Chapters cover cancer, infection, immune disorders, genetics, and disorders of each body system, highlighting pathophysiologic processes, resulting signs and symptoms, diagnostic test findings, and current treatments. Reader-friendly features include illustrations, checklists, and full-color miniguides illustrating the pathophysiology of specific disorders.This edition has new full-color miniguides on cancer pathophysiology and neuropathology. A new Focus on Genetics feature identifies gene-related discoveries and their implications for treatment or diagnosis. Review questions and answers follow current NCLEX-RN® requirements and alternate-format questions are included.

    A compelling and revolutionary work that calls for the immediate extension of our human rights to the great apes.The Great Ape Project looks forward to a new stage in the development of the community of equals, whereby the great apes-chimpanzees, gorillas, and orangutans-will actually receive many of the same protections and rights that are already accorded to humans.This profound collection of thirty-one essays by the world's most distinguished observers of free-living apes make up a uniquely satisfying whole, blending observation and interpretation in a highly persuasive case for a complete reassessment of the moral status of our closest kin.

    National Geographic answers all the questions about technology, biology, chemistry, physics, math, engineering, computers, and mechanics--in an indispensable book that reveals the science behind virtually everything. How does the voice of a distant radio announcer make it through your alarm clock in the morning? How does your gas stove work? How does the remote control open your garage door? What happens when you turn the key in the ignition? What do antibiotics really do? Divided into four big realms--Mechanics, Natural Forces, Materials & Chemistry, Biology & Medicine--The Science of Everything takes readers on a fascinating tour, using plain talk, colorful photography, instructive diagrams, and everyday examples to explain the science behind all the things we take for granted in our modern world.

    While you could probably learn a lot about each piece, you would have no idea about what the entire picture looks like. This is reductionism -- the idea that to understand the world we only need to study its pieces -- and it is how most social scientists approach their work. In A Crude Look at the Whole, social scientist and economist John H. Miller shows why we need to start looking at whole pictures. For one thing, whether we are talking about stock markets, computer networks, or biological organisms, individual parts only make sense when we remember that they are part of larger wholes. And perhaps more importantly, those wholes can take on behaviors that are strikingly different from that of their pieces. Miller, a leading expert in the computational study of complex adaptive systems, reveals astounding global patterns linking the organization of otherwise radically different structures: It might seem crude, but a beehive's temperature control system can help predict market fluctuations and a mammal's heartbeat can help us understand the "heartbeat" of a city and adapt urban planning accordingly. From enduring racial segregation to sudden stock market disasters, once we start drawing links between complex systems, we can start solving what otherwise might be totally intractable problems. Thanks to this revolutionary perspective, we can finally transcend the limits of reductionism and discover crucial new ideas. Scientifically founded and beautifully written, A Crude Look at the Whole is a powerful exploration of the challenges that we face as a society. As it reveals, taking the crude look might be the only way to truly see.

    But recent technological advances have made the question both practical and urgent. A brilliantly imaginative group of physicists at Oxford University have risen to the challenge. This is their story. At long last, there is a sensible way to think about quantum mechanics. The new view abolishes the need to believe in randomness, long-range spooky forces, or conscious observers with mysterious powers to collapse cats into a state of life or death. But the new understanding comes at a price: we must accept that we live in a multiverse wherein countless versions of reality unfold side-by-side. The philosophical and personal consequences of this are awe-inspiring.The new interpretation has allowed imaginative physicists to conceive of wonderful new technologies: measuring devices that effectively share information between worlds and computers that can borrow the power of other worlds to perform calculations. Step by step, the problems initially associated with the original many-worlds formulation have been addressed and answered so that a clear but startling new picture has emerged.Just as Copenhagen was the centre of quantum discussion a lifetime ago, so Oxford has been the epicenter of the modern debate, with such figures as Roger Penrose and Anton Zeilinger fighting for single-world views, and David Deutsch, Lev Vaidman and a host of others for many-worlds.An independent physicist living in Oxford, Bruce has had a ringside seat to the debate. In his capable hands, we understand why the initially fantastic sounding many-worlds view is not only a useful way to look at things, but logically compelling. Parallel worlds are as real as the distant galaxies detected by the Hubble Space Telescope, even though the evidence for their existence may consist only of a few photons.

