Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes.Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics.Author Dr. Alexandra Levitt is an expert on emerging diseases and other public health threats. Here she shares insider accounts she’s collected that go behind the alarming headlines we’ve seen in the media: mysterious food poisonings, unexplained deaths at a children’s hospital, a strange neurologic disease afflicting slaughterhouse workers, flocks of birds dropping dead out of the sky, and drug-resistant malaria running rampant in a refugee camp. Meet the resourceful investigators—doctors, veterinarians, and research scientists—and discover the truth behind these cases and more.

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    It also finished the career of the charismatic Napoleon Bonaparte. It ensured the final liberation of Germany and the restoration of the old European monarchies, and it represented one of very few defeats for the glorious French army, most of whose soldiers remained devoted to their Emperor until the very end. Extraordinary though it may seem much about the Battle of Waterloo has remained uncertain, with many major features of the campaign hotly debated. Most histories have depended heavily on the evidence of British officers that were gathered about twenty years after the battle. But the recent publication of an abundance of fresh first-hand accounts from soldiers of all the participating armies has illuminated important episodes and enabled radical reappraisal of the course of the campaign. What emerges is a darker, muddier story, no longer biased by notions of regimental honour, but a tapestry of irony, accident, courage, horror and human frailty.An epic page turner, rich in dramatic human detail and grounded in first-class scholarly research, Waterloo is the real inside story of the greatest land battle in British history, the defining showdown of the age of muskets, bayonets, cavalry and cannon.

    As audacious as it is edifying, here is a hilarious and irreverent—yet always historically accurate—overview of the ascent (or descent) of humankind, courtesy of the same rebel geniuses who brought you Mental Floss presents Condensed Knowledge and Mental Floss Presents Forbidden Knowledge. Updated with all the hot topics and events of the past few years, The Mental Floss History of the World is proof positive that just because something’s true doesn’t mean it’s boring.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Though he never left Italy, his inventions and discoveries were heralded around the world. Most sensationally, his telescopes allowed him to reveal a new reality in the heavens and to reinforce the astounding argument that the Earth moves around the Sun. For this belief, he was brought before the Holy Office of the Inquisition, accused of heresy, and forced to spend his last years under house arrest. Of Galileo's three illegitimate children, the eldest best mirrored his own brilliance, industry, and sensibility, and by virtue of these qualities became his confidante. Born Virginia in 1600, she was thirteen when Galileo placed her in a convent near him in Florence, where she took the most appropriate name of Suor Maria Celeste. Her loving support, which Galileo repaid in kind, proved to be her father's greatest source of strength throughout his most productive and tumultuous years. Her presence, through letters which Sobel has translated from their original Italian and masterfully woven into the narrative, graces her father's life now as it did then. Galileo's Daughter dramatically recolors the personality and accomplishment of a mythic figure whose seventeenth-century clash with Catholic doctrine continues to define the schism between science and religion. Moving between Galileo's grand public life and Maria Celeste's sequestered world, Sobel illuminates the Florence of the Medicis and the papal court in Rome during the pivotal era when humanity's perception of its place in the cosmos was being overturned. In that same time, while the bubonic plague wreaked its terrible devastation and the Thirty Years' War tipped fortunes across Europe, one man sought to reconcile the Heaven he revered as a good Catholic with the heavens he revealed through his telescope. With all the human drama and scientific adventure that distinguished Longitude, Galileo's Daughter is an unforgettable story.

