Slavery was a major industry in the American South, and Stowe worked with the Underground Railroad to help escaped slaves head north towards freedom. The publication of her book, Uncle Tom’s Cabin, a scathing anti-slavery novel, fanned the flames that started the Civil War. The book’s emotional portrayal of the impact of slavery captured the nation’s attention. A best-seller in its time, Uncle Tom’s Cabin sealed Harriet Beecher Stowe’s reputations as one of the most influential anti-slavery voices in US history.