Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer's and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night's sleep every night.

    From that day forward his life became a hell of uncontrollable tics, urges, and involuntary utterances. Eventually he is diagnosed with Tourette's Syndrome and Obsessive Compulsive disorder, and Cory embarks on an excruciating journey from specialist to specialist, enduring countless combinations of medications in wildly varying doses. Soon it becomes unclear what tics are symptoms of his disease and what are side effects of the drugs. The only certainty is that it kept getting worse. Despite his lack of control, Cory is aware of every embarrassing movement, and sensitive to every person's reaction to his often aggravating presence. Simply put: Cory Friedman's life is a living hell.Against Medical Advice is the true story of one family's decades-long battle for survival in the face of extraordinary difficulties and a rigid medical establishment.

    But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

    Dr. Martin Couney's story is a kaleidoscopic ride through the intersection of ebullient entrepreneurship, enlightened pediatric care, and the wild culture of world's fairs at the beginning of the American Century.As Dawn Raffel recounts, Dr. Couney used incubators and careful nursing to keep previously doomed infants alive, while displaying these babies alongside sword swallowers, bearded ladies, and burlesque shows at Coney Island, Atlantic City, and venues across the nation. How this turn-of-the-twentieth-century �migr� became the savior to families with premature infants--known then as "weaklings"--as he ignored the scorn of the medical establishment and fought the rising popularity of eugenics is one of the most astounding stories of modern medicine. Dr. Couney, for all his entrepreneurial gusto, is a surprisingly appealing character, someone who genuinely cared for the well-being of his tiny patients. But he had something to hide...Drawing on historical documents, original reportage, and interviews with surviving patients, Dawn Raffel tells the marvelously eccentric story of Couney's mysterious carnival career, his larger-than-life personality, and his unprecedented success as the savior of the fragile wonders that are tiny, tiny babies.A New York Times Book Review New & Noteworthy Title A Real Simple Best Book of 2018Christopher Award-winner

    To the right listener, they tell us all about themselves: where they came from, how they lived, how they died - and who killed them. Forensic scientists can unlock the mysteries of the past and help justice to be done using the messages left by a corpse, a crime scene or the faintest of human traces. Forensics uncovers the secrets of forensic medicine, drawing on interviews with top-level professionals, ground-breaking research and Val McDermid's own experience to lay bare the secrets of this fascinating science. And, along the way, she wonders at how maggots collected from a corpse can help determine time of death, how a DNA trace a millionth the size of a grain of salt can be used to convict a killer and how a team of young Argentine scientists led by a maverick American anthropologist uncovered the victims of a genocide.In her crime novels, Val McDermid has been solving complex crimes and confronting unimaginable evil for years. Now, she's looking at the people who do it for real, and real crime scenes. It's a journey that will take her to war zones, fire scenes and autopsy suites, and bring her into contact with extraordinary bravery and wickedness, as she traces the history of forensics from its earliest beginnings to the cutting-edge science of the modern day.

    On the one hand, it is a modern miracle: a ubiquitous fixture in a vast sanitation system that has helped add decades to the human life span by reducing disease. On the other hand, the toilet is also a tragic failure: less than half of the world’s population can access a toilet that safely manages body waste, including many right here in the United States. And it is inefficient, squandering clean water as well as the nutrients, energy, and information contained in the stuff we flush away. While we see radical technological change in almost every other aspect of our lives, we remain stuck in a sanitation status quo—in part because the topic of toilets is taboo. Fortunately, there’s hope—and Pipe Dreams daringly profiles the growing army of sewage-savvy scientists, engineers, philanthropists, entrepreneurs, and activists worldwide who are overcoming their aversions and focusing their formidable skills on making toilets accessible and healthier for all. This potential revolution in sanitation has many benefits, including reducing inequalities, mitigating climate change and water scarcity, improving agriculture, and optimizing health. Author Chelsea Wald takes us on a wild world tour from a compost toilet project in Haiti, to a plant in the Netherlands that salvages used toilet paper from sewage, and shows us a toilet seat that can watch users’ poop for signs of illness, among many other fascinating developments. “Toilet humor is one thing, but toilet fact, as digested by skilled science writer Wald, is quite another…[Pipe Dreams is] a highly informative, well-reasoned call to rethink the throne” (Kirkus Reviews).

