If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting fifty years of false starts, abysmal failures and miraculous triumphs, as experienced by one the world’s foremost heart surgeons, O.H. “Bud” Frazier, who has given his life to saving the un-savable. His journey takes him from a small town in west Texas to one of the country’s most prestigious medical institutions, The Texas Heart Institute, from the halls of Congress to the animal laboratories where calves are fitted with new heart designs. The roadblocks to success —medical setbacks, technological shortcomings, government regulations – are immense. Still, Bud and his associates persist, finding inspiration in the unlikeliest of places. A field beside the Nile irrigated by an Archimedes screw. A hardware store in Brisbane, Australia. A seedy bar on the wrong side of Houston. Until post WWII, heart surgery did not exist. Ticker provides a riveting history of the pioneers who gave their all to the courageous process of cutting into the only organ humans cannot live without. Heart surgeons Michael DeBakey and Denton Cooley, whose feud dominated the dramatic beginnings of heart surgery. Christian Barnaard, who changed the world overnight by performing the first heart transplant. Inventor Robert Jarvik, whose artificial heart made patient Barney Clark a worldwide symbol of both the brilliant promise of technology and the devastating evils of experimentation run amuck. Rich in supporting players, Ticker introduces us to Bud’s brilliant colleagues in his quixotic quest to develop an artificial heart: Billy Cohn, the heart surgeon and inventor who devotes his spare time to the pursuit of magic and music; Daniel Timms, the Brisbane biomedical engineer whose design of a lightweight, pulseless heart with but a single moving part offers a new way forward. And, as government money dries up, the unlikeliest of backers, Houston’s furniture king, Mattress Mack. In a sweeping narrative of one man’s obsession, Swartz raises some of the hardest questions of the human condition. What are the tradeoffs of medical progress? What is the cost, in suffering and resources, of offering patients a few more months, or years of life? Must science do harm to do good? Ticker takes us on an unforgettable journey into the power and mystery of the human heart.

    Now, on the 150th anniversary of its publication, acclaimed science writer and master of narrative nonfiction Bill Hayes has written the fascinating, never-before-told true story of how this seminal volume came to be. A blend of history, science, culture, and Hayes’s own personal experiences, The Anatomist is this author’s most accomplished and affecting work to date.With passion and wit, Hayes explores the significance of Gray’s Anatomy and explains why it came to symbolize a turning point in medical history. But he does much, much more. Uncovering a treasure trove of forgotten letters and diaries, he illuminates the astonishing relationship between the fiercely gifted young anatomist Henry Gray and his younger collaborator H. V. Carter, whose exquisite anatomical illustrations are masterpieces of art and close observation. Tracing the triumphs and tragedies of these two extraordinary men, Hayes brings an equally extraordinary era–the mid 1800s–unforgettably to life.But the journey Hayes takes us on is not only outward but inward–through the blood and tissue and organs of the human body–for The Anatomist chronicles Hayes’s year as a student of classical gross anatomy, performing with his own hands the dissections and examinations detailed by Henry Gray 150 years ago. As Hayes’s acquaintance with death deepens, he finds his understanding and appreciation of life deepening in unexpected and profoundly moving ways. The Anatomist is more than just the story of a book. It is the story of the human body, a story whose beginning and end we all know and share but that, like all great stories, is infinitely rich in between.

    From Marilyn Monroe's borderline personality disorder to Charles Darwin's anxiety, Kalb provides compelling insight into a broad range of maladies, using historical records and interviews with leading mental health experts, biographers, sociologists, and other specialists. Packed with intriguing revelations, this smart narrative brings a new perspective to one of the hottest new topics in today's cultural conversation.

