David Christian, professor of history at San Diego State University, surveys the past at all possible scales, from conventional history, to the much larger scales of biology and geology, to the universal scales of cosmology.

    Our Inheritance 2. Mendel and Genes 3. Genes and Chromosomes 4. The Search for the GeneDNA 5. DNA Structure and Replication 6. DNA Expression in Proteins 7. Genes, Enzymes, and Metabolism 8. From DNA to Protein 9. Genomes 10. Manipulating GenesRecombinant DNA 11. Isolating Genes and DNA 12. BiotechnologyGenetic Engineering 13. Biotechnology and the Environment 14. Manipulating DNA by PCR and Other Methods 15. DNA in IdentificationForensics 16. DNA and Evolution 17. DNA and Human Evolution 18. Molecular MedicineGenetic Screening 19. Molecular MedicineThe Immune System 20. Molecular MedicineCancer 21. Molecular MedicineGene Therapy 22. Molecular MedicineCloning and Stem Cells 23. Genetics and Agriculture 24. Biotechnology and Agriculture

    More than 2,500 years later, the issues they pondered continue to challenge, fascinate, and instruct us. Is reality stable and permanent or is it always changing? Are ethical values like justice and courage relative? Or are values "absolute"—simply and forever right and true? What is justice? What is happiness? How shall we best live our lives?An Introduction to Greek Philosophy beckons you to join this eternal discussion. For that is what this subject truly is: a conversation among thinkers that has continued through the centuries and remains accessible to us today. You find it constantly stimulating, sometimes controversial, and nearly always remarkably relevant.A Hunger for Reasons, not Myths or BeliefsProfessor David Roochnik has organized this series of 24 lectures as a "dialectical" approach (the word comes from the Greek dialegesthai: to converse). The philosophers are presented as if they were participating in a conversation. In this way, the course unfolds in a manner similar to the actual development of Greek philosophy.In this course, you study the development of Greek philosophy, meet its major thinkers, and explore the issues and ideas that concerned them. For example the first real philosophers were the Presocratics—literally, the philosophers who lived before Socrates. They included Thales of Miletus (585 B.C.E.–?), Anaximander (610–546), Anaximenes (approx. 550), Xenophanes (approx. 570) and Pythagoras (approx. 570–500).The Presocratics rejected myth and divine inspiration—such as had been embodied in the works of Homer and in Hesiod's creation story, the Theogony—as valid explanations of reality. Instead, they insisted that true understanding always requires a logos, a rational explanation (hence such English words as "psychology" and "biology").The Presocratics were concerned with issues such as identifying the arche or "Being": the thing that is the origin of all other things. They also introduced sophistic relativism, the notion that truth, goodness, and all other values were relative, depending entirely on the person or group that held them. This concept would become a major point of debate for the Greeks and for the ages.Are We Footnotes to Plato?The heroes of this course, and certainly of Greek philosophy, are Plato (429–347 B.C.E.) and his student, Aristotle (384–322 B.C.E.). Unlike the Presocratics, who wrote too little, Plato and Aristotle were prolific authors. Both argued against relativism and instead were staunch objectivists who believed that certain important values were absolutely and universally true. And both left a staggering mark on history.Alfred North Whitehead, the great 20th-century British philosopher, said, "The safest general characterization of the European philosophical tradition is that it consists of a series of footnotes to Plato." In the Middle Ages, Aristotle was held in such high esteem that he was simply known as "the philosopher."Among Plato's many contributions to philosophy is his ingenious device for the examination of ideas: his written dialogues. In them, Plato never uses his own voice. Instead, the dialogues take place among a changing cast of characters, and Socrates is the most notable among them. The effect is to invite us to take part in the conversation and, ultimately, to become philosophers.You study Plato's dialogues as well as his notion of the Forms. This was his response to relativism and proposed that every virtue and value has an absolute and perfect Form, which humans understand even before birth.Greek philosophy can be said to culminate with Aristotle, who wrote treatises on a breathtaking range of subjects. He is said to be the first to view knowledge as being divided into specific disciplines such as biology or astronomy. The university was later modeled on this approach. More than any other philosopher, Aristotle synthesized the views that preceded him.For Aristotle, one value was foremost and was contained in everything, from the tiniest organisms to the phenomena of fire to human beings: purpose. Everything has a purpose that can be recognized and objectively defined, and that gives meaning to life. You explore the details and rationale of Aristotle's teleological—or purposive—world-view, one of the most significant in history.An Invitation to ThinkIn this course, you not only learn about Greek philosophy but, to some extent, how to do it. Professor Roochnik emphasizes that Greek philosophy is ultimately not about facts or answers but about the give-and-take of ideas.By the end of these lectures, you will understand how Greek philosophy still heavily influences our view of life. We live today, Professor Roochnik maintains, at a time that is shaped by Presocratic, relativistic philosophy. Contemporary thinkers, and often the average person, have great difficulty finding objective truth or meaning in life.What have we lost in turning away from the world of Plato and Aristotle—a world where everything has a place and a purpose and life is saturated with value and meaning?On the other hand, what would we lose if we returned to that world?These are a few of the many questions that will give you ample food for thought. For the Greeks, that was the greatest feast of all.

