In this sensational and macabre story, we meet the surgeon who counted not only luminaries Benjamin Franklin, Lord Byron, Adam Smith, and Thomas Gainsborough among his patients but also “resurrection men” among his close acquaintances. A captivating portrait of his ruthless devotion to uncovering the secrets of the human body, and the extraordinary lengths to which he went to do so—including body snatching, performing pioneering medical experiments, and infecting himself with venereal disease—this rich historical narrative at last acknowledges this fascinating man and the debt we owe him today.

    All three astronauts were experienced pilots and had dreams of one day walking on the moon, but little did they know, nor did anyone else, that once they entered the spacecraft that cold winter day they would never leave it alive. The Apollo program would be perilously close to failure before it ever got off the ground. But rather than dooming the space program, this tragedy caused the spacecraft to be completely overhauled, creating a stellar flying machine to achieve the program’s primary goal: putting man on the moon. Apollo 1 is a candid portrayal of the astronauts, the disaster that killed them, and its aftermath. In it, readers will learn: How the Apollo 1 spacecraft was doomed from the start, with miles of uninsulated wiring and tons of flammable materials in a pure oxygen atmosphere, along with a hatch that wouldn’t open How, due to political pressure, the government contract to build the Apollo 1 craft went to a bidder with an inferior plan How public opinion polls were beginning to turn against the space control before the tragedy and got much worse after Apollo 1 is about America fulfilling its destiny of man setting foot on the moon. It’s also about the three American heroes who lost their lives in the tragedy, but whose lives were not lost in vain.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    But what were the influences that shaped his life and intellectual development? And who inspired him to become the pioneering scientist and public thinker now famous (and infamous to some) around the world?In An Appetite for Wonder we join him on a personal journey back to an enchanting childhood in colonial Africa. There the exotic natural world was his constant companion. Boarding school in England at the age of eight, and, later, public school at Oundle introduce Dawkins, and the reader, to strange rules and eccentric schoolmasters, vividly described with both humorous affection and some reservation. An initial fervent attachment to Church of England religion soon gives way to disaffection and, later, teenage rebellion. Early signs of a preference for music, poetry and reading over practical matters become apparent as he recalls the opportunities that entered his small world.Oxford, however, is the catalyst to his life. Vigorous debate in the dynamic Zoology Department unleashes his innate intellectual curiosity, and inspirational mentors together with his own creative thinking ignite the spark that results in his radical new vision of Darwinism, The Selfish Gene.From innocent child to charismatic world-famous scientist, Richard Dawkins paints a colourful, richly textured canvas of his early life. Honest self-reflection and witty anecdotes are interspersed with touching reminiscences of his family and friends, literature, poetry and songs. We are finally able to understand the private influences that shaped the public man who, more than anyone else in his generation, explained our own origins.

    At 28 years old, Scott Harrison had it all. A top nightclub promoter in New York City, his life was an endless cycle of drugs, booze, models--repeat. But 10 years in, desperately unhappy and morally bankrupt, he asked himself, "What would the exact opposite of my life look like?" Walking away from everything, Harrison spent the next 16 months on a hospital ship in West Africa and discovered his true calling. In 2006, with no money and less than no experience, Harrison founded charity: water. Today, his organization has raised over $300 million to bring clean drinking water to more than 8.2 million people around the globe.In Thirst, Harrison recounts the twists and turns that built charity: water into one of the most trusted and admired nonprofits in the world. Renowned for its 100% donation model, bold storytelling, imaginative branding, and radical commitment to transparency, charity: water has disrupted how social entrepreneurs work while inspiring millions of people to join its mission of bringing clean water to everyone on the planet within our lifetime.In the tradition of such bestselling books as Shoe Dog and Mountains Beyond Mountains, Thirst is a riveting account of how to build a better charity, a better business, a better life--and a gritty tale that proves it's never too late to make a change.100% of the author's net proceeds from Thirst will go to fund charity: water projects around the world.

