We are now all too aware of how it is applied, but we know far less about how the idea came to be--and where it may yet go.Until Proven Safe tracks the idea of quarantine around the globe, through time and space, chasing the story from the lazarettos and quarantine islands of Venice--built before communicable diseases were really understood--to the hallways of the CDC, NASA, and the cutting-edge labs and conference rooms where the future technology of quarantine is being developed. The result is a tour of an idea that could not be more urgent or relevant, a book full of stories, people, and insights that is as compelling as it is definitive.

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.

    In this remarkable symphony of essays adapted and expanded from his ground-breaking, critically acclaimed podcast, John Green reviews different facets of the human-centered planet - from the QWERTY keyboard and Halley's Comet to Penguins of Madagascar - on a five-star scale.Complex and rich with detail, the Anthropocene's reviews have been praised as 'observations that double as exercises in memoiristic empathy', with over 10 million lifetime downloads. John Green's gift for storytelling shines throughout this artfully curated collection about the shared human experience; it includes beloved essays along with six all-new pieces exclusive to the book.

    In this riveting work of true crime, he spotlights four of the most diabolical criminals he’s confronted, interviewed and learned from. Going deep into each man’s life and crimes, he outlines the factors that led them to murder and how he used his interrogation skills to expose their means, motives, and true evil. Like the hit Netflix show, The Killer Across the Table is centered around Douglas’ unique interrogation and profiling process. With his longtime collaborator Mark Olshaker, Douglas recounts the chilling encounters with these four killers as he experienced them—revealing for the first time his profile methods in detail. Going step by step through his interviews, Douglas explains how he connects each killer’s crimes to the specific conversation, and contrasts these encounters with those of other deadly criminals to show what he learns from each one. In the process, he returns to other famous cases, killers and interviews that have shaped his career, describing how the knowledge he gained from those exchanges helped prepare him for these.A glimpse into the mind of a man who has pierced the heart of human darkness, The Killer Across the Table unlocks the ultimate mystery of depravity and the techniques and approaches that have countered evil in the name of justice.

    His invention of the first practical incandescent lamp 140 years ago so dazzled the world--already reeling from his invention of the phonograph and dozens of other revolutionary devices--that it cast a shadow over his later achievements. In all, this near-deaf genius ("I haven't heard a bird sing since I was twelve years old") patented 1,093 inventions, not including others, such as the X-ray fluoroscope, that he left unlicensed for the benefit of medicine.One of the achievements of this staggering new biography, the first major life of Edison in more than twenty years, is that it portrays the unknown Edison--the philosopher, the futurist, the chemist, the botanist, the wartime defense adviser, the founder of nearly 250 companies--as fully as it deconstructs the Edison of mythological memory. Edmund Morris, winner of the Pulitzer Prize and the National Book Award, brings to the task all the interpretive acuity and literary elegance that distinguished his previous biographies of Theodore Roosevelt, Ronald Reagan, and Ludwig van Beethoven. A trained musician, Morris is especially well equipped to recount Edison's fifty-year obsession with recording technology and his pioneering advances in the synchronization of movies and sound. Morris sweeps aside conspiratorial theories positing an enmity between Edison and Nikola Tesla and presents proof of their mutually admiring, if wary, relationship.Enlightened by seven years of research among the five million pages of original documents preserved in Edison's huge laboratory at West Orange, New Jersey, and privileged access to family papers still held in trust, Morris is also able to bring his subject to life on the page--the adored yet autocratic and often neglectful husband of two wives and father of six children. If the great man who emerges from it is less a sentimental hero than an overwhelming force of nature, driven onward by compulsive creativity, then Edison is at last getting his biographical due.

    prison system, tracking down a chameleon con artist in Europe, or riding in a cyclone-tossed skiff with a scientist hunting the elusive giant squid, David Grann revels in telling stories that explore the nature of obsession and that piece together true and unforgettable mysteries.Each of the dozen stories in this collection reveals a hidden and often dangerous world and, like Into Thin Air and The Orchid Thief, pivots around the gravitational pull of obsession and the captivating personalities of those caught in its grip. There is the world's foremost expert on Sherlock Holmes who is found dead in mysterious circumstances; an arson sleuth trying to prove that a man about to be executed is innocent, and sandhogs racing to complete the brutally dangerous job of building New York City's water tunnels before the old system collapses. Throughout, Grann's hypnotic accounts display the power-and often the willful perversity-of the human spirit.Compulsively readable, The Devil and Sherlock Holmes is a brilliant mosaic of ambition, madness, passion, and folly.

