From the theoretical discussions of nuclear energy to the bright glare of Trinity there was a span of hardly more than twenty-five years. What began as merely an interesting speculative problem in physics grew into the Manhattan Project, and then into the Bomb with frightening rapidity, while scientists known only to their peers -- Szilard, Teller, Oppenheimer, Bohr, Meitner, Fermi, Lawrence, and yon Neumann -- stepped from their ivory towers into the limelight.Richard Rhodes takes us on that journey step by step, minute by minute, and gives us the definitive story of man's most awesome discovery and invention.

    In handsomely crafted prose, and with the grace and authority of his extraordinary gift for narrative history, William Manchester leads us from a civilization tottering on the brink of collapse to the grandeur of its rebirth - the dense explosion of energy that spawned some of history's greatest poets, philosophers, painters, adventurers, and reformers, as well as some of its most spectacular villains - the Renaissance.

    Between 1900 and 1907, she infected twenty-two New Yorkers with typhoid fever through her puddings and cakes; one of them died. Tracked down through epidemiological detective work, she was finally apprehended as she hid behind a barricade of trashcans. To protect the public's health, authorities isolated her on Manhattan's North Brother Island, where she died some thirty years later.This book tells the remarkable story of Mary Mallon--the real Typhoid Mary. Combining social history with biography, historian Judith Leavitt re-creates early-twentieth-century New York City, a world of strict class divisions and prejudice against immigrants and women. Leavitt engages the reader with the excitement of the early days of microbiology and brings to life the conflicting perspectives of journalists, public health officials, the law, and Mary Mallon herself.Leavitt's readable account illuminates dilemmas that continue to haunt us. To what degree are we willing to sacrifice individual liberty to protect the public's health? How far should we go in the age of AIDS, drug-resistant tuberculosis, and other diseases? For anyone who is concerned about the threats and quandaries posed by new epidemics, Typhoid Mary is a vivid reminder of the human side of disease and disease control.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

    When a scholar as careful and learned as Mr. Kennedy is prompted by contemporary issues to reexamine the great processes of the past, the result can only be an enhancement of our historical understanding.... When the study is written as simply and attractively as this work is, its publication may have a great and beneficient impact. It is to be hoped that Mr. Kennedy's will have one, at a potentially decisive moment in America's history."Michael Howard, The New York Times Book Review"Important, learned, and lucid... Paul Kennedy's great achievement is that he makes us see our current international problems against a background of empires that have gone under because they were unaible to sustain the material cost of greatness; and he does so in a universal historical perspective of which Ranke would surely have approved."James Joll, The New York Review of Books"His strategic-economic approach provides him with the context for a shapely narrative....Professor Kennedy not only exploits his framework eloquently, he also makes use of it to dig deeper and explore the historical contexts in which some 'power centers' prospered....But the most commanding purpose of his project...is the lesson he draws from 15 centuries of statecraft to apply to the present scene....[The book's] final section is for everyone concerned with the contemporary political scene."Christopher Lehmann-Haupt, The New York Times"Kennedy gives epic meaning to the nation's relative economic and industrial decline." Newsweek

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    But how does virality actually work? In The Rules of Contagion, epidemiologist Adam Kucharski explores topics including gun violence, online manipulation, and, of course, outbreaks of disease to show how much we get wrong about contagion, and how astonishing the real science is.Why did the president retweet a Mussolini quote as his own? Why do financial bubbles take off so quickly? And why are disinformation campaigns so effective? By uncovering the crucial factors driving outbreaks, we can see how things really spread -- and what we can do about it.Whether you are an author seeking an audience, a defender of truth, or simply someone interested in human social behavior, The Rules of Contagion is an essential guide to modern life.

