She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own--with very different results. Williams's experiences as a patient and a medical test subject reveal with stark honesty what it takes to weather disease, the extraordinary new developments that are rewriting the rules of science--and the healing power of human connection.

    All this changed with a phone call that set a journey of discovery in motion, leading to a series of shocking revelations that forced Stephanie to revise the meaning of almost every aspect of her very compromised childhood.American Daughter is at once the deeply moving memoir of a troubled mother-daughter relationship and a meditation on resilience, transcendence, and redemption. Stephanie's story is unique but its messages are universal, offering insight into what it means to rise above, heal, and forgive.

    Once the epicenter of the voting rights struggle, today it's Ground Zero for a new movement that is Flowers's life's work. It's a fight to ensure human dignity through a right most Americans take for granted: basic sanitation. Too many people, especially the rural poor, lack an affordable means of disposing cleanly of the waste from their toilets, and, as a consequence, live amid filth.Flowers calls this America's dirty secret. In this powerful book she tells the story of systemic class, racial, and geographic prejudice that foster Third World conditions, not just in Alabama, but across America, in Appalachia, Central California, coastal Florida, Alaska, the urban Midwest, and on Native American reservations in the West.Flowers's book is the inspiring story of the evolution of an activist, from country girl to student civil rights organizer to environmental justice champion at Bryan Stevenson's Equal Justice Initiative. It shows how sanitation is becoming too big a problem to ignore as climate change brings sewage to more backyards, and not only those of poor minorities.

    Braided with that history is the moving story of Powers's beloved son Kevin--spirited, endearing, and gifted--who triumphed even while suffering from schizophrenia until finally he did not, and the story of his courageous surviving son Dean, who is also schizophrenic.A blend of history, biography, memoir, and current affairs ending with a consideration of where we might go from here, this is a thought-provoking look at a dreaded illness that has long been misunderstood.

    Culture Warlords is the story of how Lavin, a frequent target of extremist trolls (including those at Fox News), dove into a byzantine online culture of hate and learned the intricacies of how white supremacy proliferates online.Within these pages, she reveals the extremists hiding in plain sight online: Incels. White nationalists. White supremacists. National Socialists. Proud Boys. Christian extremists. In order to showcase them in their natural habitat, Talia assumes a range of identities, going undercover as a blonde Nazi babe, a forlorn incel, and a violent Aryan femme fatale. Along the way, she discovers a whites-only dating site geared toward racists looking for love, a disturbing extremist YouTube channel run by a fourteen-year-old girl with over 800,000 followers, the everyday heroes of the antifascist movement, and much more.By combining compelling stories chock-full of catfishing and gate-crashing with her own in-depth, gut-wrenching research, she also turns the lens of anti-Semitism, racism, and white power back on itself in an attempt to dismantle and decimate the online hate movement from within. Culture Warlords explores some of the vilest subcultures on the Web-and shows us how we can fight back.

    His contribution to our understanding not only of mental illness but also of the human condition is truly stunning.The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness.The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

    The emotional, incredible true story of Neil White, a man who discovers the secret to happiness, leading a fulfilling life, and the importance of fatherhood in the most unlikely of places—the last leper colony in the continental United States.

    The enemy sits across the table and sleeps in the next room. Her husband of twenty-one years is plotting against her because he feels increasingly threatened - by Elizabeth's intellect, independence, and unwillingness to stifle her own thoughts. So Theophilus makes a plan to put his wife back in her place. One summer morning, he has her committed to an insane asylum.The horrific conditions inside the Illinois State Hospital in Jacksonville, Illinois, are overseen by Dr. Andrew McFarland, a man who will prove to be even more dangerous to Elizabeth than her traitorous husband. But most disturbing is that Elizabeth is not the only sane woman confined to the institution. There are many rational women on her ward who tell the same story: they've been committed not because they need medical treatment, but to keep them in line - conveniently labeled "crazy" so their voices are ignored.No one is willing to fight for their freedom and, disenfranchised both by gender and the stigma of their supposed madness, they cannot possibly fight for themselves. But Elizabeth is about to discover that the merit of losing everything is that you then have nothing to lose...

    Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding. Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix discusses the universal, but deeply personal, process of dying. With meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.

    Brinkley–America’s most brazen young con man–arrived in the tiny town of Milford, Kansas. He set up a medical practice and introduced an outlandish surgical method using goat glands to restore the fading virility of local farmers.It was all nonsense, of course, but thousands of paying customers quickly turned “Dr.” Brinkley into America’s richest and most famous surgeon. His notoriety captured the attention of the great quackbuster Morris Fishbein, who vowed to put the country’s “most daring and dangerous” charlatan out of business.Their cat-and-mouse game lasted throughout the 1920s and ’30s, but despite Fishbein’s efforts Brinkley prospered wildly. When he ran for governor of Kansas, he invented campaigning techniques still used in modern politics. Thumbing his nose at American regulators, he built the world’s most powerful radio transmitter just across the Rio Grande to offer sundry cures, and killed or maimed patients by the score, yet his warped genius produced innovations in broadcasting that endure to this day. By introducing country music and blues to the nation, Brinkley also became a seminal force in rock ’n’ roll. In short, he is the most creative criminal this country has ever produced.Culminating in a decisive courtroom confrontation that pit Brinkley against his nemesis Fishbein, Charlatan is a marvelous portrait of a boundlessly audacious rogue on the loose in an America that was ripe for the bamboozling.

