The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    Murderous Contagion tells the compelling and at times unbearably moving story of the devastating impact of diseases on humankind - from the Black Death of the 14th century to the Spanish flu of 1918-19 and the AIDS epidemic of the modern era. In this book Mary Dobson also relates the endeavours of physicians and scientists to understand and identify the causes of diseases and find ways of preventing them. This is a timely and revelatory work of popular history by a writer whose knowledge of, and enthusiasm for, her subject shines through her every word.

    Although necessary health care should be available to all who need it, he says, the current health-care debate assumes that everyone requires massive amounts of expensive care to stay healthy. Hadler urges that before we commit to paying for whatever pharmaceutical companies and the medical establishment tell us we need, American consumers need to adopt an attitude of skepticism and arm themselves with enough information to make some of their own decisions about what care is truly necessary. Each chapter of Worried Sick is an object lesson regarding the uses and abuses of a particular type of treatment, such as mammography, colorectal screening, statin drugs, or coronary stents. For consumers and medical professionals interested in understanding the scientific basis for Hadler's arguments, each topical chapter has an accompanying source chapter in which Hadler discusses the medical literature and studies that inform his critique. According to Hadler, a major stumbling block to rational health-care policy in the United States is contention over the very concept of what constitutes good health. By learning to distinguish good medical advice from persuasive medical marketing, consumers can make better decisions about their personal health and use that wisdom to inform their perspectives on health-policy issues.

    Inside, you'll find lots of terrific ideas for breakfasts, dinners, desserts and more, including:* Satisfying Breakfasts: from Spicy Pumpkin Pancakes to Banana-Nut Waffles and Cheesy Chile and Egg Bake* Comforting Casseroles: from Philly Beef Squares to Fajita Chicken Pot Pie and Louisiana-Style Shrimp Casserole* 30-Minute Dinners: from Barbecue Beef Cheese Melts to Buffalo-Style Chicken Nuggets and Turkey Cornbread Tostadas* Delightful Heart Smart Dinners for Two: from Curried Country Chicken to Fall Pork Dinner and Santa Fe Foldover* Impossibly Easy Pies and Pizzas: from Impossibly Easy Sloppy Joe Pie to Impossibly Easy Quesadilla Pie and Bewitched Double-Crust Cheese Pizza* Delicious Desserts: from Frosted Chocolate Malt Cupcakes to Impossibly Easy Toffee Bar Cheesecake and Peanut Butter-Chocolate Chip BarsYou also get tips on perfecting Bisquick favorites like pancakes, muffins and biscuits as well as a brief history of Bisquick over the decades. With more than double the number of recipes found in any other Bisquick cookbook along with over 100 tempting colorphotographs, this is truly the Ultimate Bisquick Cookbook!

    Beautiful, profane, complex, and sublime, the show is dreama at its very best. Entertaining and illuminating, Deadwood: Stories of the Black Hills offers a mesmerizing portrait of the most dangerous settlement in the West. This unprecedented look at the people, places, and history of Deadwood comes straight from the show’s creator, chief writer, and executive producer, David Milch.Through in-depth discussions of the themes and motivations that course through the lawless camp, Milch sheds some light on the characters and events in Deadwood. Fresh interviews with the Deadwood cast, scores of never-before-seen photographs, and historical images and illustrations bring the show and the place to life.Much more than a companion to the series, Deadwood: Stories of the Black Hills is an essential part of the show’s story, and required reading for every fan.

    Forced to remain inside until they'd "proven" themselves sane, all eight emerged with alarming diagnoses and even more troubling stories of their treatment. Rosenhan's study broke open the field of psychiatry, closing down institutions and changing mental health diagnosis forever. But, as Cahalan's new research shows, very little in this saga is exactly as it seems. What really happened behind those closed asylum doors, and what does it mean for our understanding of mental illness today?