    Acclaimed historian G. J. Meyer reveals the flesh-and-bone reality in all its wild excess.In 1485, young Henry Tudor, whose claim to the throne was so weak as to be almost laughable, crossed the English Channel from France at the head of a ragtag little army and took the crown from the family that had ruled England for almost four hundred years. Half a century later his son, Henry VIII, desperate to rid himself of his first wife in order to marry a second, launched a reign of terror aimed at taking powers no previous monarch had even dreamed of possessing. In the process he plunged his kingdom into generations of division and disorder, creating a legacy of blood and betrayal that would blight the lives of his children and the destiny of his country.The boy king Edward VI, a fervent believer in reforming the English church, died before bringing to fruition his dream of a second English Reformation. Mary I, the disgraced daughter of Catherine of Aragon, tried and failed to reestablish the Catholic Church and produce an heir. And finally came Elizabeth I, who devoted her life to creating an image of herself as Gloriana the Virgin Queen but, behind that mask, sacrificed all chance of personal happiness in order to survive.  The Tudors weaves together all the sinners and saints, the tragedies and triumphs, the high dreams and dark crimes, that reveal the Tudor era to be, in its enthralling, notorious truth, as momentous and as fascinating as the fictions audiences have come to love.

    Dunn illuminates the nuanced, often imperceptible relationships that exist between homo sapiens and other species, relationships that underpin humanity’s ability to thrive and prosper in every circumstance.

    Period. is an agenda-setting manifesto to remove the stigma and myths continuing to surround the female body. Bold and unapologetic, Emma Barnett is on a crusade to ignite conversation among women--and men--everywhere.

    In captivity, octopuses have been known to identify individual human keepers, raid neighboring tanks for food, turn off lightbulbs by spouting jets of water, plug drains, and make daring escapes. How is it that a creature with such gifts evolved through an evolutionary lineage so radically distant from our own? What does it mean that evolution built minds not once but at least twice? The octopus is the closest we will come to meeting an intelligent alien. What can we learn from the encounter?In Other Minds, Peter Godfrey-Smith, a distinguished philosopher of science and a skilled scuba diver, tells a bold new story of how subjective experience crept into being—how nature became aware of itself. As Godfrey-Smith stresses, it is a story that largely occurs in the ocean, where animals first appeared. Tracking the mind’s fitful development, Godfrey-Smith shows how unruly clumps of seaborne cells began living together and became capable of sensing, acting, and signaling. As these primitive organisms became more entangled with others, they grew more complicated. The first nervous systems evolved, probably in ancient relatives of jellyfish; later on, the cephalopods, which began as inconspicuous mollusks, abandoned their shells and rose above the ocean floor, searching for prey and acquiring the greater intelligence needed to do so. Taking an independent route, mammals and birds later began their own evolutionary journeys.But what kind of intelligence do cephalopods possess? Drawing on the latest scientific research and his own scuba-diving adventures, Godfrey-Smith probes the many mysteries that surround the lineage. How did the octopus, a solitary creature with little social life, become so smart? What is it like to have eight tentacles that are so packed with neurons that they virtually “think for themselves”? What happens when some octopuses abandon their hermit-like ways and congregate, as they do in a unique location off the coast of Australia?By tracing the question of inner life back to its roots and comparing human beings with our most remarkable animal relatives, Godfrey-Smith casts crucial new light on the octopus mind—and on our own.

    But which one? And how?Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.

