We humans are perfectly designed for life on Earth. We can walk around, breathe, drink water, eat vegetables, read books, not get poisoned or crushed to death when we go outside - it's lovely right where we are.) Not convinced? GOOD! People have been dreaming about space travel for centuries - there's something amazing about the idea of leaving our planet behind and setting out to explore the Universe - there's so much we still don't know. UK and Ireland's best-loved comedian Dara O Briain takes you on a journey from the safety of your comfiest chair to the furthest reaches of space (and beyond!)

    In this book you will see how commonly performed operations can be found to be useless or even harmful when properly evaluated. That these claims come from an experienced, practicing orthopedic surgeon who performs many of these operations himself, makes the unsettling argument particularly compelling. Of course no surgeon is recommending invasive surgery in bad faith, but Ian Harris argues that the evidence for the success for many common operations, including knee arthroscopies, back fusion or cardiac stenting, become current accepted practice without full examination of the evidence.

    An x-ray microscope would do the trick, or since we're dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.

    Has your dog ever surprised you by doing something you said the first time? You are not alone! Here are 50 stories about amazing dogs who understood what their humans said. Some even saved lives in the process!Chloe the golden Beagle braved a hurricane to obey the new command, "I need Dad, Girl." Ellie the Coonhound helped her human family escape from an angry bear by obeying the new command, "Get it!" When her human brother said jokingly, "Maybe Cocoa could dig again and find it," Cocoa did just that!

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.Sekeres, who writes regularly for the Well section of the New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimacy of the conversations Sekeres has with his patients, and watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    In 'Bad Science', Ben Goldacre hilariously exposed the tricks that quacks and journalists use to distort science. In 'Bad Pharma', he put the $600 billion global pharmaceutical industry under the microscope. Now the pick of the journalism by one of our wittiest, most indignant and most fearless commentators on the worlds of medicine and science is collected in one volume.

      In the constellation of Eridanus, there lurks a cosmic mystery: It’s as if something has taken a huge bite out of the universe. But what is the culprit? The hole in the universe is just one of many puzzles keeping cosmologists busy. Supermassive black holes, bubbles of nothingness gobbling up space, monster universes swallowing others—these and many other bizarre ideas are being pursued by scientists. Due to breathtaking progress in astronomy, the history of our universe is now better understood than the history of our own planet. But these advances have uncovered some startling riddles. In this electrifying new book, renowned cosmologist and author Paul Davies lucidly explains what we know about the cosmos and its enigmas, exploring the tantalizing—and sometimes terrifying—possibilities that lie before us. As Davies guides us through the audacious research offering mind-bending solutions to these and other mysteries, he leads us up to the greatest outstanding conundrum of all: Why does the universe even exist in the first place? And how did a system of mindless, purposeless particles manage to bring forth conscious, thinking beings? Filled with wit and wonder, What’s Eating the Universe? is a dazzling tour of cosmic questions, sure to entertain, enchant, and inspire us all.

    "A stunning memoir from the astronaut who spent a record-breaking year aboard the International Space Station – a candid account of his remarkable voyage, the journeys that preceded it, and his colorful formative years." Inside book cover comments.

    In Elephants on Acid, Boese details the results of this scientific trial, as well as answers to the questions: Why can't people tickle themselves? Would the average dog summon help in an emergency? Will babies instinctually pick a well-balanced diet? Is it possible to restore life to the dead? Read on to find out...

    The first is the astonishing achievement of the Human Genome Project, which, it was anticipated, would identify the genetic basis of those characteristics that distinguish humans from their primate cousins. The second is the phenomenal advance in brain imaging that now permits neuroscientists to observe the brain 'in action' and thus account for the remarkable properties of the human mind.But that is not how it has turned out. It is simply not possible to get from the monotonous sequence of genes along the Double Helix to the near infinite diversity of the living world, nor to translate the electrical firing of the brain into the creativity of the human mind. This is not a matter of not knowing all the facts. Rather, science has inadvertently discovered that its theories are insufficient to conjure the wonder of the human experience from the bare bones of our genes and brains.We stand on the brink of a tectonic shift in our understanding of ourselves that will witness the rediscovery of the central premise of Western philosophy that there is 'more than we can know'. Lucid, compelling and utterly engaging, ‘Why Us?’ offers a convincing and provocative vision of the new science of being human.

    It was a sea in name only. It was actually a bone dry, ancient dusty basin pockmarked with craters and littered with rocks and boulders. Somewhere in that 500 mile diameter basin, the astronauts would attempt to make Mankind’s first landing on the Moon. Neil Armstrong would pilot the Lunar Module “Eagle” during its twelve minute descent from orbit down to a landing. Col. Edwin “Buzz” Aldrin would assist him. On the way down they would encounter a host of problems, any one of which could have potentially caused them to have to call off the landing, or, even worse, die making the attempt. The problems were all technical-communications problems, computer problems, guidance problems, sensor problems. Armstrong and Aldrin faced the very real risk of dying by the very same technical sword that they had to live by in order to accomplish the enormous task of landing on the Moon for the first time. Yet the human skills Armstrong and Aldrin employed would be more than equal to the task. Armstrong’s formidable skills as an aviator, honed from the time he was a young boy, would serve him well as he piloted Eagle down amidst a continuing series of systems problems that might have fatally distracted a lesser aviator. Armstrong’s brilliant piloting was complemented by Aldrin’s equally remarkable discipline and calmness as he stoically provided a running commentary on altitude and descent rate while handling systems problems that threatened the landing. Finally, after a harrowing twelve and a half minutes, Armstrong gently landed Eagle at “Tranquility Base”, a name he had personally chosen to denote the location of the first Moon landing. In “Landing Eagle-Inside the Cockpit During the First Moon Landing”, author Mike Engle gives a minute by minute account of the events that occurred throughout Eagle’s descent and landing on the Moon. Engle, a retired NASA engineer and Mission Control flight controller, uses NASA audio files of actual voice recordings made inside Eagle’s cockpit during landing to give the reader an “inside the cockpit” perspective on the first Moon landing. Engle’s transcripts of these recordings, along with background material on the history and technical details behind the enormous effort to accomplish the first Moon landing, give a new and fascinating insight into the events that occurred on that remarkable day fifty years ago.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.