Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    Dr. Jeffrey Sterling’s authentic and enthralling collection of stories represents his unique journey as an ER physician. Both an enlightening memoir and an unforgiving mirror reflecting the best and worst of human behavior, Behind the Curtain unveils the insidious consequences of everyday risks and seemingly innocuous habits.

    Updated to reflect the latest research in the field, and enhanced with more than 1,000 illustrations, most in full-color, the 12th Edition is the most comprehensive and modern approach to understanding medical histology available anywhere.Features: NEW full-color micrographs that comprise a complete atlas of tissue sections highlight the important features of every tissue and organ in the human body. New full-color, easy-to-understand drawings provide just the right level of detail necessary to clarify the text and make learning easier A valuable introductory chapter on laboratory methods used for the study of tissues, including the most important types of microscopy A logical organization that features chapters focusing on the cytoplasmic and nuclear compartment of the cell, the four basic tissues that form the organs, and each organ system Expanded legends that accompany each figure emphasize important points and eliminate the need to jump from image to text Medical applications explain the clinical relevance of each topic Complete coverage of every tissue of the body CD-ROM with all the images from the textVisit www.LangeTextbooks.com to access valuable resources and study aids

    They force us to confront a fundamental biological problem: how can something as large and complex as a human body organize itself from the simplicity of a fertilized egg? A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of 'adaptive self-organization, ' it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before.Life Unfolding tells the story of human development from egg to adult, from this perspective, showing how our whole understanding of how we come to be has been transformed in recent years. Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Daviesexplores the profound and fascinating impacts of our newfound knowledge.

    Everywhere we turn, someone is preaching the “One True Way” to eat for maximum health. Paleo Diet advocates tell us that all foods less than 12,000 years old are the enemy. Low-carb gurus demonize carbs, then there are the low-fat prophets. But they agree on one thing: there is only one true way to eat for maximum health. The first clue that that is a fallacy is the sheer variety of diets advocated. Indeed, while all of these competing views claim to be backed by “science,” a good look at actual nutritional science itself suggests that it is impossible to identify a single best way to eat. Fitzgerald advocates an agnostic, rational approach to eating habits, based on one’s own habits, lifestyle, and genetics/body type. Many professional athletes already practice this “Good Enough” diet, and now we can too and ditch the brainwashing of these diet cults for good.

    The cases presented are somewhat graphic though I have attempted to minimize the technical aspects in the interest of not bogging down the reader with too much information. Since this is a work of nonfiction I have not spent a great deal of time with character development choosing instead to present the patients in much the same way an ER doctor sees them. When the volume and the acuity went up there was barely time to glance at the name on the chart. The patient's chief complaint became the starting and ending point for the physician's interaction with them. There was rarely time for niceties and in all likelihood the patient and doctor would never meet again, with the doctor- patient relationship reduced to; admit them, send them home or send them to the morgue.

    Mark Plaster takes readers beyond the ambulance bay doors into the stranger-than-fiction world of the Emergency Department. By turns heart-warming and gut-wrenching, "Night Shift" chronicles the ebb and flow of human life, in all of its unvarnished glory, as it passes through the doors of the ED.

    Medieval dentists burned candles in patients' mouths to kill invisible worms gnawing at their teeth. Renaissance physicians, by law, timed surgical procedures with the position of the stars, and instructed epileptics to collect fresh blood from the newly beheaded. Highlighting bad science, oafish behavior, and stomach-turning procedures that hurt more than helped, Strange Medicine presents extraordinary but true facts and an honor roll of doctors, scientists, and dreamers who gave a whole new meaning to clinical trials!

    Kelly A. Turner, founder of the Radical Remission Project, uncovers nine factors that can lead to a spontaneous remission from cancer—even after conventional medicine has failed.While getting her Ph.D. at the University of California, Berkley, Dr. Turner, a researcher, lecturer, and counselor in integrative oncology, was shocked to discover that no one was studying episodes of radical (or unexpected) remission—when people recover against all odds without the help of conventional medicine, or after conventional medicine has failed.  She was so fascinated by this kind of remission that she embarked on a ten month trip around the world, traveling to ten different countries to interview fifty holistic healers and twenty radical remission cancer survivors about their healing practices and techniques. Her research continued by interviewing over 100 Radical Remission survivors and studying over 1000 of these cases.  Her evidence presents nine common themes that she believes may help even terminal patients turn their lives around.

