A decade later, the price for any of us to order our own personal genome sequence—a comprehensive map of the 3 billion letters in our DNA—is rapidly and inevitably dropping to just $1,000. Dozens of men and women—scientists, entrepreneurs, celebrities, and patients—have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer’s or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions—and many more—by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure. Indeed, many experts are advocating that all newborns have a complete genome analysis done so that preventive measures and preemptive medicine can begin early in life. How has this astonishing achievement been accomplished? And what will it mean for our lives? To research the story of this unfolding revolution, critically acclaimed science writer Kevin Davies has spent the past few years traveling to the leading centers and interviewing the entrepreneurs and pioneers in the race to achieve the $1,000 genome. He vividly brings to life the extraordinary drama of this grand scientific achievement, revealing the masterful ingenuity that has transformed the process of decoding DNA and delivering the information it possesses to the public at large. Davies also profiles the future of genomic medicine and thoughtfully explores the many pressing issues raised by the tidal wave of personal genetic information. Will your privacy be protected? Will you be pressured, by insurance companies or by your employer, to get your genome sequenced? What psychological toll might there be to discovering you are at risk for certain diseases like Alzheimer’s? And will the government or the medical establishment come between you and your genome?One thing that is not in question is that we are moving swiftly into the personalized medicine era, and The $1,000 Genome is an essential guide to this brave new future.

    Cave paintings of the giant beasts hint at the profound role they played in early human culture-our Ice Age ancestors built igloo-shaped huts out of mammoth bones and even feasted on mammoth tongues. Eager to uncover more clues to this mystical prehistoric age, explorers since the time of Peter the Great have scoured Siberia for mammoth remains. Now a new generation of explorers has taken to the tundra. Armed with GPS, ground-penetrating radar, and Soviet-era military helicopters, they seek an elusive prize: a mammoth carcass that will help determine how the creature lived, how it died-and how it might be brought back to life.In this adventure-filled narrative, science writer Richard Stone follows two teams of explorers-one Russian/Japanese, the other a French-led consortium-as they battle bitter cold, high winds, supply shortages, and the deeply rooted superstitions of indigenous peoples who fear the consequences of awakening the "rat beneath the ice." Stone travels from St. Petersburg to the Arctic Circle, from the North Sea to high-tech Japanese laboratories, as he traces the sometimes-surreal quest of these intrepid scientists, whose work could well rewrite our planet's evolutionary history. A riveting tale of high-stakes adventure and scientific hubris, Mammoth is also an intellectual voyage through uncharted moral terrain, as we confront the promise and peril of resurrecting creatures from the deep past.

    And from the Deepwater Horizon oil disaster to Hurricane Katrina, he’s shown an astounding ability to beat the odds (and beat the bureaucrats) to get things done.Then again, Jindal is not your typical politician. The son of Indian immigrants, a Christian convert from Hinduism, and a Rhodes Scholar, Jindal presided over Louisiana’s healthcare system at age 24, headed the University of Louisiana system at 27, became a U.S. congressman at 33, and was elected governor of Louisiana at 36.Throughout his meteoric career, Jindal has dealt with some of the worst crises of our times, from natural disasters in his home state to out-of-control spending in Washington, D.C. His secret: the common sense solutions that bureaucrats (and politicians) ignore in favor of government–as–usual.In Leadership and Crisis, Jindal reveals: How the Obama administration spent too much time worrying about public perception and not enough on actually fighting the oil How the federal government actually impeded Louisiana’s efforts to stem the flood of oil Why the bureaucratic incompetence during Hurricane Katrina was even worse than you know How Bobby Jindal took on Louisiana’s infamous culture of corruption His own journey from Hinduism to Christianity, from student at Oxford to Governor of Louisiana, from policy wonk to instant midwife when he had to deliver his third child himself Filled with behind–the–scenes stories from the oil–slicked beaches of Louisiana to the corridors of power in the U.S. Capitol, Leadership and Crisis offers an insider’s view into one of the worst environmental disasters our nation has suffered—and into one of the most unique success stories of American politics.

    Most of us have unfinished business that might make us feel like we walk around dragging a heavy ball with a chain connected to our ankle. When you declutter and possibly downsize, you can free yourself of weighty matters that tie you down physically, mentally, emotionally, and spiritually.Lighter Living explains why you might want to simplify your home and your life. It shows you how to declutter and then organize what you keep. Finally, you are given a vision for lifelong decluttering and how it can lead to well-being and peace of mind.

