In a spirited tour across continents and cultures, Adam Rogers takes us from bourbon country to the world’s top gene-sequencing labs, introducing us to the bars, barflies, and evolving science at the heart of boozy technology. He chases the physics, biology, chemistry, and metallurgy that produce alcohol, and the psychology and neurobiology that make us want it. If you’ve ever wondered how your drink arrived in your glass, or what it will do to you, Proof makes an unparalleled drinking companion.

    If your anxiety about global warming is dominated by fears of sea-level rise, you are barely scratching the surface of what terrors are possible. In California, wildfires now rage year-round, destroying thousands of homes. Across the US, "500-year" storms pummel communities month after month, and floods displace tens of millions annually.This is only a preview of the changes to come. And they are coming fast. Without a revolution in how billions of humans conduct their lives, parts of the Earth could become close to uninhabitable, and other parts horrifically inhospitable, as soon as the end of this century.In his travelogue of our near future, David Wallace-Wells brings into stark relief the climate troubles that await--food shortages, refugee emergencies, and other crises that will reshape the globe. But the world will be remade by warming in more profound ways as well, transforming our politics, our culture, our relationship to technology, and our sense of history. It will be all-encompassing, shaping and distorting nearly every aspect of human life as it is lived today.Like An Inconvenient Truth and Silent Spring before it, The Uninhabitable Earth is both a meditation on the devastation we have brought upon ourselves and an impassioned call to action. For just as the world was brought to the brink of catastrophe within the span of a lifetime, the responsibility to avoid it now belongs to a single generation.

    Brinkley–America’s most brazen young con man–arrived in the tiny town of Milford, Kansas. He set up a medical practice and introduced an outlandish surgical method using goat glands to restore the fading virility of local farmers.It was all nonsense, of course, but thousands of paying customers quickly turned “Dr.” Brinkley into America’s richest and most famous surgeon. His notoriety captured the attention of the great quackbuster Morris Fishbein, who vowed to put the country’s “most daring and dangerous” charlatan out of business.Their cat-and-mouse game lasted throughout the 1920s and ’30s, but despite Fishbein’s efforts Brinkley prospered wildly. When he ran for governor of Kansas, he invented campaigning techniques still used in modern politics. Thumbing his nose at American regulators, he built the world’s most powerful radio transmitter just across the Rio Grande to offer sundry cures, and killed or maimed patients by the score, yet his warped genius produced innovations in broadcasting that endure to this day. By introducing country music and blues to the nation, Brinkley also became a seminal force in rock ’n’ roll. In short, he is the most creative criminal this country has ever produced.Culminating in a decisive courtroom confrontation that pit Brinkley against his nemesis Fishbein, Charlatan is a marvelous portrait of a boundlessly audacious rogue on the loose in an America that was ripe for the bamboozling.

    That is until 1904, when the disease broke out in a household in Oyster Bay, Long Island. Authorities suspected the family cook, Mary Mallon, of being a carrier. But before she could be tested, the woman, soon to be known as Typhoid Mary, had disappeared. Over the course of the next three years, Mary worked at several residences, spreading her pestilence as she went. In 1907, she was traced to a home on Park Avenue, and taken into custody. Institutionalized at Riverside Hospital for three years, she was released only when she promised never to work as a cook again. She promptly disappeared.For the next five years Mary worked in homes and institutions in and around New York, often under assumed names. In February 1915, a devastating outbreak of typhoid at the Sloane Hospital for Women was traced to her. She was finally apprehended and reinstitutionalized at Riverside Hospital, where she would remain for the rest of her life.Typhoid Mary is the story of her infamous life. Anthony Bourdain reveals the seedier side of the early 1900s, and writes with his renowned panache about life in the kitchen, uncovering the horrifying conditions that allowed the deadly spread of typhoid over a decade. Typhoid Mary is a true feast for history lovers and Bourdain lovers alike.

    Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.For years, Holmes had been misleading investors, FDA officials, and her own employees. When Carreyrou, working at The Wall Street Journal, got a tip from a former Theranos employee and started asking questions, both Carreyrou and the Journal were threatened with lawsuits. Undaunted, the newspaper ran the first of dozens of Theranos articles in late 2015. By early 2017, the company's value was zero and Holmes faced potential legal action from the government and her investors. Here is the riveting story of the biggest corporate fraud since Enron, a disturbing cautionary tale set amid the bold promises and gold-rush frenzy of Silicon Valley.

    Covering such turning points as the little-known Celtic and Welsh influences on English, the impact of the Viking raids and the Norman Conquest, and the Germanic invasions that started it all during the fifth century ad, John McWhorter narrates this colorful evolution with vigor. Drawing on revolutionary genetic and linguistic research as well as a cache of remarkable trivia about the origins of English words and syntax patterns, Our Magnificent Bastard Tongue ultimately demonstrates the arbitrary, maddening nature of English--and its ironic simplicity due to its role as a streamlined lingua franca during the early formation of Britain. This is the book that language aficionados worldwide have been waiting for (and no, it's not a sin to end a sentence with a preposition).