    It's weirder than we are capable of imagining. And we're all in it together: humans, blue whales, rats, birds of paradise, ridiculous numbers of beetles, molluscs the size of a bus, the sexual gladiators of slugs, bdelliod rotifers who haven't had sex for millions of years and creatures called water bears: you can boil them, freeze them and fire them off into space without killing themWe're all part of the animal kingdom, appearing in what Darwin called 'endless forms most beautiful and most wonderful'. In this breathtakingly audacious book Simon Barnes has brought us all together, seeking not what separates us but what unites us. He takes us white-water rafting through the entire animal kingdom in a book that brings in deep layers of arcane knowledge, the works of Darwin and James Joyce, Barnes's own don't-try-this-at-home adventures in the wild, David Attenborough and Sherlock Holmes.

    Just ask biotechnologist Matti Leisola. It all started when a student loaned the Finnish scientist a book criticizing evolutionary theory. Leisola reacted angrily, and set out to defend evolution, but found his efforts raised more questions than they answered. He soon morphed into a full-on Darwin skeptic, even as he was on his way to becoming a leading bio-engineer.Heretic is the story of Leisola's adventures making waves-and many friends and enemies-at major research labs and universities across Europe. Tracing his investigative path, the book draws on Leisola's expertise in molecular biology to show how the evidence points more strongly than ever to the original biotechnologist-a designing intelligence whose skill and reach dwarf those of even our finest bioengineers, and leave blind evolution in the dust.Endorsements "Award-winning Finnish biotechnologist Matti Leisola has written a fascinating account of what happens when a scientist follows the evidence wherever it leads. Leisola's account of how he succeeded should inspire up-and-coming scientists who face the same challenge." Biologist Jonathan Wells, PhD, author of Icons of Evolution and Zombie Science "Scientists, like all other intellectuals, have ideas about what constitutes and what does not constitute reality. However, they are often not aware-and sometimes not ready to admit-that such ideas represent the principles of their philosophy. Leisola and Witt's Heretic is a unique first-hand account of the life-long adventures of a scientist who dared to challenge philosophical principles of colleague scientists. In my opinion, the outcome shows that to many scientists their philosophy is dearer than their science." Biochemist and inventor Branko Kozulic, PhD "This book is an exciting story about how a scientist's relentless search for truth makes him a heretic in the eyes of a cultural community more concerned about prestige than principle." Tapio Puolimatka, PhD and EdD, University of Jyvaskyla, Finland "This book is a personal, strong, and motivated plea for intelligent design (ID) and 'swims against the current' of Darwinian evolution, now generally accepted in scientific circles and society. I personally do not endorse ID, but I am a good friend of the author, whom I also highly respect as a scientist active in academia and in the biotech industry over so many years. Heretic inspires readers to think critically and to open up a civilized discussion on neo-Darwinism versus ID. It covers the science and philosophical parts adequately; it is accessible to a large readership; and statements are underpinned by relevant research and literature data. Its value lies in the author's lifelong engagement and personal crusade to stimulate the public debate among scientists as well as laymen over Darwinism (chance/random mutation and natural selection) versus ID, a vision that Leisola strongly advocates." Dr. Erick J. Vandamme, Emeritus Professor of Bioscience Engineering, Ghent University, Belgium "Matti Leisola has written the exciting story of almost the entire spectrum of aberrant motives, absurd fears, and unreasonable reactions to intelligent design (ID) by evolutionary scientists, clergymen, and church institutions alike, notably during his career as a scientist over the last some forty years. I would add a word on the fears of so many critics that accepting ID also means accepting the dogmata of some 1700 years of church history. ID is thoroughly neutral concerning such topics. So, the reader is invited to carefully check the historical and, what is more, the enormous wealth of scientific data Matti Leisola has presented in the present book: Test them carefully with an open mind and form your own independent opinion!" Dr. Wolf-Ekkehard Lonnig, geneticist, Cologne,

    They are the powerhouses of our cells, essential for the production and management of energy at cell level. Dr Sarah Myhill, together with Dr John McLaren Howard of Acumen Laboratories and Dr Norman Booth of Mansfield College Oxford, has spent many years studying the relationship between their malfunction and the commonest problem seen by GPs in the UK – fatigue. Their research findings have been published in three scientific papers in the International Journal of Clinical and Experimental Medicine, in 2009, 2012 and 2013. These studies showed that poor functioning of the mitochondria is the central problem in CFS. Patients with the worst mitochondrial function had the worst fatigue and vice versa. This is solid scientific evidence that CFS is a problem with mitochondria and has allowed the objective measurement of fatigue for the first time. With the publication of the third study, which showed that mitochondrial function tests and symptoms improved in patients who took measures to address their mitochondrial problems, Dr Myhill was ready to write this book. Here she explains the importance of healthy mitochondria, how we can measure their functioning and what we can do to keep them healthy, or restore them to health if problems arise. CFS is all in our cells, not in our minds!

