From a fortress-like former bank building, American Pain's doctors distributed massive quantities of oxycodone to hundreds of customers a day, mostly traffickers and addicts who came by the vanload. Inked muscle-heads ran the clinic's security. Former strippers operated the pharmacy, counting out pills and stashing cash in garbage bags. Under their lab coats, the doctors carried guns and it was all legal sort of. American Pain was the brainchild of Chris George, a 27-year-old convicted drug felon. The son of a South Florida home builder, Chris George grew up in ultra-rich Wellington, where Bill Gates, Springsteen, and Madonna kept houses. Thick-necked from weightlifting, he and his twin brother hung out with mobsters, invested in strip clubs, brawled with cops, and grinned for their mug shots. After the housing market stalled, a local doctor clued in the brothers to the burgeoning underground market for lightly regulated prescription painkillers. In Florida, pain clinics could dispense the meds, and no one tracked the patients. Seizing the opportunity, Chris George teamed up with the doctor, and word got out. Just two years later Chris had raked in $40 million, and 90 percent of the pills his doctors prescribed flowed north to feed the rest of the country's insatiable narcotics addiction. Meanwhile, hundreds more pain clinics in the mold of American Pain had popped up in the Sunshine State, creating a gigantic new drug industry. American Pain chronicles the rise and fall of this game-changing pill mill, and how it helped tip the nation into its current opioid crisis, the deadliest drug epidemic in American history. The narrative swings back and forth between Florida and Kentucky, and is populated by a gaudy and diverse cast of characters. This includes the incongruous band of wealthy bad boys, thugs and esteemed physicians who built American Pain, as well as penniless Kentucky clans who transformed themselves into painkiller trafficking rings. It includes addicts whose lives were devastated by American Pain's drugs, and the federal agents and grieving mothers who labored for years to bring the clinic's crew to justice."

    The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it's supposed to do-seek pleasure and relief-in a world that's not cooperating. As a result, most treatment based on the disease model fails. Lewis shows how treatment can be retooled to achieve lasting recovery. This is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.

    The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

    Book by Naam, Ramez

    Michael Baden's first-person, no-holds-barred account of his distinguished career in forensic pathology. In determining the causes of tens of thousands of deaths, from those of presidents and rock stars to victims of serial killings, exotic sex rituals, mass disasters, child abuse and drug abuse, Baden has come to the unavoidable conclusion that the search for scientific truth is often sullied by the pressures of expediency. He produces dramatic evidence to demonstrate that political intrigue, influence peddling, and professional incompetence have created a national crisis in forensic medicine.

    Here is a delightfully entertaining and enlightening look at the unique sex lives of humans.

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    Doctor, Harvard professor, renowned infectious-disease specialist, anthropologist, the recipient of a MacArthur "genius" grant, world-class Robin Hood, Farmer was brought up in a bus and on a boat, and in medical school found his life’s calling: to diagnose and cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most.Mountains Beyond Mountains takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes minds and practices through his dedication to the philosophy that "the only real nation is humanity"—a philosophy that is embodied in the small public charity he founded, Partners in Health. He enlists the help of the Gates Foundation, George Soros, the U.N.’s World Health Organization, and others in his quest to cure the world. At the heart of this book is the example of a life based on hope, and on an understanding of the truth of the Haitian proverb "Beyond mountains there are mountains": as you solve one problem, another problem presents itself, and so you go on and try to solve that one too.

