Then, slowly, a mist settled deep inside the mind she once knew so well, blurring the world around her. She didn't know it then, but dementia was starting to take hold. In 2014, at age fifty-eight, she was diagnosed with young-onset Alzheimer's.Mitchell shares the heartrending story of her cognitive decline and how she has fought to stave it off. What lay ahead of her after the diagnosis was scary and unknowable, but Mitchell was determined and resourceful, and she vowed to outwit the disease for as long as she could.As Mitchell learned to embrace her new life, she began to see her condition as a gift, a chance to experience the world with fresh eyes and to find her own way to make a difference. Even now, her sunny outlook persists: She devotes her time to educating doctors, caregivers, and other people living with dementia, helping to reduce the stigma surrounding this insidious disease.Still living independently, Mitchell now uses Post-it notes and technology to remind her of her routines and has created a "memory room" where she displays photos--with labels--of her daughters, friends, and special places. It is a room where she feels calm and happy, especially on days when the mist descends.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    Caroline Knapp describes how the distorted world of her well-to-do parents pushed her toward anorexia and alcoholism. Fittingly, it was literature that saved her: she found inspiration in Pete Hamill's 'A Drinking Life' and sobered up. Her tale is spiced up with the characters she has known along the way. A journalist describes her twenty years as a functioning alcoholic, explaining how she used alcohol to escape personal relationships and the realities of life until a series of personal crises forced her to confront her problem.

    After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write an exploration of family, history, and love.

    Here he recounts in his inimitable voice his experience trading ideas on atomic physics with Einstein and Bohr and ideas on gambling with Nick the Greek; cracking the uncrackable safes guarding the most deeply held nuclear secrets; accompanying a ballet on his bongo drums; painting a naked female toreador. In short, here is Feynman's life in all its eccentric—a combustible mixture of high intelligence, unlimited curiosity, and raging chutzpah.

    The East Area Rapist. The Original Night Stalker. The Visalia Ransacker.The monster who preyed on Californians from 1976 to 1986 was known by many aliases. And while numerous police sketches tried to capture his often-masked visage, the Golden State Killer spent more than 40 years not only faceless, but nameless.For his victims, for their families and for the investigators tasked with finding him, the senselessness and brutality of the Golden State Killer's acts were matched only by the powerlessness they felt at failing to uncover his identity. To be sure, the chances of obtaining closure—or any form of justice—after so many years were slim to none, at best.Then, on April 24, 2018, authorities arrested 72-year-old Joseph James DeAngelo at his home in Citrus Heights, Calif., based on DNA evidence linked to the crimes. After a decades-long hunt, a suspect was behind bars. Could it be that evil finally had a name?Delivering all-new details about the investigation and a stunning final act to the events of Michelle McNamara's haunting bestseller, I'll Be Gone in the Dark, this is the true story of how the suspected Golden State Killer was captured, as told, first-hand, by those closest to the case:Paul Holes—the forensic criminologist and retired Costa County detective who spent 20 years trying to crack the Golden State Killer case, and finally did.Jim Clemente (Host)—a retired FBI profiler and former New York City prosecutor who has investigated some of the highest profile criminal cases in U.S. history, including the Unabomber.Please note: This work contains descriptions of violent crime and sexual assault and may not be suitable for all listeners.

    Kear's biggest concern is choosing a major--until she walks into a doctor's office in midtown Manhattan and gets a life-changing diagnosis. She is going blind, courtesy of an eye disease called retinitis pigmentosa, and has only a decade or so before Lights Out. Instead of making preparations as the doctor suggests, Kear decides to carpe diem and make the most of the vision she has left. She joins circus school, tears through boyfriends, travels the world, and through all these hi-jinks, she keeps her vision loss a secret.When Kear becomes a mother, just a few years shy of her vision's expiration date, she amends her carpe diem strategy, giving up recklessness in order to relish every moment with her kids. Her secret, though, is harder to surrender - and as her vision deteriorates, harder to keep hidden. As her world grows blurred, one thing becomes clear: no matter how hard she fights, she won't win the battle against blindness. But if she comes clean with her secret, and comes to terms with the loss, she can still win her happy ending.Told with humor and irreverence, Now I See You is an uplifting story about refusing to cower at life's curveballs, about the power of love to triumph over fear. But, at its core, it's a story about acceptance: facing the truths that just won't go away, and facing yourself, broken parts and all.

