Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    It is structured around six schools of thought that have received classic status. Sue Hamilton explores how the traditions have attempted to understand the nature of reality in terms of inner or spiritual quest and introduces distinctively Indian concepts, such as karma and rebirth. She also explains how Indian thinkers have understood issues of reality and knowledge--issues that are also an important part of the Western philosophical tradition.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    A criminal case can often hinge on a piece of evidence such as a hair, a blood trace, a bit of saliva on a cigarette butt, or the telltale mark of a tire tread. High profile cases have stoked this interest in recent years and some of the most popular shows on television--such as CSI: Crime Scene Investigation and its raft of spin-offs--attest to the enduring popularity of forensic science as a form of grisly entertainment. This Very Short Introduction looks at the nature of forensic science, examining what forensic science is, how it is used in the investigation of crime, how crime scenes are managed, how forensic scientists work, the different techniques used to recover evidence, and the range of methods available for analysis. It also considers how forensic science serves the criminal justice system and the challenges of communicating complex scientific evidence in a court of law.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Michael Inwood's lucid introduction to Heidegger's thought focuses on his most important work, Being and Time, and its major themes of existence in the world, inauthenticity, guilt, destiny, truth, and the nature of time. These themes are then reassessed in the light of Heidegger's later work, together with the extent of his philosophical importance and influence. This is an invaluable guide to the complex and voluminous thought of a major twentieth-century existentialist philosopher.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam

    Documents relating to the alleged marriage, bearing the Prince's signature, were impounded and examined in 1866 by the Attorney General. Learned opinion at the time leaned to the view that these documents were genuine. They were then placed in the Royal Archives at Windsor; in 1910, permission was refused a would-be author who asked to see them. If George III did make such a marriage when he was Prince of Wales, before the passing of the Royal Marriages Act in 1772, then his subsequent marriage to Queen Charlotte was bigamous, and every monarch of Britain since has been a usurper, the rightful heirs of George III being his children by Hannah Lightfoot, if they ever existed.' From Britain's Royal Families Britain's Royal Families is a unique reference book. It provides, for the first time in one volume, complete genealogical details of all members of the royal houses of England, Scotland and Great Britain - from 800AD to the present. Here is the vital biographical information relating not only to each monarch, but also to every member of their immediate family, from parents to grandchildren. Drawing on countless authorities, both ancient and modern, Alison Weir explores the royal family tree in unprecedented depth and provides a comprehensive guide to the heritage of today's royal family.

    In this Very Short Introduction, Michael Cook provides a lucid and direct account of the significance of the Koran both in the modern world and inthat of traditional Islam. He gives vivid accounts of its role in Muslim civilization, illustrates the diversity of interpretations championed by traditional and modern commentators, discusses the processes by which the book took shape, and compares it to other scriptures and classics of thehistoric cultures of Eurasia.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundredsof key topics, from philosophy to Freud, quantum theory to Islam.

    It contains more than 99% of the world's living space, produces half of its oxygen, plays a critical role in regulating its climate, and supports a remarkably diverse and exquisitely adapted array of life forms, from microscopic viruses, bacteria, and plankton to the largest existing animals. In this unique Very Short Introduction, biologist Philip Mladenov provides a comprehensive overview of marine biology, offering a tour of marine life and marine processes that ranges from the polar oceans to tropical coral reefs, and from shoreline mollusks to deep-sea hydrothermal vents. Mladenov also looks at a number of factors that pose a significant threat to the marine environment and to many of its life forms-threats such as overfishing, coastal development, plastic pollution, oil spills, nutrient pollution, the spread of exotic species, and the emission of climate changing greenhouse gases. Throughout the book he successfully weaves around the principles of marine biology a discussion of the human impacts on the oceans and the threats these pose to our welfare. About the Series: Oxford's Very Short Introductions series offers concise and original introductions to a wide range of subjects--from Islam to Sociology, Politics to Classics, Literary Theory to History, and Archaeology to the Bible. Not simply a textbook of definitions, each volume in this series provides trenchant and provocative--yet always balanced and complete--discussions of the central issues in a given discipline or field. Every Very Short Introduction gives a readable evolution of the subject in question, demonstrating how the subject has developed and how it has influenced society. Eventually, the series will encompass every major academic discipline, offering all students an accessible and abundant reference library. Whatever the area of study that one deems important or appealing, whatever the topic that fascinates the general reader, the Very Short Introductions series has a handy and affordable guide that will likely prove indispensable.

    King Edward II was murdered by the lover of his estranged Queen Isabella, Sir Roger Mortimer. This biography of 14th century England's evil genius offers a new and controversial theory regarding the fate of Edward II.

    It is democratic, everchanging and ingenious in its assimilation of other cultures. English runs through the heart of the world of finance, medicine and the Internet, and it is understood by around two thousand million people across the world. It seems set to go on. Yet it was nearly wiped out in its early years.Embracing elements of Latin, French, Spanish, Italian, Portuguese, Arabic, Hindi and Gullah, this 1500-year story covers a huge range of countries and people. The Adventure of English is not only an enthralling story of power, religion and trade, but also the story of people, and how their day-to-day lives shaped and continue to change the extraordinary language that is English.

    Between the death of Queen Victoria and the end of the Second World War, the nation was shaken by war and peace. The two wars were the worst we had ever known and the episodes of peace among the most turbulent and surprising. As the political forum moved from Edwardian smoking rooms to an increasingly democratic Westminster, the people of Britain experimented with extreme ideas as they struggled to answer the question "How should we live?" Socialism? Fascism? Feminism? Meanwhile, fads such as eugenics, vegetarianism, and nudism were gripping the nation, while the popularity of the music hall soared. It was also a time that witnessed the birth of the media as we know it today and the beginnings of the welfare state. Beyond trenches, flappers, and Spitfires, this is a story of strange cults and economic madness, of revolutionaries and heroic inventors, sexual experiments and raucous stage heroines. From organic food to drugs, nightclubs and celebrities to package holidays, crooked bankers to sleazy politicians, the echoes of today's Britain ring from almost every page.

    But what about Britain's role in the world? A People's History of the British Empire challenges the claim that the British Empire was a kinder, gentler empire and suggests that the description of 'Rogue State' is more fitting. How many people today know about Britain's deep involvement in the opium drug trade in China, or that Tony Blair's hero Gladstone devoted his maiden parliamentary speech to defending his family's slave plantation in Jamaica?John Newsinger has written a wonderful popular history of key episodes in British imperial history. He pays particular attention to the battles of the colonised to free themselves of its baleful rule, including Rebellion in Jamaica; The Irish Famine; The Opium Wars; The Great Indian Rebellion; The Conquest of Egypt; Palestine in Revolt; 'Quit India' and the struggle for Independence; Suez; Malaya; Kenya and Rhodesia; and, Britain and American Imperialism.

    Between 1400 and 1600, European perceptions of society, culture, politics and even humanity itself emerged in ways that continue to affect not only Europe but the entire world. In this wide-ranging exploration of the Renaissance, Jerry Brotton shows the period as a time of unprecedented intellectual excitement, cultural experimentation, and interaction on a global scale, alongside a darker side of religion, intolerance, slavery, and massive inequality of wealth and status. Brotton skillfully guides us through the key issues that defined the Renaissance period, from its art, architecture, and literature, to advancements in the fields of science, trade, and travel. In its incisive account of the complexities of the political and religious upheavals of the period, the book argues that there are significant parallels between the Renaissance and our own era. This is the first clear and concise account of the Renaissance as a global phenomenon, an important new vision of the Renaissance for the 21st century written by a young Renaissance scholar of a new generation.