But are there limits to what we can discover about our physical universe?In this very personal journey to the edges of knowledge, Marcus du Sautoy investigates how leading experts in fields from quantum physics and cosmology, to sensory perception and neuroscience, have articulated the current lie of the land. In doing so, he travels to the very boundaries of understanding, questioning contradictory stories and consulting cutting edge data.Is it possible that we will one day know everything? Or are there fields of research that will always lie beyond the bounds of human comprehension? And if so, how do we cope with living in a universe where there are things that will forever transcend our understanding?In What We Cannot Know, Marcus du Sautoy leads us on a thought-provoking expedition to the furthest reaches of modern science. Prepare to be taken to the edge of knowledge to find out if there’s anything we truly cannot know.

    But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.

    But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

    Gina Rippon finally challenges this damaging myth by showing how the science community has engendered bias and stereotype by rewarding studies that show difference rather than sameness. Drawing on cutting edge research in neuroscience and psychology, Rippon presents the latest evidence which she argues, finally proves that brains are like mosaics comprised of both male and female components, and that they remain plastic, adapting throughout the course of a person’s life. Discernable gender identities, she asserts, are shaped by society where scientific misconceptions continue to be wielded and perpetuated to the detriment of our children, our own lives, and our culture.

    It's also about pain. Most important, it's about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We're living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting... The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we've all become vulnerable to compulsive overconsumption.In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain...and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery."Brilliant... riveting, scary, cogent, and cleverly argued."--Beth Macy, author of DopesickINSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER“Brilliant… riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of DopesickAs heard on Fresh Air

    It gives your body its shape and the ability to move. It grows and changes with you, an undeniable document of who you are and how you lived. Arguably, no other part of the human anatomy has such rich scientific and cultural significance, both brimming with life and a potent symbol of death.In this delightful natural and cultural history of bone, Brian Switek explains where our skeletons came from, what they do inside us, and what others can learn about us when these artifacts of mineral and protein are all we've left behind.Bone is as embedded in our culture as it is in our bodies. Our species has made instruments and jewelry from bone, treated the dead like collectors' items, put our faith in skull bumps as guides to human behavior, and arranged skeletons into macabre tributes to the afterlife. Switek makes a compelling case for getting better acquainted with our skeletons, in all their surprising roles. Bridging the worlds of paleontology, anthropology, medicine, and forensics, Skeleton Keys illuminates the complex life of bones inside our bodies and out.

    We can actually observe a person's brain registering a joke or experiencing a painful memory. Drawing on the latest imaging technology and the expertise of distinguished scientists, Rita Carter explores the geography of the human brain. Her writing is clear, accessible, witty, and the book's 150 illustrations—most in color—present an illustrated guide to that wondrous, coconut-sized, wrinkled gray mass we carry inside our heads.Mapping the Mind charts the way human behavior and culture have been molded by the landscape of the brain. Carter shows how our personalities reflect the biological mechanisms underlying thought and emotion and how behavioral eccentricities may be traced to abnormalities in an individual brain. Obsessions and compulsions seem to be caused by a stuck neural switch in a region that monitors the environment for danger. Addictions stem from dysfunction in the brain's reward system. Even the sense of religious experience has been linked to activity in a certain brain region. The differences between men and women's brains, the question of a "gay brain," and conditions such as dyslexia, autism, and mania are also explored.Looking inside the brain, writes Carter, we see that actions follow from our perceptions, which are due to brain activity dictated by a neuronal structure formed from the interplay between our genes and the environment. Without sidestepping the question of free will, Carter suggests that future generations will use our increasing knowledge of the brain to "enhance those mental qualities that give sweetness and meaning to our lives, and to eradicate those that are destructive."

     And You're About to Learn How to Use His Memory Strategies to Learn Faster, Be More Productive and Achieve More Success Most people never tap into 10% of their potential for memory. In this book, you're about to learn: How the World's Top Memory Experts Concentrate and Remember Any Information at Will, and How You Can Too Do you ever feel like you're too busy, too stressed or just too distracted to concentrate and get work done? In Unlimited Memory, you'll learn how the world's best memory masters get themselves to concentrate at will, anytime they want. When you can easily focus and concentrate on the task at hand, and store and recall useful information, you can easily double your productivity and eliminate wasted time, stress and mistakes at work. In this book, you'll find all the tools, strategies and techniques you need to improve your memory. About the Author For over 20 years, KEVIN HORSLEY has been analyzing the mind and memory and its capacity for brilliance. He is one of only a few people in the world to have received the title International Grandmaster of Memory. He is a World Memory Championship medalist, and a two-time World Record holder for The Everest of memory tests. Kevin is also an author of four books, and the designer of a times table game with the Serious Games Institute at North-West University Vaal Campus. Kevin is a professional speaker, and assists organizations in improving their learning, motivation, creativity, and thinking.