    While it’seasy to see that stress affects health and well-being, or that your blood pressure rises when you’re angry, cutting-edge research shows that the mind-body connection goes much further.Numerous studies on the brain’s interaction with the body demonstrate that health is directly affected by our social environments, socioeconomic status, culture, behaviors, relationships, psychological states, and habits of mind, among many factors. Current mind-body science reveals facts such as these: As few as eight weeks of mindfulness meditation can meaningfully boost your immune system. Extreme stress and low social support increase the risk of breast cancer by a factor of 9. Contact with nature is correlated with numerous positive health outcomes, including improved attention for children, reduced stress, and enhanced work performance. Chronic hostility portends calcification of the coronary arteries, even in young people. Expressive writing by patients is correlated with improved outcomes for both asthma and rheumatoid arthritis.Mind-body medicine—working in tandem with traditional medical practice—makes use of a large spectrum of psychological, physical, and behavioral treatments, drawn from many disciplines, in an approach to health care that aims to treat the whole person. It provides highly effective resources for preventing and treating a wide range of medical conditions, such as cardiovascular disease, stress, cancer, and depression—as well as for fostering the ultimate goals of health care: truly optimal and lasting physical health, and emotional and psychological well-being.A knowledge of this exciting field offers you critical understanding of the state of the art of health care and a significant new direction in medicine. But beyond valuable knowledge, a grounding in mind-body medicine gives you numerous practical, empowering tools for your own health care, as well as that of your family—tools that can make a profound difference for healthful, vibrant living.In Mind-Body Medicine: The New Science of Optimal Health, you’ll study this subject in compelling depth, with the expert guidance of Professor Jason M. Satterfield of the University of California, San Francisco. These 36 eye-opening lectures offer you a comprehensive overview of the field, providing rigorous answers to the questions of what makes us sick, what makes us well, and what we can do about it.You’ll look closely at the anatomical and biological systems through which what is “outside” in the environment gets “inside” to affect our minds and bodies. You’ll also examine recent research on subjects ranging from the impact our emotions and psychology have on health to the crucial roles that social, cultural, and behavioral factors play. And you’ll learn about effective mind-body treatments for numerous common medical conditions and diseases.Finally, you’ll finish the course with a toolbox of ideas and interventions for your personal wellness goals, empowering you to partner more effectively with your medical providers and maximize your own health.A Remarkable New Context for Health Care Professor Satterfield, a highly respected professor of clinical medicine and a specialist on the intersection of psychological factors and physical health, brings to the table his deep knowledge of mind-body science and extensive clinical experience in its application.In the course’s opening, he introduces you to the model of “biopsychosocial medicine,” which looks at the relationship between biological, psychological, and social factors in health.In studying how the biopsychosocial model is applied in modern medicine, you delve into these core subject areas:Biological pathways:You first investigate the anatomy and physiology of four biological systems through which the “outside” gets “in.” By reviewing a detailed study of the autonomic nervous system and the neuroendocrine system, discover how the brain activates the body’s two stress-response systems, and how these systems crucially affect health and well-being. Learn also about the physiology of immune function and the effects of stress on immune response and healing. Study the mechanisms of genetics as well as fascinating research indicating that your behavior can alter your genetic material, for better or worse—changes that can be passed on to future generations.Psychological factors in health: In the course of nine lectures, you look in depth at the critical ways in which psychology affects the body. Learn how negative emotional states such as anger and hostility can influence both the onset and progression of disease, and how positive emotions aid substantially in healing and wellness. Study how cognition—the ways in which we think and process our experiences—affects emotional states and behavior. Drawing from cognitive and other behavioral therapies, learn effective techniques for reshaping thinking, emotions, and behavior. Review evidence that certain personality types may be predisposed to conditions such as cardiovascular disease and depression, and learn how we can compensate for risk-carrying personality traits by working with cognitions and emotions. Investigate the neuroscience of behavior and the important effects of our behaviors on both disease and disease prevention. Look at stress as an integration of biological, cognitive, and social factors, and see how we can approach stress response and coping as a developmental skill. Social and ecological factors: You also study the important effects on health of factors such as culture, identity, socioeconomic status, social support, communities, and public health policy. Examine the studied correlations of income to health, education level to longevity, and ethnicity to susceptibility to disease, and consider how we can use this knowledge to benefit both individual and public health. Review research linking social support to health in many medical conditions, such as heart disease, cancer, and pregnancy; and do a detailed assessment to evaluate and strengthen your own social support network. Investigate how spiritual affiliations and practices have distinct physical benefits, such as reducing blood pressure, cortisol, and inflammation; improving lipid profiles and cardiovascular health; and extending life expectancy. Assess how physical environments affect health, how national and local culture impacts health-related behaviors, and how public initiatives can create healthier behaviors, environments, and communities.Tools and Strategies for Optimal WellnessBuilding on the biopsychosocial model, you study mind-body treatments for common conditions such as cardiovascular disease, stress, cancer, obesity, chronic pain, depression, anxiety, and post-traumatic stress disorder.Here, you learn about specific practices and interventions that you can use in your own health care program, such as these. Stress management: For both personal and occupational stress, learn about a spectrum of stress management approaches, from cognitive restructuring and perspective shifting to meditation, breathing techniques, relaxation training, and the learnable skill of resilience. Strategies for successful behavior change: With reference to concerns such as lifestyle change, weight management, and disease prevention, study the leading models of effective behavior change, as well as specific approaches such as the strategies of motivational interviewing, the four key elements of change, and the internal skills of self-regulation. Heart disease—prevention and treatment: Survey psychosocial interventions for heart disease, including a range of behavior change approaches, stress and emotion management, somatic quieting, social connection, and dramatic evidence that cardiac disease can be reversed through lifestyle change. Treatment of pain: Study mind-body factors in pain experience, and learn about treatments including cognitive and behavior change, acupuncture, mindfulness-based stress reduction, and biofeedback. Fatigue, headaches, insomnia: Investigate the variety of medical conditions that show no clear organic cause, such as chronic fatigue, tension headaches, and sleep disorders; and review effective psychological, physical, and behavioral approaches to treatment.Professor Satterfield’s teaching combines an extraordinary breadth of knowledge, clear and accessible explanations of the science involved, and a highly compassionate approach to patient care. He enriches the lectures with stories and case studies of patients in treatment for stress, heart conditions, insomnia, trauma, and other health challenges, showing you what mind-body medicine looks like in clinical practice and how you can integrate its lessons into your health program and daily life.With the knowledge and tools you’ll learn in Mind-Body Medicine: The New Science of Optimal Health, you can begin your own biopsychosocial assessment, identify your strengths and challenges in partnership with your medical providers, and take authentic steps toward your fullest physical and mental wellness.