    On playing fields across America, lives are being derailed by seemingly innocuous jolts to the head. From the peewees to the pros, concussions are reaching epidemic proportions. This book brings that hidden epidemic and its consequences out of the shadows. As frightening as the numbers are—estimates of sports-related concussions range from 1.6 million to 3.8 million annually in the United States—they can’t begin to explain the profound impact of a hidden health problem that can strike any of us. It is becoming increasingly clear that concussions, like severe head traumas, can rob us of our memory, our mental abilities, our very sense of self. Because the damage caused by a concussion is rarely visible to the naked eye or even on a brain scan, no one knows how many millions might be living lives devastated by an invisible injury too often shrugged off as “just a bump on the head.” This book puts a human face on a huge public health crisis. Through narratives that chronicle the poignant experiences of real people struggling with this invisible and often unrecognized brain injury, Linda Carroll and David Rosner bring home its potentially devastating consequences. Among those you will meet are a high school football player whose college dreams were derailed by a series of undiagnosed concussions, a hard-driving soccer star whose own struggles with concussions pushed her to crusade for safety reform as a coach and soccer mom, and an economist who lost her career because of lingering concussion symptoms from a fender bender. The Concussion Crisis weaves these human dramas with compelling stories of scientists and doctors who are unraveling the mysteries of how an invisible injury can wreak such havoc. It takes readers into the top labs, where scientists are teasing out what goes wrong in the brain after a jolt to the head, and into the nation’s leading concussion clinic, where patients get cutting-edge management and treatment. Carroll and Rosner analyze the cultural factors that allowed this burgeoning epidemic to fester unseen and untreated. They chronicle the growing public awareness sparked by the premature retirements of superstars like NFL quarterbacks Troy Aikman and Steve Young. And they argue for an immediate change in a macho culture that minimizes the dangers inherent in repeated jolts to the head. The Concussion Crisis sounds an urgent wake-up call to parents, coaches, trainers, doctors, and the athletes themselves. The book will stand as the definitive exploration of this heretofore-silent health crisis. It should be required reading for every parent with a child playing sports—in fact, by everyone who has ever suffered a hard bump on the head.

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

    

    Margaret I. Cuomo is inspired to seek out new strategies for waging a smarter war on cancer.This year, about 1.6 million new cases of cancer will be diagnosed and more than 1,500 people will die "per day." We've been asked to accept the disappointing strategy to "manage cancer as a chronic disease." We've allowed pharmaceutical companies to position cancer drugs that extend life by just weeks and may cost $100,000 for a single course of treatment as breakthroughs. Where is the bold leadership that will transform our system from treatment to prevention? Have we forgotten the mission of the National Cancer Act of 1971 to "conquer cancer"?Through an analysis of more than 40 years of medical evidence and interviews with the top cancer researchers, drug company executives, and health policy advisers, Dr. Cuomo reveals intriguing answers to these questions. She shows us how all cancer stakeholders--the pharmaceutical industry, the government, physicians, and concerned Americans--can change the way we view and fight cancer in this country.

    Since that time, many countries have undergone a transformation from disease cesspools to much safer, healthier habitats. Starting in the mid-1800s, there was a steady drop in deaths from all infectious diseases, decreasing to relatively minor levels by the early 1900s. The history of that transformation involves famine, poverty, filth, lost cures, eugenicist doctrine, individual freedoms versus state might, protests and arrests over vaccine refusal, and much more. Today, we are told that medical interventions increased our lifespan and single-handedly prevented masses of deaths. But is this really true? Dissolving Illusions details facts and figures from long-overlooked medical journals, books, newspapers, and other sources. Using myth-shattering graphs, this book shows that vaccines, antibiotics, and other medical interventions are not responsible for the increase in lifespan and the decline in mortality from infectious diseases. If the medical profession could systematically misinterpret and ignore key historical information, the question must be asked, “What else is ignored and misinterpreted today?” Perhaps the best reason to know our history is so that the worst parts are never repeated.

    In existence for some hundred million years, it was discovered only recently. Exploring its evolution, its daily existence, and its journey from ticks to mice to deer to humans, Karlen lucidly examines the life and world of this recently prominent germ. He also describes how it attacks the human body, and how by changing the environment, people are now much more likely to come into contact with it. Charming and thorough and smart, this book is a wonderfully written biography of your not so typical biographical subject.

