For centuries, those afflicted by Alzheimer's disease have suffered its debilitating effects while family members sit by, watching their loved ones disappear a little more each day until the person they used to know is gone forever. The disease was first described by German psychologist and neurologist Alois Alzheimer in 1906. One hundred years and a great deal of scientific effort later, much more is known about Alzheimer's, but it still affects millions around the world, and there is no cure in sight.In The End of Memory, award-winning science author Jay Ingram writes a biography of this disease that attacks the brains of patients. He charts the history of the disease from before it was noted by Alois Alzheimer through to the twenty-first century, explains the fascinating science of plaques and tangles, recounts the efforts to understand and combat the disease, and introduces us to the passionate researchers who are working to find a cure.An illuminating biography of "the plague of the twenty-first century" and scientists' efforts to understand and, they hope, prevent it, The End of Memory is a book for those who want to find out the true story behind an affliction that courses through families and wreaks havoc on the lives of millions.

    The threat of the disease kept ships close to home and doomed those vessels that ventured too far from port. The willful ignorance of the royal medical elite, who endorsed ludicrous medical theories based on speculative research while ignoring the life-saving properties of citrus fruit, cost tens of thousands of lives and altered the course of many battles at sea. The cure for scurvy ranks among the greatest of human accomplishments, yet its impact on history has, until now, been largely ignored.From the earliest recorded appearance of the disease in the sixteenth century, to the eighteenth century, where a man had only half a chance of surviving the scourge, to the early nineteenth century, when the British conquered scurvy and successfully blockaded the French and defeated Napoleon, Scurvy is a medical detective story for the ages, the fascinating true story of how James Lind (the surgeon), James Cook (the mariner), and Gilbert Blane (the gentleman) worked separately to eliminate the dreaded affliction.Scurvy is an evocative journey back to the era of wooden ships and sails, when the disease infiltrated every aspect of seafaring life: press gangs "recruit" mariners on the way home from a late night at the pub; a terrible voyage in search of riches ends with a hobbled fleet and half the crew heaved overboard; Cook majestically travels the South Seas but suffers an unimaginable fate. Brimming with tales of ships, sailors, and baffling bureaucracy, Scurvy is a rare mix of compelling history and classic adventure story.

    Includes Crowley's "An Initiated Interpretation of Ceremonial Magic," his version of "The Bornless Ritual," Enochian translations of some of the Goetic invocations, an introduction, and notes. Illustrated. Smythe-sewn and printed on acid-free paper.

    It was into this world that Jennifer Worth entered as a trainee midwife. But life was tough, and babies were often born in slum conditions.In Call The Midwife, Shadows Of The Workhouse and Farewell To The East End, Jennifer recounts her time among nuns, prostitutes, abortionists, bigamists, gangsters and expectant mothers, eloquently portraying the East Enders' amazing resilience, their warmth and humour in the face of hardship, and the traditions and tales of a bygone era.

    Perry Baird was a rising medical star in the late 1920s and 1930s. Early in his career, ahead of his time, he grew fascinated with identifying the biochemical root of manic depression, just as he began to suffer from it himself. By the time the results of his groundbreaking experiments were published, Dr. Baird had been institutionalized multiple times, his medical license revoked, and his wife and daughters estranged. He later received a lobotomy and died from a consequent seizure, his research incomplete, his achievements unrecognized.Mimi Baird grew up never fully knowing this story, as her family went silent about the father who had been absent for most of her childhood. Decades later, a string of extraordinary coincidences led to the recovery of a manuscript which Dr. Baird had worked on throughout his brutal institutionalization, confinement, and escape. This remarkable document, reflecting periods of both manic exhilaration and clear-headed health, presents a startling portrait of a man who was a uniquely astute observer of his own condition, struggling with a disease for which there was no cure, racing against time to unlock the key to treatment before his illness became impossible to manage.Fifty years after being told her father would forever be “ill” and “away,” Mimi Baird set off on a quest to piece together the memoir and the man. In time her fingers became stained with the lead of the pencil he had used to write his manuscript, as she devoted herself to understanding who he was, why he disappeared, and what legacy she had inherited. The result of his extraordinary record and her journey to bring his name to light is He Wanted the Moon, an unforgettable testament to the reaches of the mind and the redeeming power of a determined heart.Soon to be a major motion picture, from Brad Pitt and Tony Kushner

