But the Black Death was arguably the most significant event in Western history, profoundly affecting every aspect of human life, from the economic and social to the political, religious, and cultural. In its wake the plague left a world that was utterly changed, forever altering the traditional structure of European societies and forcing a rethinking of every single system of Western civilization: food production and trade, the church, political institutions, law, art, and more. In large measure, by the profundity of the changes it brought, the Black Death produced the modern world we live in today.While the story of the Black Death is one of destruction and loss, its breathtaking scope and effects make it one of the most compelling and deeply intriguing episodes in human history. Understanding the remarkable unfolding of the plague and its aftermath provides a highly revealing window not only on the medieval world but also on the forces that brought about the Renaissance, the Protestant Reformation, and modernity itself.Speaking to the full magnitude of this world-changing historical moment, The Black Death: The World's Most Devastating Plague, taught by celebrated medievalist Dorsey Armstrong of Purdue University, takes you on an unforgettable excursion into the time period of the plague, its full human repercussions, and its transformative effects on European civilization. In 24 richly absorbing lectures, you'll follow the path of the epidemic in its complete trajectory across medieval Europe. Majestic in scope and remarkable in detail, this course goes to the heart of one of Western history's most catalytic and galvanizing moments, the effects of which gave us the modern world.

    But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.

    For centuries, royal families have feared the gut-roiling, vomit-inducing agony of a little something added to their food or wine by an enemy. To avoid poison, they depended on tasters, unicorn horns, and antidotes tested on condemned prisoners. Servants licked the royal family’s spoons, tried on their underpants and tested their chamber pots.Ironically, royals terrified of poison were unknowingly poisoning themselves daily with their cosmetics, medications, and filthy living conditions. Women wore makeup made with mercury and lead. Men rubbed turds on their bald spots. Physicians prescribed mercury enemas, arsenic skin cream, drinks of lead filings, and potions of human fat and skull, fresh from the executioner. The most gorgeous palaces were little better than filthy latrines. Gazing at gorgeous portraits of centuries past, we don’t see what lies beneath the royal robes and the stench of unwashed bodies; the lice feasting on private parts; and worms nesting in the intestines.In The Royal Art of Poison, Eleanor Herman combines her unique access to royal archives with cutting-edge forensic discoveries to tell the true story of Europe’s glittering palaces: one of medical bafflement, poisonous cosmetics, ever-present excrement, festering natural illness, and, sometimes, murder.

    The COO fired back with a dismissive and insulting email, to which Tyler replied: "Consider this my two weeks’ notice."From there, his life spun out of control at the hand of Elizabeth, her team of high-powered lawyers, and the patriarch of Tyler’s own family, George Shultz—one of America’s most prominent statesmen, who sat among the top of the Theranos Board of Directors. And yet, Tyler forged on. To protect his own conscience, the honor and reputation of his grandfather, and the health of patients worldwide.Thicker than Water is Tyler’s as-told-to story—a harrowing and heartbreaking roller coaster of biomedical drama, family intrigue, and redemption—that will ultimately make you feel as though you are at a dinner party, seated next to a brilliant friend with one hell of a story.

    Northgate Plaza.5:20 PM.Inside Michael’s craft supply store, cashier Ann Chapman rings up another customer. Then it happens. A loud crack; a gust of wind; the light in register five goes dark.Over the next 23 days, the entire DC area will be thrust into a reign of terror unprecedented in American history. Sniper attacks targeting and murdering everyday citizens will bring the entire region to its knees, as a nation still reeling from the recent attacks of 9/11 and the anthrax scare, are forced to confront a new type of brutal assault—this time in their own backyard. As law enforcement grapples with the mass carnage and chaos, media’s ravenous 24-hour cycle amplifies the very real fear, while steadily pumping new theories and bad leads onto a paralyzed public desperate for it all to end.But who can stop it? And exactly how?Call Me God is the never-before-told story of the fascinating and turbulent investigation that led to the diabolical and elusive killers' capture; one that pitted protocol against instinct, sacred institutions against individual insight. Told firsthand by those few who had the vision and expertise to solve it, and including a fascinating look into the behavioral, ballistic, forensic, and electronic analysis vital to cracking the case, FBI agent brothers Jim Clemente (former FBI behavioral profiler) and Tim Clemente (former FBI counter-terrorism expert) take us through every facet and flaw of a nationwide manhunt that pressure tested nearly every aspect of law enforcement capabilities—and its glaring vulnerabilities.Anchored by harrowing accounts from victims, intimate conversations with family members of those deceased, as well as candid accounts from those who knew the perpetrators best, relive the haunting events of the DC Sniper attack and piece together a true crime phenomenon that's impact can still be felt today.