    Tirelessly trekking across miles of the Thames’ muddy shores, where others only see the detritus of city life, Maiklem unearths evidence of England’s captivating, if sometimes murky, history—with some objects dating back to 43 AD, when London was but an outpost of the Roman Empire. From medieval mail worn by warriors on English battlefields to nineteenth-century glass marbles mass-produced for the nation’s first soda bottles, Maiklem deduces the historical significance of these artifacts with the quirky enthusiasm and sharp-sightedness of a twenty-first century Sherlock Holmes.Seamlessly interweaving reflections from her own life with meditations on the art of wandering, Maiklem ultimately delivers—for Anglophiles and history lovers alike—a memorable treatise on the objects we leave in our wake, and the stories they can reveal if only we take a moment to look.

    In his eagerly anticipated, deeply researched new book, Schreier trains his investigative eye on the volatility of the video game industry and the resilience of the people who work in it. The business of videogames is both a prestige industry and an opaque one. Based on dozens of first-hand interviews that cover the development of landmark games -- Bioshock Infinite, Epic Mickey, Dead Space, and more -- on to the shocking closures of the studios that made them, PRESS RESET tells the stories of how real people are affected by game studio shutdowns, and how they recover, move on, or escape the industry entirely. Schreier's insider interviews cover hostile takeovers, abusive bosses, corporate drama, bounced checks, and that one time the Boston Red Sox's Curt Schilling decided he was going to lead a game studio that would take out World of Warcraft. Along the way, he asks pressing questions about why, when the video game industry is more successful than ever, it's become so hard to make a stable living making video games -- and whether the business of making games can change before it's too late.

     Stretching between these figures is a cast of artists, writers, and scientists--mostly women, mostly queer--whose public contribution has risen out of their unclassifiable and often heartbreaking private relationships to change the way we understand, experience, and appreciate the universe. Among them are the astronomer Maria Mitchell, who paved the way for women in science; the sculptor Harriet Hosmer, who did the same in art; the journalist and literary critic Margaret Fuller, who sparked the feminist movement; and the poet Emily Dickinson.Emanating from these lives are larger questions about the measure of a good life and what it means to leave a lasting mark of betterment on an imperfect world: Are achievement and acclaim enough for happiness? Is genius? Is love? Weaving through the narrative is a set of peripheral figures--Ralph Waldo Emerson, Charles Darwin, Elizabeth Barrett Browning, Herman Melville, Frederick Douglass, Nathaniel Hawthorne, and Walt Whitman--and a tapestry of themes spanning music, feminism, the history of science, the rise and decline of religion, and how the intersection of astronomy, poetry, and Transcendentalist philosophy fomented the environmental movement.

    Among them: a successful, first generation Chinese immigrant musician suffering sexual dysfunction; a young woman whose father abandoned her at age nine with her younger siblings in an isolated cottage in the depth of winter; and a glamorous workaholic whose narcissistic, negligent mother greeted her each morning of her childhood with Good morning, Monster.Each patient presents a mystery, one that will only be unpacked over years. They seek Gildiner's help to overcome an immediate challenge in their lives, but discover that the source of their suffering has been long buried.As in such recent classics as The Glass Castle and Educated, each patient embodies self-reflection, stoicism, perseverance, and forgiveness as they work unflinchingly to face the truth. Gildiner's account of her journeys with them is moving, insightful, and sometimes very funny. Good Morning Monster offers an almost novelistic, behind-the-scenes look into the therapist's office, illustrating how the process can heal even the most unimaginable wounds.

    But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.Cullen's murderous career in the world's most trusted profession spanned sixteen years and nine hospitals across New Jersey and Pennsylvania. When, in March of 2006, Charles Cullen was marched from his final sentencing in an Allentown, Pennsylvania, courthouse into a waiting police van, it seemed certain that the chilling secrets of his life, career, and capture would disappear with him. Now, in a riveting piece of investigative journalism nearly ten years in the making, journalist Charles Graeber presents the whole story for the first time. Based on hundreds of pages of previously unseen police records, interviews, wire-tap recordings and videotapes, as well as exclusive jailhouse conversations with Cullen himself and the confidential informant who helped bring him down, THE GOOD NURSE weaves an urgent, terrifying tale of murder, friendship, and betrayal.Graeber's portrait of Cullen depicts a surprisingly intelligent and complicated young man whose promising career was overwhelmed by his compulsion to kill, and whose shy demeanor masked a twisted interior life hidden even to his family and friends. Were it not for the hardboiled, unrelenting work of two former Newark homicide detectives racing to put together the pieces of Cullen's professional past, and a fellow nurse willing to put everything at risk, including her job and the safety of her children, there's no telling how many more lives could have been lost.In the tradition of In Cold Blood, THE GOOD NURSE does more than chronicle Cullen's deadly career and the breathless efforts to stop him; it paints an incredibly vivid portrait of madness and offers a penetrating look inside America's medical system. Harrowing and irresistibly paced, this book will make you look at medicine, hospitals, and the people who work in them, in an entirely different way.