    From Mary Lamb, sister of Charles, who in the throes of a nervous breakdown turned on her mother with a kitchen knife, to Freud, Jung, and Lacan, who developed the new women-centered therapies, Lisa Appignanesi’s research traces how more and more of the inner lives and emotions of women have become a matter for medics and therapists. Here too is the story of how over the years symptoms and diagnoses have developed together to create fashions in illness and how treatments have succeeded or sometimes failed. Mad, Bad, and Sad takes us on a fascinating journey through the fragile, extraordinary human mind.

    She has managed to achieve this in spite of being diagnosed as schizophrenic and given a "grave" prognosis—and suffering the effects of her illness throughout her life.Saks was only eight, and living an otherwise idyllic childhood in sunny 1960s Miami, when her first symptoms appeared in the form of obsessions and night terrors. But it was not until she reached Oxford University as a Marshall Scholar that her first full-blown episode, complete with voices in her head and terrifying suicidal fantasies, forced her into a psychiatric hospital.Saks would later attend Yale Law School where one night, during her first term, she had a breakdown that left her singing on the roof of the law school library at midnight. She was taken to the emergency room, force-fed antipsychotic medication, and tied hand-and-foot to the cold metal of a hospital bed. She spent the next five months in a psychiatric ward.So began Saks's long war with her own internal demons and the equally powerful forces of stigma. Today she is a chaired professor of law who researches and writes about the rights of the mentally ill. She is married to a wonderful man.In The Center Cannot Hold, Elyn Saks discusses frankly and movingly the paranoia, the inability to tell imaginary fears from real ones, and the voices in her head insisting she do terrible things, as well as the many obstacles she overcame to become the woman she is today. It is destined to become a classic in the genre.

    It may feel as if your world has shifted on its axis, and you'll never get your bearings. Navigating your way through the morass of doctors, medical terms, and the healthcare system can be daunting, especially when you want only what's best for the person you love. Dr. John Cassidy has devoted the past twenty-five years to helping families cope with traumatic brain injury; Mindstorms is his compassionate, comprehensive manual to demystifying this often frightening and life-changing condition. More than 6.3 million Americans live with a severe disability caused by a traumatic brain injury. In fact, because it's so commonplace, but little talked of, TBI is often referred to as the "silent epidemic." In these pages, Dr. Cassidy walks you through the different types of brain injury; explodes the common myths surrounding it; demonstrates the ways in which TBI may affect memory, behavior, and social interaction; explores the newest options in treatment and rehabilitation; and shows you how to hold on to your own sense of self as you journey through. Along with the practical information you'll need, Mindstorms offers a constellation of instructive, moving stories from families and patients who are slowly, but surely, finding their way back. Their experiences are sure to inspire you and yours.

    129 - ca. 216) began his remarkable career tending to wounded gladiators in provincial Asia Minor. Later in life he achieved great distinction as one of a small circle of court physicians to the family of Emperor Marcus Aurelius, at the very heart of Roman society. Susan Mattern's The Prince of Medicine offers the first authoritative biography in English of this brilliant, audacious, and profoundly influential figure. Like many Greek intellectuals living in the high Roman Empire, Galen was a prodigious polymath, writing on subjects as varied as ethics and eczema, grammar and gout. Indeed, he was (as he claimed) as highly regarded in his lifetime for his philosophical works as for his medical treatises. However, it is for medicine that he is most remembered today, and from the later Roman Empire through the Renaissance, medical education was based largely on his works. Even up to the twentieth century, he remained the single most influential figure in Western medicine. Yet he was a complicated individual, full of breathtaking arrogance, shameless self- promotion, and lacerating wit. He was fiercely competitive, once disemboweling a live monkey and challenging the physicians in attendance to correctly replace its organs. Relentless in his pursuit of anything that would cure the patient, he insisted on rigorous observation and, sometimes, daring experimentation. Even confronting one of history's most horrific events- a devastating outbreak of smallpox-he persevered, bearing patient witness to its predations, year after year. The Prince of Medicine gives us Galen as he lived his life, in the city of Rome at its apex of power and decadence, among his friends, his rivals, and his patients. It offers a deeply human and long- overdue portrait of one of ancient history's most significant and engaging figures.

