It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    Stray is a moving, sometimes devastating, brilliantly written and ultimately inspiring exploration of the landscapes of damage and survival.After selling her first novel--a dream she'd worked long and hard for--Stephanie Danler knew she should be happy. Instead, she found herself driven to face the difficult past she'd left behind a decade ago: a mother disabled by years of alcoholism, further handicapped by a tragic brain aneurysm; a father who abandoned the family when she was three, now a meth addict in and out of recovery. After years in New York City she's pulled home to Southern California by forces she doesn't totally understand, haunted by questions of legacy and trauma. Here, she works toward answers, uncovering hard truths about her parents and herself as she explores whether it's possible to change the course of her history. Lucid and honest, heart-breaking and full of hope, Stray, is an examination of what we inherit and what we don't have to, of what we have to face in ourselves to move forward, and what it's like to let go of one's parents in order to find a peace--and family--of one's own.

    Someday, we know, we will all die. And, we know, so too will the universe itself.Until the End of Time is Brian Greene's breathtaking new exploration of the cosmos and our quest to understand it. Greene takes us on a journey across time, from our most refined understanding of the universe's beginning, to the closest science can take us to the very end. He explores how life and mind emerged from the initial chaos, and how our minds, in coming to understand their own impermanence, seek in different ways to give meaning to experience: in story, myth, religion, creative expression, science, the quest for truth, and our longing for the timeless, or eternal. Through a series of nested stories that explain distinct but interwoven layers of reality-from the quantum mechanics to consciousness to black holes-Greene provides us with a clearer sense of how we came to be, a finer picture of where we are now, and a firmer understanding of where we are headed.Yet all this understanding, which arose with the emergence of life, will dissolve with its conclusion. Which leaves us with one realization: during our brief moment in the sun, we are tasked with the charge of finding our own meaning.Let us embark.

    But underneath the gleaming mid-century house, the flawless hostess mom, and the thriving businessman dad ran an unspoken tension that, amid the upheaval of the late 1960s, was destined to fracture their precarious facade.His older sister Donna introduces him to the charismatic Valentine, who places a tab of acid on twelve-year-old Rush's tongue, proclaiming: "This is sacrament. You are one of us now."After an unceremonious ejection from an experimental art school, Rush heads to Tuscon to make a major drug purchase and, still barely a teenager, disappears into the nascent American counterculture. Stitching together a ragged assemblage of lowlifes, prophets, and fellow wanderers, he seeks kinship in the communes of the west. His adolescence is spent looking for knowledge, for the divine, for home. Given what Rush confronts on his travels--from ordinary heartbreak to unimaginable violence--it is a miracle he is still alive.The Light Years is a prayer for vanished friends, an odyssey signposted with broken and extraordinary people. It transcends one boy's story to perfectly illustrate the slow slide from the optimism of the 1960s into the darker and more sinister 1970s. This is a riveting, heart-stopping journey of discovery and reconciliation, as Rush faces his lost childhood and, finally, himself.

    With reported cases of sexual assault and homicide on the rise, the FBI created a specialized team—the “Mindhunters” better known as the Behavioral Science Unit—to track down the country's most dangerous criminals. And yet narrowing down a seemingly infinite list of potential suspects seemed daunting at best and impossible at worst—until Dr. Ann Wolbert Burgess stepped on the scene.In A Killer By Design, Burgess reveals how her pioneering research on sexual assault and trauma caught the attention of the FBI, and steered her right into the middle of a chilling serial murder investigation in Nebraska. Over the course of the next two decades, she helped the budding unit identify, interview, and track down dozens of notoriously violent offenders, including Ed Kemper ("The Co-Ed Killer"), Dennis Rader ("("BTK"), Henry Wallace ("The Taco Bell Strangler"), Jon Barry Simonis ("The Ski-Mask Rapist"), and many others. As one of the first women trailblazers within the FBI’s hallowed halls, Burgess knew many were expecting her to crack under pressure and recoil in horror—but she was determined to protect future victims at any cost. This book pulls us directly into the investigations as she experienced them, interweaving never-before-seen interview transcripts and crime scene drawings alongside her own vivid recollections to provide unprecedented insight into the minds of deranged criminals and the victims they left behind. Along the way, Burgess also paints a revealing portrait of a formidable institution on the brink of a seismic scientific and cultural reckoning—and the men forced to reconsider everything they thought they knew about crime.Haunting, heartfelt, and deeply human, A Killer By Design forces us to confront the age-old question that has long plagued our criminal justice system: “What drives someone to kill, and how can we stop them?”