    No academic analysis or bystander’s account can capture it. Now Doug Edwards, Employee Number 59, offers the first inside view of Google, giving readers a chance to fully experience the bizarre mix of camaraderie and competition at this phenomenal company. Edwards, Google’s first director of marketing and brand management, describes it as it happened. We see the first, pioneering steps of Larry Page and Sergey Brin, the company’s young, idiosyncratic partners; the evolution of the company’s famously nonhierarchical structure (where every employee finds a problem to tackle or a feature to create and works independently); the development of brand identity; the races to develop and implement each new feature; and the many ideas that never came to pass. Above all, Edwards—a former journalist who knows how to write—captures the “Google Experience,” the rollercoaster ride of being part of a company creating itself in a whole new universe. I’m Feeling Lucky captures for the first time the unique, self-invented, yet profoundly important culture of the world’s most transformative corporation.

    His journey provides an unprecedented entry into the corridors of power, and a remarkable lesson in what makes an effective leader.Mr. Comey served as Director of the FBI from 2013 to 2017, appointed to the post by President Barack Obama. He previously served as U.S. attorney for the Southern District of New York, and the U.S. deputy attorney general in the administration of President George W. Bush. From prosecuting the Mafia and Martha Stewart to helping change the Bush administration's policies on torture and electronic surveillance, overseeing the Hillary Clinton e-mail investigation as well as ties between the Trump campaign and Russia, Comey has been involved in some of the most consequential cases and policies of recent history.

    She moved from New York to San Francisco, where she landed at a big-data startup in the heart of the Silicon Valley bubble: a world of surreal extravagance, dubious success, and fresh-faced entrepreneurs hell-bent on domination, glory, and, of course, progress.Anna arrived amidst a massive cultural shift, as the tech industry rapidly transformed into a locus of wealth and power rivaling Wall Street. But amid the company ski vacations and in-office speakeasies, boyish camaraderie and ride-or-die corporate fealty, a new Silicon Valley began to emerge: one in far over its head, one that enriched itself at the expense of the idyllic future it claimed to be building.Part coming-age-story, part portrait of an already-bygone era, Anna Wiener’s memoir is a rare first-person glimpse into high-flying, reckless startup culture at a time of unchecked ambition, unregulated surveillance, wild fortune, and accelerating political power. With wit, candor, and heart, Anna deftly charts the tech industry’s shift from self-appointed world savior to democracy-endangering liability, alongside a personal narrative of aspiration, ambivalence, and disillusionment.Unsparing and incisive, Uncanny Valley is a cautionary tale, and a revelatory interrogation of a world reckoning with consequences its unwitting designers are only beginning to understand.

    Patrick Smith, airline pilot and author of the web's popular Ask the Pilot feature, separates the fact from fallacy and tells you everything you need to know...-How planes fly, and a revealing look at the men and women who fly them-Straight talk on turbulence, pilot training, and safety-The real story on congestion, delays, and the dysfunction of the modern airport-The myths and misconceptions of cabin air and cockpit automation-Terrorism in perspective, and a provocative look at security-Airfares, seating woes, and the pitfalls of airline customer service-The colors and cultures of the airlines we love to hateCockpit Confidential covers not only the nuts and bolts of flying, but also the grand theater of air travel, from airport architecture to inflight service to the excitement of travel abroad. It's a thoughtful, funny, at times deeply personal look into the strange and misunderstood world of commercial flying.It's the ideal book for frequent flyers, nervous passengers, and global travelers.Refreshed and vastly expanded from the original Ask the Pilot, with approximately 75 percent new material.

    As a flight director in NASA’s Mission Control, Kranz witnessed firsthand the making of history. He participated in the space program from the early days of the Mercury program to the last Apollo mission, and beyond. He endured the disastrous first years when rockets blew up and the United States seemed to fall further behind the Soviet Union in the space race. He helped to launch Alan Shepard and John Glenn, then assumed the flight director’s role in the Gemini program, which he guided to fruition. With his teammates, he accepted the challenge to carry out President John F. Kennedy’s commitment to land a man on the Moon before the end of the 1960s. Kranz recounts these thrilling historic events and offers new information about the famous flights. What appeared as nearly flawless missions to the Moon were, in fact, a series of hair-raising near misses. When the space technology failed, as it sometimes did, the controllers’ only recourse was to rely on their skills and those of their teammates. He reveals behind-the-scenes details to demonstrate the leadership, discipline, trust, and teamwork that made the space program a success. A fascinating firsthand account by a veteran mission controller of one of America’s greatest achievements, Failure is Not an Option reflects on what has happened to the space program and offers his own bold suggestions about what we ought to be doing in space now.

