Its contributors—some of the most brilliant young scientists working today—provide not only an introduction to their cutting-edge research, but discuss the social, ethical, and philosophical ramifications of their work. With essays covering fields as diverse as astrophysics, paleoanthropology, climatology, and neuroscience, What's Next? is a lucid and informed guide to the new frontiers of science.

    Evo Devo Evolutionary Developmental Biology is the new science that has finally cracked open the box. Within the pages of his rich and riveting book, Sean B. Carroll explains how we are discovering that complex life is ironically much simpler than anyone ever expected.

    Now, in Shadows of the Mind, Penrose offers another exhilarating look at modern science as he mounts an even more powerful attack on artificial intelligence. But perhaps more important, in this volume he points the way to a new science, one that may eventually explain thephysical basis of the human mind. Penrose contends that some aspects of the human mind lie beyond computation. This is not a religious argument (that the mind is something other than physical) nor is it based on the brain's vast complexity (the weather is immensely complex, says Penrose, but it is still a computable thing, atleast in theory). Instead, he provides powerful arguments to support his conclusion that there is something in the conscious activity of the brain that transcends computation--and will find no explanation in terms of present-day science. To illuminate what he believes this something might be, andto suggest where a new physics must proceed so that we may understand it, Penrose cuts a wide swathe through modern science, providing penetrating looks at everything from Turing machines (computers programmed from artificial intelligence) to the implications of Godel's theorem maintaining thatconscious thinking must indeed involve ingredients that cannot adequately be stimulated by mere computation. Of particular interest is Penrose's extensive examination of quantum mechanics, which introduces some new ideas that differ markedly from those advanced in The Emperor's New Mind, especiallyconcerning the mysterious interface where classical and quantum physics meet. But perhaps the most interesting wrinkle in Shadows of the Mind is Penrose's excursion into microbiology, where he examines cytoskeletons and microtubules, minute substructures lying deep within the brain's neurons. (Heargues that microtubules--not neurons--may indeed be the basic units of the brain, which, if nothing else, would dramatically increase the brain's computational power.) Furthermore, he contends that in consciousness some kind of global quantum state must take place across large areas of the brain, and that it within microtubules that these collective quantum effects are most likely to reside. For physics to accommodate something that is as foreign to our current physical picture as is the phenomenon of consciousness, we must expect a profound change--one that alters the very underpinnings of our philosophical viewpoint as to the nature of reality. Shadows of the Mind provides anilluminating look at where these profound changes may take place and what our future understanding of the world may be.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    13 extraordinary essays shed new light on the mysteries of the universe & on one of the most brilliant thinkers of our time.In his phenomenal bestseller A Brief History of Time, Stephen Hawking literally transformed the way we think about physics, the universe, reality itself. In these thirteen essays and one remarkable extended interview, the man widely regarded as the most brilliant theoretical physicist since Einstein returns to reveal an amazing array of possibilities for understanding our universe. Building on his earlier work, Hawking discusses imaginary time, how black holes can give birth to baby universes, and scientists’ efforts to find a complete unified theory that would predict everything in the universe. With his characteristic mastery of language, his sense of humor and commitment to plain speaking, Stephen Hawking invites us to know him better—and to share his passion for the voyage of intellect and imagination that has opened new ways to understanding the very nature of the cosmos.

