But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    The proof could be found in her mother’s elegance, her uppercrust London accent—and in a cryptic letter hinting at her claim to a country estate. But beneath the polished veneer lay a fearsome, unpredictable temper that drove Justine from home the moment she was old enough to escape. Years later, when her mother sent her an envelope filled with secrets from the past, Justine buried it in the back of an old filing cabinet.Overcome with grief after her mother’s death, Justine found herself drawn back to that envelope. Its contents revealed a mystery that stretched back to the early years of World War II and beyond, into the dark corridors of the Hospital for the Maintenance and Education of Exposed and Deserted Young Children. Established in the eighteenth century to raise “bastard” children to clean chamber pots for England’s ruling class, the institution was tied to some of history’s most influential figures and events. From its role in the development of solitary confinement and human medical experimentation to the creation of the British Museum and the Royal Academy of Arts, its impact on Western culture continues to reverberate. It was also the environment that shaped a young girl known as Dorothy Soames, who bravely withstood years of physical and emotional abuse at the hands of a sadistic headmistress—a resilient child who dreamed of escape as German bombers rained death from the skies.Heartbreaking, surprising, and unforgettable, The Secret Life of Dorothy Soames is the true story of one woman’s quest to understand the secrets that had poisoned her mother’s mind, and her startling discovery that her family’s fate had been sealed centuries before.

    Born to survivalists in the mountains of Idaho, she prepared for the end of the world by stockpiling home-canned peaches and sleeping with her "head-for-the-hills bag". In the summer she stewed herbs for her mother, a midwife and healer, and in the winter she salvaged in her father's junkyard.Her father forbade hospitals, so Tara never saw a doctor or nurse. Gashes and concussions, even burns from explosions, were all treated at home with herbalism. The family was so isolated from mainstream society that there was no one to ensure the children received an education and no one to intervene when one of Tara's older brothers became violent.Then, lacking any formal education, Tara began to educate herself. She taught herself enough mathematics and grammar to be admitted to Brigham Young University, where she studied history, learning for the first time about important world events like the Holocaust and the civil rights movement. Her quest for knowledge transformed her, taking her over oceans and across continents, to Harvard and to Cambridge. Only then would she wonder if she'd traveled too far, if there was still a way home.Educated is an account of the struggle for self-invention. It is a tale of fierce family loyalty and of the grief that comes with severing the closest of ties. With the acute insight that distinguishes all great writers, Westover has crafted a universal coming-of-age story that gets to the heart of what an education is and what it offers: the perspective to see one's life through new eyes and the will to change it.

    Trump and the toxic family that made him, Mary L. Trump, a trained clinical psychologist and Donald’s only niece, shines a bright light on the dark history of their family in order to explain how her uncle became the man who now threatens the world’s health, economic security, and social fabric.Mary Trump spent much of her childhood in her grandparents’ large, imposing house in the heart of Queens, where Donald and his four siblings grew up. She describes a nightmare of traumas, destructive relationships, and a tragic combination of neglect and abuse. She explains how specific events and general family patterns created the damaged man who currently occupies the Oval Office, including the strange and harmful relationship between Fred Trump and his two oldest sons, Fred Jr. and Donald.A first-hand witness to countless holiday meals and family interactions, Mary brings an incisive wit and unexpected humor to sometimes grim, often confounding family events. She recounts in unsparing detail everything from her uncle Donald’s place in the family spotlight and Ivana’s penchant for re-gifting to her grandmother’s frequent injuries and illnesses and the appalling way Donald, Fred Trump’s favorite son, dismissed and derided him when he began to succumb to Alzheimer’s.Numerous pundits, armchair psychologists, and journalists have sought to parse Donald J. Trump’s lethal flaws. Mary L. Trump has the education, insight, and intimate familiarity needed to reveal what makes Donald, and the rest of her clan, tick. She alone can recount this fascinating, unnerving saga, not just because of her insider’s perspective but also because she is the only Trump willing to tell the truth about one of the world’s most powerful and dysfunctional families.