    Mirroring his theory, Minsky boldly casts The Society of Mind as an intellectual puzzle whose pieces are assembled along the way. Each chapter -- on a self-contained page -- corresponds to a piece in the puzzle. As the pages turn, a unified theory of the mind emerges, like a mosaic. Ingenious, amusing, and easy to read, The Society of Mind is an adventure in imagination.

    It can feel like a constant battle to stay away from the temptations we know we shouldn't give in to. Where exactly do these urges come from? If we know we shouldn't do something, for the sake of our health, our pockets or our reputation, why is it often so very hard to do the right thing? Anyone who has ever wondered why they never seem to be able to stick to their diet, anyone to whom the world seems more vain and self-obsessed than ever, anyone who can't understand why love-cheats pursue their extra-marital affairs, anyone who struggles to resist the lure of the comfy sofa, or anyone who makes themselves bitter through endless comparison with other people - this book is for you. The Science of Sin brings together the latest findings from neuroscience research to shed light on the universally fascinating subject of temptation - where it comes from, how to resist it and why we all tend to succumb from time to time. With each chapter inspired by one of the seven deadly sins, neurobiologist Jack Lewis illuminates the neural battles between temptation and restraint that take place within our brains, suggesting strategies to help us better manage our most troublesome impulses with the explicit goal of improving our health, our happiness and our productivity - helping us to say `no!' more often, especially when it really counts.

    Now in paperback, Dr Jeffrey Schwartz and Sharon Begley's groundbreaking work, The Mind and the Brain, argues exactly the opposite: that the mind has a life of its own.Dr Schwartz, a leading researcher in brain dysfunctions, and Wall Street Journal science columnist Sharon Begley demonstrate that the human mind is an independent entity that can shape and control the functioning of the physical brain. Their work has its basis in our emerging understanding of adult neuroplasticity–the brain's ability to be rewired not just in childhood, but throughout life, a trait only recently established by neuroscientists.Through decades of work treating patients with obsessive–compulsive disorder (OCD), Schwartz made an extraordinary finding: while following the therapy he developed, his patients were effecting significant and lasting changes in their own neural pathways. It was a scientific first: by actively focusing their attention away from negative behaviors and toward more positive ones, Schwartz's patients were using their minds to reshape their brains–and discovering a thrilling new dimension to the concept of neuroplasticity.The Mind and the Brain follows Schwartz as he investigates this newly discovered power, which he calls self–directed neuroplasticity or, more simply, mental force. It describes his work with noted physicist Henry Stapp and connects the concept of 'mental force' with the ancient practice of mindfulness in Buddhist tradition. And it points to potential new applications that could transform the treatment of almost every variety of neurological dysfunction, from dyslexia to stroke–and could lead to new strategies to help us harness our mental powers. Yet as wondrous as these implications are, perhaps even more important is the philosophical dimension of Schwartz's work. For the existence of mental force offers convincing scientific evidence of human free will, and thus of man's inherent capacity for moral choice.