    Acupuncture. Superfoods. Healing magnets. What does the scientific evidence really say about these and other "alternative medicine" treatments for personal wellness?How can we know if a natural remedy is safe and effective? How can people become their own best skeptical consumer of health news in the media? Join neurologist and science educator Dr. Steven Novella for a fascinating exploration of these and other important questions about the truths-and myths-behind alternative medicine.Perhaps the most important skill to have in this brave new world of ever-changing medical news is the ability to evaluate sources and information, and to think critically about how alternative medicine is marketed, regulated, and used. Dr. Novella takes a rigorous, science-based approach in exploring so-called "popular" and "cutting-edge" trends. Armed with this knowledge, listeners will be in a much better position to assess alternative pathways to physical health.Dr. Novella's 10 leading-edge lectures will answer such questions as: Do magnetic fields really have useful biological properties? Why is chiropractic treatment no more effective for pain management than simple physical therapy? Can brain games truly make one smarter or help in staving off dementia? Can homeopathic remedies, such as those derived from plants and minerals, really cure ailments? Does cupping therapy really help to reduce pain and inflammation, while increasing blood flow?Dr. Novella provides insights on the ever-widening gap between alternative medicine and

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    That one bite changed her life forever, pulling her into the abyss of a devastating illness that took ten doctors to diagnose and years to recover: Newby had become one of the 300,000 Americans who are afflicted with Lyme disease each year.As a science writer, she was driven to understand why this disease is so misunderstood, and its patients so mistreated. This quest led her to Willy Burgdorfer, the Lyme microbe's discoverer, who revealed that he had developed bug-borne bioweapons during the Cold War, and believed that the Lyme epidemic was started by a military experiment gone wrong.In a superb, meticulous work of narrative journalism, Bitten takes readers on a journey to investigate these claims, from biological weapons facilities to interviews with biosecurity experts and microbiologists doing cutting-edge research, all the while uncovering darker truths about Willy. It also leads her to uncomfortable questions about why Lyme can be so difficult to both diagnose and treat, and why the government is so reluctant to classify chronic Lyme as a disease.A gripping, infectious page-turner, Bitten will shed a terrifying new light on an epidemic that is exacting an incalculable toll on us, upending much of what we believe we know about it.

    While they were indeed ostentatious, calculating, worldly, cruel—and even, occasionally, murderous—listeners may be surprised to find that the Borgias were not terribly different from other powerful and ambitious families of their day. So why has history set them apart as one of the most corrupt and reviled families in history?In the Rise and Fall of the Borgias, listeners will spend 10 revealing lectures untangling the web of rumors, speculation, and historical embellishment from what is actually known about the infamous Roman family. With Dr. William Landon, listeners will explore the historical context that helped the Borgias make their fortune and better understand how they could be both magnanimous and ruthless, pious and morally suspect.The story of the Borgias is rich with intrigue, even without the fictional enhancement it has received from the numerous films, novels, and television shows that have been created based on the family’s notoriety. Dr. Landon introduces listeners to the major players and lays bare their machinations to reach the highest offices of church and state. Were their exploits as salacious as listeners have been led to believe? Did they manipulate the papacy for their own gain? Are the rumors of incest, bribery, political assassinations, and other morally questionable behaviors true or the stuff of historical gossip?As listeners explore these and other rumors surrounding the Borgias, they will pull back the curtain on the historian’s craft and see how the story of this Renaissance dynasty has been shaped over time and how new research and a healthy dose of skepticism has allowed us to get a little closer to the truth—without losing any of the drama.

