With a cast of famous faces including Rob Reiner, Tom Hanks, Meg Ryan, and Billy Crystal, Carlson takes readers on a rollicking, revelatory trip to Ephron's New York City, where reality took a backseat to romance and Ephron--who always knew what she wanted and how she wanted it--ruled the set with an attention to detail that made her actors feel safe but sometimes exasperated crew members. Along the way, Carlson examines how Ephron explored in the cinema answers to the questions that plagued her own romantic life and how she regained faith in love after one broken engagement and two failed marriages. Carlson also explores countless other questions Ephron's fans have wondered about: What sparked Reiner to snap out of his bachelor blues during the making of When Harry Met Sally? Why was Ryan, a gifted comedian trapped in the body of a fairytale princess, not the first choice for the role? After she and Hanks each separatel balked at playing Mail's Kathleen Kelly and Sleepless' Sam Baldwin, what changed their minds? And perhaps most importantly: What was Dave Chappelle doing ... in a turtleneck? An intimate portrait of a one of America's most iconic filmmakers and a look behind the scenes of her crowning achievements, I'll Have What She's Having is a vivid account of the days and nights when Ephron, along with assorted cynical collaborators, learned to show her heart on the screen.

    It is a symptom.Recent years have seen a shocking increase in antidepressant use the world over, with 1 in 4 women starting their day with medication. These drugs have steadily become the panacea for everything from grief, irritability, panic attacks, to insomnia, PMS, and stress.  But the truth is, what women really need can’t be found at a pharmacy.According to Dr. Kelly Brogan, antidepressants not only overpromise and underdeliver, but their use may permanently disable the body’s self-healing potential. We need a new paradigm: The best way to heal the mind is to heal the whole body.In this groundbreaking, science-based and holistic approach, Dr. Brogan shatters the mythology conventional medicine has built around the causes and treatment of depression. Based on her expert interpretation of published medical findings, combined with years of experience from her clinical practice, Dr. Brogan illuminates the true cause of depression: it is not simply a chemical imbalance, but a lifestyle crisis that demands a reset. It is a signal that the interconnected systems in the body are out of balance – from blood sugar, to gut health, to thyroid function– and inflammation is at the root.A Mind of Your Own offers an achievable, step-by-step 30-day action plan—including powerful dietary interventions, targeted nutrient support, detoxification, sleep, and stress reframing techniques—women can use to heal their bodies, alleviate inflammation, and feel like themselves again without a single prescription.Bold, brave, and revolutionary, A Mind of Your Own takes readers on a journey of self-empowerment for radical transformation that goes far beyond symptom relief.

    Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding. Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix discusses the universal, but deeply personal, process of dying. With meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.

    Saunders' book is uncharted territory in the writing on dementia, a diagnosis one in nine Americans will receive. Based on the "field notes" she keeps in her journal, Memory's Last Breath is Saunders' astonishing window into a life distorted by dementia. She writes about shopping trips cut short by unintentional shoplifting, car journeys derailed when she loses her bearings, and the embarrassment of forgetting what she has just said to a room of colleagues. Coping with the complications of losing short-term memory, Saunders nonetheless embarks on a personal investigation of the brain and its mysteries, examining science and literature, and immersing herself in vivid memories of her childhood in South Africa. Written in a distinctive voice without a trace of self-pity, Memory's Last Breath is a remarkable, aphorism-free contribution to the literature of dementia--and an eye-opening personal memoir that will grip all adventurous readers.

    Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.For years, Holmes had been misleading investors, FDA officials, and her own employees. When Carreyrou, working at The Wall Street Journal, got a tip from a former Theranos employee and started asking questions, both Carreyrou and the Journal were threatened with lawsuits. Undaunted, the newspaper ran the first of dozens of Theranos articles in late 2015. By early 2017, the company's value was zero and Holmes faced potential legal action from the government and her investors. Here is the riveting story of the biggest corporate fraud since Enron, a disturbing cautionary tale set amid the bold promises and gold-rush frenzy of Silicon Valley.

    Powered by Amy’s charming and hilarious, biting yet wise voice, Yes Please is a book full of words to live by.

    Paul's School recently came under state investigation after extensive reports of sexual abuse on campus, Lacy Crawford thought she'd put behind her the assault she'd suffered at St. Paul's decades before, when she was fifteen. Still, when detectives asked for victims to come forward, she sent a note.Her criminal case file reopened, she saw for the first time evidence that corroborated her memories. Here were depictions of the naïve, hard-working girl she'd been, a chorister and debater, the daughter of a priest; of the two senior athletes who assaulted her and were allowed to graduate with awards; and of the faculty, doctors, and priests who had known about Crawford's assault and gone to great lengths to bury it.Now a wife, mother, and writer living on the other side of the country, Crawford learned that police had uncovered astonishing proof of an institutional silencing years before, and that unnamed powers were still trying to block her case. The slander, innuendo, and lack of adult concern that Crawford had experienced as a student hadn't been imagined as the effects of trauma, after all: these were the actions of a school that prized its reputation above anything, even a child.This revelation launched Crawford on an extraordinary inquiry into the ways gender, privilege, and power shaped her experience as a girl at the gates of America's elite. Her investigation looks beyond the sprawling playing fields and soaring chapel towers of crucibles of power like St. Paul's, whose reckoning is still to come. And it runs deep into the channels of shame and guilt, witness and silencing, that dictate who can speak and who is heard in American society.An insightful, mature, beautifully written memoir, Notes on a Silencing is an arresting coming-of-age story that wrestles with an essential question for our time: what telling of a survivor's story will finally force a remedy?