    Mindsight allows you to make positive changes in your brain-and in your life.- Is there a memory that torments you, or an irrational fear you can' t shake?- Do you sometimes become unreasonably angry or upset and find it hard to calm down?- Do you ever wonder why you can't stop behaving the way you do, no matter how hard you try?- Are you and your child (or parent, partner, or boss) locked in a seemingly inevitable pattern of conflict?What if you could escape traps like these and live a fuller, richer, happier life? This isn't mere speculation but the result of twenty-five years of careful hands-on clinical work by Daniel J. Siegel, M.D. A Harvard-trained physician, Dr. Siegel is one of the revolutionary global innovators in the integration of brain science into the practice of psychotherapy. Using case histories from his practice, he shows how, by following the proper steps, nearly everyone can learn how to focus their attention on the internal world of the mind in a way that will literally change the wiring and architecture of their brain.Through his synthesis of a broad range of scientific research with applications to everyday life, Dr. Siegel has developed novel approaches that have helped hundreds of patients heal themselves from painful events in the past and liberate themselves from obstacles blocking their happiness in the present. And now he has written the first book that will help all of us understand the potential we have to create our own lives. Showing us mindsight in action, Dr. Siegel describes- a sixteen-year-old boy with bipolar disorder who uses meditation and other techniques instead of drugs to calm the emotional storms that made him suicidal- a woman paralyzed by anxiety, who uses mindsight to discover, in an unconscious memory of a childhood accident, the source of her dread- a physician-the author himself-who pays attention to his intuition, which he experiences as a "vague, uneasy feeling in my belly, a gnawing restlessness in my heart and my gut," and tracks down a patient who could have gone deaf because of an inaccurately written prescription for an ear infection- a twelve-year-old girl with OCD who learns a meditation that is "like watching myself from outside myself" and, using a form of internal dialogue, is able to stop the compulsive behaviors that have been tormenting herThese and many other extraordinary stories illustrate how mindsight can help us master our emotions, heal our relationships, and reach our fullest potential.A book as inspiring as it is informative, as practical as it is profound, Mindsight offers exciting new proof that we aren't hardwired to behave in certain ways, but instead have the ability to harness the power of our minds to resculpt the neural pathways of our brains in ways that will be life-transforming.

    Structured around a plane journey that sees encounters with substances from water and glue to coffee and wine, Liquid Rules shows how these liquids can bring death and destruction as well as wonder and fascination.From László Bíró's revolutionary pen and Abraham Gesner's kerosene to cutting-edge research on self-repairing roads and liquid computers, Miodownik uses his winning formula of scientific storytelling to bring the everyday to life. He reveals why liquids can flow up a tree but down a hill, why oil is sticky, how waves can travel so far, and how to make the perfect cup of tea. Here are the secret lives of substances.

    What is going on? Anatomy of an Epidemic challenges readers to think through that question themselves. First, Whitaker investigates what is known today about the biological causes of mental disorders. Do psychiatric medications fix “chemical imbalances” in the brain, or do they, in fact, create them? Researchers spent decades studying that question, and by the late 1980s, they had their answer. Readers will be startled—and dismayed—to discover what was reported in the scientific journals. Then comes the scientific query at the heart of this book: During the past fifty years, when investigators looked at how psychiatric drugs affected long-term outcomes, what did they find? Did they discover that the drugs help people stay well? Function better? Enjoy good physical health? Or did they find that these medications, for some paradoxical reason, increase the likelihood that people will become chronically ill, less able to function well, more prone to physical illness?  This is the first book to look at the merits of psychiatric medications through the prism of long-term results. Are long-term recovery rates higher for medicated or unmedicated schizophrenia patients? Does taking an antidepressant decrease or increase the risk that a depressed person will become disabled by the disorder? Do bipolar patients fare better today than they did forty years ago, or much worse? When the National Institute of Mental Health (NIMH) studied the long-term outcomes of children with ADHD, did they determine that stimulants provide any benefit?  By the end of this review of the outcomes literature, readers are certain to have a haunting question of their own: Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public?  In this compelling history, Whitaker also tells the personal stories of children and adults swept up in this epidemic. Finally, he reports on innovative programs of psychiatric care in Europe and the United States that are producing good long-term outcomes. Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up.

    The four principles that can help us to overcome our brains' natural biases to make better, more informed decisions -- in our lives, careers, families and organizations.In Decisive, Chip Heath and Dan Heath, the bestselling authors of Made to Stick and Switch, tackle the thorny problem of how to overcome our natural biases and irrational thinking to make better decisions, about our work, lives, companies and careers.    When it comes to decision making, our brains are flawed instruments.  But given that we are biologically hard-wired to act foolishly and behave irrationally at times, how can we do better?  A number of recent bestsellers have identified how irrational our decision making can be.  But being aware of a bias doesn't correct it, just as knowing that you are nearsighted doesn't help you to see better.  In Decisive, the Heath brothers, drawing on extensive studies, stories and research, offer specific, practical tools that can help us to think more clearly about our options, and get out of our heads, to improve our decision making, at work and at home.