantly, he reassures us that we're not alone. In fact, we never were. Because if you mess with one queer, you mess with us all.

    In 2017, as Ben Rhodes was helping Barack Obama begin his next chapter, the legacy they worked to build for eight years was being taken apart. To understand what was happening in America, Rhodes decided to look outward. Over the next three years, he traveled to dozens of countries, meeting with politicians, activists, and dissidents confronting the same nationalism and authoritarianism that was tearing America apart. Along the way, a Russian opposition leader he spends time with is poisoned, the Hong Kong protesters he comes to know see their movement snuffed out, and America itself reaches the precipice of losing democracy before giving itself a second chance. Equal parts memoir and reporting, After the Fall is a hugely ambitious and essential work of discovery. Throughout, Rhodes comes to realize how much America’s fingerprints are on a world we helped to shape: through the excesses of our post-Cold War embrace of unbridled capitalism, post-9/11 nationalism and militarism, mania for technology and social media, and the racism that shaped the backlash to the Obama presidency. At the same time, he learns from a diverse set of characters - from Obama to rebels to a rising generation of leaders - how looking squarely at where America has gone wrong only makes it more essential to fight for what America is supposed to be at home - for our own country, and the entire world.