    And we know that another global disaster is eventually headed our way. Can we survive it? How?As a species, Homo sapiens is at a crossroads. Study of our planet’s turbulent past suggests that we are overdue for a catastrophic disaster, whether caused by nature or by human interference.It’s a frightening prospect, as each of the Earth’s past major disasters—from meteor strikes to bombardment by cosmic radiation—resulted in a mass extinction, where more than 75 percent of the planet’s species died out. But in Scatter, Adapt, and Remember, Annalee Newitz, science journalist and editor of the science Web site io9.com explains that although global disaster is all but inevitable, our chances of long-term species survival are better than ever. Life on Earth has come close to annihilation—humans have, more than once, narrowly avoided extinction just during the last million years—but every single time a few creatures survived, evolving to adapt to the harshest of conditions.      This brilliantly speculative work of popular science focuses on humanity’s long history of dodging the bullet, as well as on new threats that we may face in years to come. Most important, it explores how scientific breakthroughs today will help us avoid disasters tomorrow. From simulating tsunamis to studying central Turkey’s ancient underground cities; from cultivating cyanobacteria for “living cities” to designing space elevators to make space colonies cost-effective; from using math to stop pandemics to studying the remarkable survival strategies of gray whales, scientists and researchers the world over are discovering the keys to long-term resilience and learning how humans can choose life over death.     Newitz’s remarkable and fascinating journey through the science of mass extinctions is a powerful argument about human ingenuity and our ability to change. In a world populated by doomsday preppers and media commentators obsessively forecasting our demise, Scatter, Adapt, and Remember is a compelling voice of hope. It leads us away from apocalyptic thinking into a future where we live to build a better world—on this planet and perhaps on others. Readers of this book will be equipped scientifically, intellectually, and emotionally to face whatever the future holds.

    What began as the chronicle of an imminent and early death became something much more--a powerful exhortation to the living.That Julie Yip-Williams survived infancy was a miracle. Born blind in Vietnam, she narrowly escaped euthanasia at the hands of her grandmother, only to flee with her family the political upheaval of her country in the late 1970s. Loaded into a rickety boat with three hundred other refugees, Julie made it to Hong Kong and, ultimately, America, where a surgeon at UCLA gave her partial sight. She would go on to become a Harvard-educated lawyer, with a husband, a family, and a life she had once assumed would be impossible. Then, at age thirty-seven, with two little girls at home, Julie was diagnosed with terminal metastatic colon cancer, and a different journey began.The Unwinding of the Miracle is the story of a vigorous life refracted through the prism of imminent death. When she was first diagnosed, Julie Yip-Williams sought clarity and guidance through the experience and, finding none, began to write her way through it--a chronicle that grew beyond her imagining. Motherhood, marriage, the immigrant experience, ambition, love, wanderlust, tennis, fortune-tellers, grief, reincarnation, jealousy, comfort, pain, the marvel of the body in full rebellion--this book is as sprawling and majestic as the life it records. It is inspiring and instructive, delightful and shattering. It is a book of indelible moments, seared deep--an incomparable guide to living vividly by facing hard truths consciously.With humor, bracing honesty, and the cleansing power of well-deployed anger, Julie Yip-Williams set the stage for her lasting legacy and one final miracle: the story of her life.

    With the Big Bang, it went from a state of unimaginable density to an all-encompassing cosmic fireball to a simmering fluid of matter and energy, laying down the seeds for everything from dark matter to black holes to one rocky planet orbiting a star near the edge of a spiral galaxy that happened to develop life. But what happens at the end of the story? In billions of years, humanity could still exist in some unrecognizable form, venturing out to distant space, finding new homes and building new civilizations. But the death of the universe is final. What might such a cataclysm look like? And what does it mean for us? Dr. Katie Mack has been contemplating these questions since she was eighteen, when her astronomy professor first informed her the universe could end at any moment, setting her on the path toward theoretical astrophysics. Now, with lively wit and humor, she unpacks them in The End of Everything, taking us on a mind-bending tour through each of the cosmos’ possible finales: the Big Crunch; the Heat Death; Vacuum Decay; the Big Rip; and the Bounce. In the tradition of Neil DeGrasse’s bestseller Astrophysics for People in a Hurry, Mack guides us through major concepts in quantum mechanics, cosmology, string theory, and much more, in a wildly fun, surprisingly upbeat ride to the farthest reaches of everything we know.

    In fact, a plethora of parasites affect our behavior in ways we have barely begun to understand.  In this mind-bending book, McAuliffe reveals the eons-old war between parasites and other creatures that is playing out in our very own bodies. And more surprising still, she uncovers the decisive role that parasites may have played in the rise and demise of entire civilizations. Our obsession with cleanliness and our experience of disgust are both evolutionary tools for avoiding infection, but they evolved differently for different populations. Political, social, and religious differences among societies may be caused, in part, by the different parasites that prey on us. In the tradition of Jared Diamond’s Guns, Germs, and Steel and Neil Shubin’s Your Inner Fish, This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.