    Just a half century ago, this idea was revolutionary. In April 1953, James Watson and Francis Crick published in Nature their groundbreaking work revealing the double helix structure of DNA. While this discovery received wide attention from both mainstream media and the academic community, it was just one part of the bigger story in this history of molecular biology. By the mid-1950s, the scientific community confirmed that genes were indeed comprised of DNA; they just needed to crack the genetic code—and the race was on. Life’s Greatest Secret is the full and rich history of this challenge and the characters—many of whom were not biologists—whose work contributed to this grand scientific endeavor: mathematician and father of cybernetics Norbert Wiener, physicist Erwin Schrödinger, information theorist Claude Shannon, and biologists Jacques Monod and Marshall Nirenberg.In Life’s Greatest Secret, science historian and zoologist Matthew Cobb shows that the race to crack the genetic code was mostly a matter of craft—individuals or small groups struggling with ideas and concepts as much as they were with facts, trying to find the right experiment to answer the right questions, even if they didn’t know what the questions were, and finding that, even when the most definitive answer served mostly to reveal more ignorance, whether in 1953, with Watson and Crick, or in 1961, when Nirenberg and Matthaei showed how DNA codes for specific amino acids, and again and again thereafter, or in 2000, with the first publication of a human genome. Each discovery was a leap forward in our understanding of the natural world and our place within in, akin to the discoveries of Galileo and Einstein in the realm of physics, or the publication of Darwin’s On the Origin of Species. And each served to show how much bigger the problem was that anyone had previously imagined, a trend that continues, as Cobb shows, even today, whether we are discussing gene regulation, epigenetics, or GMOs.Life’s Greatest Secret is a story of ideas and of experimentation, of ingenuity, insight, and dead-ends, in the hunt to make the greatest discovery of twentieth century biology. Ultimately, though, this is a story of humans exploring what it is that makes us human.

      Leonard Mlodinow takes us on a passionate and inspiring tour through the exciting history of human progress and the key events in the development of science. In the process, he presents a fascinating new look at the unique characteristics of our species and our society that helped propel us from stone tools to written language and through the birth of chemistry, biology, and modern physics to today’s technological world.   Along the way he explores the cultural conditions that influenced scientific thought through the ages and the colorful personalities of some of the great philosophers, scientists, and thinkers: Galileo, who preferred painting and poetry to medicine and dropped out of university; Isaac Newton, who stuck needlelike bodkins into his eyes to better understand changes in light and color; and Antoine Lavoisier, who drank nothing but milk for two weeks to examine its effects on his body. Charles Darwin, Albert Einstein, Werner Heisenberg, and many lesser-known but equally brilliant minds also populate these pages, each of their stories showing how much of human achievement can be attributed to the stubborn pursuit of simple questions (why? how?), bravely asked.  The Upright Thinkers is a book for science lovers and for anyone interested in creative thinking and in our ongoing quest to understand our world. At once deeply informed, accessible, and infused with the author’s trademark wit, this insightful work is a stunning tribute to humanity’s intellectual curiosity.  (With black-and-white illustrations throughout.)

    Coated in red dust, the terrain is bewilderingly empty. And yet multiple spacecraft are circling Mars, sweeping over Terra Sabaea, Syrtis Major, the dunes of Elysium, and Mare Sirenum—on the brink, perhaps, of a staggering find, one that would inspire humankind as much as any discovery in the history of modern science.In this beautifully observed, deeply personal book, Georgetown scientist Sarah Stewart Johnson tells the story of how she and other researchers have scoured Mars for signs of life, transforming the planet from a distant point of light into a world of its own.Johnson’s fascination with Mars began as a child in Kentucky, turning over rocks with her father and looking at planets in the night sky. She now conducts fieldwork in some of Earth’s most hostile environments, such as the Dry Valleys of Antarctica and the salt flats of Western Australia, developing methods for detecting life on other worlds. Here, with poetic precision, she interlaces her own personal journey—as a female scientist and a mother—with tales of other seekers, from Percival Lowell, who was convinced that a utopian society existed on Mars, to Audouin Dollfus, who tried to carry out astronomical observations from a stratospheric balloon. In the process, she shows how the story of Mars is also a story about Earth: This other world has been our mirror, our foil, a telltale reflection of our own anxieties and yearnings.Empathetic and evocative, The Sirens of Mars offers an unlikely natural history of a place where no human has ever set foot, while providing a vivid portrait of our quest to defy our isolation in the cosmos.