    Night Falls Fast is tragically timely: suicide has become one of the most common killers of Americans between the ages of fifteen and forty-five.An internationally acknowledged authority on depressive illnesses, Dr. Jamison has also known suicide firsthand: after years of struggling with manic-depression, she tried at age twenty-eight to kill herself. Weaving together a historical and scientific exploration of the subject with personal essays on individual suicides, she brings not only her remarkable compassion and literary skill but also all of her knowledge and research to bear on this devastating problem. This is a book that helps us to understand the suicidal mind, to recognize and come to the aid of those at risk, and to comprehend the profound effects on those left behind. It is critical reading for parents, educators, and anyone wanting to understand this tragic epidemic.

    A writer for The New Yorker and The Atlantic Monthly, Carl Elliott ventures into the uncharted dark side of medicine, shining a light on the series of social and legislative changes that have sacrificed old-style doctoring to the values of consumer capitalism. Along the way, he introduces us to the often shifty characters who work the production line in Big Pharma: from the professional guinea pigs who test-pilot new drugs and the ghostwriters who pen “scientific” articles for drug manufacturers to the PR specialists who manufacture “news” bulletins. We meet the drug reps who will do practically anything to make quota in an ever-expanding arms race of pharmaceutical gift-giving; the “thought leaders” who travel the world to enlighten the medical community about the wonders of the latest release; even, finally, the ethicists who oversee all that commercialized medicine has to offer from their pharma-funded perches.   Taking the pulse of the medical community today, Elliott discovers the culture of deception that has become so institutionalized many people do not even see it as a problem. Head-turning stories and a rogue’s gallery of colorful characters become his springboard for exploring larger ethical issues surrounding money. Are there certain things that should not be bought and sold? In what ways do the ethics of business clash with the ethics of medical care? And what is wrong with medical consumerism anyway? Elliott asks all these questions and more as he examines the underbelly of medicine.

    The Repository for Germinal Choice–nicknamed the Nobel Prize sperm bank–opened to notorious fanfare in 1980, and for two decades, women flocked to it from all over the country to choose a sperm donor from its roster of Nobel-laureate scientists, mathematical prodigies, successful businessmen, and star athletes. But the bank quietly closed its doors in 1999–its founder dead, its confidential records sealed, and the fate of its children and donors unknown. In early 2001, award-winning columnist David Plotz set out to solve the mystery of the Nobel Prize sperm bank.Plotz wrote an article for Slate inviting readers to contact him–confidentially–if they knew anything about the bank. The next morning, he received an email response, then another, and another–each person desperate to talk about something they had kept hidden for years. Now, in The Genius Factory, Plotz unfolds the full and astonishing story of the Nobel Prize sperm bank and its founder’s radical scheme to change our world.Believing America was facing genetic catastrophe, Robert Graham, an eccentric millionaire, decided he could reverse the decline by artificially inseminating women with the sperm of geniuses. In February 1980, Graham opened the Repository for Germinal Choice and stocked it with the seed of gifted scientists, inventors, and thinkers. Over the next nineteen years, Graham’s “genius factory” produced more than two hundred children.What happened to them? Were they the brilliant offspring that Graham expected? Did any of the “superman” fathers care about the unknown sons and daughters who bore their genes? What were the mothers like? Crisscrossing the country and logging countless hours online, Plotz succeeded in tracking down previously unknown family members–teenage half-brothers who ended up following vastly different paths, mothers who had wondered for years about the identities of the donors they had selected on the basis of code names and brief character profiles, fathers who were proud or ashamed or simply curious about the children who had been created from their sperm samples. The children of the “genius factory” are messengers from the future–a future that is bearing down on us fast. What will families be like when parents routinely “shop” for their kids’ genes? What will children be like when they’re programmed for greatness? In this stunning, eye-opening book, one of our finest young journalists previews America’s coming age of genetic expectations.From the Hardcover edition.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    From church basements to hospital wards to prison cells, Neumann charts the social, political, religious, and medical landscape to explore how we die today. The Good Death weaves personal accounts with a historical exploration of the movements and developments that have changed the ways we experience death. With the diligence of a journalist and the compassion of a caregiver, Neumann provides a portrait of death in the United States that is humane, beautifully written, and essential to our greater understanding of the future of end-of-life care.

    Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer's outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene.The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer's brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.