Chaotic politics. Billionaire entrepreneurs. Award-winning journalist Brendan Borrell brings the defining story of our times alive through compulsively readable, first-time reporting on the players leading the fight against a vicious virus. The First Shots, soon to be the subject of an HBO limited series with superstar director and producer Adam McKay (Succession, Vice, The Big Short), draws on exclusive, high-level access to weave together the intense vaccine-race conflicts among hard-driving, heroic scientists and the epic rivalries among Washington power players that shaped 18 months of fear, resolve, and triumph. From infectious disease expert Michael Callahan, an American doctor secretly on the ground in Wuhan in January 2020 to gauge the terrifying ravages of Disease X; to Robert (Dr. Bob) Kadlec, one of Operation Warp Speed’s architects, whose audacious plans for the American people run straight into the buzz saw of the Trump White House factions; to Stéphane Bancel of upstart Moderna Therapeutics going toe-to-toe with pharma behemoth Pfizer, The First Shots lays bare, in a way we have not seen, the full stunning story behind the medical science “moon shot” of our lifetimes.

    They evolved from land-roaming, dog-like creatures into animals that move like fish, breathe like us, can grow to 300,000 pounds, live 200 years and roam entire ocean basins. Whales fill us with terror, awe, and affection--yet we know hardly anything about them, and they only enter our awareness when they die, struck by a ship or stranded in the surf. Why did it take whales over 50 million years to evolve to such big sizes, and how do they eat enough to stay that big? How did their ancestors return from land to the sea? Why do they beach themselves? What do their lives tell us about our oceans, and evolution as a whole? Importantly, in the sweepstakes of human-driven habitat and climate change, will whales survive?Nick Pyenson's research has given us the answers to some of our biggest questions about whales. Nick's rich storytelling takes us to the cool halls deep inside the Smithsonian's priceless fossil collection, to the frigid fishing decks on Antarctic whaling stations, and to the blazing hot desert of Chile where scientists race against time to document the largest fossil whalebone site on earth. Spying on Whales is science writing at its best: an author who is an incredible, passionate writer, at the forefront of his field, on a topic that invokes deep fascination.

    Nobody is perfect. And that includes five of the greatest scientists in history—Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle, and Albert Einstein. But the mistakes that these great luminaries made helped advance science. Indeed, as Mario Livio explains, science thrives on error, advancing when erroneous ideas are disproven.As a young scientist, Einstein tried to conceive of a way to describe the evolution of the universe at large, based on General Relativity—his theory of space, time, and gravity. Unfortunately he fell victim to a misguided notion of aesthetic simplicity. Fred Hoyle was an eminent astrophysicist who ridiculed an emerging theory about the origin of the universe that he dismissively called “The Big Bang.” The name stuck, but Hoyle was dead wrong in his opposition.They, along with Darwin (a blunder in his theory of Natural Selection), Kelvin (a blunder in his calculation of the age of the earth), and Pauling (a blunder in his model for the structure of the DNA molecule), were brilliant men and fascinating human beings. Their blunders were a necessary part of the scientific process. Collectively they helped to dramatically further our knowledge of the evolution of life, the Earth, and the universe.

    In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    A seven-million-year journey to the very origins of the human lineage, First Steps shows how upright walking was a gateway to many of the other attributes that make us human—from our technological abilities, our thirst for exploration, our use of language–and may have laid the foundation for our species’ traits of compassion, empathy, and altruism. Moving from developmental psychology labs to ancient fossil sites throughout Africa and Eurasia, DeSilva brings to life our adventure walking on two legs. First Steps examines how walking upright helped us rise above all over species on this planet.First Steps includes an eight-page color photo insert.

    In this book, he expands the points he has made, and claims that this debate is not so much about religion versus science, as about the nature of science itself. With infectious enthusiasm, he reveals the mechanics of evolutionary theory, explains how it is rooted in the testable and verifiable scientific method, and why it is therefore a sound explanation of our beginning. He argues passionately that to continue to assert otherwise, to continue to insist that creationism has a place in the science classroom is harmful not only to our children, but to the future of the greater world as well.

    And before there were fish in the sea, there were cephalopods - the ancestors of modern squid and Earth’s first truly substantial animals. Cephalopods became the first creatures to rise from the seafloor, essentially inventing the act of swimming. With dozens of tentacles and formidable shells, they presided over an undersea empire for millions of years. But when fish evolved jaws, the ocean’s former top predator became its most delicious snack. Cephalopods had to step up their game. Many species streamlined their shells and added defensive spines, but these enhancements only provided a brief advantage. Some cephalopods then abandoned the shell entirely, which opened the gates to a flood of evolutionary innovations: masterful camouflage, fin-supplemented jet propulsion, perhaps even dolphin-like intelligence. Squid Empire is an epic adventure spanning hundreds of millions of years, from the marine life of the primordial ocean to the calamari on tonight’s menu. Anyone who enjoys the undersea world—along with all those obsessed with things prehistoric—will be interested in the sometimes enormous, often bizarre creatures that ruled the seas long before the first dinosaurs.

