With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    She also lectures widely on autism—because Temple Grandin is autistic, a woman who thinks, feels, and experiences the world in ways that are incomprehensible to the rest of us. In this unprecedented book, Grandin delivers a report from the country of autism. Writing from the dual perspectives of a scientist and an autistic person, she tells us how that country is experienced by its inhabitants and how she managed to breach its boundaries to function in the outside world. What emerges in Thinking in Pictures is the document of an extraordinary human being, one who, in gracefully and lucidly bridging the gulf between her condition and our own, sheds light on the riddle of our common identity.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    Carol North was diagnosed with schizophrenia in college. The story of her life is traced from her early life in a middle class small-town family in the Midwest. For many years, Carol struggled against overwhelming odds to achieve in school in spite of her illness and was finally admitted to medical school to pursue her hopes and dreams of becoming a doctor. In medical school, however, she slid further into psychosis and finally succumbed the inexorable incapacitation so often characteristic of the illness. Carol was fortunate enough, however, to find a skilled psychiatrist who understood her dedication to becoming a physician and who worked with her to stay well enough to remain in school. When all hope seemed lost, her doctor enrolled her in an experimental dialysis program, similar to the treatment given to patients with kidney failure. With this treatment, her illness went away and she no longer required medication for it. This engrossing and ultimately triumphant story of courageous struggle against mental illness will inspire anyone who has ever had to battle for achievement against overwhelming odds. After recovering from her illness, Carol returned to school and received her medical degree from Washington University School of Medicine in St. Louis, Missouri in 1983. She then completed her internship and residency at Barnes Hospital/Washington University, and subsequently obtained a masters degree in psychiatric epidemiology (the study of psychiatric disorders in populations) while simultaneously pursuing a NIMH fellowship in psychiatric epidemiology at Washington University. Dr. Carol North is currently a board-certified psychiatrist and full Professor of Psychiatry at Washington University School of Medicine. She treats patients with schizophrenia and a range of psychiatric illness, trains young physicians and psychiatrists, and pursues federally funded research in psychiatric epidemiology. She is the recipient of numerous national awards and has appeared on many national television and radio programs.

    Topics covered include Bi-polar disorder, self harming, suicide, depression and theauthor also shows how for some famous people mental disorders were part of what may have made them great. Frank, hard hitting and moving.

    When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    By investing some of the lesser-known corners of psychology, neuroscience, physics, history, and even crime, all through the lens of trickery and illusion, Fooling Houdini arrives at a host of startling revelations about how the mind works--and why, sometimes, it doesn’t.

    It tells the story of the epic line of cell research that is right now coming together with discoveries that take us across the borders of biology into some of its most fascinating and bewildering frontiers, including cloning, genomic, molecular genetics, genetic engineering, and embryonic stem cells. This is a book that explores the moment when life science in the pursuit of medicine achieves the power to direct new steps in the evolution of the human body and spirit.The story is told through the lives of two amazing brothers: Stephen Heywood, a carpenter, who discovers he has A.L.S., a gradual, mysterious deterioration of the nervous system, also known as Lou Gehrig `s disease, and Jamie Heywood, an engineer who quits his lucrative job to start a foundation where he obsessively works with cutting-edge scientists in a race to find a cure. Through this remarkable journey with a family in crisis, we are given an overview of the various gene therapies that are still on the horizon, capable of potentially bringing back those suffering from such neurological diseases as A.L.S., Alzheimer's, Parkinson's, and other various disorders of the brain. Through the translucent prose of Jonathan Weiner, we experience not only the passion and torment of the Heywoods, but we learn a vast amount about the groundbreaking technologies that may one day save our own lives and certainly change the way we live them.

