An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    As part of the healing process, she decided to use DNA research to learn more about herself, her family, and the interconnectedness of society. She went deep in search of her genealogy, having her DNA sequenced and tested, and effectively becoming an experimental subject. Remarkably, she was able to trace the path of her ancestors through recorded history and into prehistory. Through the course of her research, she met dozens of scientists working in genetic research. The narrative travels the length and breadth of Europe, from the Neanderthals of central Germany to the Cro-Magnon in France. Bojs visited the ancient caves, realizing that her direct ancestors must have been living in the area when the cave art was painted. A second DNA analysis later revealed she has Sami (i.e. Lapp) genetic material in her genome, and there were further revelations about her hunter-gatherer, Bronze-Age, and Iron-Age relatives, including the Vikings. This fresh, first-person exploration of genes and genetics goes well beyond personal genealogy and reveals much about the shared history of European peoples.

    Though the process obeyed all the rules of chemistry and physics, the details of that original event pose as deep a mystery as any facing science. How did non-living chemicals become alive? While the question is (deceivingly) simple, the answers are unquestionably complex. Science inevitably plays a key role in any discussion of life's origins, dealing less with the question of why life appeared on Earth than with where, when, and how it emerged on the blasted, barren face of our primitive planet. Astrobiologist Robert Hazen has spent many years dealing with the fundamental questions of life's genesis. As an active research scientist, he is down deep in all the messy details that science has to offer on the subject, tracing the inexorable sequence of events that led to the complicated interactions of carbonbased molecules. As he takes us through the astounding process of emergence, we are witness to the first tentative steps toward life?from the unfathomable abundance of carbon biomolecules synthesized in the black vacuum of space to the surface of the Earth to deep within our planet's restless crust. We are privy to the breathtaking drama that rapidly unfolds as life prevails. The theory of emergence is poised to answer a multitude of questions?even as it raises the possibility that natural processes exist beyond what we now know, perhaps beyond what we even comprehend. Genesis tells the tale of transforming scientific advances in our quest for life's origins. Written with grace, beauty, and authority, it goes directly to the heart of who we are and why we are here.

    In late 2017, scientists at a Hawaiian observatory glimpsed an object soaring through our inner solar system, moving so quickly that it could only have come from another star. Avi Loeb, Harvard’s top astronomer, showed it was not an asteroid; it was moving too fast along a strange orbit, and left no trail of gas or debris in its wake. There was only one conceivable explanation: the object was a piece of advanced technology created by a distant alien civilization.   In Extraterrestrial, Loeb takes readers inside the thrilling story of the first interstellar visitor to be spotted in our solar system. He outlines his controversial theory and its profound implications: for science, for religion, and for the future of our species and our planet. A mind-bending journey through the furthest reaches of science, space-time, and the human imagination, Extraterrestrial challenges readers to aim for the stars—and to think critically about what’s out there, no matter how strange it seems.

    In the seventy thousand years that modern human beings have walked this earth, we've come a long way. Art, science, culture, trade - on the evolutionary food chain, we're real winners. But, frankly, it's not exactly been plain sailing, and sometimes - just occasionally - we've managed to really, truly, quite unbelievably f*ck things up.From Chairman Mao's Four Pests Campaign, to the American Dustbowl; from the Austrian army attacking itself one drunken night, to the world's leading superpower electing a reality TV mogul as President... it's pretty safe to say that, as a species, we haven't exactly grown wiser with age. So, next time you think you've really f*cked up, this book will remind you: it could be so much worse

    Design journalist Kassia St. Clair guides us through the technological advancements and cultural customs that would redefine human civilization—from the fabric that allowed mankind to achieve extraordinary things (traverse the oceans and shatter athletic records) and survive in unlikely places (outer space and the South Pole). She peoples her story with a motley cast of characters, including Xiling, the ancient Chinese empress credited with inventing silk, to Richard the Lionhearted and Bing Crosby. Offering insights into the economic and social dimensions of clothmaking—and countering the enduring, often demeaning, association of textiles as “merely women’s work”—The Golden Thread offers an alternative guide to our past, present, and future.