    In the past two decades, deaths of despair from suicide, drug overdose, and alcoholism have risen dramatically, and now claim hundreds of thousands of American lives each year--and they're still rising. Anne Case and Angus Deaton, known for first sounding the alarm about deaths of despair, explain the overwhelming surge in these deaths and shed light on the social and economic forces that are making life harder for the working class. They demonstrate why, for those who used to prosper in America, capitalism is no longer delivering.Deaths of Despair and the Future of Capitalism paints a troubling portrait of the American dream in decline. For the white working class, today's America has become a land of broken families and few prospects. As the college educated become healthier and wealthier, adults without a degree are literally dying from pain and despair. In this critically important book, Case and Deaton tie the crisis to the weakening position of labor, the growing power of corporations, and, above all, to a rapacious health-care sector that redistributes working-class wages into the pockets of the wealthy. Capitalism, which over two centuries lifted countless people out of poverty, is now destroying the lives of blue-collar America.This book charts a way forward, providing solutions that can rein in capitalism's excesses and make it work for everyone.

    Since 2001, newspaper and music revenues have fallen by 70%, book publishing, film and television profits have also fallen dramatically. Revenues at Google in this same period grew from $400 million to $74.5 billion. Google's YouTube today controls 60% of the streaming audio business and pays only 11% of the streaming audio revenues. More creative content is being consumed than ever before, but less revenue is flowing to creators and owners of the content.With the reallocation of money to monopoly platforms comes a shift in power. Google, Facebook, and Amazon now enjoy political power on par with Big Oil and Big Pharma, which in part explains how such a tremendous shift in revenues from artists to platforms could have been achieved and why it has gone unchallenged for so long.The stakes in this story go far beyond the livelihood of any one musician or journalist. As Taplin observes, the fact that more and more Americans receive their news, music and other forms of entertainment from a small group of companies poses a real threat to democracy. Move Fast and Break Things offers a vital, forward-thinking prescription for how artists can reclaim their audiences using knowledge of the past and a determination to work together. Using his own half-century career as a music and film producer and early pioneer of streaming video online, Taplin offers new ways to think about the design of the World Wide Web and specifically the way we live with the firms that dominate it.Table of contentsIntroduction1. The Great Disruption2. Levon's Story3. Tech's Counterculture Roots4. The Libertarian Counterinsurgency5. Digital Destruction6. Monopoly in the Digital Age7. Google's Regulatory Capture8. The Social Media Revolution9. Pirates of the Internet10. Libertarian and the 1 Percent11. What It Means to Be Human12. The Digital RenaissanceAfterword

    Perry Baird was a rising medical star in the late 1920s and 1930s. Early in his career, ahead of his time, he grew fascinated with identifying the biochemical root of manic depression, just as he began to suffer from it himself. By the time the results of his groundbreaking experiments were published, Dr. Baird had been institutionalized multiple times, his medical license revoked, and his wife and daughters estranged. He later received a lobotomy and died from a consequent seizure, his research incomplete, his achievements unrecognized.Mimi Baird grew up never fully knowing this story, as her family went silent about the father who had been absent for most of her childhood. Decades later, a string of extraordinary coincidences led to the recovery of a manuscript which Dr. Baird had worked on throughout his brutal institutionalization, confinement, and escape. This remarkable document, reflecting periods of both manic exhilaration and clear-headed health, presents a startling portrait of a man who was a uniquely astute observer of his own condition, struggling with a disease for which there was no cure, racing against time to unlock the key to treatment before his illness became impossible to manage.Fifty years after being told her father would forever be “ill” and “away,” Mimi Baird set off on a quest to piece together the memoir and the man. In time her fingers became stained with the lead of the pencil he had used to write his manuscript, as she devoted herself to understanding who he was, why he disappeared, and what legacy she had inherited. The result of his extraordinary record and her journey to bring his name to light is He Wanted the Moon, an unforgettable testament to the reaches of the mind and the redeeming power of a determined heart.Soon to be a major motion picture, from Brad Pitt and Tony Kushner

    CNN host and best-selling author Fareed Zakaria helps readers to understand the nature of a post-pandemic world: the political, social, technological, and economic impacts that may take years to unfold.In the form of ten straightforward “lessons,” covering topics from globalization and threat-preparedness to inequality and technological advancement, Zakaria creates a structure for readers to begin thinking beyond the immediate impacts of COVID-19. Ten Lessons for a Post-Pandemic World speaks to past, present, and future, and, while urgent and timely, is sure to become an enduring staple.

    When attorney Chris Hansen learned that the U.S. government was issuing patents for human genes to biotech companies, his first thought was, How can a corporation own what makes us who we are? Then he discovered that women were being charged exorbitant fees to test for hereditary breast and ovarian cancers, tests they desperately needed—all because Myriad Genetics had patented the famous BRCA genes. So he sued them. Jorge L. Contreras, one of the nation’s foremost authorities on human genetics law, has devoted years to investigating the groundbreaking civil rights case known as AMP v. Myriad. In The Genome Defense Contreras gives us the view from inside as Hansen and his team of ACLU lawyers, along with a committed group of activists, scientists, and physicians, take their one-in-a-million case all the way to the U.S. Supreme Court. Contreras interviewed more than a hundred key players involved in all aspects of the case—from judges and policy makers to ethicists and genetic counselors, as well as cancer survivors and those whose lives would be impacted by the decision—expertly weaving together their stories into a fascinating narrative of this pivotal moment in history.  The Genome Defense is a powerful and compelling story about how society must balance scientific discovery with corporate profits and the rights of all people.