    Without warning, life as they knew it changed as paranoid schizophrenia overtook Sally. Whether it was accusing Laura’s father of trying to win her over to the side of Satan, or buying only certain products that were evil-free, glimmers of her mother’s future paranoia grew brighter as Laura’s early years passed. Once her husband left the family and filed for divorce, Sally’s symptoms bloomed in earnest, and the three girls united in flights of fancy of the sort their mother had taught them in order to deflect danger. Set in 1970s San Francisco, Swallow the Ocean is a searing, beautifully written memoir of a childhood under siege and three young girls determined to survive. In luminous prose, this memoir paints a most intimate portrait of what might have been a catastrophic childhood.

    In his madness, the world was revealed to him as an enormous architecture of nerves, dominated by a predatory God. It became clear to Schreber that his personal crisis was implicated in what he called a "crisis in God's realm," one that had transformed the rest of humanity into a race of fantasms. There was only one remedy; as his doctor noted: Schreber "considered himself chosen to redeem the world, and to restore to it the lost state of Blessedness. This, however, he could only do by first being transformed from a man into a woman...."

    Styron is perhaps the first writer to convey the full terror of depression's psychic landscape, as well as the illuminating path to recovery.

    Yet estimates are that upwards of eight million Americans are chronic self-injurers. They are people who use knives, razor blades, or broken glass to cut themselves. Their numbers include the actor Johnny Depp, Girl Interrupted author Susanna Kaysen, and the late Princess Diana.Mistakenly viewed as suicide attempts or senseless masochism--even by many health professionals--"cutting" is actually a complex means of coping with emotional pain. Marilee Strong explores this hidden epidemic through case studies, startling new research from psychologists, trauma experts, and neuroscientists, and the heartbreaking insights of cutters themselves--who range from troubled teenagers to middle-age professionals to grandparents. Strong explains what factors lead to self-mutilation, why cutting helps people manage overwhelming fear and anxiety, and how cutters can heal both their internal and external wounds and break the self-destructive cycle. A Bright Red Scream is a groundbreaking, essential resource for victims of self-mutilation, their families, teachers, doctors, and therapists.

    "A graphic account of what it's like when a doctor crosses to the other side of the table and becomes a patient himself."—Parade Magazine

    Yalom uncovers the mysteries, frustrations, pathos, and humor at the heart of the therapeutic encounter. In recounting his patients' dilemmas, Yalom not only gives us a rare and enthralling glimpse into their personal desires and motivations but also tells us his own story as he struggles to reconcile his all-too human responses with his sensibility as a psychiatrist. Not since Freud has an author done so much to clarify what goes on between a psychotherapist and a patient.

    Just twelve, she’s tall, skinny, and weak. It’s four o’clock, and she hasn’t been allowed to eat anything all day. Her mother, on the other hand, seems curiously excited. She's about to suggest open-heart surgery on her child to "get to the bottom of this." She checks her teeth for lipstick and, as the doctor enters, shoots the girl a warning glance. This child will not ruin her plans.SickenedFrom early childhood, Julie Gregory was continually X-rayed, medicated, and operated on—in the vain pursuit of an illness that was created in her mother’s mind. Munchausen by proxy (MBP) is the world’s most hidden and dangerous form of child abuse, in which the caretaker—almost always the mother—invents or induces symptoms in her child because she craves the attention of medical professionals. Many MBP children die, but Julie Gregory not only survived, she escaped the powerful orbit of her mother's madness and rebuilt her identity as a vibrant, healthy young woman.Sickened is a remarkable memoir that speaks in an original and distinctive Midwestern voice, rising to indelible scenes in prose of scathing beauty and fierce humor. Punctuated with Julie's actual medical records, it re-creates the bizarre cocoon of her family's isolated double-wide trailer, their wild shopping sprees and gun-waving confrontations, the astonishing naïveté of medical professionals and social workers. It also exposes the twisted bonds of terror and love that roped Julie's family together—including the love that made a child willing to sacrifice herself to win her mother's happiness. The realization that the sickness lay in her mother, not in herself, would not come to Julie until adulthood. But when it did, it would strike like lightning. Through her painful metamorphosis, she discovered the courage to save her own life—and, ultimately, the life of the girl her mother had found to replace her. Sickened takes us to new places in the human heart and spirit. It is an unforgettable story, unforgettably told.