    Everything in Its Place is a celebration of Sacks's myriad interests, all told with his characteristic compassion, erudition, and luminous prose. From the celebrated case history of Spalding Gray that appeared in The New Yorker four months before his death to reflections on mental asylums; from piercing accounts of Schizophrenia to a reminiscence of Robin Williams; from the riveting tale of a medical colleague falling victim to Alzheimer's to the cinematography of Michael Powell, this volume celebrates and reflects the wondrous curiosity of Oliver Sacks.

    Delving into an immense range of topics, from philosophy and literature to social criticism to mathematics and science, with essays that date from 1930s to the 1990s, Martin Gardner has astounded readers with his insight and erudition. The Night Is Large is the crowning achievement of his extraordinary career.

    But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking. Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all.  In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today. To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.

    Things can exist in two places at once and travel backwards and forwards in time. Waves and particles are one and the same, and objects change their behaviour according to whether they are being watched. This is not some alternative universe but the realm of the very small, where quantum mechanics rules. In this weird world of atoms and their constituents, our common sense understanding of reality breaks down - yet quantum mechanics has never failed an experimental test. What does it all mean? For all its weirdness, quantum mechanics has given us many practical technologies including lasers and the transistors that underlie computers and all digital technology. In the future, it promises computers more powerful than any built before, the ability to communicate with absolute privacy, and even quantum teleportation. The Quantum World explores the past, present and future of quantum science, its applications and mind-bending implications. Discover how ideas from quantum mechanics are percolating out into the vast scale of the cosmos - perhaps, in the future, to reveal a new understanding of the big bang and the nature of space and time.ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.

    For two decades, historian Alice Dreger has led a life of extraordinary engagement, combining activist service to victims of unethical medical research with defense of scientists whose work has outraged identity politics activists. With spirit and wit, Dreger offers in Galileo’s Middle Finger an unforgettable vision of the importance of rigorous truth seeking in today’s America, where both the free press and free scholarly inquiry struggle under dire economic and political threats.This illuminating chronicle begins with Dreger’s own research into the treatment of people born intersex (once called hermaphrodites). Realization of the shocking surgical and ethical abuses conducted in the name of “normalizing” intersex children’s gender identities moved Dreger to become an internationally recognized patient rights’ activist. But even as the intersex rights movement succeeded, Dreger began to realize how some fellow progressive activists were employing lies and personal attacks to silence scientists whose data revealed uncomfortable truths about humans. In researching one such case, Dreger suddenly became the target of just these kinds of attacks.Troubled, she decided to try to understand more—to travel the country to ferret out the truth behind various controversies, to obtain a global view of the nature and costs of these battles. Galileo’s Middle Finger describes Dreger’s long and harrowing journeys between the two camps for which she felt equal empathy: social justice activists determined to win and researchers determined to put hard truths before comfort. Ultimately what emerges is a lesson about the intertwining of justice and of truth—and a lesson of the importance of responsible scholars and journalists to our fragile democracy.

    In this amazingly comprehensible history of the universe, Simon Singh decodes the mystery behind the Big Bang theory, lading us through the development of one of the most extraordinary, important, and awe-inspiring theories in science.

    That word is formication, and the implied sense of horror and fascination, contends Richard Conniff, is something many of us actually crave. His Spineless Wonders presents an unabashed wallow in the joy of formication. Spineless Wonders is an engaging, sophisticated, and humorous mix of natural history and human lore. Through his journalistic assignments, Richard Conniff has been in contact with invertebrates for more than twenty years - tarantulas in the upper Amazon region, dragonflies in Arizona, squid in Florida, and flies on the rim of his beer glass. Discoveries about the extraordinary habits and idiosyncrasies of the moth, the leech, the ant, and the slime eel are opening new frontiers in the exploration of our natural universe. Spineless Wonders takes us directly to these wild and wonderful outposts to observe the hazards of being around invertebrates, the bizarre adaptions that enable them to survive in the world, and also the astonishing work they do - work that enables us to survive.