    In the wake of rape allegations made against director and actor Nate Parker, Union—a forty-four-year-old actress who launched her career with roles in iconic ’90s movies—instantly became the insightful, outspoken actress that Hollywood has been desperately awaiting. With honesty and heartbreaking wisdom, she revealed her own trauma as a victim of sexual assault: "It is for you that I am speaking. This is real. We are real." In this moving collection of thought provoking essays infused with her unique wisdom and deep humor, Union uses that same fearlessness to tell astonishingly personal and true stories about power, color, gender, feminism, and fame. Union tackles a range of experiences, including bullying, beauty standards, and competition between women in Hollywood, growing up in white California suburbia and then spending summers with her black relatives in Nebraska, coping with crushes, puberty, and the divorce of her parents. Genuine and perceptive, Union bravely lays herself bare, uncovering a complex and courageous life of self-doubt and self-discovery with incredible poise and brutal honesty. Throughout, she compels us to be ethical and empathetic, and reminds us of the importance of confidence, self-awareness, and the power of sharing truth, laughter, and support.

    Through her music and performing, this beloved Australian artist has touched hundreds of thousands of lives. But what of the stories she used to tell herself? That 'real life' only begins once you're thin or beautiful, that good things only happen to other people.YOUR OWN KIND OF GIRL reveals a childhood punctuated by grief, anxiety and compulsion, and tells how these forces shaped Clare's life for better and for worse. This is a heartbreaking, wise and at times playful memoir. Clare's own story told raw and as it happened. A reminder that even on the darkest of nights, victory is closer than it seems.With startling candour, Clare lays bare her truth in the hope that doing so will inspire anyone who's ever done battle with their inner critic. This is the work of a woman who has found her true power - and wants to pass it on. Happiness, we discover, is only possible when we take charge of the stories we tell ourselves.

    The setting: Los Angeles. A gorgeous virtuoso of an actress had agreed to star in a random play, and a basement-dwelling scenic carpenter had said he would assay a supporting role in the selfsame pageant. At the first rehearsal, she surveyed her fellow cast members, as one does, determining if any of the men might qualify to provide her with a satisfying fling. Her gaze fell upon the carpenter, and like a bolt of lightning, the thought struck her: No dice. Moving on.Yet, unbeknownst to our protagonists, Cupid had merely set down his bow and picked up a rocket launcher. Then fired a love rocket (not a euphemism). The players were Megan Mullally and Nick Offerman, and the resulting romance, once it ignited, was . . . epic. Beyond epic. It resulted in a coupling that has endured to this day; a sizzling, perpetual tryst that has captivated the world with its kindness, athleticism, astonishingly low-brow humor, and true (fire emoji) passion.How did they do it? They came from completely different families, endured a significant age difference, and were separated by the gulf of several social strata. Megan loved books and art history; Nick loved hammers. But much more than these seemingly unsurpassable obstacles were the values they held in common: respect, decency, the ability to mention genitalia in almost any context, and an abiding obsession with the songs of Tom Waits.Eighteen years later, they're still very much in love, and have finally decided to reveal the philosophical mountains they have conquered, the lessons they've learned, and the myriad jigsaw puzzles they've completed, in a book. Featuring anecdotes, hijinks, interviews, photos, and a veritable grab bag of tomfoolery, this is not only the intoxicating book that Mullally's and Offerman's fans have been waiting for, it might just hold the solution to the greatest threat facing our modern world: the single life.