    "Here’s a partial list of things I don’t believe in: God. The Devil. Heaven. Hell. Bigfoot. Ancient Aliens. Past lives. Life after death. Vampires. Zombies. Reiki. Homeopathy. Rolfing. Reflexology. Note that 'witches' and 'witchcraft' are absent from this list. The thing is, I wouldn’t believe in them, and I would privately ridicule any idiot who did, except for one thing: I am a witch."For as long as Augusten Burroughs could remember, he knew things he shouldn't have known. He manifested things that shouldn't have come to pass. And he told exactly no one about this, save one person: his mother. His mother reassured him that it was all perfectly normal, that he was descended from a long line of witches, going back to the days of the early American colonies. And that this family tree was filled with witches. It was a bond that he and his mother shared--until the day she left him in the care of her psychiatrist to be raised in his family (but that's a whole other story). After that, Augusten was on his own. On his own to navigate the world of this tricky power; on his own to either use or misuse this gift.From the hilarious to the terrifying, Toil & Trouble is a chronicle of one man's journey to understand himself, to reconcile the powers he can wield with things with which he is helpless. There are very few things that are coincidences, as you will learn in Toil & Trouble. Ghosts are real, trees can want to kill you, beavers are the spawn of Satan, houses are alive, and in the end, love is the most powerful magic of all.

    A harrowing incident years before left her a virtual prisoner in her own home, forever wary of the heartbreak and limitation of a girl’s life.Eleven years after they began fostering, the Moscatellis are raising three children as their own and Dahlia and Louie consider their family complete, but when the social worker begs them to take a young girl who has been horrifically abused and neglected, they can’t say no.Six-year-old Agnes Juniper arrives with no knowledge of her Native American heritage or herself beyond a box of trinkets given to her by her mother and dreamlike memories of her sister. Before long, this stranger in their midst has strengthened the bond in this unusual family, showing them how to contend with outside forces that want to tear them apart. Heartfelt and enthralling, All the Children Are Home is a moving testament to how love can survive in the face of devastating losses.

    In Tudor, England, when Mary, Queen of Scots, was under house arrest, her needlework carried her messages to the outside world. From the political propaganda of the Bayeux Tapestry, World War I soldiers coping with PTSD, and the maps sewn by schoolgirls in the New World, to the AIDS quilt, Hmong story clothes, and pink pussyhats, women and men have used the language of sewing to make their voices heard, even in the most desperate of circumstances. Threads of Life is a chronicle of identity, protest, memory, power, and politics told through the stories of needlework. Clare Hunter, master of the craft, threads her own narrative as she takes us over centuries and across continents—from medieval France to contemporary Mexico and the United States, and from a POW camp in Singapore to a family attic in Scotland—to celebrate the age-old, universal, and underexplored beauty and power of sewing. Threads of Life is an evocative and moving book about the need we have to tell our story.

    At the dawn of the Industrial Revolution in eighteenth-century England, standards of measurement were established, giving way to the development of machine tools—machines that make machines. Eventually, the application of precision tools and methods resulted in the creation and mass production of items from guns and glass to mirrors, lenses, and cameras—and eventually gave way to further breakthroughs, including gene splicing, microchips, and the Hadron Collider.Simon Winchester takes us back to origins of the Industrial Age, to England where he introduces the scientific minds that helped usher in modern production: John Wilkinson, Henry Maudslay, Joseph Bramah, Jesse Ramsden, and Joseph Whitworth. It was Thomas Jefferson who later exported their discoveries to the fledgling United States, setting the nation on its course to become a manufacturing titan. Winchester moves forward through time, to today’s cutting-edge developments occurring around the world, from America to Western Europe to Asia.As he introduces the minds and methods that have changed the modern world, Winchester explores fundamental questions. Why is precision important? What are the different tools we use to measure it? Who has invented and perfected it? Has the pursuit of the ultra-precise in so many facets of human life blinded us to other things of equal value, such as an appreciation for the age-old traditions of craftsmanship, art, and high culture? Are we missing something that reflects the world as it is, rather than the world as we think we would wish it to be? And can the precise and the natural co-exist in society?