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    From body lotion to tonic water, the popular new element shines bright in the otherwise dark years of the First World War.Meanwhile, hundreds of girls toil amidst the glowing dust of the radium-dial factories. The glittering chemical covers their bodies from head to toe; they light up the night like industrious fireflies. With such a coveted job, these "shining girls" are the luckiest alive—until they begin to fall mysteriously ill.But the factories that once offered golden opportunities are now ignoring all claims of the gruesome side effects, and the women's cries of corruption. And as the fatal poison of the radium takes hold, the brave shining girls find themselves embroiled in one of the biggest scandals of America's early 20th century, and in a groundbreaking battle for workers' rights that will echo for centuries to come.Written with a sparkling voice and breakneck pace, The Radium Girls fully illuminates the inspiring young women exposed to the "wonder" substance of radium, and their awe-inspiring strength in the face of almost impossible circumstances. Their courage and tenacity led to life-changing regulations, research into nuclear bombing, and ultimately saved hundreds of thousands of lives.

    On an annual basis, the industry is even more profitable than Hollywood. Today’s video games feature stunning, lifelike visuals and complex storylines - but they didn’t start out that way. The origin of video games can be traced back to World War II. In the 10 lectures of A History of Video Games, listeners will follow the development of the digital game from its roots in the war room to its proliferation in the 21st-century living room. Taught by journalist, podcast host, and video game historian Jeremy Parish, this lively course will track the tremendous leaps made in computing technology that allowed games to become increasingly sophisticated and the popular trends that pushed the boundaries of technology forward. The story of video games is not just about technology. It’s also about popular culture, economics, and globalization. Throughout these lectures, students will learn about the extremely profitable gaming industry, as well as the creative minds and ambitious projects that helped build it - and even encounter a few spectacular failures. Be prepared to: Witness the precipitous rise and fall of AtariExperience the birth of blockbuster gaming systems like NES and Sega GenesisLearn about the evolution of the console, PC, and portable gamingExplore the creation of iconic game series, such as Mario Bros., Pac-Man, and Pokémon From the simple pleasures of Pong to the complex online world of Fortnite, video games have come a long way over the course of seven decades, with no signs of slowing down anytime soon. Listeners will surely reminisce about their own experience with gaming as they learn more about this exciting industry, phenomenon, and pastime.

    And in this bold 24-lecture series, you can do just that.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    in Manhattan, where a woman's body had fallen from a twelfth-story window. The woman s husband, Herbert Weinstein, soon confessed to having hit and strangled his wife after an argument, then dropping her body out of their apartment window to make it look like a suicide. The 65-year-old Weinstein, a quiet, unassuming retired advertising executive, had no criminal record, no history of violent behavior not even a short temper. How, then, to explain this horrific act? Journalist Kevin Davis uses the perplexing story of the Weinstein murder to present a riveting, deeply researched exploration of the intersection of neuroscience and criminal justice. Shortly after Weinstein was arrested, an MRI revealed a cyst the size of an orange on his brain's frontal lobe, the part of the brain that governs judgment and impulse control. Weinstein's lawyer seized on that discovery, arguing that the cyst had impaired Weinstein's judgment and that he should not be held criminally responsible for the murder. It was the first case in the United States in which a judge allowed a scan showing a defendant's brain activity to be admitted as evidence to support a claim of innocence. The Weinstein case marked the dawn of a new era in America's courtrooms, raising complex and often troubling questions about how we define responsibility and free will, how we view the purpose of punishment, and how strongly we are willing to bring scientific evidence to bear on moral questions. Davis brings to light not only the intricacies of the Weinstein case but also the broader history linking brain injuries and aberrant behavior, from the bizarre stories of Phineas Gage and Charles Whitman, perpetrator of the 1966 Texas Tower massacre, to the role that brain damage may play in violence carried out by football players and troubled veterans of America s twenty-first century wars. The Weinstein case opened the door for a novel defense that continues to transform the legal system: Criminal lawyers are increasingly turning to neuroscience and introducing the effects of brain injuries whether caused by trauma or by tumors, cancer, or drug or alcohol abuse and arguing that such damage should be considered in determining guilt or innocence, the death penalty or years behind bars. As he takes stock of the past, present and future of neuroscience in the courts, Davis offers a powerful account of its potential and its hazards. Thought-provoking and brilliantly crafted, The Brain Defensemarries a murder mystery complete with colorful characters and courtroom drama with a sophisticated discussion of how our legal system has changed and must continue to change as we broaden our understanding of the human mind."