    Why then was she driving through Chicago fantasizing about her own death? Why was she envisioning putting an end to the isolation and sadness that still plagued her in spite of her achievements?Enter Dr. Rosen, a therapist who calmly assures her that if she joins one of his psychotherapy groups, he can transform her life. All she has to do is show up and be honest. About everything—her eating habits, childhood, sexual history, etc. Christie is skeptical, insisting that that she is defective, beyond cure. But Dr. Rosen issues a nine-word prescription that will change everything: “You don’t need a cure, you need a witness.So begins her entry into the strange, terrifying, and ultimately life-changing world of group therapy. Christie is initially put off by Dr. Rosen’s outlandish directives, but as her defenses break down and she comes to trust Dr. Rosen and to depend on the sessions and the prescribed nightly phone calls with various group members, she begins to understand what it means to connect.Group is a deliciously addictive read, and with Christie as our guide—skeptical of her own capacity for connection and intimacy, but hopeful in spite of herself—we are given a front row seat to the daring, exhilarating, painful, and hilarious journey that is group therapy—an under-explored process that breaks you down, and then reassembles you so that all the pieces finally fit.

    Both Nick and his character, Ron Swanson, are known for their humor and patriotism in equal measure.After the great success of his autobiography, Paddle Your Own Canoe, Offerman now focuses on the lives of those who inspired him. From George Washington to Willie Nelson, he describes twenty-one heroic figures and why they inspire in him such great meaning. He combines both serious history with light-hearted humor—comparing, say, Benjamin Franklin’s abstinence from daytime drinking to his own sage refusal to join his construction crew in getting plastered on the way to work. The subject matter also allows Offerman to expound upon his favorite topics, which readers love to hear—areas such as religion, politics, woodworking and handcrafting, agriculture, creativity, philosophy, fashion, and, of course, meat.

    That's all it took to change Stephanie Wittels Wachs' life forever..Her younger brother Harris, a star in the comedy world known for his work on shows like Parks and Recreation, had died of a heroin overdose. How do you make sense of such a tragic end to a life of so much hilarious brilliance?In beautiful, unsentimental, and surprisingly funny prose, Stephanie Wittels Wachs alternates between her brother's struggle with addiction, which she learned about three days before her wedding, and the first year after his death, in all its emotional devastation. This compelling portrait of a comedic genius and a profound exploration of the love between siblings is A Year of Magical Thinking for a new generation of readers.A heartbreaking but hopeful memoir of addiction, grief, and family, Everything is Horrible and Wonderful will make you laugh, cry, and wonder if that possum on the fence is really your brother's spirit animal.

    But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn’t everything, it’s the only thing—no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process.The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra’s dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison’s mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren’t all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong.Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

    Months later, several health professionals faced criminal allegations that they deliberately injected numerous patients with drugs to hasten their deaths. Five Days at Memorial, the culmination of six years of reporting, unspools the mystery of what happened in those days, bringing the reader into a hospital fighting for its life and into a conversation about the most terrifying form of health care rationing.In a voice at once involving and fair, masterful and intimate, Fink exposes the hidden dilemmas of end-of-life care and reveals just how ill-prepared we are in America for the impact of large-scale disasters—and how we can do better. A remarkable book, engrossing from start to finish, Five Days at Memorial radically transforms your understanding of human nature in crisis.

    In this extraordinary memoir, she opens a window into the experience of wordlessness—the language paralysis called aphasia. In narrating the recovery of her husband, Paul West, from a stroke that reduced his vast vocabulary to a single syllable, she evokes the joy and mystery of the brain’s ability to find and connect words. Deeply rewarding to readers of all kinds, Ackerman has given us a literary love story, accessible insight into the science and medicine of brain injury,and invaluable spiritual sustenance in the face of life’s myriad physical sufferings.

    As she searches for answers nearly thirty years later, Kimball embarks on a journey into the secrets her family has kept for decades. Using old diary entries, hospital records, home videos, and other archives, Margaret pieces together a narrative map of her childhood—her mother's bipolar disorder, her grandmother's institutionalization, and her brother's increasing struggles—in an attempt to understand what no one likes to talk about: the fractures in her family.

    His new and initially intimidating classmates were high achievers from the Ivy League and other elite universities around the nation. Stern pulls back the curtain on the intense and emotionally challenging lessons he and his fellow doctors learned while studying the human condition, and ultimately, the value of connection. The narrative focuses on these residents, their growth as doctors, and the life choices they make as they try to survive their grueling four-year residency. Most importantly, as they study how to help distressed patients in search of a better life, they discover the meaning of failure and the preciousness of success.