    One day he was a doctor treating the dying, and the next he was a patient struggling to live. And just like that, the future he and his wife had imagined evaporated. When Breath Becomes Air chronicles Kalanithi's transformation from a naïve medical student "possessed," as he wrote, "by the question of what, given that all organisms die, makes a virtuous and meaningful life" into a neurosurgeon at Stanford working in the brain, the most critical place for human identity, and finally into a patient and new father confronting his own mortality. What makes life worth living in the face of death? What do you do when the future, no longer a ladder toward your goals in life, flattens out into a perpetual present? What does it mean to have a child, to nurture a new life as another fades away? These are some of the questions Kalanithi wrestles with in this profoundly moving, exquisitely observed memoir. Paul Kalanithi died in March 2015, while working on this book, yet his words live on as a guide and a gift to us all. "I began to realize that coming face to face with my own mortality, in a sense, had changed nothing and everything," he wrote. "Seven words from Samuel Beckett began to repeat in my head: 'I can't go on. I'll go on.'" When Breath Becomes Air is an unforgettable, life-affirming reflection on the challenge of facing death and on the relationship between doctor and patient, from a brilliant writer who became both.

    In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    The tiger isn’t just killing people, it’s annihilating them, and a team of men and their dogs must hunt it on foot through the forest in the brutal cold. As the trackers sift through the gruesome remains of the victims, they discover that these attacks aren’t random: the tiger is apparently engaged in a vendetta. Injured, starving, and extremely dangerous, the tiger must be found before it strikes again.As he re-creates these extraordinary events, John Vaillant gives us an unforgettable portrait of this spectacularly beautiful and mysterious region. We meet the native tribes who for centuries have worshipped and lived alongside tigers, even sharing their kills with them. We witness the arrival of Russian settlers in the nineteenth and early twentieth centuries, soldiers and hunters who greatly diminished the tiger populations. And we come to know their descendants, who, crushed by poverty, have turned to poaching and further upset the natural balance of the region.This ancient, tenuous relationship between man and predator is at the very heart of this remarkable book. Throughout we encounter surprising theories of how humans and tigers may have evolved to coexist, how we may have developed as scavengers rather than hunters, and how early Homo sapiens may have fit seamlessly into the tiger’s ecosystem. Above all, we come to understand the endangered Siberian tiger, a highly intelligent super-predator that can grow to ten feet long, weigh more than six hundred pounds, and range daily over vast territories of forest and mountain.Beautifully written and deeply informative, The Tiger circles around three main characters: Vladimir Markov, a poacher killed by the tiger; Yuri Trush, the lead tracker; and the tiger himself. It is an absolutely gripping tale of man and nature that leads inexorably to a final showdown in a clearing deep in the taiga.

    bataar bones he was impressed. The enormous skull and teeth betrayed the apex predators close relation to the storied Tyrannosaurus rex, the most famous animal that ever lived. Prokopi's obsession with fossils had begun decades earlier, when he was a Florida boy scouring for shark teeth and Ice Age remnants, and it had continued as he built a thriving business hunting, preparing, and selling specimens to avid collectors and private museums around the world. To scientists' fury and dismay, there was big money to be made in certain corners of the fossil trade. Prokopi didn't consider himself merely a businessman, though. He also thought of himself as a vital part of paleontology--as one of the lesser-known artistic links in bringing prehistoric creatures back to life--and saw nothing wrong with turning a profit in the process. Bone hunting was expensive, risky, controversial work, and he increasingly needed bigger "scores." By the time he acquired a largely complete skeleton of T. bataar and restored it in his workshop, he was highly leveraged and drawing quiet scorn from peers who worried that by bringing such a big, beautiful Mongolian dinosaur to market he would tarnish the entire trade. Presenting the skeleton for sale at a major auction house in New York City, he was relieved to see the bidding start at nearly $1 million---only to fall apart when the president of Mongolia unexpectedly stepped in to question the specimen's origins and demand its return. An international custody battle ensued, shining new light on the black market for dinosaur fossils, the angst of scientists who fear for their field, and the precarious political tensions in post-Communist Mongolia. The Prokopi case, unprecedented in American jurisprudence, continues to reverberate throughout the intersecting worlds of paleontology, museums, art, and geopolitics.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.