    Here is a delightfully entertaining and enlightening look at the unique sex lives of humans.

    It touches on its evolutionary development, its algorithmic nature and its scientific history by bridging ideas across Neuroscience, Computer Science, Biotechnology, Evolutionary History, Cognitive Science, Political Philosophy, and Artificial Intelligence.Never before had there been nearly as many scientists, resources or productive research focused on these topics, and humanity has achieved some understanding and some clarification. With the speed of progress it is timely to communicate an overreaching perspective, this book puts an emphasis on conveying the essential questions and what we know about their answers in a simple, clear and exciting way.Humans, along with the first RNA molecules, the first life forms, the first brains, the first conscious animals, the first societies and the first artificial agents constitute an amazing and crucial development in a path of increasingly complex computational intelligence. And yet, we occupy a minuscule time period in the history of Earth, a history that has been written by Genes, by Cultures and by Consciousnesses. If we abandon our anthropomorphic bias it becomes obvious that Humans are not so special after all. We are an important but short and transitory step among many others in a bigger story. The story of our computational minds, which is ours but not only ours. What is the relationship between computation, cognition and everything else? What is life and how did it originate? What is the role of culture in human minds? What do we know about the algorithmic nature of the mind, can we engineer it? What is the computational explanation of consciousness? What are some possible future steps in the evolution of minds? The underlying thread is the computational nature of the Mind which results from the mixture of Genes, Cultures and Consciousness. While these three interact in complex ways, they are ultimately computational systems on their own which appeared at different stages of history and which follow their own selective processes operating at different time scales. As technology progresses, the distinction between the three components materializes and will be a key determinant of the future.Among the many topics covered are the origin of life, the concept of computation and its relation to Turing Machines, cultural evolution and the notion of a Selfish Meme, free will and determinism, moral relativity, the hard problem of consciousness, the different theories of concepts from the perspective of cognitive science, the current status of AI and Machine Learning including the symbolic vs sub-symbolic dichotomy, the contrast between logical reasoning and neural networks, and the recent history of Deep Learning, Geoffrey Hinton, DeepMind and its algorithm AlphaGo. It also develops on the history of science and looks into the possible future building on the work of authors like Daniel Dennett, Yuval Harari, Richard Dawkins, Francis Crick, George Church, David Chalmers, Susan Carey, Stanislas Dehaene, Robert Boyd, Joseph Henrich, Daniel Kahneman, Moran Cerf, Josh Tenenbaum, David Deutsch, Steven Pinker, Ray Kurzweil, John von Neumann, Herbert Simon and many more. Andres Campero is a researcher and PhD student at the Brain and Cognitive Sciences Department and at the Computer Science and Artificial Intelligence Laboratory at the Massachusetts Institute of Technology (MIT).

    Your life, your thoughts, your diseases, and your health are all the function of cells.But what do you really know about what goes on inside you?The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant.The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world.Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover:A deeper understanding of how cells work and the basic nature of life on earth.Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research.The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells.The ability to make better decisions about health and to debunk the misinformation that comes in daily via media.Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.

    A twenty-eight year old — and not widely famous — Christopher Wren was giving a lecture on astronomy. As his audience listened to him speak, they decided that it would be a good idea to create a Society to promote the accumulation of useful knowledge.With that, the Royal Society was born. Since its birth, the Royal Society has pioneered scientific exploration and discovery. Isaac Newton, Charles Darwin, Albert Einstein, Robert Hooke, Robert Boyle, Joseph Banks, Humphry Davy, Isambard Kingdom Brunel, John Locke, Alexander Fleming — all were fellows.Bill Bryson’s favourite fellow was Reverend Thomas Bayes, a brilliant mathematician who devised Bayes’ theorem. Its complexity meant that it had little practical use in Bayes’ own lifetime, but today his theorem is used for weather forecasting, astrophysics and stock market analysis. A milestone in mathematical history, it only exists because the Royal Society decided to preserve it — just in case. The Royal Society continues to do today what it set out to do all those years ago. Its members have split the atom, discovered the double helix, the electron, the computer and the World Wide Web. Truly international in its outlook, it has created modern science.Seeing Further celebrates its momentous history and achievements, bringing together the very best of science writing. Filled with illustrations of treasures from the Society’s archives, this is a unique, ground-breaking and beautiful volume, and a suitable reflection of the immense achievements of science.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.