    On the eve of this centenary, journalist Johann Hari set off on an epic three-year, thirty-thousand-mile journey into the war on drugs. What he found is that more and more people all over the world have begun to recognize three startling truths: Drugs are not what we think they are. Addiction is not what we think it is. And the drug war has very different motives to the ones we have seen on our TV screens for so long.In Chasing the Scream, Hari reveals his discoveries entirely through the stories of people across the world whose lives have been transformed by this war. They range from a transsexual crack dealer in Brooklyn searching for her mother, to a teenage hit-man in Mexico searching for a way out. It begins with Hari's discovery that at the birth of the drug war, Billie Holiday was stalked and killed by the man who launched this crusade--and it ends with the story of a brave doctor who has led his country to decriminalize every drug, from cannabis to crack, with remarkable results.Chasing the Scream lays bare what we really have been chasing in our century of drug war--in our hunger for drugs, and in our attempt to destroy them. This book will challenge and change how you think about one of the most controversial--and consequential--questions of our time.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    Every new reader's brain possesses the extraordinary capacity to rearrange itself beyond its original abilities in order to understand written symbols. But how does the brain learn to read? As world-renowned cognitive neuroscientist and scholar of reading Maryanne Wolf explains in this impassioned book, we taught our brain to read only a few thousand years ago, and in the process changed the intellectual evolution of our species.Wolf tells us that the brain that examined tiny clay tablets in the cuneiform script of the Sumerians is configured differently from the brain that reads alphabets or of one literate in today's technology.There are critical implications to such an evolving brain. Just as writing reduced the need for memory, the proliferation of information and the particular requirements of digital culture may short-circuit some of written language's unique contributions—with potentially profound consequences for our future.Turning her attention to the development of the individual reading brain, Wolf draws on her expertise in dyslexia to investigate what happens when the brain finds it difficult to read. Interweaving her vast knowledge of neuroscience, psychology, literature, and linguistics, Wolf takes the reader from the brains of a pre-literate Homer to a literacy-ambivalent Plato, from an infant listening to Goodnight Moon to an expert reader of Proust, and finally to an often misunderstood child with dyslexia whose gifts may be as real as the challenges he or she faces.As we come to appreciate how the evolution and development of reading have changed the very arrangement of our brain and our intellectual life, we begin to realize with ever greater comprehension that we truly are what we read. Ambitious, provocative, and rich with examples, Proust and the Squid celebrates reading, one of the single most remarkable inventions in history. Once embarked on this magnificent story of the reading brain, you will never again take for granted your ability to absorb the written word.

    At once a powerful evocation of James Baldwin’s early life in Harlem and a disturbing examination of the consequences of racial injustice, the book is an intensely personal and provocative document. It consists of two “letters,” written on the occasion of the centennial of the Emancipation Proclamation, that exhort Americans, both black and white, to attack the terrible legacy of racism. Described by The New York Times Book Review as “sermon, ultimatum, confession, deposition, testament, and chronicle…all presented in searing, brilliant prose,” The Fire Next Time stands as a classic of our literature.

    Taking as territory everything from the Big Bang to the rise of civilization, Bryson seeks to understand how we got from there being nothing at all to there being us. To that end, he has attached himself to a host of the world’s most advanced (and often obsessed) archaeologists, anthropologists, and mathematicians, travelling to their offices, laboratories, and field camps. He has read (or tried to read) their books, pestered them with questions, apprenticed himself to their powerful minds. A Short History of Nearly Everything is the record of this quest, and it is a sometimes profound, sometimes funny, and always supremely clear and entertaining adventure in the realms of human knowledge, as only Bill Bryson can render it. Science has never been more involving or entertaining.

