As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Described by one reviewer as “like getting stabbed in the head,” the $6 million film earned a grand total of $1,800 at the box office and closed after two weeks. Now in its tenth anniversary year, The Room is an international phenomenon to rival The Rocky Horror Picture Show. Thousands of fans wait in line for hours to attend screenings complete with costumes, audience rituals, merchandising, and thousands of plastic spoons.Readers need not have seen The Room to appreciate its costar Greg Sestero’s account of how Tommy Wiseau defied every law of artistry, business, and interpersonal relationships to achieve the dream only he could love. While it does unravel mysteries for fans, The Disaster Artist is more than just an hilarious story about cinematic hubris: It is ultimately a surprisingly inspiring tour de force that reads like a page-turning novel, an open-hearted portrait of a supremely enigmatic man who will capture your heart.

    He tells of the large science-steeped family who fostered his early fascination with chemistry. There follow his years at boarding school where, though unhappy, he developed the intellectual curiosity that would shape his later life. And we hear of his return to London, an emotionally bereft ten-year-old who found solace in his passion for learning. Uncle Tungsten radiates all the delight and wonder of a boy’s adventures, and is an unforgettable portrait of an extraordinary young mind.

    We see the visionary, whose desire for escape honed an innate sense of what people wanted to see on the screen and, when combined with iron determination and obsessive perfectionism, led him to the reinvention of animation. It was Disney, first with Mickey Mouse and then with his feature films - most notably Snow White, Pinocchio, Fantasia, Dumbo, and Bambi - who transformed animation from a novelty based on movement to an art form that presented an illusion of life.We see him reimagine the amusement park with Disneyland, prompting critics to coin the word Disneyfication to describe the process by which reality can be modified to fit one's personal desires. At the same time, he provided a new way to connect with American history through his live-action films and purveyed a view of the country so coherent that even today one can speak meaningfully of "Walt Disney's America." We see how the True-Life Adventure nature documentaries he produced helped create the environmental movement by sensitizing the general public to issues of conservation. And we see how he reshaped the entertainment industry by building a synergistic empire that combined film, television, theme parks, music, book publishing, and merchandise in a way that was unprecedented and was later widely imitated.Gabler also reveals a wounded, lonely, and often disappointed man, who, despite worldwide success, was plagued with financial problems much of his life, suffered a nervous breakdown, and at times retreated into pitiable seclusion in his workshop making model trains. Gabler explores accusations that Disney was a red-baiter, an anti-Semite, an embittered alcoholic. But whatever the characterizations of Disney's personal life, he appealed to the nation by demonstrating the power of wish fulfillment and the triumph of the American imagination. Walt Disney showed how one could impose one's will on the world.This is a masterly biography, a revelation of both the work and the man - of both the remarkable accomplishment and the hidden life.

    It has been inspired by the scientific ferment that swept through Britain at the end of the 18th century, and which Holmes now radically redefines as 'the revolution of Romantic Science'.

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    Based on original material and previously unavailable documents, this acclaimed book is the definitive biography of the man considered by many to be the founding father of modern electrical technology. Among Tesla's creations were the channeling of alternating current, fluorescent and neon lighting, wireless telegraphy, and the giant turbines that harnessed the power of Niagara Falls.

    She moved from New York to San Francisco, where she landed at a big-data startup in the heart of the Silicon Valley bubble: a world of surreal extravagance, dubious success, and fresh-faced entrepreneurs hell-bent on domination, glory, and, of course, progress.Anna arrived amidst a massive cultural shift, as the tech industry rapidly transformed into a locus of wealth and power rivaling Wall Street. But amid the company ski vacations and in-office speakeasies, boyish camaraderie and ride-or-die corporate fealty, a new Silicon Valley began to emerge: one in far over its head, one that enriched itself at the expense of the idyllic future it claimed to be building.Part coming-age-story, part portrait of an already-bygone era, Anna Wiener’s memoir is a rare first-person glimpse into high-flying, reckless startup culture at a time of unchecked ambition, unregulated surveillance, wild fortune, and accelerating political power. With wit, candor, and heart, Anna deftly charts the tech industry’s shift from self-appointed world savior to democracy-endangering liability, alongside a personal narrative of aspiration, ambivalence, and disillusionment.Unsparing and incisive, Uncanny Valley is a cautionary tale, and a revelatory interrogation of a world reckoning with consequences its unwitting designers are only beginning to understand.