    For more than a millennium, Polynesians have occupied the remotest islands in the Pacific Ocean, a vast triangle stretching from Hawaii to New Zealand to Easter Island. Until the arrival of European explorers they were the only people to have ever lived there. Both the most closely related and the most widely dispersed people in the world before the era of mass migration, Polynesians can trace their roots to a group of epic voyagers who ventured out into the unknown in one of the greatest adventures in human history.How did the earliest Polynesians find and colonize these far-flung islands? How did a people without writing or metal tools conquer the largest ocean in the world? This conundrum, which came to be known as the Problem of Polynesian Origins, emerged in the eighteenth century as one of the great geographical mysteries of mankind.For Christina Thompson, this mystery is personal: her Maori husband and their sons descend directly from these ancient navigators. In Sea People, Thompson explores the fascinating story of these ancestors, as well as those of the many sailors, linguists, archaeologists, folklorists, biologists, and geographers who have puzzled over this history for three hundred years. A masterful mix of history, geography, anthropology, and the science of navigation, Sea People combines the thrill of exploration with the drama of discovery in a vivid tour of one of the most captivating regions in the world.Sea People includes an 8-page photo insert, illustrations throughout, and 2 endpaper maps.

    Mann radically alters our understanding of the Americas before the arrival of Columbus in 1492.Contrary to what so many Americans learn in school, the pre-Columbian Indians were not sparsely settled in a pristine wilderness; rather, there were huge numbers of Indians who actively molded and influenced the land around them. The astonishing Aztec capital of Tenochtitlan had running water and immaculately clean streets, and was larger than any contemporary European city. Mexican cultures created corn in a specialized breeding process that it has been called man’s first feat of genetic engineering. Indeed, Indians were not living lightly on the land but were landscaping and manipulating their world in ways that we are only now beginning to understand. Challenging and surprising, this a transformative new look at a rich and fascinating world we only thought we knew.

    one of the most important and readable works on the human past published in recent years."Winner of the Pulitzer Prize and a national bestseller: the global account of the rise of civilization that is also a stunning refutation of ideas of human development based on race.In this "artful, informative, and delightful" (William H. McNeill, New York Review of Books) book, Jared Diamond convincingly argues that geographical and environmental factors shaped the modern world. Societies that had a head start in food production advanced beyond the hunter-gatherer stage, and then developed writing, technology, government, and organized religion—as well as nasty germs and potent weapons of war—and adventured on sea and land to conquer and decimate preliterate cultures. A major advance in our understanding of human societies, Guns, Germs, and Steel chronicles the way that the modern world came to be and stunningly dismantles racially based theories of human history.Winner of the Pulitzer Prize, the Phi Beta Kappa Award in Science, the Rhone-Poulenc Prize, and the Commonwealth Club of California's Gold Medal

    As Tom Standage relates with authority and charm, six of them have had a surprisingly pervasive influence on the course of history, becoming the defining drink during a pivotal historical period. A History of the World in 6 Glasses tells the story of humanity from the Stone Age to the 21st century through the lens of beer, wine, spirits, coffee, tea, and cola. Beer was first made in the Fertile Crescent and by 3000 B.C.E. was so important to Mesopotamia and Egypt that it was used to pay wages. In ancient Greece wine became the main export of her vast seaborne trade, helping spread Greek culture abroad. Spirits such as brandy and rum fueled the Age of Exploration, fortifying seamen on long voyages and oiling the pernicious slave trade. Although coffee originated in the Arab world, it stoked revolutionary thought in Europe during the Age of Reason, when coffeehouses became centers of intellectual exchange. And hundreds of years after the Chinese began drinking tea, it became especially popular in Britain, with far-reaching effects on British foreign policy. Finally, though carbonated drinks were invented in 18th-century Europe they became a 20th-century phenomenon, and Coca-Cola in particular is the leading symbol of globalization.For Tom Standage, each drink is a kind of technology, a catalyst for advancing culture by which he demonstrates the intricate interplay of different civilizations. You may never look at your favorite drink the same way again.

    But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

    According to revolutionary new research, some birds rival primates and even humans in their remarkable forms of intelligence. In The Genius of Birds, acclaimed author Jennifer Ackerman explores their newly discovered brilliance and how it came about. As she travels around the world to the most cutting-edge frontiers of research, Ackerman not only tells the story of the recently uncovered genius of birds but also delves deeply into the latest findings about the bird brain itself that are shifting our view of what it means to be intelligent. At once personal yet scientific, richly informative and beautifully written, The Genius of Birds celebrates the triumphs of these surprising and fiercely intelligent creatures.

    Most of the time this math works quietly behind the scenes . . . until it doesn't. All sorts of seemingly innocuous mathematical mistakes can have significant consequences.Math is easy to ignore until a misplaced decimal point upends the stock market, a unit conversion error causes a plane to crash, or someone divides by zero and stalls a battleship in the middle of the ocean.Exploring and explaining a litany of glitches, near misses, and mathematical mishaps involving the internet, big data, elections, street signs, lotteries, the Roman Empire, and an Olympic team, Matt Parker uncovers the bizarre ways math trips us up, and what this reveals about its essential place in our world. Getting it wrong has never been more fun.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    Eerie aspects of the incident—unexplained violent injuries, signs that they cut open and fled the tent without proper clothing or shoes, a strange final photograph taken by one of the hikers, and elevated levels of radiation found on some of their clothes—have led to decades of speculation over what really happened. This gripping work of literary nonfiction delves into the mystery through unprecedented access to the hikers' own journals and photographs, rarely seen government records, dozens of interviews, and the author's retracing of the hikers' fateful journey in the Russian winter. A fascinating portrait of the young hikers in the Soviet era, and a skillful interweaving of the hikers narrative, the investigators' efforts, and the author's investigations, here for the first time is the real story of what happened that night on Dead Mountain