Claymores are half-humans, half-demons who willingly transformed themselves by mixing their blood with monster's blood. Claire, nicknamed silver-eyed killer, is such a powerful Claymore, she can slay a Yoma using only one hand. But she must constantly struggle to keep from becoming a monster herself.

    Her troubles compound exponentially when she is rescued and befriended by a handsome Young man by the name of Izark. He may be brave and courageous, but inside Izark lurks the darkest evil imaginable. And according to an ancient prophecy, Noriko possesses the power to unleash that evil. Now, inexorably bound together, these two unlikely allies must navigate a world both wondrous and hostile.

    In this alternate universe, they walk among us--shunned by society--as they search for others who have similar traits. Cooro is a crow-like boy who is on a quest to find other +Anima. When he meets Husky, a disrespectful boy with a past shrouded in mystery, he finds a kindred spirit who also possesses animal-like powers. Together, they try to gain acceptance in a world cruel to anyone or anything that is different...

    When high school girl Hatsumi has to go buy a pregnancy test because her popular sister Akane is "late," who does she run into but her creepy bully neighbor Ryoki! And now he's blackmailing her to become his slave! How will mild-mannered Hatsumi get out of this mess? Will Hatsumi's childhood crush (and male model) Azusa be able to save her from Riyoki's clutches?

    Getting tired of all those movings, she finally decides to quit school and work to support her brother on her own. As they sat on a park bench, her teacher appears in front of her and agrees to her demanding of marrying and supporting both her and her brother!! Is he serious or just playing around...!?