    Yet despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu to the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 “parrot fever” pandemic, through the more recent SARS, Ebola, and Zika epidemics, the last one hundred years have been marked by a succession of unanticipated pandemic alarms.In The Pandemic Century, a lively account of scares both infamous and less known, Mark Honigsbaum combines reportage with the history of science and medical sociology to artfully reconstruct epidemiological mysteries and the ecology of infectious diseases. We meet dedicated disease detectives, obstructive or incompetent public health officials, and brilliant scientists often blinded by their own knowledge of bacteria and viruses. We also see how fear of disease often exacerbates racial, religious, and ethnic tensions—even though, as the epidemiologists Malik Peiris and Yi Guan write, “‘nature’ remains the greatest bioterrorist threat of all.”Like man-eating sharks, predatory pathogens are always present in nature, waiting to strike; when one is seemingly vanquished, others appear in its place. These pandemics remind us of the limits of scientific knowledge, as well as the role that human behavior and technologies play in the emergence and spread of microbial diseases.

    There have been exhilarating highs and devastating lows, but his love for the practice of neurosurgery has never wavered. Following the publication of his celebrated New York Times bestseller Do No Harm, Marsh retired from his full-time job in England to work pro bono in Ukraine and Nepal. In Admissions, he describes the difficulties of working in these troubled, impoverished countries and the further insights it has given him into the practice of medicine. Marsh also faces up to the burden of responsibility that can come with trying to reduce human suffering. Unearthing memories of his early days as a medical student and the experiences that shaped him as a young surgeon, he explores the difficulties of a profession that deals in probabilities rather than certainties and where the overwhelming urge to prolong life can come at a tragic cost for patients and those who love them. Reflecting on what forty years of handling the human brain has taught him, Marsh finds a different purpose in life as he approaches the end of his professional career and a fresh understanding of what matters to us all in the end.

    Robert Oppenheimer, "father of the atomic bomb," the brilliant, charismatic physicist who led the effort to capture the awesome fire of the sun for his country in time of war. Immediately after Hiroshima, he became the most famous scientist of his generation-one of the iconic figures of the twentieth century, the embodiment of modern man confronting the consequences of scientific progress. He was the author of a radical proposal to place international controls over atomic materials-an idea that is still relevant today. He opposed the development of the hydrogen bomb and criticized the Air Force's plans to fight an infinitely dangerous nuclear war. In the now almost-forgotten hysteria of the early 1950s, his ideas were anathema to powerful advocates of a massive nuclear buildup, and, in response, Atomic Energy Commission chairman Lewis Strauss, Superbomb advocate Edward Teller and FBI director J. Edgar Hoover worked behind the scenes to have a hearing board find that Oppenheimer could not be trusted with America's nuclear secrets. American Prometheus sets forth Oppenheimer's life and times in revealing and unprecedented detail. Exhaustively researched, it is based on thousands of records and letters gathered from archives in America and abroad, on massive FBI files and on close to a hundred interviews with Oppenheimer's friends, relatives and colleagues.We follow him from his earliest education at the turn of the twentieth century at New York City's Ethical Culture School, through personal crises at Harvard and Cambridge universities. Then to Germany, where he studied quantum physics with the world's most accomplished theorists; and to Berkeley, California, where he established, during the 1930s, the leading American school of theoretical physics, and where he became deeply involved with social justice causes and their advocates, many of whom were communists. Then to Los Alamos, New Mexico, where he transformed a bleak mesa into the world's most potent nuclear weapons laboratory-and where he himself was transformed. And finally, to the Institute for Advanced Study in Princeton, which he directed from 1947 to 1966. American Prometheus is a rich evocation of America at midcentury, a new and compelling portrait of a brilliant, ambitious, complex and flawed man profoundly connected to its major events—the Depression, World War II and the Cold War. It is at once biography and history, and essential to our understanding of our recent past—and of our choices for the future.

    In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT.David Quammen chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.

    individual whose contributions to the scientific, business and cultural realms are extensive."—BookpageBefore slim laptops that fit into briefcases, computers looked like strange, alien vending machines. But in "the most staggering burst of technical invention by a single person in high-tech history" (BusinessWeek​) Steve Wozniak invented the first true personal computer. Wozniak teamed up with Steve Jobs, and Apple Computer was born, igniting the computer revolution and transforming the world. Here, thirty years later, the mischievous genius with the low profile treats readers to a rollicking, no-holds-barred account of his life—for once, in the voice of the wizard himself.