Roy Porter's historical overview of madness reveals the radically different perceptions of madness and approaches to its treatment, from antiquity to the beginning of the 21st century.Looking back on his confinement to Bethlem, Restoration playwright Nathaniel Lee declared: "They called me mad, and I called them mad, and damn them, they outvoted me." As Roy Porter shows in Madness: A Brief History, thinking about who qualifies as insane, what causes mental illness, and how such illness should be treated has varied wildly throughout recorded history, sometimes veering dangerously close to the arbitrariness Lee describes and often encompassing cures considerably worse than the illness itself.Drawing upon eyewitness accounts of doctors, writers, artists, and the mad themselves, Roy Porter tells the story of our changing notions of insanity and of the treatments for mental illness that have been employed from antiquity to the present day. Beginning with 5,000-year-old skulls with tiny holes bored in them (to allow demons to escape), through conceptions of madness as an acute phase in the trial of souls, as an imbalance of "the humors," as the "divine fury" of creative genius, or as the malfunctioning of brain chemistry, Porter shows the many ways madness has been perceived and misperceived in every historical period. He takes us on a fascinating round of treatments, ranging from exorcism and therapeutic terror--including immersion in a tub of eels--to the first asylums, shock therapy, the birth of psychoanalysis, and the current use of psychotropic drugs.Throughout, Madness: A Brief History offers a balanced view, showing both the humane attempts to help the insane as well as the ridiculous and often cruel misunderstanding that have bedeviled our efforts to heal the mind of its myriad afflictions.

    Lyme disease, and SARS. According to Walters, we are not only victims of these emerging diseases; we are helping exacerbate their creation and spread.

    

    Between 1900 and 1907, she infected twenty-two New Yorkers with typhoid fever through her puddings and cakes; one of them died. Tracked down through epidemiological detective work, she was finally apprehended as she hid behind a barricade of trashcans. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later.This book tells the remarkable story of Mary Mallon--the real Typhoid Mary. Combining social history with biography, historian Judith Leavitt re-creates early-twentieth-century New York City, a world of strict class divisions and prejudice against immigrants and women. Leavitt engages the reader with the excitement of the early days of microbiology and brings to life the conflicting perspectives of journalists, public health officials, the law, and Mary Mallon herself.Leavitt's readable account illuminates dilemmas that continue to haunt us. To what degree are we willing to sacrifice individual liberty to protect the public's health? How far should we go in the age of AIDS, drug-resistant tuberculosis, and other diseases? For anyone who is concerned about the threats and quandaries posed by new epidemics, Typhoid Mary is a vivid reminder of the human side of disease and disease control.

    

    And, should you ever get to hold one, you will find the human heart to be rubbery and shockingly light.'What Could Possibly Go Wrong? is a report from the front line of emergency medicine, the first ever account of what it is like to work as an air ambulance doctor. Whether describing cutting through a patient's breastbone to plug a stab wound or barrel rolling a light aircraft at 5,000 feet, Tony Bleetman captures the sheer adrenaline of racing through the sky to save lives. You will learn how to land a helicopter on the side of a mountain, what it means to encounter death every day, and how to perform a tracheotomy in real life (clue: it doesn’t involve a ball-point pen).Funny, shocking and moving, What Could Possibly Go Wrong? is a glimpse at a world where the wrong decision can mean the difference between life and death.Originally published as You Can't Park There: The Highs and Lows of an Air Ambulance Doctor.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    And as outbreaks of COVID-19, Ebola, MERS, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can -- and must -- we do in order to protect ourselves from mankind's deadliest enemy?Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Deadliest Enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease. The authors show how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza or coronavirus pandemic looms ever larger. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.Deadliest Enemy is high scientific drama, a chronicle of medical mystery and discovery, a reality check, and a practical plan of action.

    Readers of "The New Yorker" may be familiar with the author's suspenseful tales of strange illnesses, rare diseases, poisons and parasites.

    Desowitz asks, has biotechnical research on malaria produced so little when it had promised so much? An expert in tropical diseases, Desowtiz searches for answers in this provocative book.

    It is too bad, write scientist-historian couple Robert and Michèle Root-Bernstein, who deplore the loss of proven methods developed without the blessing of the academy, noting that "formal academic systems are only one of many ways in which knowledge is discovered, accumulated, and transmitted." Many scientists are now coming to agree with this view, they write in this fascinating collection of case studies. Researchers have showed that black tea, for instance, has powerful antibiotic properties and that maggots do an extraordinary job of cleaning wounds--as traditional healers have known all along.

    Bonnie Henry has been called one of the most effective public health figures in the world by The New York Times. She has been called a calming voice in a sea of coronavirus madness, and our hero in national newspapers. But in the waning days of 2019, when the first rumours of a strange respiratory ailment in Wuhan, China began to trickle into her office in British Colombia, these accolades lay in a barely imaginable future.Only weeks later, the whole world would look back on the previous year with the kind of nostalgia usually reserved for the distant past. With a staggering suddenness, our livelihoods, our closest relationships, our habits and our homes had all been transformed.In a moment when half-truths threatened to drown out the truth, when recklessness all too often exposed those around us to very real danger, and when it was difficult to tell paranoia from healthy respect for an invisible threat, Dr. Henry's transparency, humility, and humanity became a beacon for millions of Canadians.And her trademark enjoinder to be kind, be calm, and be safe became words for us all to live by.Coincidentally, Dr. Henry's sister, Lynn, arrived in BC for a long-planned visit on March 12, just as the virus revealed itself as a pandemic. For the four ensuing weeks, Lynn had rare insight into the whirlwind of Bonnie's daily life, with its moments of agony and gravity as well as its occasional episodes of levity and grace. Both a global story and a family story, Be Kind, Be Calm, Be Safe combines Lynn's observations and knowledge of Bonnie's personal and professional background with Bonnie's recollections of how and why decisions were made, to tell in a vivid way the dramatic tale of the four weeks that changed all our lives.Be Kind, Be Calm, Be Safe is about communication, leadership, and public trust; about the balance between politics and policy; and, at heart, about what and who we value, as individuals and a society.The authors' advance from the publisher will be donated to charities with a focus on alleviating communities hit particularly hard by the pandemic: True North Aid with its Covid-19 response in Northern Indigenous communities, and First Book Canada, with its focus on reading and literacy for underserved, marginalized youth.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    This trial serves as the backdrop for Superbugs, and the results will impact nothing less than the future of humanity.Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more.