    Iconoclast. Apostate. Drunk. Many words have been used to describe Doug Stanhope, but rarely has “hopeful” been one of them. However, heading into 2016, Stanhope peered through the apocalyptic fog and saw a forecast that was more rainbows than acid rain: His first book was set for release, his new stand-up special was in the can, and he was about to film a television pilot with his friend and confidant Johnny Depp. The sharks of Hollywood were circling, and Stanhope’s pockets were filled with chum. The only thing that could stop Doug was himself, and that’s exactly what he did.First came the booze, then came the pills, then came the stripper, and then, Doug came. A tryst aboard a cruise ship leaves him literally and figuratively adrift when his scorned wife, Bingo, reveals she is in love with another man: a jug-sippin’, guitar-pickin’ hobo. A simple, black-out fling turns out to be a pebble tossed into the lake of you-know-what named 2016, and in No Encore for the Donkey, Stanhope traces the resulting rings.Written and performed by Stanhope, his third memoir follows the veteran comedian on a quest to save his marriage, his wife, and eventually his wife’s life. Our hero's journey finds Stanhope cuddling with Johnny Depp in his Los Angeles mansion, receiving some much-needed TLC from Marilyn Manson, and - most daunting - building a new hour of comedy in the rusted-out hellscapes of post-industrial America.Equal parts love letter, road romp, and harrowing condemnation of the failures of America’s mental health care system, No Encore for the Donkey is a hilarious and heartbreaking account of a man balancing on the edge of damnation. With Bingo in a coma and Trump about to be elected, Stanhope sifts through the ruins of his own personal cataclysm in order to answer the big questions: What does it mean to love someone when you can’t love yourself? What is the point of success if you have no one to share it with? And is the end of the world BYOB?

    It wasn’t drugs, alcohol, or sex: it was film. After moving to Los Angeles, Oswalt became a huge film buff (or as he calls it, a sprocket fiend), absorbing classics, cult hits, and new releases at the famous New Beverly Cinema. Silver screen celluloid became Patton’s life schoolbook, informing his notion of acting, writing, comedy, and relationships.Set in the nascent days of LA’s alternative comedy scene, Silver Screen Fiend chronicles Oswalt’s journey from fledgling stand-up comedian to self-assured sitcom actor, with the colorful New Beverly collective and a cast of now-notable young comedians supporting him all along the way.

     Celebrated historian David Nasaw, whom The New York Times Book Review has called "a meticulous researcher and a cool analyst," brings new life to the story of one of America's most famous and successful businessmen and philanthropists- in what will prove to be the biography of the season. Born of modest origins in Scotland in 1835, Andrew Carnegie is best known as the founder of Carnegie Steel. His rags to riches story has never been told as dramatically and vividly as in Nasaw's new biography. Carnegie, the son of an impoverished linen weaver, moved to Pittsburgh at the age of thirteen. The embodiment of the American dream, he pulled himself up from bobbin boy in a cotton factory to become the richest man in the world. He spent the rest of his life giving away the fortune he had accumulated and crusading for international peace. For all that he accomplished and came to represent to the American public-a wildly successful businessman and capitalist, a self-educated writer, peace activist, philanthropist, man of letters, lover of culture, and unabashed enthusiast for American democracy and capitalism-Carnegie has remained, to this day, an enigma. Nasaw explains how Carnegie made his early fortune and what prompted him to give it all away, how he was drawn into the campaign first against American involvement in the Spanish-American War and then for international peace, and how he used his friendships with presidents and prime ministers to try to pull the world back from the brink of disaster. With a trove of new material-unpublished chapters of Carnegie's Autobiography; personal letters between Carnegie and his future wife, Louise, and other family members; his prenuptial agreement; diaries of family and close friends; his applications for citizenship; his extensive correspondence with Henry Clay Frick; and dozens of private letters to and from presidents Grant, Cleveland, McKinley, Roosevelt, and British prime ministers Gladstone and Balfour, as well as friends Herbert Spencer, Matthew Arnold, and Mark Twain-Nasaw brilliantly plumbs the core of this facinating and complex man, deftly placing his life in cultural and political context as only a master storyteller can.

    His profile and reach is lightyears beyond where it was for Chins.Hail to the Chin will be bursting with pictures and the signature humor that Bruce brought to If Chins Could Kill and will be devoured by his legions of fans across the country.

    In the book, Sanders shares experiences from the campaign trail and outlines his ideas for continuing a political revolution to fight for a progressive economic, environmental, racial and social justice agenda that creates jobs, raises wages, protects the environment and provides health care for all.