    They are promises. They are the only way to walk from one night to the other."Nina Riggs was just thirty-seven years old when initially diagnosed with breast cancer--one small spot. Within a year, the mother of two sons, ages seven and nine, and married sixteen years to her best friend, received the devastating news that her cancer was terminal.How does one live each day, "unattached to outcome"? How does one approach the moments, big and small, with both love and honesty?Exploring motherhood, marriage, friendship, and memory, even as she wrestles with the legacy of her great-great-great grandfather, Ralph Waldo Emerson, Nina Riggs's breathtaking memoir continues the urgent conversation that Paul Kalanithi began in his gorgeous When Breath Becomes Air. She asks, what makes a meaningful life when one has limited time?Brilliantly written, disarmingly funny, and deeply moving, The Bright Hour is about how to love all the days, even the bad ones, and it's about the way literature, especially Emerson, and Nina's other muse, Montaigne, can be a balm and a form of prayer. It's a book about looking death squarely in the face and saying "this is what will be."Especially poignant in these uncertain times, The Bright Hour urges us to live well and not lose sight of what makes us human: love, art, music, words.

    In these pages, I’ve tried to do this.” —Bruce Springsteen, from the pages of Born to RunIn 2009, Bruce Springsteen and the E Street Band performed at the Super Bowl’s halftime show. The experience was so exhilarating that Bruce decided to write about it. That’s how this extraordinary autobiography began. Over the past seven years, Bruce Springsteen has privately devoted himself to writing the story of his life, bringing to these pages the same honesty, humor, and originality found in his songs. He describes growing up Catholic in Freehold, New Jersey, amid the poetry, danger, and darkness that fueled his imagination, leading up to the moment he refers to as “The Big Bang”: seeing Elvis Presley’s debut on The Ed Sullivan Show. He vividly recounts his relentless drive to become a musician, his early days as a bar band king in Asbury Park, and the rise of the E Street Band. With disarming candor, he also tells for the first time the story of the personal struggles that inspired his best work, and shows us why the song “Born to Run” reveals more than we previously realized. Born to Run will be revelatory for anyone who has ever enjoyed Bruce Springsteen, but this book is much more than a legendary rock star’s memoir. This is a book for workers and dreamers, parents and children, lovers and loners, artists, freaks, or anyone who has ever wanted to be baptized in the holy river of rock and roll. Rarely has a performer told his own story with such force and sweep. Like many of his songs (“Thunder Road,” “Badlands,” “Darkness on the Edge of Town,” “The River,” “Born in the U.S.A.,” “The Rising,” and “The Ghost of Tom Joad,” to name just a few), Bruce Springsteen’s autobiography is written with the lyricism of a singular songwriter and the wisdom of a man who has thought deeply about his experiences.

    Until now.For years, behind the closed doors of their farmhouse in Raymond, Washington, their sadistic mother, Shelly, subjected her girls to unimaginable abuse, degradation, torture, and psychic terrors. Through it all, Nikki, Sami, and Tori developed a defiant bond that made them far less vulnerable than Shelly imagined. Even as others were drawn into their mother’s dark and perverse web, the sisters found the strength and courage to escape an escalating nightmare that culminated in multiple murders.

    George Hodel, a prominent Hollywood physician was acquitted in a sensational incest trial, 16-year-old Tamar gave birth to a blue-eyed, white skinned baby girl. She insisted that the father was "Negro." Outraged by the audacity of their daughter and the stigma attached to a mixed-race child within their midst, her mother quickly arranged to have the baby permanently given away to Jimmie Lee, a black maid in a Nevada casino.Overwhelmed by the problems of raising a white-skinned baby in her black community, Jimmie spent the next twenty years struggling to secretly raise Fauna. Together they endured extreme poverty, alcoholism, starvation, sexual abuse, pregnancy and death, hopelessly bound and knotted together by relentless bigotry.Fauna survived this difficult world with a vow to find the one person who knew her beginnings, her biological mother, Tamar, the woman of her dreams. Fauna sets out to discover the truth, only to uncover her family's notorious secret: her extraordinary grandfather and the murder of the Black Dahlia."Haunting, poignant and heart-wrenching. The stuff of which movies are made." —Cliff Rothman, contributor, Vanity Fair"Laughter, sass, spirit and tears leaves the readers awash in hope." —Alfre Woodard, actor