    Aspirin, the world's most widely used drug, is based on compounds originally extracted from the bark of a willow tree, and more than a quarter of medicines found on pharmacy shelves contain plant compounds. Now Western medicine, faced with health crises such as AIDS, Alzheimer's disease, and cancer, has begun to look to the healing plants used by indigenous peoples to develop powerful new medicines. Nowhere is the search more promising than in the Amazon, the world's largest tropical forest, home to a quarter of all botanical species on this planet—as well as hundreds of Indian tribes whose medicinal plants have never been studied by Western scientists. In Tales of a Shaman's Apprentice, ethnobotanist Mark J. Plotkin recounts his travels and studies with some of the most powerful Amazonian shamans, who taught him the plant lore their tribes have spent thousands of years gleaning from the rain forest.For more than a decade, Dr. Plotkin has raced against time to harvest and record new plants before the rain forests' fragile ecosystems succumb to overdevelopment—and before the Indians abandon their own culture and learning for the seductive appeal of Western material culture. Tales of a Shaman's Apprentice relates nine of the author's quests, taking the reader along on a wild odyssey as he participates in healing rituals; discovers the secret of curare, the lethal arrow poison that kills in minutes; tries the hallucinogenic snuff epena that enables the Indians to speak with their spirit world; and earns the respect and fellowship of the mysterious shamans as he proves that he shares both their endurance and their reverence for the rain forest. Mark Plotkin combines the Darwinian spirit of the great writer-explorers of the nineteenth century—curious, discursive, and rigorously scientific—with a very modern concern for the erosion of our environment and the vanishing culture of native peoples.

    In Elephants on Acid, Boese details the results of this scientific trial, as well as answers to the questions: Why can't people tickle themselves? Would the average dog summon help in an emergency? Will babies instinctually pick a well-balanced diet? Is it possible to restore life to the dead? Read on to find out...

    Robert Ferguson's new interpretation of the Viking Age, whilst rejecting the cliches aims to return some of the violence to the mix. He argues that the Viking raids were qualitatively different than anything that had gone before precisely because of this violence, and his largely narrative account gives plentiful details of battles and conquest alongside evidence for their more peaceful activities. The thread which runs through the account though is the confrontation between a Heathen Scandinavia and the Christian kingdoms to its south and west, and the processes whereby the Viking kingdoms came to be Christianised.

    Martin as source material for Game of Thrones, comes a classic book on innovation and technological change in medieval EuropeIn this account of Europe’s rise to world leadership in technology, Frances and Joseph Gies show how early modern technology and experimental science were direct outgrowths of the decisive innovations of medieval Europe, in the tools and techniques of agriculture, craft industry, metallurgy, building construction, navigation, and war. The Gieses report that many of Europe’s most important inventions—the horse harness, the stirrup, the magnetic compass, cotton and silk cultivation and manufacture, papermaking, firearms, and “Arabic” numerals—had their origins outside Europe, in China, India, and the Middle East. Europe synthesized its own innovations—the three-field system, water power in industry, the full-rigged ship, the putting-out system—into a powerful new combination of technology, economics, and politics.

    Dunn illuminates the nuanced, often imperceptible relationships that exist between homo sapiens and other species, relationships that underpin humanity’s ability to thrive and prosper in every circumstance.

    For the past two millennia, the ability to produce it in ever more efficient ways has supported the proliferation of literacy, media, religion, education, commerce, and art; it has formed the foundation of civilizations, promoting revolutions and restoring stability. One has only to look at history’s greatest press run, which produced 6.5 billion copies of Máo zhuxí yulu, Quotations from Chairman Mao Tse-tung (Zedong)—which doesn’t include editions in 37 foreign languages and in braille—to appreciate the range and influence of a single publication, in paper. Or take the fact that one of history’s most revered artists, Leonardo da Vinci, left behind only 15 paintings but 4,000 works on paper. And though the colonies were at the time calling for a boycott of all British goods, the one exception they made speaks to the essentiality of the material; they penned the Declaration of Independence on British paper.Now, amid discussion of “going paperless”—and as speculation about the effects of a digitally dependent society grows rampant—we’ve come to a world-historic juncture. Thousands of years ago, Socrates and Plato warned that written language would be the end of “true knowledge,” replacing the need to exercise memory and think through complex questions. Similar arguments were made about the switch from handwritten to printed books, and today about the role of computer technology. By tracing paper’s evolution from antiquity to the present, with an emphasis on the contributions made in Asia and the Middle East, Mark Kurlansky challenges common assumptions about technology’s influence, affirming that paper is here to stay. Paper will be the commodity history that guides us forward in the twenty-first century and illuminates our times.

    Diaries, notebooks, and other first-person accounts tell the fascinating stories from the perspective of people who witnessed medical history firsthand.