    Here is the never-before-told story of the nuclear arms race that changed history-and of the visionary American Air Force officer Bernard Schriever, who led the high-stakes effort. A Fiery Peace in a Cold War is a masterly work about Schriever's quests to prevent the Soviet Union from acquiring nuclear superiority, to penetrate and exploit space for America, and to build the first weapons meant to deter an atomic holocaust rather than to be fired in anger. Sheehan melds biography and history, politics and science, to create a sweeping narrative that transports the reader back and forth from individual drama to world stage. The narrative takes us from Schriever's boyhood in Texas as a six-year-old immigrant from Germany in 1917 through his apprenticeship in the open-cockpit biplanes of the Army Air Corps in the 1930s and his participation in battles against the Japanese in the South Pacific during the Second World War. On his return, he finds a new postwar bipolar universe dominated by the antagonism between the United States and the Soviet Union. Inspired by his technological vision, Schriever sets out in 1954 to create the one class of weapons that can enforce peace with the Russians-intercontinental ballistic missiles that are unstoppable and can destroy the Soviet Union in thirty minutes. In the course of his crusade, he encounters allies and enemies among some of the most intriguing figures of the century: John von Neumann, the Hungarian-born mathematician and mathematical physicist, who was second in genius only to Einstein; Colonel Edward Hall, who created the ultimate ICBM in the Minuteman missile, and his brother, Theodore Hall, who spied for the Russians at Los Alamos and hastened their acquisition of the atomic bomb; Curtis LeMay, the bomber general who tried to exile Schriever and who lost his grip on reality, amassing enough nuclear weapons in his Strategic Air Command to destroy the entire Northern Hemisphere; and Hitler's former rocket maker, Wernher von Braun, who along with a colorful, riding-crop-wielding Army general named John Medaris tried to steal the ICBM program. The most powerful men on earth are also put into astonishing relief: Joseph Stalin, the cruel, paranoid Soviet dictator who spurred his own scientists to build him the atomic bomb with threats of death; Dwight Eisenhower, who backed the ICBM program just in time to save it from the bureaucrats; Nikita Khrushchev, who brought the world to the edge of nuclear catastrophe during the Cuban Missile Crisis, and John Kennedy, who saved it. Schriever and his comrades endured the heartbreak of watching missiles explode on the launching pads at Cape Canaveral and savored the triumph of seeing them soar into space. In the end, they accomplished more than achieving a fiery peace in a cold war. Their missiles became the vehicles that opened space for America.

    Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

    Drawing on both native and Spanish chronicles, he vividly describes the dramatic story of the conquest, with all its savagery and suspense. This authoritative, exciting history is among the most powerful and important accounts of the culture of the South American Indians and the Spanish Conquest.

    The ship is instantly transformed into a fiery cauldron and sinks within minutes. Some 300 men go down with the ship. Nearly 900 make it into the water alive. For the next five nights and four days, almost three hundred miles from the nearest land, the men battle injuries, sharks, dehydration, insanity, and eventually each other. Only 316 will survive. For the better part of a century, the story of USS Indianapolis has been understood as a sinking tale. The reality, however, is far more complicated—and compelling. Now, for the first time, thanks to a decade of original research and interviews with 107 survivors and eyewit­nesses, Lynn Vincent and Sara Vladic tell the complete story of the ship, her crew, and their final mission to save one of their own. It begins in 1932, when Indianapolis is christened and launched as the ship of state for President Franklin Roosevelt. After Pearl Harbor, Indianapolis leads the charge to the Pacific Islands, notching an unbroken string of victories in an uncharted theater of war. Then, under orders from President Harry Truman, the ship takes aboard a superspy and embarks on her final world-changing mission: delivering the core of the atomic bomb to the Pacific for the strike on Hiroshima. Vincent and Vladic provide a visceral, moment-by-moment account of the disaster that unfolds days later after the Japanese torpedo attack, from the chaos on board the sinking ship to the first moments of shock as the crew plunge into the remote waters of the Philippine Sea, to the long days and nights during which terror and hunger morph into delusion and desperation, and the men must band together to survive. Then, for the first time, the authors go beyond the men’s rescue to chronicle Indianapolis’s extraordinary final mission: the survivors’ fifty-year fight for justice on behalf of their skipper, Captain Charles McVay III, who is wrongly court-martialed for the sinking. What follows is a captivating courtroom drama that weaves through generations of American presidents, from Harry Truman to George W. Bush, and forever entwines the lives of three captains—McVay, whose life and career are never the same after the scandal; Mochitsura Hashimoto, the Japanese sub commander who sinks Indianapolis but later joins the battle to exonerate McVay; and William Toti, the captain of the modern-day submarine Indianapolis, who helps the survivors fight to vindicate their captain. A sweeping saga of survival, sacrifice, justice, and love, Indianapolis stands as both groundbreaking naval history and spellbinding narrative—and brings the ship and her heroic crew back to full, vivid, unforgettable life. It is the definitive account of one of the most remarkable episodes in American history.