    

    The number of brands grows every day and bartenders - and consumers - are now beginning to re-examine gin as a quality base spirit for drinks both simple and complex.Now, with more brands available than ever before, it is the time to set out what makes gin special, what its flavors are and how to get the most out of the brands you buy. With this book as your guide, discover:How gin is madeWhat a botanical is and how they impact a gin's flavorWhat the difference between Dutch, London, Scottish, Spanish and American gins isHow you drink them to maximize your pleasureWhether there is life beyond the gin & tonic (yes!)The body of the book covers 120 gins which Dave has tested four ways - with tonic, with lemonade, in a negroni and in a martini - and then scored. In addition, each gin is categorized according to an ingenious flavor camp system, which highlights its core properties and allows you to understand how you can best drink it, and therefore enjoy it.

    Arguably the greatest adventure skier to ever live, Doug Coombs pioneered hundreds of first descents....

    In this collection of essays, Knapp intentionally flies away from the flock, reveling in insights gleaned from birds, his students, and the wide-eyed wonder his children experience.The Delightful Horror of Family Birding navigates the world in hopes that appreciation of nature will burn intensely for generations to come, not peter out in merely a flicker. Whether traveling solo or with his students or children, Knapp levels his gaze on the birds that share our skies, showing that birds can be a portal to deeper relationships, ecological understanding, and newfound joy.

    Full of advice on how surgeons should use their heads as well as their hands - how to think, plan, and improvise - when, for example, operating on a massively bleeding trauma patient. Starts with general principles, continues with specific injuries to abdomen, chest, neck, and peripheral vessels. Generously illustrated throughout, with drawings produced specifically for this book. For residents, general surgeons with an interest in trauma, and for surgeons operating on badly wounded patients in isolated military, rural, or humanitarian settings. Asher Hirshberg and Kenneth L Mattox are trauma surgeons at the Ben Taub General Hospital, Houston, and professors at the Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA. Kenneth L Maddox is famous as the lead editor of McGraw Hill's classic text, Trauma, now in its fifth edition. This is going to be a GREAT book!

    A biography of Brazilian soccer player Kaká detailing his life and career.

    Horowitz lays out how we have ended up in the worst national crisis since the Civil War. He details: • The Left’s embrace of Critical Race Theory and Cultural Marxism—the underpinnings of their totalitarian ideology • The decades-long infiltration of our education system by ideologies hostile to America, our institutions, and our freedom • Why the Obama administration marked a point of no return in the division of America into two irreconcilable political factions • The Democrats’ unprincipled campaign to destroy a duly elected U.S. president • Their political exploitation of the coronavirus pandemic • Their complicity in the riots of the summer of 2020, which left twenty-five dead, injured two thousand police officers, caused billions of dollars in property damage, and revealed the fragility of our civic order.

    Birders will find it indispensable: this single, portable volume features more than 750 species, along with more than 2,000 stunning images by leading nature photographers showing birds in their natural habitats. Captions highlight important field marks, and comprehensive species accounts describe habitats, behavior, flight, migration, songs, and plumages. Other features include: more than 600 maps showing bird distribution in every season; strategies for watching and identifying birds; a complete species index plus a quick-flip index; a glossary of terms; and a checklist of birds. The guide’s unique waterproof cover makes it especially valuable for use in the field.

    officials were turning the surveillance powers of the federal government -- designed to stop terrorist attacks -- against the Republican presidential team. These were the ruthless tactics of a Soviet-style police state, not a democratic republic.The Red Thread asks the simple question: Why? What is it that motivated these anti-Trump conspirators from inside and around the Obama administration and Clinton networks to depart so drastically from "politics as usual" to participate in a seditious effort to overturn an election?Finding clues in an array of sources, Diana West uses her trademark investigative skills, honed in her dazzling work, American Betrayal, to construct a fascinating series of ideological profiles of well-known but little understood anti-Trump actors, from James Comey to Christopher Steele to Nellie Ohr, and the rest of the Fusion GPS team; from John Brennan to the numerous Clintonistas still patrolling the Washington Swamp after all these years, and more.Once, we knew these officials by august titles and reputation; after The Red Thread, readers will recognize their multi-generational and inter-connecting communist and socialist pedigrees, and see them for what they really are: foot-soldiers of the Left, deployed to take down America's first "America First" and most anti-Communist president.If we just give it a pull, the "red thread" is very long and very deep.

    Every religion has angels, Sylvia tells us. Different from spirit guides, angels are spiritual messengers who are available to help us if we will simply ask for their assistance. Sylvia goes on to discuss the properties of angels; the true nature of God, good, evil, and the Other Side; and explains how we can overcome guilt, accept ourselves, and thereby understand our own particular “contract.” In the second half of the program, Sylvia leads a meditation that invokes the presence of our angels and individual spirit guides, and invites them to communicate with us. We feel their protection, receive their healing, and with Sylvia’s encouragement, learn how to ask them for the help we desire.