    It combines the latest findings from the field of neuroscience with expert text and state-of-the-art illustrations and imaging techniques to provide an incomparable insight into every facet of the brain. Layer by layer, it reveals the fascinating details of this remarkable structure, covering all the key anatomy and delving into the inner workings of the mind, unlocking its many mysteries, and helping you to understand what's going on in those millions of little gray and white cells.Tricky concepts are illustrated and explained with clarity and precision, as The Human Brain Book looks at how the brain sends messages to the rest of the body, how we think and feel, how we perform unconscious actions (for example breathing), explores the nature of genius, asks why we behave the way we do, explains how we see and hear things, and how and why we dream. Physical and psychological disorders affecting the brain and nervous system are clearly illustrated and summarized in easy-to-understand terms.The unique DVD brings the subject to life with interactive elements. These include a clickable model of the brain's structure that allows the user to zoom in and discover deeper layers of detail, while complex processes, such as the journey of a nerve impulse, are broken down and simplified through intuitive animations.

    We currently see no evidence of any kind indicating that extraterrestrials exist outside of our solar system. But at this moment, millions of engineers, scientists, corporations, universities and entrepreneurs are racing to create the second intelligent species right here on planet earth. And we can see the second intelligent species coming from all directions in the form of self-driving cars, automated call centers, chess-playing and Jeopardy-playing computers that beat all human players, airport kiosks, restaurant tablet systems, etc. The frightening thing is that these robots will soon be eliminating human jobs in startling numbers. The first wave of unemployed workers is likely to be a million truck drivers who are replaced by self-driving trucks. Pilots will be eliminated soon as well. Then, as new computer vision systems come online, we will see tens of millions of workers in retail stores, fast food restaurants and construction sites replaced by robots. Unless we take steps now to change the economy, we will soon have tens of millions of workers who are unemployed and seeking welfare because they will have no other choice. Marshall Brain's new book "The Second Intelligent Species: How Humans Will Become as Irrelevant as Cockroaches" explores how the future will unfold as the second intelligent species emerges. The book answers questions like: - How will new computer vision systems affect the job market? - How many people will become unemployed by the second intelligent species? - What will happen to millions of newly unemployed workers? - How can modern society and modern economies cope with run-away unemployment caused by robots? - What will happen when the first sentient, conscious computer appears? - What moral and ethical principles will guide the second intelligent species? - Why do we see no extraterrestrials in our universe? "The Second Intelligent Species" offers a unique and fascinating look at the future of the human race, and the choices we will need to make to avoid massive unemployment and poverty worldwide as intelligent machines start eliminating millions of jobs.

    We see it, touch it, and live in it every day. It is a habitat for a mesmerizingly complex world of micro-organisms and physical functions that are vital to our health and our survival. It is also a waste removal plant, a warning system for underlying disease and a dynamic immune barrier to infection. One of the first things people see about us, skin is crucial to our sense of identity, providing us with social significance and psychological meaning. And yet our skin and the fascinating way it functions is largely unknown to us. In prose as lucid as his research underlying it is rigorous, blending in memorable stories from the past and from his own medical experience, Monty Lyman has written a revelatory book exploring our outer surface that will surprise and enlighten in equal measure. Through the lenses of science, sociology, and history--on topics as diverse as the mechanics and magic of touch (how much goes on in the simple act of taking keys out of a pocket and unlocking a door is astounding), the close connection between the skin and the gut, what happens instantly when one gets a paper cut, and how a midnight snack can lead to sunburn--Lyman leads us on a journey across our most underrated and unexplored organ and reveals how our skin is far stranger, more wondrous, and more complex than we have ever imagined.

    Even before recorded history began, disease plagued human civilizations, claiming more lives than natural disasters and warfare combined. The ongoing battle with new and resurgent diseases has challenged physicians, scientists, and historians in their struggle to identify causes, antidotes, and preventative measures to combat these epidemics. Analyzing case studies including the Black Death, Spanish Flu, cholera, leprosy, syphilis, cancer, and Ebola, this book systematically maps the development of trends and the latest research on disease into a concise and enlightening timeline. Offering a fascinating and compelling insight into a popular area of social history, this easy-to-read introduction will tell you all you need to know about disease and the ongoing quest to protect human health.

