(Great Courses, #660)

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s.One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline.In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.

    James Cleaves II seek to answer the most crucial question in science: How did life begin? They trace the trials and triumphs of the iconoclastic scientists who have sought to solve the mystery, from Darwin’s theory of evolution to Crick and Watson’s unveiling of DNA. This fascinating exploration not only examines the origin-of-life question, but also interrogates the very nature of scientific discovery and objectivity.

    The intriguing cast of characters includes Mary Anning, a working-class woman who became one of the most successful fossil collectors of all time; Thomas Hawkins, another amateur collector who "improved upon" fossils in order to increase their market value; the eccentric William Buckland, discoverer of the world's first dinosaur (Megalosaurus), and Richard Owen, an expert anatomist, who synthesized the discoveries of the age and ultimately coined the word "dinosaur" in 1842. Christopher McGowan takes us back to a time when the new sciences of geology and paleontology were as young and vibrant as genetic engineering is today. Through heated public debates on everything from the age of the earth to the notion of extinction, the Dragon Seekers initiated the shift from a biblical to a scientific interpretation of the remote past. In this way, they laid the intellectual groundwork for Darwin's revolutionary ideas, and launched a global obsession with the Age of Reptiles that continues even today.

    But how has the earth itself determined our destiny? Our planet wobbles, driving changes in climate that forced the transition from nomadism to farming. Mountainous terrain led to the development of democracy in Greece. Atmospheric circulation patterns later on shaped the progression of global exploration, colonization, and trade. Even today, voting behavior in the south-east United States ultimately follows the underlying pattern of 75 million-year-old sediments from an ancient sea. Everywhere is the deep imprint of the planetary on the human.From the cultivation of the first crops to the founding of modern states, Origins reveals the breathtaking impact of the earth beneath our feet on the shape of our human civilizations.

    No other living things combine their elegant simplicity with their incredibly complex role: Bacteria keep us alive, supply our food, and regulate our biosphere. We can't live a day without them, and no chemical, antibiotic, or irradiation has ever successfully eradicated them. They're our partners, like it or not--even though some of them will happily kill us. Allies and Enemies tells the story of this amazing, intimate partnership. Authored by Anne Maczulak, a microbiologist who's hunted and worked with an extraordinary array of bacteria, this book offers a powerful new perspective on Earth's oldest creatures. You'll discover how bacteria work, how they evolve, their surprising contributions and uses, the roles they've played in human history, and why you can't survive without them. No form of life is more important, and in Maczulak's hands, none is more fascinating. Outlasted, outnumbered, outsmarted They've been here four billion years--and they even outnumber you in your own body How bacteria keep you alive... ...and how to keep them from killing you "Humans Defeat Germs!" But not for long... The Invisible Universe The stunning hidden relationships between bacteria and the rest of nature

    This discovery dramatically reshaped how humans understood their place in the cosmos, and once and for all laid to rest the idea that the Milky Way galaxy was alone in the universe. Six years later, continuing research by Hubble and others forced Albert Einstein to renounce his own cosmic model and finally accept the astonishing fact that the universe was not immobile but instead expanding. The fascinating story of these interwoven discoveries includes battles of will, clever insights, and wrong turns made by the early investigators in this great twentieth-century pursuit. It is a story of science in the making that shows how these discoveries were not the work of a lone genius but the combined efforts of many talented scientists and researchers toiling away behind the scenes. The intriguing characters include Henrietta Leavitt, who discovered the means to measure the vast dimensions of the cosmos . . . Vesto Slipher, the first and unheralded discoverer of the universe’s expansion . . . Georges Lemaître, the Jesuit priest who correctly interpreted Einstein’s theories in relation to the universe . . . Milton Humason, who, with only an eighth-grade education, became a world-renowned expert on galaxy motions . . . and Harlow Shapley, Hubble’s nemesis, whose flawed vision of the universe delayed the discovery of its true nature and startling size for more than a decade.Here is a watershed moment in the history of astronomy, brought about by the exceptional combination of human curiosity, intelligence, and enterprise, and vividly told by acclaimed science writer Marcia Bartusiak.

    In this fascinating account, the impassioned Henry Hobhouse explains the consequences of these plants with attention-grabbing historical moments. While most records of history focus on human influence, Hobhouse emphasizes how plants too are a central and influential factor in the historical process. Seeds of Change is a captivating and invaluable addition to our understanding of modern culture.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking. Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all.  In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today. To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.

    In The Dance of Life, developmental and stem-cell biologist Magdalena Zernicka-Goetz takes us to the front lines of efforts to understand the creation of a human life. She has spent two decades unraveling the mysteries of development, as a simple fertilized egg becomes a complex human being of forty trillion cells. Zernicka-Goetz's work is both incredibly practical and astonishingly vast: her groundbreaking experiments with mouse, human, and artificial embryo models give hope to how more women can sustain viable pregnancies. Set at the intersection of science's greatest powers and humanity's greatest concern, The Dance of Life is a revelatory account of the future of fertility -- and life itself.

    But as Stephen Asma shows in Stuffed Animals and Pickled Heads, there is moregoing on in these great institutions than just smart fun. Asma takes us on a wide-ranging tour of natural history museums in New York and Chicago, London and Paris, interviewing curators, scientists, and exhibit designers, and providing a wealth of fascinating observations. We learn how the first museums were little more than high-toned side shows, with such garish exhibits as the pickled head of Peter the Great's lover. In contrast, today's museums are hot-beds of serious science, funding major research in such fields as anthropology and archaeology. Rich in detail, lucid explanation, telling anecdotes, and fascinating characters.... Asma has rendered a fascinating and credible account of how natural history museums are conceived and presented. It's the kind of book that will not only engage a wide and diverse readership, but it should, best of all, send them flocking to see how we look at nature and ourselves in those fabulous legacies of the curiosity cabinet.--The Boston Herald.

    How did they come to be the villains of the natural world? And why can the same plant be considered beautiful in some places but be deemed a menace in others?In Weeds, renowned nature writer Richard Mabey embarks on an engaging journey with the verve and historical breadth of Michael Pollan. Weaving together the insights of botanists, gardeners, artists, and writers with his own travels and lifelong fascination, Mabey shows how these "botanical thugs" can destroy ecosystems but also can restore war zones and derelict cities; he reveals how weeds have been portrayed, from the "thorns and thistles" of Genesis to Shakespeare, Walden, and Invasion of the Body Snatchers; and he explains how kudzu overtook the American South, how poppies sprang up in First World War battlefields, and how "American weed" replaced the forests of Vietnam ravaged by Agent Orange.Hailed as "a profound and sympathetic meditation on weeds in relation to human beings" (Sunday Times), Weeds shows how useful these unloved plants can be, from serving as the first crops and medicines, to bur-dock inspiring the invention of Velcro, to cow parsley becoming the latest fashionable wedding adornment. Mabey argues that we have caused plants to become weeds through our reckless treatment of the earth, and he delivers a provocative defense of the plants we love to hate.