Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    In their bizarre way, these were carefully controlled wars, carefully controlled in the sense that neither great power allowed itself to become directly engaged in a hot war with the other. Equally, neither allowed itself to go for broke in a grand sweep across the Third World in fear of provoking that final confrontation. But this fear of direct confrontation was never as rigidly controlled as one would think. Again and again events veered towards a clash between Eagle and Bear. The authors of this book make real such terrifying possibilities as Korea or the 67 War dragging in both superpowers; they predict the consequences of the United States or the Soviet Union attempting radical strategies in Vietnam or in a divided Germany, either to follow the British success in Malaya or to invade the North; they imagine the invasion of Cuba when the delicate signals failed to find a way out of the Missile Crisis and bring to life a scenario in which the Soviet Union knocks the Great Game off the board by using Afghanistan as base to bring down Pakistan and achieve its warm water port on the Indian Ocean. Cold War Hot vividly brings to life these and many other alternate scenarios, taking the reader behind the scenes at these momentous moments in history. In showing what could have happened, the authors show how precarious the Cold War peace actually was, and how little it would have taken to tip the balance into World War Three.

    After six years at the NIH, he took the reins as president of the world-renowned Memorial Sloan-Kettering Cancer Center, a position he still holds. Along the way, Varmus has continued his own laboratory work, remains committed to collaborative science, and still finds time to ride his bike to work.Beyond the elegant combination of science and biography, this is a book about health issues of truly global importance. Varmus’s work on cancer-causing genes foreshadowed the development of the recent targeted therapies for cancer. At the NIH, he not only persuaded Congress to commit record funds to national health programs but also turned attention to international concerns like the worldwide malaria crisis. And, as he discusses in these pages, he has long been an enthusiastic yet nuanced supporter of stem cell research. The Art and Politics of Science is a glimpse into the world of high-stakes, big-budget science narrated by a man intimately acquainted with its everyday applications—an education for people in all walks of life from a scientist whose own research and professional commitments helped to shape our scientific age.

    On the last day of summer, an ordinary Utah college student named Reggie Shaw fatally struck two rocket scientists while texting and driving along a majestic stretch of highway bordering the Rocky Mountains. Richtel follows Reggie from the moment of the tragedy, through the police investigation, the state's groundbreaking prosecution (at the time there was little precedent to guide the court), and ultimately, Reggie's wrenching admission of responsibility. Richtel parallels Reggie's journey with leading-edge scientific findings regarding human attention and the impact of technology on our brains--showing how these devices, now thoroughly embedded in all aspects of our lives, play to our deepest social instincts and prey on parts of the brain that crave stimulation, creating loops of compulsion, even addiction. A propulsive read filled with fascinating scientific detail, riveting narrative tension, and rare emotional depth, A Deadly Wandering is a book that can change--and save--lives.

    Modern medicine has failed to halt the spread of the flesh-consuming parasite, and humans have been forced to hide, even from each other.The infected roam the cities and suburbs of a ruined nation. But the devastating effects on human physiology are only the beginning. Something has been let loose, something that the team were not prepared for human nature itself.Matt and Carla must make it back to the CDC headquarters, crossing the apocalyptic countryside that proves every bit as dangerous and deadly as the South American jungle. The race is on to test their eradication cure, before their world suffers the same fate as that of the giant saurians of prehistory.But there is something they don’t count on the solution has a high price. If they don’t use the cure it means the end of mankind, but what if the remedy is worse than the disease?

    "Beautiful and inspiring."--Maria Shriver's Sunday Paper (Book of the Week)When Madeleine Dean discovered that her son Harry was stealing from the family to feed a painkiller addiction, she was days away from taking the biggest risk of her life: running for statewide office in Pennsylvania. For years, she had sensed something was wrong. Harry was losing weight and losing friends. He had lost the brightness in his eyes and voice, changing from a young boy with boundless enthusiasm to a shadow of himself, chasing something she could not see. Now her worst fears had come to light. Under Our Roof is the story of a national crisis suffered in the intimacy of so many homes, told with incredible candor through the dual perspectives of a mother rising in politics and a son living a double life, afraid of what might happen if his secret is exposed. In this honest, bracing, yet ultimately uplifting memoir, they discuss the patterns of a family dealing with an unspoken disease, the fear that keeps addicts hiding in shame, and the moments of honesty, faith, and personal insight that led to Harry's recovery.In a country searching for answers to the devastating effects of opioids and drug abuse, Under Our Roof is a ray of hope in the darkness. It is not only a love story between mother and son but also an honest account of a pressing national crisis by a family poised to make a difference.