    Seventy-five years later, in Kitzmiller v. Dover, the ACLU sued to prevent the teaching of an alternative to Darwin’s theory known as "Intelligent Design"—and won. Why did the ACLU turn from defending the free-speech rights of Darwinists to silencing their opponents? Jonathan Wells reveals that, for today’s Darwinists, there may be no other choice: unable to fend off growing challenges from scientists, or to compete with rival theories better adapted to the latest evidence, Darwinism—like Marxism and Freudianism before it—is simply unfit to survive. Wells begins by explaining the basic tenets of Darwinism, and the evidence both for and against it. He reveals, for instance, that the fossil record, which according to Darwin should be teeming with "transitional" fossils showing the development of one species to the next, so far hasn’t produced a single incontestable example. On the other hand, certain well-documented aspects of the fossil record—such as the Cambrian explosion, in which innumerable new species suddenly appeared fully formed—directly contradict Darwin’s theory. Wells also shows how most of the other "evidence" for evolution— including textbook "icons" such as peppered moths, Darwin’s finches, Haeckel’s embryos, and the Tree of Life—has been exaggerated, distorted . . . and even faked. Wells then turns to the theory of intelligent design (ID), the idea that some features of the natural world, such as the internal machinery of cells, are too "irreducibly complex" to have resulted from unguided natural processes alone. In clear-cut layman’s language, he reveals the growing evidence for ID coming out of scientific specialties from microbiology to astrophysics. As Wells explains, religion does play a role in the debate over Darwin—though not in the way evolutionists claim. Wells shows how Darwin reasoned that evolution is true because divine creation "must" be false—a theological assumption oddly out of place in a scientific debate. In other words, Darwinists’ materialistic, atheistic assumptions rule out any theories but their own, and account for their willingness to explain away the evidence—or lack of it. Darwin is an emperor who has no clothes— but it takes a brave man to say so. Jonathan Wells, a microbiologist with two Ph.D.s (from Berkeley and Yale), is that brave man. Most textbooks on evolution are written by Darwinists with an ideological ax to grind. Brave dissidents—qualified scientists—who try to teach or write about intelligent design are silenced and sent to the academic gulag. But fear not: Jonathan Wells is a liberator. He unmasks the truth about Darwinism— why it is wrong and what the real evidence is. He also supplies a revealing list of "Books You’re Not Supposed to Read" (as far as the Darwinists are concerned) and puts at your fingertips all the evidence you need to challenge the most closed-minded Darwinist.

    The story begins in Africa, six to seven million years ago, and encompasses twenty known human species, of which Homo sapiens is the sole survivor. Illustrated with spectacular, three-dimensional scientific reconstructions portrayed in their natural habitat developed by a team of physical anthropologists at the American Museum of Natural History and in concert with experts from around the world, the book is both a guide to extinct human species and an astonishing hominid family photo album.The Last Human presents a comprehensive account of each species with information on its emergence, chronology, geographic range, classification, physiology, lifestyle, habitat, environment, cultural achievements, co-existing species, and possible reasons for extinction. Also included are summaries of fossil discoveries, controversies, and publications. What emerges from the fossil story is a new understanding of Homo sapiens. No longer credible is the notion that our species is the end product of a single lineage, improved over generations by natural selection. Rather, the fossil record shows, we are a species with widely varied precursors, and our family tree is characterized by many branchings and repeated extinctions.Exhibition information:Photographs of most of the reconstructions that appear in this book will be featured in exhibits appearing in the new Hall of Human Origins at the American Museum of Natural History in New York City.  The opening of the Hall is planned for November 2006.

    Now astrophysicist John Gribbin draws on his expertise to explore, in prose that communicates not only the wonder but the substance of cutting-edge science, the principles behind chaos and complexity. He reveals the remarkable ways these two revolutionary theories have been applied over the last twenty years to explain all sorts of phenomena–from weather patterns to mass extinctions.Grounding these paradigm-shifting ideas in their historical context, Gribbin also traces their development from Newton to Darwin to Lorenz, Prigogine, and Lovelock, demonstrating how–far from overturning all that has gone before–chaos and complexity are the triumphant extensions of simple scientific laws. Ultimately, Gribbin illustrates how chaos and complexity permeate the universe on every scale, governing the evolution of life and galaxies alike.