Brinkley–America’s most brazen young con man–arrived in the tiny town of Milford, Kansas. He set up a medical practice and introduced an outlandish surgical method using goat glands to restore the fading virility of local farmers.It was all nonsense, of course, but thousands of paying customers quickly turned “Dr.” Brinkley into America’s richest and most famous surgeon. His notoriety captured the attention of the great quackbuster Morris Fishbein, who vowed to put the country’s “most daring and dangerous” charlatan out of business.Their cat-and-mouse game lasted throughout the 1920s and ’30s, but despite Fishbein’s efforts Brinkley prospered wildly. When he ran for governor of Kansas, he invented campaigning techniques still used in modern politics. Thumbing his nose at American regulators, he built the world’s most powerful radio transmitter just across the Rio Grande to offer sundry cures, and killed or maimed patients by the score, yet his warped genius produced innovations in broadcasting that endure to this day. By introducing country music and blues to the nation, Brinkley also became a seminal force in rock ’n’ roll. In short, he is the most creative criminal this country has ever produced.Culminating in a decisive courtroom confrontation that pit Brinkley against his nemesis Fishbein, Charlatan is a marvelous portrait of a boundlessly audacious rogue on the loose in an America that was ripe for the bamboozling.

    A killer with little respect for class or wealth, cholera ravaged the squalid streets of Soho and rocked the great centers of Victorian power. In this gripping book, Sandra Hempel tells the story of John Snow, a reclusive doctor without money or social position, who—alone and unrecognized—had the genius to look beyond the conventional wisdom of his day and uncover the truth behind the pandemic. She describes how Snow discovered that cholera was spread through drinking water and how this subsequently laid the foundations for the modern, scientific investigation of today's fatal plagues. A dramatic account with a colorful cast of characters, The Strange Case of the Broad Street Pump features diversions into fascinating facets of medical and social history, such as Snow's tending of Queen Victoria in childbirth, Dutch microbiologist Leeuwenhoek's deliberate breeding of lice in his socks, Dickensian children's farms, and riotous nineteenth-century anesthesia parties. An afterword discusses the new threat of infectious diseases—including malaria, yellow fever, and cholera—with today's global warming. Copub: Granta

    World War II is nearly over in Europe but is escalating in the Pacific, where American soldiers face an opponent who will go to any length to avoid defeat. The Japanese army follows the samurai code of Bushido, stipulating that surrender is a form of dishonor. Killing the Rising Sun takes readers to the bloody tropical-island battlefields of Peleliu and Iwo Jima and to the embattled Philippines, where General Douglas MacArthur has made a triumphant return and is plotting a full-scale invasion of Japan.Across the globe in Los Alamos, New Mexico, Dr. J. Robert Oppenheimer and his team of scientists are preparing to test the deadliest weapon known to mankind. In Washington, DC, FDR dies in office and Harry Truman ascends to the presidency, only to face the most important political decision in history: whether to use that weapon. And in Tokyo, Emperor Hirohito, who is considered a deity by his subjects, refuses to surrender, despite a massive and mounting death toll. Told in the same page-turning style of Killing Lincoln, Killing Kennedy, Killing Jesus, Killing Patton, and Killing Reagan, this epic saga details the final moments of World War II like never before.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    In Jefferson's Daughters, Catherine Kerrison, a scholar of early American and women's history, recounts the remarkable journey of these three women - and how their struggle to define themselves reflects both the possibilities and the limitations that resulted from the American Revolution. Although the three women shared a father, the similarities end there. Martha and Maria received a fine convent school education while they lived with their father during his diplomatic posting in Paris - a hothouse of intellectual ferment whose celebrated salonnières are vividly brought to life in Kerrison's narrative. Once they returned home, however, the sisters found their options limited by the laws and customs of early America. Harriet Hemings followed a different path. She escaped slavery - apparently with the assistance of Jefferson himself. Leaving Monticello behind, she boarded a coach and set off for a decidedly uncertain future. For this groundbreaking triple biography, Kerrison has uncovered never-before-published documents written by the Jefferson sisters when they were in their teens, as well as letters written by members of the Jefferson and Hemings families. She has interviewed Hemings family descendants (and, with their cooperation, initiating DNA testing) and searched for possible descendants of Harriet Hemings.The eventful lives of Thomas Jefferson's daughters provide a unique vantage point from which to examine the complicated patrimony of the American Revolution itself. The richly interwoven story of these three strong women and their fight to shape their own destinies sheds new light on the ongoing movement toward human rights in America - and on the personal and political legacy of one of our most controversial Founding Fathers.