    Squirming parasites, bursting pustules, rotting limbs, and cascading diarrhea: it's all depicted here in vivid detail. Sometimes the remedy proved as unbearable as the sickness itself. Whether performing dire dentistry or ice-pick lobotomies, bloodletting or blistering, the medical practitioners of history were ever inventive, if not effective. Disease played a role in shaping human history, too: read how measles and smallpox hastened the decline of the native peoples of the Americas, and how typhus helped to defeat Napoleon. Extraordinary anecdotes abound, such as the cautionary tale of Typhoid Mary and how a cow called Blossom saved the day. Packed with startling medical illustrations, this morbidly fascinating study of all that ails is bound to grip you from page one and leave you reaching for the disinfectant."

    Yalom makes a strong case for the efficacy of group therapy on all acute wards. He discusses how to structure the session and the kind of support that should be offered. The emphasis is on the here-and-now. He then presents two models of groups: one for the higher functioning and one for the more regressed psychotic patients.

    In 2005, Maimonides Hospital in Brooklyn, New York, unveiled a new state-of-theart, multimillion-dollar cancer center. Determined to understand the whole spectrum of factors that determine what kind of medical care people receive in this country, bestselling author Julie Salamon spent one year tracking the progress of the center and getting to know the characters who make the hospital run. Located in a community where sixty-seven different languages are spoken, Maimonides is a case study for the particular kinds of concerns that arise in institutions that serve an increasingly multicultural American demographic. Granted an astonishing “warts and all” level of access by the hospital higher-ups, Salamon followed the doctors, patients, administrators, nurses, ambulance drivers, cooks, and cleaning staff. She explored not just the action on the ground—what happens between doctors and patients—but also the financial, ethical, technological, sociological, and cultural matters that the hospital community encounters every day. Drawing on her skills as interviewer, observer, and social critic, Salamon presents the story of modern medicine, uniquely viewed from the vantage point of those who make it run. She draws out the internal and external political machinations that exist between doctors and staff as well as between hospital and community. And she grounds the science and emotion of medical drama in the financial realities of operating a huge, private institution that must contend with issues like adapting to the specific needs of immigrant groups that make up a large and growing portion of our society. Salamon exposes struggles of both the profound and humdrum variety. There are bitter internal feuds, warm personal connections, comedy, egoism, greed, love, and loss. There are rabbinic edicts to contend with as well as imams and herbalists and local politicians. There are system foul-ups that keep blood test results from being delivered on time, careless record keepers, shortages of everything except forms to fill, recalcitrant and greedy insurance reimbursement systems, and the surprising difficulty of getting doctors to wash their hands. This is the dynamic universe of small and large concerns and personalities that, taken together, determine the nature of our care and assume the utmost importance. As Martin Payson—chairman of the board at Maimonides and ex-Time-Warner vice chairman—puts it: “Hospitals have a lot in common with the movie business. You’ve got your talent, entrepreneurs, ambition, ego stroking, the business versus the creative part. The big difference is that in the hospital you don’t get second takes. Movies are make-believe. This is real life.”

    Hephaestus Books represents a new publishing paradigm, allowing disparate content sources to be curated into cohesive, relevant, and informative books. To date, this content has been curated from Wikipedia articles and images under Creative Commons licensing, although as Hephaestus Books continues to increase in scope and dimension, more licensed and public domain content is being added. We believe books such as this represent a new and exciting lexicon in the sharing of human knowledge. This particular book contains chapters focused on Don Quixote, Works inspired by Don Quixote, and Characters in Don Quixote. More info: (;, see spelling and pronunciation below), fully titled The Ingenious Hidalgo Don Quixote of La Mancha, is a novel written by Spanish author Miguel de Cervantes. Cervantes created a fictional origin for the story by inventing a Moorish chronicler for Don Quixote named Cide Hamete Benengeli. Published in two volumes a decade apart (in 1605 and 1615), Don Quixote is the most influential work of literature from the Spanish Golden Age in the Spanish literary canon. As a founding work of modern Western literature, it regularly appears high on lists of the greatest works of fiction ever published.

    Pulitzer Prize–winning author Siddhartha Mukherjee, a leading cancer physician and researcher, selects the year’s top science and nature writing from journalists who dive into their fields with curiosity and passion, delivering must-read articles from a wide array of fields.