    Katharine's account of her years as subservient daughter and wife is so painful that by the time she finally asserts herself at the Post following Phil's suicide in 1963 (more than halfway through the book), readers will want to cheer. After that, Watergate is practically an anticlimax.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    But it would take the world some time to believe what had happened: the age of flight had begun, with the first heavier-than-air, powered machine carrying a pilot.Who were these men and how was it that they achieved what they did?David McCullough, two-time winner of the Pulitzer Prize, tells the surprising, profoundly American story of Wilbur and Orville Wright.Far more than a couple of unschooled Dayton bicycle mechanics who happened to hit on success, they were men of exceptional courage and determination, and of far-ranging intellectual interests and ceaseless curiosity, much of which they attributed to their upbringing. The house they lived in had no electricity or indoor plumbing, but there were books aplenty, supplied mainly by their preacher father, and they never stopped reading.When they worked together, no problem seemed to be insurmountable. Wilbur was unquestionably a genius. Orville had such mechanical ingenuity as few had ever seen. That they had no more than a public high school education, little money and no contacts in high places, never stopped them in their mission to take to the air. Nothing did, not even the self-evident reality that every time they took off in one of their contrivances, they risked being killed.In this thrilling book, master historian David McCullough draws on the immense riches of the Wright Papers, including private diaries, notebooks, scrapbooks, and more than a thousand letters from private family correspondence to tell the human side of the Wright Brothers' story, including the little-known contributions of their sister, Katharine, without whom things might well have gone differently for them.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    The Muppets made Jim Henson a household name, but they were only part of his remarkable story.This extraordinary biography--written with the generous cooperation of the Henson family--covers the full arc of Henson's all-too-brief life: from his childhood in Leland, Mississippi, through the years of burgeoning fame in Washington D.C., New York, and London, to the decade of international celebrity that preceded his untimely death at age fifty-three. Drawing on hundreds of hours of new interviews with Jim Henson's family, friends, and closest collaborators, as well as unprecedented access to private family and company archives--including never-before-seen interviews, business documents, and Henson's private letters--Brian Jay Jones explores the creation of the Muppets, Henson's contributions to Sesame Street and Saturday Night Live, and his nearly ten year campaign to bring The Muppet Show to television. Jones provides the imaginative context for Henson's non-Muppet projects, including the richly imagined worlds of The Dark Crystal and Labyrinth-as well as fascinating misfires like Henson's dream of opening an inflatable psychedelic nightclub or of staging an elaborate, all-puppet Broadway show.An uncommonly intimate portrait, Jim Henson captures all the facets of this American original: the master craftsman who revolutionized the presentation of puppets on television, the savvy businessman whose deal making prowess won him a reputation as "the new Walt Disney," and the creative team leader whose collaborative ethos earned him the undying loyalty of everyone who worked for him. Here also is insight into Henson's intensely private personal life: his Christian Science upbringing; his love of fast cars, high-stakes gambling, and expensive art; and his weakness for women. Though an optimist by nature, Henson was haunted by the notion that he would not have time to do all the things he wanted to do in life-a fear that his heartbreaking final hours would prove all too well-founded.An up-close look at the charmed life of a legend, Jim Henson gives the full measure to a man whose joyful genius transcended age, language, geography, and culture-and continues to beguile audiences worldwide.

    Jon Benjamin--the lead voice behind Archer and Bob's Burgers--helps us all feel a little better about our own failures by sharing his own in a hilarious memoir-ish chronicle of failure.Most people would consider H. Jon Benjamin a comedy show business success. But he'd like to remind everyone that as great as success can be, failure is also an option. And maybe the best option. In this book, he tells stories from his own life, from his early days ("wherein I'm unable to deliver a sizzling fajita") to his romantic life ("how I failed to quantify a threesome") to family ("wherein a trip to P.F. Chang's fractures a family") to career ("how I failed at launching a kid's show").As Jon himself says, breaking down one's natural ability to succeed is not an easy task, but also not an insurmountable one. Society as we know it is, sadly, failure averse. But more acceptance of failure, as Jon sees it, will go a long way to making this world a different place . . . a kinder, gentler place, where gardens are overgrown and most people stay home with their pets. A vision of failure, but also a vision of freedom.With stories, examples of artistic and literary failure, and a powerful can't-do attitude, Failure Is an Option is the book the world doesn't need right now but will get regardless.

    Wittman, the founder of the FBI’s Art Crime Team, pulls back the curtain on his career for the first time.Rising from humble roots as the son of an antiques dealer, Wittman built a twenty-year career that was nothing short of extraordinary. He went undercover, usually unarmed, to catch art thieves, scammers, and black market traders in Paris and Philadelphia, Rio and Santa Fe, Miami and Madrid.In this memoir, Wittman relates the stories behind his recoveries of priceless art and antiquities: The golden armor of an ancient Peruvian warrior king. The Rodin sculpture that inspired the Impressionist movement. The headdress Geronimo wore at his final Pow-Wow. The rare Civil War battle flag carried into battle by one of the nation’s first African-American regiments.The breadth of Wittman’s exploits is unmatched: He traveled the world to rescue paintings by Rockwell and Rembrandt, Pissarro, Monet and Picasso, often working undercover overseas at the whim of foreign governments. Closer to home, he recovered an original copy of the Bill of Rights and cracked the scam that rocked the PBS series Antiques Roadshow.By the FBI’s accounting, Wittman saved hundreds of millions of dollars worth of art and antiquities. He says the statistic isn’t important. After all, who’s to say what is worth more --a Rembrandt self-portrait or an American flag carried into battle? They're both priceless.The art thieves and scammers Wittman caught run the gamut from rich to poor, smart to foolish, organized criminals to desperate loners.  The smuggler who brought him a looted 6th-century treasure turned out to be a high-ranking diplomat.  The appraiser who stole countless heirlooms from war heroes’ descendants was a slick, aristocratic con man.  The museum janitor who made off with locks of George Washington's hair just wanted to make a few extra bucks, figuring no one would miss what he’d filched.In his final case, Wittman called on every bit of knowledge and experience in his arsenal to take on his greatest challenge: working undercover to track the vicious criminals behind what might be the most audacious art theft of all.