    They were poorly fed, ill-equipped, coming off a string of demoralizing defeats at the hands of the British, and faced a harsh winter ahead. Their general, a focused and forceful man named George Washington, was at the lowest point in his career. The Continental Congress was in exile, its treasury depleted. When the rebels arrived at Valley Forge, it looked like they would be on the losing side of history.As days passed, however, Washington realized that the British would not attack, and he embarked on a mission to reshape his army from the top-down. Aided by his close advisors Alexander Hamilton, John Laurens, Henry Knox, and William Howe, his wife Martha, and new friends and allies, Washington transformed the troops from a rag-tag band of volunteers to a fighting force that was ready to take on the British. In six months, he turned the tide of the Revolution and changed the future of the United States forever.Valley Forge is a riveting, true American underdog story, with a cast of iconic characters and remarkable moments that perfectly capture the innovation, energy, and birth of our nation. In this breathtaking account of this seminal moment in the battle for independence, New York Times bestselling authors Bob Drury and Tom Clavin uncover new and rarely seen documents and research to finally give it the credit it deserves.

    But in eagerly pursuing what would a century later become known as the "American dream," this optimistic-yet-motley crew of emigrants was met with a chilling nightmare; in the following months, their jingoistic excitement would be replaced by desperate cries for help that would fall silent in the deadly snow-covered mountains of the Sierra Nevada.We know these early pioneers as the Donner Party, a name that has elicited horror since the late 1840s. Now, celebrated historian Michael Wallis—beloved for his myth-busting portraits of legendary American figures—continues his life’s work of parsing fact from fiction to tell the true story of one of the most embroidered sagas in Western history.Wallis begins the story in 1846, a momentous "year of decision" for the nation, when incredible territorial strides were being made in Texas, New Mexico, and California. Against this dramatic backdrop, an unlikely band of travelers appeared, stratified in age, wealth, education and ethnicity. At the forefront were the Donners: brothers George and Jacob, true sons of the soil determined to tame the wild land of California; and the Reeds, headed by adventurous, business-savvy patriarch James. In total, the Donner-Reed group would reach eighty-seven men, women, and children, and though personal motives varied—bachelors thirsting for adventure, parents wanting greater futures for their children—everyone was linked by the same unwavering belief that California was theirs for the taking.Skeptical of previous accounts of how the group ended up in peril, Wallis has spent years retracing its ill-fated journey, uncovering hundreds of new documents that illuminate how a combination of greed, backbiting, and recklessness led the group to become hopelessly snowbound at the infamous Donner Pass in present-day California. Climaxing with the grim stories of how the party’s paltry rations soon gave way to unimaginable hunger, Wallis not only details the cannibalism that has in perpetuity haunted their legacy but also the heroic rescue parties that managed to reach the stranded, only to discover that just forty-eight had survived the ordeal.An unflinching and historically invaluable account of the darkest side of Manifest Destiny, The Best Land Under Heaven offers a brilliant, revisionist examination of one of America's most calamitous and sensationalized catastrophes.

    Though the world at first recoiled at the notion of a woman studying medicine, her intelligence and intensity ultimately won her the acceptance of the male medical establishment. In 1849, she became the first woman in America to receive an M.D. She was soon joined in her iconic achievement by her younger sister, Emily, who was actually the more brilliant physician.Exploring the sisters’ allies, enemies, and enduring partnership, Janice P. Nimura presents a story of trial and triumph. Together, the Blackwells founded the New York Infirmary for Indigent Women and Children, the first hospital staffed entirely by women. Both sisters were tenacious and visionary, but their convictions did not always align with the emergence of women’s rights—or with each other. From Bristol, Paris, and Edinburgh to the rising cities of antebellum America, this richly researched new biography celebrates two complicated pioneers who exploded the limits of possibility for women in medicine. As Elizabeth herself predicted, "a hundred years hence, women will not be what they are now."

    Lab 257 blows the lid off the stunning true nature and checkered history of Plum Island. It shows that the seemingly bucolic island in the shadow of New York City is a ticking biological time bomb that none of us can safely ignore.Based on declassified government documents, in-depth interviews, and access to Plum Island itself, this is an eye-opening, suspenseful account of a federal government germ laboratory gone terribly wrong. For the first time, Lab 257 takes you deep inside this secret world and presents startling revelations on virus outbreaks, biological meltdowns, infected workers, the periodic flushing of contaminated raw sewage into area waters, and the insidious connections between Plum Island, Lyme disease, and the deadly West Nile virus. The book also probes what's in store for Plum Island's new owner, the Department of Homeland Security, in this age of bioterrorism.Lab 257 is a call to action for those concerned with protecting present and future generations from preventable biological catastrophes.

