Suppose, instead of thinking about organisms using genes to reproduce themselves, as we had since Mendel's work was rediscovered, we turn it around and imagine that "our" genes build and maintain us in order to make more genes. That simple reversal seems to answer many puzzlers which had stumped scientists for years, and we haven't thought of evolution in the same way since. Drawing fascinating examples from every field of biology, he paved the way for a serious re-evaluation of evolution. He also introduced the concept of self-reproducing ideas, or memes, which (seemingly) use humans exclusively for their propagation. If we are puppets, he says, at least we can try to understand our strings.

    How many of us understand the way seizures affect the brain, how the heart is connected to wellbeing, or the why the foot carries the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels.Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in living and in dying. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

    Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

    But in Catching Fire, renowned primatologist Richard Wrangham presents a startling alternative: our evolutionary success is the result of cooking. In a groundbreaking theory of our origins, Wrangham shows that the shift from raw to cooked foods was the key factor in human evolution. when our ancestors adapted to using fire, humanity began.Once our hominid ancestors began cooking their food, the human digestive tract shrank and the brain grew. Time once spent chewing tough raw food could be used instead to hunt and to tend camp. Cooking became the basis for pair bonding and marriage, created the household, and even led to a sexual division of labor.Tracing the contemporary implications of our ancestors' diets, Catching Fire sheds new light on how we came to be the social, intelligent, and sexual species we are today. A pathbreaking new theory of human evolution, Catching Fire will provoke controversy and fascinate anyone interested in our ancient origins--or in our modern eating habits.--from the dustjacket

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    Like most people, you probably wake up, get hungry for meals and doze off in bed around the same time every day. If you’ve ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off kilter. But for some people, that imbalance—difficulty sleeping at night, hunger at odd times, or sudden fatigue at noon—is a constant. If you're one of those people, Dr. Satchin Panda, one of the leading researchers on circadian rhythms, has a plan to reset your body clock.Beginning with an in-depth explanation of the circadian clock—why it’s important, how it works, and how to know it isn’t working—The Circadian Code outlines lifestyle changes to make to get back on track. It's a concrete plan to enhance weight loss, improve sleep, optimize exercise, and manage technology so that it doesn’t interfere with your body’s natural rhythm. Dr. Panda’s life-changing methods show you how to prevent and reverse ailments like diabetes, cancer, and dementia, as well as microbiome conditions like acid reflux, heartburn, and irritable bowel disease.

    A mix of popular psychology and trivia, McRaney’s insights have struck a chord with thousands, and his blog--and now podcasts and videos--have become an Internet phenomenon. Like You Are Not So Smart, You Are Now Less Dumb is grounded in the idea that we all believe ourselves to be objective observers of reality--except we’re not. But that’s okay, because our delusions keep us sane. Expanding on this premise, McRaney provides eye-opening analyses of fifteen more ways we fool ourselves every day, including: - The Misattribution of Arousal (Environmental factors have a greater affect on our emotional arousal than the person right in front of us) - Sunk Cost Fallacy (We will engage in something we don’t enjoy just to make the time or money already invested “worth it”) - Deindividuation (Despite our best intentions, we practically disappear when subsumed by a mob mentality) McRaney also reveals the true price of happiness, why Benjamin Franklin was such a badass, and how to avoid falling for our own lies. This smart and highly entertaining book will be wowing readers for years to come.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.

    The latest studies are revealing exciting new discoveries, such as how the DNA and related chemical compounds in our cells work together to direct the processes of life. Scientists are not only unraveling how life evolved in the ancient past, but are also finding the keys to creating a healthier future.  How does the minuscule chemical cluster in each of our 100 trillion cells accomplish the amazing feat of creating and maintaining our bodies? Frank Ryan, a physician and an evolutionary biologist, describes the complex ways in which the genome operates as a holistic system and not solely through genes coding for proteins—the building blocks of life. Also involved are elaborate switching mechanisms that regulate and control portions of our DNA, as well as the interplay of retroviruses and bacteria.This groundbreaking book explains that we are on the cusp of an amazing era of disease treatment and eradication.

    Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

    Wright unveils the genetic strategies behind everything from our sexual preferences to our office politics--as well as their implications for our moral codes and public policies. Illustrations.

    No one can stop him--but he walks away. A miracle? No...dysentery. Microbes saved the Roman Empire. Nearly a millennium later, the microbes of the Black Death ended the Middle Ages, making possible the Renaissance, western democracy, and the scientific revolution. Soon after, microbes ravaged the Americas, paving the way for their European conquest. Again and again, microbes have shaped our health, our genetics, our history, our culture, our politics, even our religion and ethics. This book reveals much that scientists and cultural historians have learned about the pervasive interconnections between infectious microbes and humans. It also considers what our ongoing fundamental relationship with infectious microbes might mean for the future of the human species. The "good side" of history's worst epidemics The surprising debt we owe to killer diseases Where diseases came from... ...and where they may be going Children of pestilence: disease and civilization From Egypt to Mexico, the Romans to Attila the Hun STDs, sexual behavior, and culture How microbes may shape cultural cycles of puritanism and promiscuity

    Our ancestors crossed the Alps in animal skins and colonized the New World in loin cloths. They evaded predators and built civilizations with just their raw brainpower and inner grit. But things have changed and now comfort is king. Today we live in the thrall of constant climate control and exercise only when our office schedules permit. The technologies that we use to make us comfortable are so all-encompassing that they sever the biological link to a changing environment. Now we hate the cold and the heat. We suffer from autoimmune diseases. And many of us are chronically overweight. Most of us don't even realize that natural variation—sweating and shivering—is actually good for us. What Doesn't Kill Us uncovers how just about anyone can reclaim a measure of our species' evolutionary strength by tapping into the things that feel uncomfortable. When we slightly reimagine how our body fits into the world, we can condition ourselves to find resilience in unfamiliar environments. The feeling that something is missing from our daily routines is growing and has spawned a movement. Every year, millions of people forgo traditional gyms and push the limits of human endurance by doing boot camp style workouts in raw conditions. These extreme athletes train in CrossFit boxes, compete in Tough Mudders and challenge themselves in Spartan races. They are connecting with their environment and, whether they realize it or not, are changing their bodies. No one exemplifies this better than Dutch fitness guru Wim Hof, whose remarkable ability to control his body temperature in extreme cold has sparked a whirlwind of scientific study. Because of him, scientists in the United States and Europe are just beginning to understand how cold adaptation might help combat autoimmune diseases and chronic pains and, in some cases, even reverse diabetes. Award winning investigative journalist, Scott Carney dives into the fundamental philosophy at the root of this movement in three interlocking narratives. His own journey culminates in a record bending 28-hour climb up to the snowy peak of Mt. Kilimanjaro wearing nothing but a pair of running shorts and sneakers.

    Konrad Lorenz was gifted with a similar power of understanding the animal world. He was that rare beast, a brilliant scientist who could write (and indeed draw) beautifully. He did more than any other person to establish and popularize the study of how animals behave, receiving a Nobel Prize for his work. King Solomon's Ring, the book which brought him worldwide recognition, is a delightful treasury of observations and insights into the lives of all sorts of creatures, from jackdaws and water-shrews to dogs, cats and even wolves. Charmingly illustrated by Lorenz himself, this book is a wonderfully written introduction to the world of our furred and feathered friends, a world which often provides an uncanny resemblance to our own. A must for any animal-lover!