Longtime sports columnist Bryan Burwell has written the first comprehensive biography of this living legend, whose incredible football knowledge, down-home sensibilities, and tireless work ethic made him arguably the most popular sports analyst in any sport. As a coach, he has the highest winning percentage in history, and he led the Oakland Raiders to a 1979 Super Bowl Championship. He followed that up by becoming the most beloved and popular football announcer in the country, and in the third stage of his public life, the Hall of Fame coach became known to new generations of fans through his eponymous line of groundbreaking video games, which are among the bestselling titles of all time."

    Explaining the nature of genetic variation in the human population, how hereditary factors were identified as molecules of DNA, and how certain specific mutations can lead to disease, Slack highlights how DNA variants are used to trace human ancestry and migration, and can also be used by forensic scientists to identify individuals in crime. Slack also explores issues such as the role of genetic heritability and IQ as well as the changes that occur in the genes of populations during evolution. An ideal guide for anyone curious about what genes are and how genetics can be put to use, this Very Short Introduction demonstrates the ways in which the gene concept has been understood and used by molecular biologists, population biologists, and social scientists around the world. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

    While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

    The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published.This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA.

    This book will equally deepen the awareness of clinicians and enlighten the lay reader. It is a gift to both.' Donald M. Berwick, MD, MPPIn this highly articulate, down-to-earth, generous book, Dr David Galler tells stories of life and death from his position as Intensive Care specialist at Middlemore Hospital. Written lyrically and warmly, these stories are based on real life events describing the everyday dilemmas and challenges that doctors and patients commonly face.It aims to explain and demystify much of the work doctors do, cast light on the workings of the medical establishment and how medicine operates, in the hope that it will encourage patients to seek to be better informed and play a greater role in the decisions that will affect them and their loved ones.It speaks to the resilience of individuals and families and their extraordinary generosity and dignity under the most extreme pressure. This book is about realistic optimism and is a celebration of life.It is also a very personal story about David Galler's life, his family and about his own slow coming of age as a doctor, from the sadness and helplessness he felt about his father's death to at last feeling that he was of some use to his most important patient, his mother.

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    It documents the scale of devastation, the likely causes and consequences, and the resilience with which people faced those pandemics.The book also provides the first comprehensive coverage of the world's greatest demographic disaster ever to descend upon a country in a short period of time - the influenza pandemic in India in 1918, which claimed more lives than all the battle casualties of World War I. And it shows the continuing relevance of learning from those times to tackle contemporary challenges, such as COVID-19.

    Brilliant, driven, but haunted by demons, William Stewart Halsted took surgery from a horrific, dangerous practice to what we now know as a lifesaving art. Halsted was born to wealth and privilege in New York City in the mid-1800s. He attended the finest schools, but he was a mediocre student. His academic interests blossomed at medical school and he quickly became a celebrated surgeon. Experimenting with cocaine as a local anesthetic, he became addicted. He was hospitalized and treated with morphine to control his craving for cocaine. For the remaining 40 years of his life he was addicted to both drugs.Halsted resurrected his career at Johns Hopkins, where he became the first chief of surgery. Among his accomplishments, he introduced the residency training system, the use of sterile gloves, the first successful hernia repair, radical mastectomy, fine silk sutures, and anatomically correct surgical technique. Halsted is without doubt the father of modern surgery, and his eccentric behavior, unusual lifestyle, and counterintuitive productivity in the face of lifelong addiction make his story unusually compelling.Gerald Imber, a renowned surgeon himself, evokes Halsted's extraordinary life and achievements and places them squarely in the historical and social context of the late 19th century. The result is an illuminating biography of a complex and troubled man, whose genius we continue to benefit from today.

    But ask a physicist and there’s no doubt that James Clerk Maxwell will be near the top of the list.  Maxwell, an unassuming Victorian Scotsman, explained how we perceive colour. He uncovered the way gases behave. And, most significantly, he transformed the way physics was undertaken in his explanation of the interaction of electricity and magnetism, revealing the nature of light and laying the groundwork for everything from Einstein’s special relativity to modern electronics.   Along the way, he set up one of the most enduring challenges in physics, one that has taxed the best minds ever since. ‘Maxwell’s demon’ is a tiny but thoroughly disruptive thought experiment that suggests the second law of thermodynamics, the law that governs the flow of time itself, can be broken. This is the story of a groundbreaking scientist, a great contributor to our understanding of the way the world works, and his duplicitous demon.

    Shapiro's Evolution: A View from the 21st Century proposes an important new paradigm for understanding biological evolution. Shapiro demonstrates why traditional views of evolution are inadequate to explain the latest evidence, and presents a compelling alternative. His information- and systems-based approach integrates advances in symbiogenesis, epigenetics, and mobile genetic elements, and points toward an emerging synthesis of physical, information, and biological sciences.

    Comparing gene sequences, examining atomic structures of proteins, and looking into the geochemistry of rocks have helped explain evolution in more detail than ever before. Nick Lane expertly reconstructs the history of life by describing the ten greatest inventions of evolution (including DNA, photosynthesis, sex, and sight), based on their historical impact, role in organisms today, and relevance to current controversies. Who would have guessed that eyes started off as light-sensitive spots used to calibrate photosynthesis in algae? Or that DNA’s building blocks form spontaneously in hydrothermal vents? Lane gives a gripping, lucid account of nature’s ingenuity, and the result is a work of essential reading for anyone who has ever pondered or questioned the science underlying evolution’s greatest gifts to man.

    An attractive and comprehensive guidebook, this work has been completely revised and updated by the author. The reader will find an easy-to-use text which details the natural history of the plants and animals found in the Galápagos Islands. Management and conservation of the Galápagos National Park is discussed, and visitor information and notes about the various tourist sites are given. An index and checklist of plants and animals with page references and a glossary of technical terms are provided. New photographs have been added.

    Hughes chronicles the history of Churches of Christ in America from their inception in the early nineteenth century to the 1990s, taking full account of the complexity of their origins, the mainstream of their heritage for almost two hundred years, and their voices of protest and dissent, especially in the twentieth century. From The Critics "Hughes...here provides the definitive history of the Churches of Christ from their beginnings in the Stone-Campbell movement of the early 19th century through the split with the Disciples of Christ at the turn of the century and all the way into the 1990s. Central to this richly detailed and highly readable narrative is Hughes's assertion that this religious movement has evolved from a 19th-century sect into a 20th-century denomination." - Choice "Because of Hughes's elegant writing and his awareness of the social history surrounding the developing denomination, this study transcends mere denominational history and should be read as cultural history. It should remain the standard volume on the subject for years to come." - Publishers Weekly "Hughes provides a clear, balanced account of an American religious movement that has heretofore received insufficient scholarly attention." - Journal of American History "An excellent denominational history of Churches of Christ.... Richard T. Hughes, who admirably balances an empathy born of his lifelong membership in the denomination with the standards of a professional historian, labored on this book for a decade and a half, and the result is a study both thoroughly researched and clearly written." - American Historical Review "Hughes is the foremost interpreter today ofthe Churches of Christ, as this book illustrates.... Well written and meticulously documented, this book could serve as the definitive history of this movement for a generation." - Religious Studies Review

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."