    They never saw her again. Her abduction was one of the most notorious episodes of the vicious conflict known as The Troubles. Everyone in the neighborhood knew the I.R.A. was responsible. But in a climate of fear and paranoia, no one would speak of it. In 2003, five years after an accord brought an uneasy peace to Northern Ireland, a set of human bones was discovered on a beach. McConville's children knew it was their mother when they were told a blue safety pin was attached to the dress--with so many kids, she had always kept it handy for diapers or ripped clothes.Patrick Radden Keefe's mesmerizing book on the bitter conflict in Northern Ireland and its aftermath uses the McConville case as a starting point for the tale of a society wracked by a violent guerrilla war, a war whose consequences have never been reckoned with. The brutal violence seared not only people like the McConville children, but also I.R.A. members embittered by a peace that fell far short of the goal of a united Ireland, and left them wondering whether the killings they committed were not justified acts of war, but simple murders.Patrick Radden Keefe writes an intricate narrative about a notorious killing in Northern Ireland and its devastating repercussions.

    In an attempt to stop the legendary Barbary Pirates of North Africa from hijacking American ships, William Eaton set out on a secret mission to overthrow the government of Tripoli. The operation was sanctioned by President Thomas Jefferson, who at the last moment grew wary of "intermeddling" in a foreign government and sent Eaton off without proper national support. Short on supplies, given very little money and only a few men, Eaton and his mission seemed doomed from the start. He triumphed against all odds, recruited a band of European mercenaries in Alexandria, and led them on a march across the Libyan Desert. Once in Tripoli, the ragtag army defeated the local troops and successfully captured Derne, laying the groundwork for the demise of the Barbary Pirates. Now, Richard Zacks brings this important story of America's first overseas covert op to life.

    The world was changing, moving away from ingrained beliefs about religion, reason, society, and the rights of the individual and turning more towards the laws of nature as interpreted by the scientific method. Nowhere was the influence of this radical new way of thinking more apparent than in France, and the upheaval this caused would come to bloody fruition in the form of revolution. Inside you will read about... - An Environment of Revolution - Rise of the Third Estate - The Rights of Man - Vive la Revolution! - Reign of Terror - The Last Revolutionaries And more! Explore the triumph and terror that existed in France during the French Revolution. Review the causes and the lasting effects brought about during this tumultuous time period when the common people of France struggled to remake their world upon the cornerstone of liberty.

    In the eighteenth century, this palace was a world of skulduggery, intrigue, politicking, etiquette, wigs, and beauty spots, where fans whistled open like switchblades and unusual people were kept as curiosities. Lucy Worsley's The Courtiers charts the trajectory of the fantastically quarrelsome Hanovers and the last great gasp of British court life. Structured around the paintings of courtiers and servants that line the walls of the King's Staircase of Kensington Palace-paintings you can see at the palace today-The Courtiers goes behind closed doors to meet a pushy young painter, a maid of honor with a secret marriage, a vice chamberlain with many vices, a bedchamber woman with a violent husband, two aging royal mistresses, and many more. The result is an indelible portrait of court life leading up to the famous reign of George III , and a feast for both Anglophiles and lovers of history and royalty.

    He was bound for a New Jersey dueling ground to settle his bitter dispute with Aaron Burr. Hamilton took just two men with him: his “second” for the duel, and Dr. David Hosack.As historian Victoria Johnson reveals in her groundbreaking biography, Hosack was one of the few points the duelists did agree on. Summoned that morning because of his role as the beloved Hamilton family doctor, he was also a close friend of Burr. A brilliant surgeon and a world-class botanist, Hosack—who until now has been lost in the fog of history—was a pioneering thinker who shaped a young nation.Born in New York City, he was educated in Europe and returned to America inspired by his newfound knowledge. He assembled a plant collection so spectacular and diverse that it amazes botanists today, conducted some of the first pharmaceutical research in the United States, and introduced new surgeries to American. His tireless work championing public health and science earned him national fame and praise from the likes of Thomas Jefferson, James Madison, Alexander von Humboldt, and the Marquis de Lafayette.One goal drove Hosack above all others: to build the Republic’s first botanical garden. Despite innumerable obstacles and near-constant resistance, Hosack triumphed when, by 1810, his Elgin Botanic Garden at last crowned twenty acres of Manhattan farmland. “Where others saw real estate and power, Hosack saw the landscape as a pharmacopoeia able to bring medicine into the modern age” (Eric W. Sanderson, author of Mannahatta). Today what remains of America’s first botanical garden lies in the heart of midtown, buried beneath Rockefeller Center.Whether collecting specimens along the banks of the Hudson River, lecturing before a class of rapt medical students, or breaking the fever of a young Philip Hamilton, David Hosack was an American visionary who has been too long forgotten. Alongside other towering figures of the post-Revolutionary generation, he took the reins of a nation. In unearthing the dramatic story of his life, Johnson offers a lush depiction of the man who gave a new voice to the powers and perils of nature.