    Kennedy astonished the world on May 25, 1961, when he announced to Congress that the United States should land a man on the Moon by 1970. No group was more surprised than the scientists and engineers at NASA, who suddenly had less than a decade to invent space travel. When Kennedy announced that goal, no one knew how to navigate to the Moon. No one knew how to build a rocket big enough to reach the Moon, or how to build a computer small enough (and powerful enough) to fly a spaceship there. No one knew what the surface of the Moon was like, or what astronauts could eat as they flew there. On the day of Kennedy’s historic speech, America had a total of fifteen minutes of spaceflight experience—with just five of those minutes outside the atmosphere. Russian dogs had more time in space than U.S. astronauts. Over the next decade, more than 400,000 scientists, engineers, and factory workers would send 24 astronauts to the Moon. Each hour of space flight would require one million hours of work back on Earth to get America to the Moon on July 20, 1969. More than fifty years later, One Giant Leap is the sweeping, definitive behind-the-scenes account of the furious race to complete one of mankind’s greatest achievements. It’s a story filled with surprises—from the item the astronauts almost forgot to take with them (the American flag), to the extraordinary impact Apollo would have back on Earth, and on the way we live today. Charles Fishman introduces readers to the men and women who had to solve 10,000 problems before astronauts could reach the Moon. From the research labs of MIT, where the eccentric and legendary pioneer Charles Draper created the tools to fly the Apollo spaceships, to the factories where dozens of women sewed spacesuits, parachutes, and even computer hardware by hand, Fishman captures the exceptional feats of these ordinary Americans. One Giant Leap is the captivating story of men and women charged with changing the world as we knew it—their leaders, their triumphs, their near disasters, all of which led to arguably the greatest success story, and the greatest adventure story, of the twentieth century.

    Very, very real. Actor, writer and comedian, Celeste Barber is one very funny woman - not to mention a global social media comedy phenomenon. Amassing over 3 million followers in only 18 months with her hilarious #challengeaccepted pics, she has been dubbed 'Australian Comedy Queen' by ABC Online; voted The Funniest Lady on Instagram; gone on sold-out comedy tours of US and UK; and won herself fans ranging from Tom Ford and Ruby Rose, to Amy Schumer and Dawn French. In the tradition of Tina Fey's Bossypants, Celeste's memoir is part memoir, part comedy routine, part advice manual. Calling out our ridiculous celebrity Instagram culture and the obsession we all seem to have with how we look, Celeste reveals all, including her thoughts on keeping it real and feeling good (instead of worrying about looking good); the secrets to love, friendship, family and marriage (#hothusband); how to deal with life's many challenges, like, well, motherhood, among other things; and how to stay nice in Spanx. Celeste is real, hilarious and the world can't get enough of her.

    Nothing Good Can Come from This is her debut--a frank, funny, and feminist essay collection by a keen-eyed observer no longer numbed into complacency.When Kristi stopped drinking, she started noticing things. Like when you give up a debilitating habit, it leaves a space, one that can't easily be filled by mocktails or ice cream or sex or crafting. And when you cancel Ros� Season for yourself, you're left with just Summer, and that's when you notice that the women around you are tanked--that alcohol is the oil in the motors that keeps them purring when they could be making other kinds of noise.In her sharp, incisive debut essay collection, Coulter reveals a portrait of a life in transition. By turns hilarious and heartrending, Nothing Good Can Come from This introduces a fierce new voice to fans of Sloane Crosley, David Sedaris, and Cheryl Strayed--perfect for anyone who has ever stood in the middle of a so-called perfect life and looked for an escape hatch.