    Kear's biggest concern is choosing a major--until she walks into a doctor's office in midtown Manhattan and gets a life-changing diagnosis. She is going blind, courtesy of an eye disease called retinitis pigmentosa, and has only a decade or so before Lights Out. Instead of making preparations as the doctor suggests, Kear decides to carpe diem and make the most of the vision she has left. She joins circus school, tears through boyfriends, travels the world, and through all these hi-jinks, she keeps her vision loss a secret.When Kear becomes a mother, just a few years shy of her vision's expiration date, she amends her carpe diem strategy, giving up recklessness in order to relish every moment with her kids. Her secret, though, is harder to surrender - and as her vision deteriorates, harder to keep hidden. As her world grows blurred, one thing becomes clear: no matter how hard she fights, she won't win the battle against blindness. But if she comes clean with her secret, and comes to terms with the loss, she can still win her happy ending.Told with humor and irreverence, Now I See You is an uplifting story about refusing to cower at life's curveballs, about the power of love to triumph over fear. But, at its core, it's a story about acceptance: facing the truths that just won't go away, and facing yourself, broken parts and all.

    Louis. With a theater degree in hand, she was certain everything would fall easily into place. Never mind that she didn’t know a single person in the entertainment industry. She was determined, she was confident, she was ready to work hard. So, what could go wrong?Uh, basically everything. It would be eight long years before she landed her Emmy-nominated role of Pam Beesley on The Office—nearly a decade of failure, struggle, rejection and doubt. The path to professional acting was more competitive than she’d ever imagined. Headshots, agents, classes, auditions . . . there was a lot to learn. And with so many obstacles to navigate, it wasn’t always easy to fight off discouragement. If only she’d had a handbook for the struggling actor. Or, better yet, someone to show her the way—an established actor who could manage her expectations, educate her about the business, and reassure her in those moments of despair.Jenna Fischer wants to be that person for you. With candor and wit, Fischer lays out what it takes to establish yourself in the profession. Based on her own memorable and hilarious experiences, she provides invaluable advice on how to get the right head shot, what to look for in representation, and the importance of getting out there and just doing something. She also provides helpful hints on how to be gutsy and take risks, the tricks to good auditioning and callbacks, and how not to fall for certain scams. (Auditions in a guy’s apartment are probably not legit—or at least not for the kind of part you’re looking for!)Fischer’s inspiring guidance will make you feel like you have a trusted friend who’s made the journey and has now returned to walk beside you, pointing out the pitfalls as you blaze your own path toward the life of a professional actor.

    And yet, very few of its readers know that the subject of the novel was inspired by a real-life case: the 1948 abduction of eleven-year-old Sally Horner.Weaving together suspenseful crime narrative, cultural and social history, and literary investigation, The Real Lolita tells Sally Horner’s full story for the very first time. Drawing upon extensive investigations, legal documents, public records, and interviews with remaining relatives, Sarah Weinman uncovers how much Nabokov knew of the Sally Horner case and the efforts he took to disguise that knowledge during the process of writing and publishing Lolita.Sally Horner’s story echoes the stories of countless girls and women who never had the chance to speak for themselves. By diving deeper in the publication history of Lolita and restoring Sally to her rightful place in the lore of the novel’s creation, The Real Lolita casts a new light on the dark inspiration for a modern classic.