    Odder still, she reveals that she’s suffering from a persistent memory problem. Routinely, she “loses” parts of her day, finding herself in places she doesn’t remember going to or being told about conversations she doesn’t remember having. Her problems are so pervasive that she often feels like an impersonator in her own life; she doesn’t recognize the people who call themselves her friends, and she can’t even remember being intimate with her own husband. Baer recognizes that Karen is on the verge of suicide and, while trying various medications to keep her alive, attempts to discover the root cause of her strange complaints. It’s the work of months, and then years, to gain Karen’s trust and learn the true extent of the trauma buried in her past. What she eventually reveals is nearly beyond belief, a narrative of a childhood spent grappling with unimaginable horror. How has Karen survived with even a tenuous grasp on sanity?Then Baer receives an envelope in the mail. It’s marked with Karen’s return address but contains a letter from a little girl who writes that she’s seven years old and lives inside of Karen. Soon Baer receives letters from others claiming to be parts of Karen. Under hypnosis, these alternate Karen personalities reveal themselves in shocking variety and with undeniable traits—both physical and psychological. One “alter” is a young boy filled with frightening aggression; another an adult male who considers himself Karen’s protector; and a third a sassy flirt who seeks dominance over the others. It’s only by compartmentalizing her pain, guilt, and fear in this fashion—by “switching time” with alternate selves as the situation warrants—that Karen has been able to function since childhood.Realizing that his patient represents an extreme case of multiple personality disorder, Baer faces the daunting task of creating a therapy that will make Karen whole again. Somehow, in fact, he must gain the trust of each of Karen’s seventeen “alters” and convince them of the necessity of their own annihilation.As powerful as Sybil or The Three Faces of Eve, Switching Time is the first complete account of such therapy to be told from the perspective of the treating physician, a stunningly devoted healer who worked selflessly for decades so that Karen could one day live as a single human being.From the Hardcover edition.

    Chronicling her life from her earliest memories through her life as a university lecturer, writer, wife and mother, Liane Holliday Willey shares, with insight and warmth, the daily struggles and challenges that face many of those who have Asperger's Syndrome. Pretending to be Normal invites its readers to welcome the Asperger community with open acceptance, for it makes it clear that, more often than not, they are capable, viable, interesting and kind people who simply find unique ways to exhibit those qualities.The last part of the book consists of a series of substantial appendices which provide helpful coping strategies and guidance, based on the author's own experience, for a range of situations. This positive and humane book will provide not only insight into the Asperger world which will prove invaluable for the professionals who work with people with Asperger's Syndrome, but also hope and encouragement for other people with Asperger's Syndrome, their families, and their friends.

    However, according to Hofstadter, the formal system that underlies all mental activity transcends the system that supports it. If life can grow out of the formal chemical substrate of the cell, if consciousness can emerge out of a formal system of firing neurons, then so too will computers attain human intelligence. Gödel, Escher, Bach is a wonderful exploration of fascinating ideas at the heart of cognitive science: meaning, reduction, recursion, and much more.

    He is frustrated, confused, baffled and, quite frequently, very funny. He is also a GP. These are his confessions.A woman troubled by pornographic dreams about Tom Jones. An 80-year-old man who can't remember why he's come to see the doctor. A woman with a common cold demanding (but not receiving) antibiotics. A man with a sore knee. A young woman who has been trying to conceive for a while but now finds herself pregnant and isn't sure she wants to go through with it. A 7-year-old boy with 'tummy aches' that don't really exist.These are his patients.Confessions of a GP is a witty insight into the life of a family doctor. Funny and moving in equal measure it will change the way you look at your GP next time you pop in with the sniffles.

    He has kept a blog of his daily working life since 2003 and his award-winning writing is, by turn, moving, cynical, funny, heart-rending, and compassionate. From the tragic to the hilarious, the stories Tom tells give a fascinatingand at times alarming picture of life in inner-city Britain, and the people who are paid to mop up after it.

    His contribution to our understanding not only of mental illness but also of the human condition is truly stunning.The Noonday Demon examines depression in personal, cultural, and scientific terms. Drawing on his own struggles with the illness and interviews with fellow sufferers, doctors and scientists, policymakers and politicians, drug designers and philosophers, Solomon reveals the subtle complexities and sheer agony of the disease. He confronts the challenge of defining the illness and describes the vast range of available medications, the efficacy of alternative treatments, and the impact the malady has had on various demographic populations around the world and throughout history. He also explores the thorny patch of moral and ethical questions posed by emerging biological explanations for mental illness.The depth of human experience Solomon chronicles, the range of his intelligence, and his boundless curiosity and compassion will change the reader's view of the world.

    So Tyson brings the universe down to Earth succinctly and clearly, with sparkling wit, in tasty chapters consumable anytime and anywhere in your busy day.