    More than a possibility, it is becoming a necessity: whether our hand is forced by climate change and resource depletion or whether future catastrophes compel us to abandon Earth, one day we will make our homes among the stars.World-renowned physicist and futurist Michio Kaku explores in rich, accessible detail how humanity might gradually develop a sustainable civilization in outer space. With his trademark storytelling verve, Kaku shows us how science fiction is becoming reality: mind-boggling developments in robotics, nanotechnology, and biotechnology could enable us to build habitable cities on Mars; nearby stars might be reached by microscopic spaceships sailing through space on laser beams; and technology might one day allow us to transcend our physical bodies entirely.With irrepressible enthusiasm and wonder, Dr. Kaku takes readers on a fascinating journey to a future in which humanity could finally fulfil its long-awaited destiny among the stars - and perhaps even achieve immortality.

    And yet, very few of its readers know that the subject of the novel was inspired by a real-life case: the 1948 abduction of eleven-year-old Sally Horner.Weaving together suspenseful crime narrative, cultural and social history, and literary investigation, The Real Lolita tells Sally Horner’s full story for the very first time. Drawing upon extensive investigations, legal documents, public records, and interviews with remaining relatives, Sarah Weinman uncovers how much Nabokov knew of the Sally Horner case and the efforts he took to disguise that knowledge during the process of writing and publishing Lolita.Sally Horner’s story echoes the stories of countless girls and women who never had the chance to speak for themselves. By diving deeper in the publication history of Lolita and restoring Sally to her rightful place in the lore of the novel’s creation, The Real Lolita casts a new light on the dark inspiration for a modern classic.

    At the outset this group included the wives, sisters, and daughters of the resident astronomers, but soon the female corps included graduates of the new women's colleges--Vassar, Wellesley, and Smith. As photography transformed the practice of astronomy, the ladies turned from computation to studying the stars captured nightly on glass photographic plates.The "glass universe" of half a million plates that Harvard amassed over the ensuing decades--through the generous support of Mrs. Anna Palmer Draper, the widow of a pioneer in stellar photography--enabled the women to make extraordinary discoveries that attracted worldwide acclaim. They helped discern what stars were made of, divided the stars into meaningful categories for further research, and found a way to measure distances across space by starlight. Their ranks included Williamina Fleming, a Scottish woman originally hired as a maid who went on to identify ten novae and more than three hundred variable stars; Annie Jump Cannon, who designed a stellar classification system that was adopted by astronomers the world over and is still in use; and Dr. Cecilia Helena Payne, who in 1956 became the first ever woman professor of astronomy at Harvard--and Harvard's first female department chair.

    A member of the first astronaut class to include women, she broke through a quarter-century of white male fighter jocks when NASA chose her for the seventh shuttle mission, cracking the celestial ceiling and inspiring several generations of women.After a second flight, Ride served on the panels investigating the Challenger explosion and the Columbia disintegration that killed all aboard. In both instances she faulted NASA's rush to meet mission deadlines and its organizational failures. She cofounded a company promoting science and education for children, especially girls.Sherr also writes about Ride's scrupulously guarded personal life-she kept her sexual orientation private-with exclusive access to Ride's partner, her former husband, her family, and countless friends and colleagues. Sherr draws from Ride's diaries, files, and letters. This is a rich biography of a fascinating woman whose life intersected with revolutionary social and scientific changes in America. Sherr's revealing portrait is warm and admiring but unsparing. It makes this extraordinarily talented and bold woman, an inspiration to millions, come alive.