    Now, we meet the actor who is every bit as loveable as the character he plays on TV. In this revealing collection of essays written in his irreverent, hilarious, and self-deprecating voice, Kunal Nayyar traces his journey from a little boy in New Delhi who mistakes an awkward first kiss for a sacred commitment, gets nosebleeds chugging Coca-Cola to impress other students, and excels in the sport of badminton, to the confident, successful actor on the set of TV’s most-watched sitcom since Friends.Going behind the scenes of The Big Bang Theory and into his personal experiences, Kunal introduces readers to the people who helped him grow, such as his James Bond-loving, mustachioed father who taught him the most important lessons in life: Treat a beggar as you would a king. There are two sides to every story. A smile goes a long way. And, when in doubt, use a spreadsheet. Kunal also walks us through his college years in Portland, where he takes his first sips of alcohol and learns to let loose with his French, 6’8” gentle-giant roommate, works his first-ever job for the university’s housekeeping department cleaning toilets for minimum wage, and begins a series of romantic exploits that go just about as well as they would for Raj. (That is, until he meets and marries a former Miss India in an elaborate seven-day event that we get to experience in a chapter titled “My Big Fat Indian Wedding.”)Full of heart, but never taking itself too seriously, this witty and often inspiring collection of underdog tales follows a young man as he traverses two continents in search of a dream, along the way transcending culture and language (and many, many embarrassing incidents) to somehow miraculously land the role of a lifetime.

    Critics have called her "sweet, adorable, and vicious." But there is so much more to be said about Samantha Bee. For one, she's Canadian. Whatever that means. And now, she opens up for the very first time about her checkered Canadian past. With charming candor, she admits to her Lennie from "Of Mice and Men"-style love of baby animals, her teenage crime spree as one-half of a car-thieving couple (Bonnie and Clyde in Bermuda shorts and braces), and the fact that strangers seem compelled to show her their genitals. She also details her intriguing career history, which includes stints working in a frame store, at a penis clinic, and as a Japanese anime character in a touring children's show.Samantha delves into all these topics and many more in this thoroughly hilarious, unabashedly frank collection of personal essays. Whether detailing the creepiness that ensues when strangers assume that your mom is your lesbian lover, or recalling her girlhood crush on Jesus (who looked like Kris Kristofferson and sang like Kenny Loggins), Samantha turns the spotlight on her own imperfect yet highly entertaining life as relentlessly as she skewers hapless interview subjects on "The Daily Show." She shares her unique point of view on a variety of subjects as wide ranging as her deep affinity for old people, to her hatred of hot ham. It's all here, in irresistible prose that will leave you in stitches and eager for more.

    Her story is raw like that first bite of wild onion, alive with startling imagery, and told with uncommon emotional power.Regan grew up the youngest of four headstrong girls on a small farm in Northwest Indiana. While gathering raspberries as a toddler, Regan preternaturally understood to pick just the ripe fruit and leave the rest for another day. In the family’s leaf-strewn fields, the orange flutes of chanterelles beckoned her while they eluded others.Regan has had this intense, almost otherworldly connection with food and the earth it comes from since her childhood, but connecting with people has always been more difficult. She was a little girl who longed to be a boy, gay in an intolerant community, an alcoholic before she turned twenty, and a woman in an industry dominated by men—she often felt she “wasn’t made for this world,” and as far as she could tell, the world tended to agree. But as she learned to cook in her childhood farmhouse, got her first restaurant job at age fifteen, taught herself cutting-edge cuisine while running a “new gatherer” underground supper club, and worked her way from front-of-house staff to running her own kitchen, Regan found that food could help her navigate the strangeness of the world around her.Regan cooks with instinct, memory, and an emotional connection to her ingredients that can’t be taught. Written from that same place of instinct and emotion, Burn the Place tells Regan’s story in raw and vivid prose and brings readers into a world—from the Indiana woods to elite Chicago kitchens—that is entirely original and unforgettable.

    Within days he had confessed to fifteen gruesome murders over a period of four years. His victims, all young homosexual men, had never been reported missing. Brian Masters, with Nilsen's full cooperation, has produced a unique study of a serial killer's mind, revealing the disturbing psychology of a mass murderer.