    Bill Rawls understands Lyme disease sufferers seeking clarity and relief because, like myself, he has experienced the pain and frustration firsthand. Through this ground-breaking book, he shares everything he has discovered on his journey to reclaiming his health... it may just be the answer you've been waiting for." – Neil Spector, MD, Author of Gone in a Heartbeat Lyme disease is one of the most puzzling illnesses on the planet. Anyone who has suffered from its debilitating symptoms knows the frustrations of trying to find a cure. Many sufferers drag themselves from one doctor or alternative practitioner to the next, getting lost in a maze of lab tests, prescription drugs, and treatments. Thousands of dollars and months (or years) later, they realize they are no better off than where they started. Unlocking Lyme puts an end to this desperate quest. Written by Dr. Bill Rawls, a physician who overcame Lyme disease himself, this book is a comprehensive, practical resource full of solutions that work. What took Dr. Rawls 10 years to learn through intense research and personal experience, you can now learn and implement in a matter of months. DR. RAWLS’ STORY Dr. Rawls was in the middle of a successful OB/GYN career when Lyme disease interrupted his life. In his struggle to overcome it, he explored every treatment option – from conventional medicine to the full range of alternative therapies. Ultimately, he embraced modern herbal therapy as his preferred solution, but he recognizes that the path may be different for each person. INSIDE THE BOOK Unlocking Lyme is the sum of Dr. Rawls’ experience, research, and practical solutions to date. The book is divided into four parts, each part addressing a critical aspect of recovery: PART 1 - Provides an overview of common misconceptions about what Lyme disease is (hint: it’s more than just a tick bite and Borrelia infection) PART 2 - Provides information on how to obtain a diagnosis, despite current limitations in diagnostic testing for Lyme PART 3 - Discusses limitations of long-term antibiotic use, and offers an overview of holistic and non-toxic therapies for healing and symptom control (including pain, depression, insomnia) PART 4 - Explains how to embrace a healthier lifestyle so you can stay well; learn how to strengthen your immune system, microbiome, and balance in your body In the years since his recovery, Dr. Rawls has helped thousands of patients find their path to healing from Lyme disease. Unlocking Lyme brings together Dr. Rawls’ accumulated knowledge and is the key you need to get your life back. TESTIMONIALS “Dr. Rawls understands the misery of chronic Lyme disease firsthand. Unlocking Lyme shares the approaches that he used to successfully recover his own health, and helps the reader understand that there is so much that can be done to regain a state of wellness and optimal health.” – Scott Forsgren Editor & Founder, BetterHealthGuy.com “Dr. Rawls has spoken on his approach to Lyme disease for the past several years; his comprehensive approach and lifestyle guidance has helped many of our members. We heartily endorse his approach to helping deal with the symptoms of Lyme and other tick-borne illnesses.” – John Dorney, President NC Lyme Disease Foundation "Unlocking Lyme delves into the science behind Lyme disease, explaining what it is, but more importantly how it can be overcome. Dr. Rawls carefully explains the various treatments for Lyme, leaving the reader feeling informed and empowered.

    These kids often have violent outbursts, steal, engage in outlandish lying, play with feces, and hoard food. They are broken children who too often break even the most loving of caregivers. Many parents of these children feel utterly isolated as family, friends, and professionals minimize their struggles. Reactive Attachment Disorder (RAD) - The Essential Guide for Parents is written by a parent who is in the trenches with you. Keri has lived the journey of raising a son with RAD and has navigated the mental health system for over a decade. This is the resource you’ve been waiting for – you won’t find platitudes or false hopes. What you will find is essential information, practical suggestions, and resource recommendations to provide a way forward. If you desperately need help navigating the difficult RAD journey with your child, this book is for you.

    I didn't want to intrude on these moments, but John insisted. He felt that I captured him in ways that no one else did because of his comfort level with me...For years, only my closest friends got to see these photos--which were literally tucked away in a shoebox in my closet. They were surprised that these images did not convey the John that was portrayed in the press during our time together. In fact, they saw a side of John seldom seen."--From INSTAMATIC KARMAJohn Lennon is the most famously photographed Beatle--everyone from Iain MacMillian to Annie Lebowitz took iconic images of him--but there have never been pictures of him like these taken by May Pang, Lennon's girlfriend from 1973 to 1975. In INSTAMATIC KARMA, they're collected for the first time. With very few exceptions, these photos are that rare thing: never-before-seen images of an icon. The photos here show Lennon in a variety of settings: at work, at play, at home, and away. They show a playful Lennon, a casual, unguarded Lennon; they're the kind of photos one lover takes of another. May has written rich captions to accompany her photos--taken together, they tell a simple story of the time May and Lennon spent together; a time, according to legend, when Lennon was unhappy and unproductive, estranged from his family and bandmates. Pang's photos clearly tell another story--they show Lennon clowning around, working on his hit album "Walls and Bridges," embracing old friends and family, hanging out in their apartment on Manhattan's East 52nd Street, relaxing in the country in upstate New York or spending peaceful days swimming in the waters of Long Island.The photographs in INSTAMATIC KARMA are both color and black & white, casual Polaroids and more composed shots. Each one is an intimate glimpse into a fascinating time in John Lennon's life.