    This text, which is the first volume in the best-selling History of England series, tells how a small and insignificant outpost of the Roman empire evolved into a nation that has produced and disseminated so many significant ideas and institutions.

    Eros and Magic in the Renaissance challenges this view, providing an in-depth scholarly explanation of the workings of magic and showing that magic continues to exist in an altered form even today.Renaissance magic, according to Ioan Couliano, was a scientifically plausible attempt to manipulate individuals and groups based on a knowledge of motivations, particularly erotic motivations. Its key principle was that everyone (and in a sense everything) could be influenced by appeal to sexual desire. In addition, the magician relied on a profound knowledge of the art of memory to manipulate the imaginations of his subjects. In these respects, Couliano suggests, magic is the precursor of the modern psychological and sociological sciences, and the magician is the distant ancestor of the psychoanalyst and the advertising and publicity agent.In the course of his study, Couliano examines in detail the ideas of such writers as Giordano Bruno, Marsilio Ficino, and Pico della Mirandola and illuminates many aspects of Renaissance culture, including heresy, medicine, astrology, alchemy, courtly love, the influence of classical mythology, and even the role of fashion in clothing.Just as science gives the present age its ruling myth, so magic gave a ruling myth to the Renaissance. Because magic relied upon the use of images, and images were repressed and banned in the Reformation and subsequent history, magic was replaced by exact science and modern technology and eventually forgotten. Couliano's remarkable scholarship helps us to recover much of its original significance and will interest a wide audience in the humanities and social sciences.

    In Samuel Pepys, Claire Tomalin offers us a fully realized and richly nuanced portrait of this man, whose inadvertent masterpiece would establish him as the greatest diarist in the English language.Against the backdrop of plague, civil war, and regicide, with John Milton composing diplomatic correspondence for Oliver Cromwell, Christopher Wren drawing up plans to rebuild London, and Isaac Newton advancing the empirical study of the world around us, Tomalin weaves a breathtaking account of a figure who has passed on to us much of what we know about seventeenth-century London. We witness Pepys’s early life and education, see him advising King Charles II before running to watch the great fire consume London, learn about the great events of the day as well as the most intimate personal details that Pepys encrypted in the Diary, follow him through his later years as a powerful naval administrator, and come to appreciate how Pepys’s singular literary enterprise would in many ways prefigure our modern selves. With exquisite insight and compassion, Samuel Pepys captures the uniquely fascinating figure whose legacy lives on more than three hundred years after his death.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

     Publicly declared a bastard at the age of three, daughter of a disgraced and executed mother, last in the line of succession to the throne of England, Elizabeth I inherited an England ravaged by bloody religious conflict, at war with Spain and France, and badly in debt. When she died in 1603, after a forty-five year reign, her empire spanned two continents and was united under one church, victorious in war, and blessed with an overflowing treasury. What's more, her favorites--William Shakespeare, Sir Francis Drake, and Sir Walter Raleigh--had made the Elizabethan era a cultural Golden Age still remembered today. But for Elizabeth the woman, tragedy went hand in hand with triumph. Politics and scandal forced the passionate queen to reject her true love, Robert Dudley, and to execute his stepson, her much-adored Lord Essex. Now in this spellbinding novel, Rosalind Miles brings to life the woman behind the myth. By turns imperious, brilliant, calculating, vain, and witty, this is the Elizabeth the world never knew. From the days of her brutal father, Henry VIII, to her final dying moments, Elizabeth tells her story in her own words.

    His new-found knowledge spurred him to write Mysteries: An Investigation into the Occult, the Paranormal & the Supernaturalan attempt to apply his theory to all paranormal phenomena, from precognition to Uri Geller's spoon bending. He presents detailed studies of hauntings, possession & demonic hypnosis, as well as magic, the Kabbalah & astrology. At the heart of his work is a fascinating discussion of the Great Secret of the alchemists, which he sees as the key to the mystery of the ladder of selves.