    Not only did one hundred fifty Sioux die at the hands of the U. S. Cavalry, the sense was, but Native civilization did as well. Growing up Ojibwe on a reservation in Minnesota, training as an anthropologist, and researching Native life past and present for his nonfiction and novels, David Treuer has uncovered a different narrative. Because they did not disappear—and not despite but rather because of their intense struggles to preserve their language, their traditions, their families, and their very existence—the story of American Indians since the end of the nineteenth century to the present is one of unprecedented resourcefulness and reinvention. In The Heartbeat of Wounded Knee, Treuer melds history with reportage and memoir. Tracing the tribes' distinctive cultures from first contact, he explores how the depredations of each era spawned new modes of survival. The devastating seizures of land gave rise to increasingly sophisticated legal and political maneuvering that put the lie to the myth that Indians don't know or care about property. The forced assimilation of their children at government-run boarding schools incubated a unifying Native identity. Conscription in the US military and the pull of urban life brought Indians into the mainstream and modern times, even as it steered the emerging shape of self-rule and spawned a new generation of resistance. The Heartbeat of Wounded Knee is the essential, intimate story of a resilient people in a transformative era.

    From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, the history of disease is the history of humankind. With the identification of AIDS in the early 1980s, another chapter has been added to this chronicle of events, which William McNeill explores in his new introduction to this updated editon.Thought-provoking, well-researched, and compulsively readable, Plagues and Peoples is that rare book that is as fascinating as it is scholarly, as intriguing as it is enlightening. "A brilliantly conceptualized and challenging achievement" (Kirkus Reviews), it is essential reading, offering a new perspective on human history.

    A national bestseller in hardcover for more than a year after its initial publication, it has sold almost four million copies and has been translated into seventeen languages. For this elegant thirtieth-anniversary edition—published in both hardcover and paperback—Brown has contributed an incisive new preface.Using council records, autobiographies, and firsthand descriptions, Brown allows the great chiefs and warriors of the Dakota, Ute, Sioux, Cheyenne, and other tribes to tell us in their own words of the battles, massacres, and broken treaties that finally left them demoralized and defeated. A unique and disturbing narrative told with force and clarity, Bury My Heart at Wounded Knee changed forever our vision of how the West was really won.

    It proved fatal to at least a half-million Americans. Yet, the Spanish flu pandemic is largely forgotten today. In this vivid narrative, Alfred W. Crosby recounts the course of the pandemic during the panic-stricken months of 1918 and 1919, measures its impact on American society, and probes the curious loss of national memory of this cataclysmic event. In a new edition, with a new preface discussing the recent outbreaks of diseases, including the Asian flu and the SARS epidemic, America's Forgotten Pandemic remains both prescient and relevant. Alfred W. Crosby is a Professor Emeritus in American Studies, History and Geography at the University of Texas at Austin, where he taught for over 20 years. His previous books include Throwing Fire (Cambrige, 2002), the Measure of Reality (Cambridge, 1997) and Ecological Imperialism (cambridge, 1986). Ecological Imperialism was the winner of the 1986 Phi Beta Kappa book prize. The Measure of Reality was chosen by the Los Angeles Times as one of the 100 most important books of 1997.

    When the great blizzard of 1888 crippled the entire northeast, a solution had to be found. Two brothers from one of the nation's great families-Henry Melville Whitney of Boston and William Collins Whitney of New York-pursued the dream of his city digging America's first subway, and the great race was on. The competition between Boston and New York played out in an era not unlike our own, one of economic upheaval, life-changing innovations, class warfare, bitter political tensions, and the question of America's place in the world.The Race Underground is peopled with the famous, like Boss Tweed, Grover Cleveland and Thomas Edison, and the not-so-famous, from brilliant engineers to the countless "sandhogs" who shoveled, hoisted and blasted their way into the earth's crust, sometimes losing their lives in the construction of the tunnels. Doug Most chronicles the science of the subway, looks at the centuries of fears people overcame about traveling underground and tells a story as exciting as any ever ripped from the pages of U.S. history. The Race Underground is a great American saga of two rival American cities, their rich, powerful and sometimes corrupt interests, and an invention that changed the lives of millions.