The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    

    You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code—the DNA sequence that is the biochemical basis of heredity—can play a minor role in the way you age.The scientific reality is that 90 percent of the signs of aging and disease are caused by lifestyle choices, not your genes. In other words, you have the capability to overcome and transform your genetic history and tendencies. Harvard/MIT—trained physician Sara Gottfried, M.D. has created a revolutionary 7-week program that empowers us to make the critical choices necessary to not just look young, but also feel young.Dr. Gottfried identifies and builds this book around the five-key factors that lead to accelerated aging -the muscle factor, the brain factor, the hormone factor, the gut factor, and the toxic fat factor. The 7-week program addresses these factors and treats them in an accessible and highly practical protocol and is as follows:Feed—Week 1Sleep—Week 2Move—Week 3Release—Week 4Expose—Week 5Soothe—Week 6Think—Week 7Younger increases not only your lifespan, but also your healthspan. Dr. Gottfried's program makes it possible to change the way you age, stay younger longer, and remain healthy and vibrant for all of your days.

    The country has suffered floods on an unprecedented scale in recent years, but have we seen the worst, an inundation that threatens millions of lives? Doyle’s vision is incontestable, backed up by over twenty-five years of research. Flood is the disaster novel of today.A storm rages over the north of Britain, a troop carrier founders in the Irish Sea, flood indicators go off the scale, the seas are mountainous and a spring tide is about to strike the East Coast. Air sea rescue and military personnel struggle to save lives all down the coast. The worse is yet to come. When the storm reaches the south the two forces of wind and tide will combine and send a huge one-in-a-thousand tidal surge up the Thames.But surely London is safe: the Thames Barrier will save the capital from disaster as it was intended to do? The river is a titanic presence by now, higher than anyone has known it, and the surge thunders towards the Barrier. Scientists begin to talk of the possibility of overtopping. Can fifty feet high gates be overwhelmed by a wave? Then there is an explosion the size of a small Hiroshima: a supertanker is ablaze in the estuary and most of the Essex petrochemical works are going up with it. The Thames catches fire and the wall of fire and water thunders towards Britain’s capital. This is the story of what happens next, and the desperate attempts to save the capital from destruction.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    I was mentally and physically broken. So fractured, I hadn't eaten properly or slept well, or even changed my expression for months. I sat in a cubicle, behind paper-thin curtains, listening to the rest of the hospital happen around me, and I shook with the effort of not crying. I was an inch away from defeat, from the acceptance of a failure I assumed would be inevitable, but I knew I had to carry on. I had to somehow walk through it.Because I wasn't the patient. I was the doctor."A frank account of mental health from both sides of the doctor-patient divide, from the bestselling author of The Trouble with Goats and Sheep and Three Things About Elsie, based on her own experience as a doctor working on a psychiatric ward.

    Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding. Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix discusses the universal, but deeply personal, process of dying. With meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.

    After an emergency landing, she discovered that Dave—a healthy thirty-year-old athlete and surgical resident—had suffered a rare and life-threatening stroke. Next thing Allison knew, she was sitting alone in the ER in Fargo, North Dakota, waiting to hear if her husband would survive the night. When Dave woke up, he could not carry memories from hour to hour, much less from one day to the next. Allison lost the Dave she knew and loved when he lost consciousness on the plane. Within a few months, she found herself caring for both a newborn and a sick husband, struggling with the fear of what was to come. As a way to make sense of the pain and chaos of their new reality, Allison started to write daily letters to Dave. Not only would she work to make sense of the unfathomable experiences unfolding around her, but her letters would provide Dave with the memories he could not make on his own. She was writing to preserve their past, protect their present, and fight for their future. Those letters became the foundation for this beautiful, intimate memoir. And in the process, she fell in love with her husband all over again. This is a manifesto for living, an ultimately uplifting story about the transformative power of faith and resilience. It’s a tale of a husband’s turbulent road to recovery, the shifting nature of marriage, and the struggle of loving through pain and finding joy in the broken places.

