But something more “global” appears to be at work, and in any case he is distracted from his dreary rounds of diagnosis-seeking when a more urgent tragedy befalls the family. Joseph’s father, a former steelworker, was driving home from his new maintenance job when he swerved to avoid a deer and crashed his car, landing in the hospital. A week later he died of a heart attack.The deer, it turns out, was a stuffed decoy placed there by a high school student as a prank. This enrages Joseph’s older and ailing uncle, Bill (Yusef Bulos), who is even more disgusted when it is learned that the culprit is the star of the local football team, Vin (Jonathan Louis Dent), a town hero who is given a dispensation by a judge to serve his sentence in juvenile detention after the football season has concluded. Joseph and his younger brother, Charles (Chris Perfetti) — who are both gay — are more sympathetic to Vin, an African-American boy who has grown up in a foster home, and whose chance at a professional career may be jeopardized.Gloria (Joanna Gleason), Joseph’s new boss and a book packaging expert, knows a little about career jeopardy herself. She was run out of the publishing business — and Manhattan — when she sold a memoir by a Holocaust survivor that turned out to be fictionalized. (Gloria’s story and Vin’s are inspired by actual events.)Now she latches on to the discovery that Joseph’s family, of Lebanese extraction, is distantly related to Kahlil Gibran, author of the perennial best-selling spiritual book “The Prophet.” In her hilariously addled mind — complaining about her fall from grace, she defensively remarks, “I wasn’t at the Holocaust” — she decides that a memoir by Joseph about his family’s journey will be her ticket back to the big time.Mr. Karam’s play, which runs a little less than two hours and is performed in one seamless act , may sound top-heavy with plot and character. (Did I mention that Gloria’s emotional frailty also stems from the suicide of her husband?) Some of the relationships would benefit from being fleshed out in greater detail: the integration of Gloria into the lives of Joseph and his family, for example. The play’s climax shoehorns all the elements of the story into a farcical scene that seems a little forced, funny though it is.But one of Mr. Karam’s themes is the indiscriminate nature of misfortune — one calamity does not immunize you from the next, worse one — so the multiplication of disasters roiling the characters’ lives is to the point. And he writes with such precision that even the more peripheral characters emerge as sharply drawn, multifaceted individuals.

    What we as her audience take away from this remarkable drama is a keener sense that, while death is real and unavoidable, our lives are ours to cherish or throw away—a lesson that can be both uplifting and redemptive. As the playwright herself puts it, “The play is not about doctors or even about cancer. It’s about kindness, but it shows arrogance. It’s about compassion, but it shows insensitivity.” In Wit, Edson delves into timeless questions with no final answers: How should we live our lives knowing that we will die? Is the way we live our lives and interact with others more important than what we achieve materially, professionally, or intellectually? How does language figure into our lives? Can science and art help us conquer death, or our fear of it? What will seem most important to each of us about life as that life comes to an end?The immediacy of the presentation, and the clarity and elegance of Edson’s writing, make this sophisticated, multilayered play accessible to almost any interested reader. As the play begins, Vivian Bearing, a renowned professor of English who has spent years studying and teaching the intricate, difficult Holy Sonnets of the seventeenth-century poet John Donne, is diagnosed with advanced ovarian cancer. Confident of her ability to stay in control of events, she brings to her illness the same intensely rational and painstakingly methodical approach that has guided her stellar academic career. But as her disease and its excruciatingly painful treatment inexorably progress, she begins to question the single-minded values and standards that have always directed her, finally coming to understand the aspects of life that make it truly worth living.

    Closer to home, though, language is failing him. He doesn't know what to say to his wife, Mary, to keep her from leaving him, and he doesn't recognize the deep feelings that his lab assistant, Emma, has for him.

    Greg's career as a financial trader is winding down, while Kate's career, as a public-school English teacher, is beginning to offer her more opportunities. Greg brings home a dog he found in the park or that has found him bearing only the name "Sylvia" on her name tag. A street-smart mixture of Lab and Poodle, Sylvia becomes a major bone of contention between husband and wife. She offers Greg an escape from the frustrations of this job and the unknowns of middle age. To Kate, Sylvia becomes a rival for affection. And Sylvia thinks Kate just doesn't understand the relationship between man and dog. The marriage is put in serious jeopardy until, after a series of hilarious and touching complications, Greg and Kate learn to compromise, and Sylvia becomes a valued part of their lives.