    The Great Ideas of Classical Physics 2. Describing MotionA Break from Aristotle 3. Describing Ever More Complex Motion 4. Astronomy as a Bridge to Modern Physics 5. Isaac NewtonThe Dawn of Classical Physics 6. Newton QuantifiedForce and Acceleration 7. Newton and the Connections to Astronomy 8. Universal Gravitation 9. Newton's Third Law 10. Conservation of Momentum 11. Beyond NewtonWork and Energy 12. Power and the Newtonian Synthesis 13. Further DevelopmentsStatic Electricity 14. Electricity, Magnetism, and Force Fields 15. Electrical Currents and Voltage 16. The Origin of Electric and Magnetic Fields 17. Unification IMaxwell's Equations 18. Unification IIElectromagnetism and Light 19. Vibrations and Waves 20. Sound Waves and Light Waves 21. The Atomic Hypothesis 22. Energy in SystemsHeat and Thermodynamics 23. Heat and the Second Law of Thermodynamics 24. The Grand Picture of Classical Physics

    Sanjay Gupta reflects on his life as a parent during this unprecedented time. He shares his fears and questions about raising his three young daughters amid our current public health crisis—and gives listeners a candid glimpse into how he’s navigating the pandemic at home. The neurosurgeon and CNN chief medical correspondent helps parents think about this time from the perspective he knows best: the workings of the brain. Equal parts essay, advice, and reassurance, Gupta reminds us that despite the relentless challenges of growing up during a pandemic, the kids will be all right.©2020 Sanjay Gupta, M.D. (P)2020 Audible Originals, LLC.Length: 46 mins

      In this transporting book, David Oliver Relin shines a light on the work of Geoffrey Tabin and Sanduk Ruit, gifted ophthalmologists who have dedicated their lives to restoring sight to some of the world’s most isolated, impoverished people through the Himalayan Cataract Project, an organization they founded in 1995. Tabin was the high-achieving bad boy of Harvard Medical School, an accomplished mountain climber and adrenaline junkie as brilliant as he was unconventional. Ruit grew up in a remote Nepalese village, where he became intimately acquainted with the human costs of inadequate access to health care. Together they found their life’s calling: tending to the afflicted people of the Himalayas, a vast mountainous region with an alarmingly high incidence of cataract blindness.  Second Suns takes us from improvised plywood operating tables in villages without electricity or plumbing to state-of-the-art surgical centers at major American universities where these two driven men are restoring sight—and hope—to patients from around the world. With their revolutionary, inexpensive style of surgery, Tabin and Ruit have been able to cure tens of thousands—all for about twenty dollars per operation. David Oliver Relin brings the doctors’ work to vivid life through poignant portraits of patients helped by the surgery, from old men who cannot walk treacherous mountain trails unaided to cataract-stricken children who have not seen their mothers’ faces for years. With the dexterity of a master storyteller, Relin shows the profound emotional and practical impact that these operations have had on patients’ lives.  Second Suns is the moving, unforgettable story of how two men with a shared dream are changing the world, one pair of eyes at a time.Praise for Second Suns   “As miracles go, it’s hard to beat making the blind see. Yet that’s exactly what the eye surgeon Dr. Geoffrey Tabin can do. He services poor people in the developing world who have developed cataracts—a clouding of the lens of the eye that is the world’s leading cause of blindness. . . . Second Suns is a hopeful work, a profile of two doctors who have dedicated their lives to bringing light to those in darkness.”—Time   “A compelling and inspiring book . . . Second Suns portrays heroic health care delivered under harrowing conditions: Ruit and his teams carry their equipment on multi-day treks up steep mountain trails, sometimes hiking at night with flashlights or head lamps, to reach settlements where they typically spend several days operating on hundreds of villagers in makeshift surgical theaters.”—The Washington Post   “Second Suns should be required reading for anybody with an interest in humanitarian philanthropy—or, for that matter, a desire to feel a little better about the world.”—Outside   “A detailed, heartfelt account of the work of [two] dedicated pioneers.”—Kirkus Reviews

    Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

    President George W. Bush leads our nation in a time of unprecedented peril. But how well do we really know him or his remarkable family, whose history often mirrors the history of America? Now, in the first full-scale biography of the Bushes, Peter and Rochelle Schweizer trace the extraordinary trajectory of their rise to power. Through a series of exclusive, surprisingly candid interviews with members of the family and close friends, the inner workings of this very private family are revealed: their marriages and friendships; the intense sibling rivalry between George W. and Jeb Bush; divisions between father and son over the Iraq war; even Jeb Bush's plans to run for president in 2008. Never-before-seen private photos add even greater detail and depth to this fascinating family portrait. And above all, we see George W. Bush the way his family does, as an intensely driven person who has a much more complex relationship with his father than has often been portrayed in the media. Family members talk about how he deals with the stresses of the war on terrorism, why he sees it as a "religious war," and how his personal faith influences what he says and does. The Schweizers also delve into the Bushes' sensitive and secret business dealings, including their long history of involvement in the oil business. Their shrewd alliances with other American dynasties--including the Kennedys, Rockefellers, and Tafts--have all helped to quietly consolidate their power within the Republican Party.Indeed, what makes the Bushes so successful is that they function less like the great political families before them andmore like a high-tech startup: free-flowing, pragmatic, and opportunistic. It is this distinction that assures them an enduring presence on the nation's political stage, making "The Bushes" essential reading for anyone who cares about America's future.

    On every page I learned something new. Read it every night if you want to restore your faith in our country." —James Mattis, General, U.S. Marines (ret.) & 26th Secretary of Defense The Pulitzer Prize-winning journalist and #1 New York Times bestselling author offers a revelatory new book about the founding fathers, examining their educations and, in particular, their devotion to the ancient Greek and Roman classics—and how that influence would shape their ideals and the new American nation.On the morning after the 2016 presidential election, Thomas Ricks awoke with a few questions on his mind: What kind of nation did we now have? Is it what was designed or intended by the nation’s founders? Trying to get as close to the source as he could, Ricks decided to go back and read the philosophy and literature that shaped the founders’ thinking, and the letters they wrote to each other debating these crucial works—among them the Iliad, Plutarch’s Lives, and the works of Xenophon, Epicurus, Aristotle, Cato, and Cicero. For though much attention has been paid the influence of English political philosophers, like John Locke, closer to their own era, the founders were far more immersed in the literature of the ancient world.The first four American presidents came to their classical knowledge differently. Washington absorbed it mainly from the elite culture of his day; Adams from the laws and rhetoric of Rome; Jefferson immersed himself in classical philosophy, especially Epicureanism; and Madison, both a groundbreaking researcher and a deft politician, spent years studying the ancient world like a political scientist. Each of their experiences, and distinctive learning, played an essential role in the formation of the United States. In examining how and what they studied, looking at them in the unusual light of the classical world, Ricks is able to draw arresting and fresh portraits of men we thought we knew.First Principles follows these four members of the Revolutionary generation from their youths to their adult lives, as they grappled with questions of independence, and forming and keeping a new nation. In doing so, Ricks interprets not only the effect of the ancient world on each man, and how that shaped our constitution and government, but offers startling new insights into these legendary leaders.

    In Baseball's Great Experiment: Jackie Robinson and His Legacy, Tygiel penned a classic work, a landmark book that towers above most writing about the sport. Now he ranges across the last century and a half in anintriguing look at baseball as history, and history as reflected in baseball.In Past Time, Tygiel gives us a seat behind home plate, where we catch the ongoing interplay of baseball and American society. We begin in New York in the 1850s, where pre-Civil War nationalism shaped the emergence of a national pastime. We witness the true birth of modern baseball with thedevelopment of its elaborate statistics--the brainchild of English-born reformer, Henry Chadwick. Chadwick, Tygiel writes, created the sport's historical essence and even imparted a moral dimension to the game with his concepts of errors and unearned runs. Tygiel offers equally insightfullooks at the role of rags-to-riches player-owners in the formation of the upstart American League and he describes the complex struggle to establish African-American baseball in a segregated world. He also examines baseball during the Great Depression (when Branch Rickey and Larry MacPhail savedthe game by perfecting the farm system, night baseball, and radio broadcasts), the ironies of Bobby Thomson's immortal shot heard 'round the world, the rapid relocation of franchises in the 1950s and 1960s, and the emergence of rotisserie leagues and fantasy camps in the 1980s.In Past Time, Jules Tygiel provides baseball history with a difference. Instead of a pitch-by-pitch account of great games, in this groundbreaking book, the field is American history and baseball itself is the star.