    You think you know what happened. You do not.On the morning of January 28, 1986, NASA’s space shuttle Challenger exploded shortly after blasting off from Cape Canaveral. Christa McAuliffe, America’s “Teacher in Space,” was instantly killed, along with the other six members of the mission. Right? Wrong.Thirty-five years after NASA’s revitalization program literally went up in smoke, Kevin Cook uncovers the untold story of the disastrous order to launch on an ice-cold Florida day. For the first time, he takes readers inside the shuttle for those agonizing two minutes and forty-five seconds after the fire, which, yes, some of the astronauts survived.But this is more than a simple corrective to a now-dimming memory. Centering on McAuliffe, a charmingly ordinary civilian on the cusp of history, The Burning Blue animates the mission’s colorful cast of characters, which featured the second female astronaut (who was also the first Jewish astronaut), the second Black one, and the first Asian-American and Buddhist in space. Drawing intimate portraits of the people wearing the spacesuits and detailing how they earned the right to suit up, Cook makes readers temporarily forget the tragedy toward which the tale is hurtling. Infused with drama, immediacy, and compelling characters, The Burning Blue reveals the human price paid for politics and capital-P Progress on that ill-fated, unforgettable morning.

    With a cast of famous faces including Rob Reiner, Tom Hanks, Meg Ryan, and Billy Crystal, Carlson takes readers on a rollicking, revelatory trip to Ephron's New York City, where reality took a backseat to romance and Ephron--who always knew what she wanted and how she wanted it--ruled the set with an attention to detail that made her actors feel safe but sometimes exasperated crew members. Along the way, Carlson examines how Ephron explored in the cinema answers to the questions that plagued her own romantic life and how she regained faith in love after one broken engagement and two failed marriages. Carlson also explores countless other questions Ephron's fans have wondered about: What sparked Reiner to snap out of his bachelor blues during the making of When Harry Met Sally? Why was Ryan, a gifted comedian trapped in the body of a fairytale princess, not the first choice for the role? After she and Hanks each separatel balked at playing Mail's Kathleen Kelly and Sleepless' Sam Baldwin, what changed their minds? And perhaps most importantly: What was Dave Chappelle doing ... in a turtleneck? An intimate portrait of a one of America's most iconic filmmakers and a look behind the scenes of her crowning achievements, I'll Have What She's Having is a vivid account of the days and nights when Ephron, along with assorted cynical collaborators, learned to show her heart on the screen.

     “A pleasure. Ellie Kemper is the kind of stable, intelligent, funny, healthy woman that usually only exists in yogurt commercials. But she’s real and she’s all ours!” —Tina Fey “Ellie is a hilarious and talented writer, although we’ll never know how much of this book the squirrel wrote.”—Mindy KalingMeet Ellie, the best-intentioned redhead next door. You’ll laugh right alongside her as she shares tales of her childhood in St. Louis, whether directing and also starring in her family holiday pageant, washing her dad’s car with a Brillo pad, failing to become friends with a plump squirrel in her backyard, eating her feelings while watching PG-13 movies, or becoming a “sports monster” who ends up warming the bench of her Division 1 field hockey team in college. You’ll learn how she found her comedic calling in the world of improv, became a wife, mother and New Yorker, and landed the role of a bridesmaid (while simultaneously being a bridesmaid) in Bridesmaids. You’ll get to know and love the comic, upbeat, perpetually polite actress playing Erin Hannon on The Office, and the exuberant, pink-pants-wearing star of Unbreakable Kimmy Schmidt. If you’ve ever been curious about what happens behind the scenes of your favorite shows, what it really takes to be a soul cycle “warrior,” how to recover if you accidentally fall on Doris Kearns Goodwin or tell Tina Fey on meeting her for the first time that she has “great hair—really strong and thick,” this is your chance to find out. But it’s also a laugh-out-loud primer on how to keep a positive outlook in a world gone mad and how not to give up on your dreams. Ellie “dives fully into each role—as actor, comedian, writer, and also wife and new mom—with an electric dedication, by which one learns to reframe the picture, and if not exactly become a glass-half-full sort of person, at least become able to appreciate them” (Vogue.com).