    

    Michio Kaku. Dr. Michio Kaku, one of the most influential living scientists and a New York Times best-selling author, selects the year’s top science and nature writing from writers who balance research with humanity and, in the process, uncover riveting stories of discovery across the disciplines.

    It was there where she first saw a lamb being born, giving her the drive to defy her urban roots and become a professional shepherd. She never looked back.In this uplifting and inspirational memoir, Hannah shares how she broke the stereotypes of her 'townie' beginnings, took risks and faced up to the challenges of being a young woman in a male-dominated industry, and followed her heart to become the Red Shepherdess. But behind the beautiful landscape, talented sheepdogs and eye-catching red hair was a steep learning curve. The physically and mentally demanding conditions she faced as she chased her dreams to build her own Cumbrian farm taught Hannah the values the holds true, including community, leadership, patience and resilience.In Call Me Red, Hannah gives a unique insight into farming life and reveals a mindset and determination that proves no matter your background, with hard graft (and a loyal sheepdog) you can make your dreams a reality.

    Today, we hear stories of over-worked midwives and short-staffed hospitals, but the truth is that childbirth has never been easier. For our grandmothers, pregnancy was a journey into the unknown. Rather than ponder which pushchair to buy or fret over towelling versus disposable nappies, they worried about what lay ahead. Home births were often lonely affairs with the midwife or doctor only visiting when birth was imminent. During hospital births, medical staff rarely gave explanations and would push and prod with little offer of pain relief let alone sympathy. Standard care in labour was the O.B.E. - Oil, Bath and Enema. Nursing staff gave firm rules on how long to stay in bed, how to lie in bed and even when to go to the toilet. And life didn't get much easier after giving birth. Taking care of a home and baby was hard work when there were few washing machines, no disposable nappies and heating came from coal carried in from the back yard.

    Chopra offers an alternative approach based upon the principles of Ayurvedic medicine. Among the topics covered are the relationship between emotions and intestinal functions, biological rhythms and neuromuscular integration, and the importance of diet.

    In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today. Whipsawed by daily crises and frustrations, Reilly must deal with several daunting challenges simultaneously: the extraordinary patients under his care on the teeming wards of a renowned teaching hospital; the life-threatening illnesses of both of his ninety-year-old parents; and the tragic memory of a cold case from long ago that haunts him still. As Reilly’s patients and their families survive close calls, struggle with heartrending decisions, and confront the limits of medicine’s power to cure, One Doctor lays bare a fragmented, depersonalized, business-driven health-care system where real caring is hard to find. Every day, Reilly sees patients who fall through the cracks and suffer harm because they lack one doctor who knows them well and relentlessly advocates for their best interests.Filled with fascinating characters in New York City and rural New England — people with dark secrets, mysterious illnesses, impossible dreams, and many kinds of courage — One Doctor tells their stories with sensitivity and empathy, reminding us of professional values once held dear by all physicians. But medicine has changed enormously during Reilly’s career, for both better and worse, and One Doctor is a cautionary tale about those changes. It is also a hopeful, inspiring account of medicine’s potential to improve people’s lives, Reilly’s quest to understand the "truth" about doctoring, and a moving testament to the difference one doctor can make.

     Elinor Cleghorn became an unwell woman ten years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis.In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect. The result is an authoritative and groundbreaking exploration of the relationship between women and medical practice, from the wandering womb of Ancient Greece to the rise of witch trials across Europe, and from the dawn of hysteria as a catchall for difficult-to-diagnose disorders to the first forays into autoimmunity and the shifting understanding of hormones, menstruation, menopause, and conditions like endometriosis.Packed with character studies and case histories of women who have suffered, challenged, and rewritten medical orthodoxy--and the men who controlled their fate--this is a revolutionary examination of the relationship between women, illness, and medicine. With these case histories, Elinor pays homage to the women who suffered so strides could be made, and shows how being unwell has become normalized in society and culture, where women have long been distrusted as reliable narrators of their own bodies and pain. But the time for real change is long overdue: answers reside in the body, in the testimonies of unwell women--and their lives depend on medicine learning to listen.