How do you identify a serial killer?What are the tell-tale signs of guilt?Can we now solve the unsolvable?Since even before the first season of Silent Witness in 1996, forensic science has played an increasingly important role in the investigation of violent crimes.With a boom in cold-blooded cases throughout the 1980s, police began to rely on DNA evidence to help them find perpetrators and since then forensic science has taken off as a powerful tool in solving murders. Bestselling true crime author Wensley Clarkson takes us beyond the headlines to examine the real-life stories where forensics have played a crucial role. He speaks to experts who have worked on the most gruesome, most chilling and most shocking crime scenes and explains how notorious criminal cases from across the world were solved.And he shows how the silent witness is often the one who screams the loudest.

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    Their reactions inspired her to compile her experiences. The result was Call It, an entertaining and refreshingly honest memoir of her nursing career. Follow her in the adrenaline charged Emergency Department, the Intensive Care Unit and during her daily routine as an Infection Control Nurse. She also worked as a Quality Improvement nurse and Case Manager for the health insurance industry. The book details successes, failures and some great laughs in every area. Medical show afficionados will not be disappointed and student nurses might learn some valuable lessons and insight about potential career paths.

    The ability to duplicate that process in a lab, once thought impossible, may now be closer than we think. Today, teams of scientists around the world are being assembled by the boldest entrepreneurs, big business, and governments to solve what is the most difficult technological challenge humanity has ever faced: building the equivalent of a star on earth. If their plans to capture star power are successful, they will unlock thousands, potentially millions, of years of clean, carbon-free energy. Not only would controlled nuclear fusion help solve the climate crisis, it could also make other highly desired technological ambitions possible—like journeying to the stars. Given the rising alarm over deterioration of the environment, and the strides being made in laser and magnetic field technology, powerful momentum is gathering behind fusion and the possibilities it offers. In The Star Builders, award-winning young plasma physicist Arthur Turrell “offers an optimistic outlook for the future of fusion power and is adamant about the need to invest in it” (The New York Times). Turrell describes fascinating star machines with ten times as many parts as the NASA Space Shuttle, and structures that extend over 400 acres in an accessible and entertaining account, spotlighting the individuals, firms, and institutions racing for the finish line: science-minded entrepreneurs like Jeff Bezos and Peter Thiel, companies like Goldman Sachs and Google, universities like Oxford and MIT, and virtually every rich nation. It’s an exciting and game-changing international quest that will make all of us winners.

    We all have one, but most of us will never see one. The heart surgeon now has that privilege but, for centuries, the heart was out of reach even for surgeons. So when a surgeon nowadays opens up a ribcage and mends a heart, it remains something of a miracle, even if, to some, it is merely plumbing. As with plumbers, the quality of surgeons’ work varies. As with plumbers, surgeons’ opinion of their own prowess and their own attitude to risk are not always reliable. Measurement is key. We’ve had a century of effective evidence-based medicine. We’ve had barely a decade of thorough monitoring of clinical outcomes. Thanks to the ground-breaking risk modelling of pioneering surgeons like Samer Nashef, we at last know how to judge whether an operation is in a patient’s best interest, which hospital and surgeon would be best for that operation, when it might best be performed and what the exact level of risk is. We have at last made what is important in surgery measurable. But how should surgeons, and their patients, use these newfound insights? Ever since his days as a medical student, Samer Nashef has challenged the medical profession to be more open and more accurate about the success of surgical procedures, for the sake of the patients. In The Naked Surgeon, he unclothes his own profession to demonstrate to his reader (and prospective patient) many revelations, such as the paradox at the heart of the cardiac surgeon’s craft: the more an operation is likely to kill you, the better it is for you. And he does so with absolute clarity, fluency and not a little wit.

    This is a disturbing, well-researched wake-up call for improving the current system of drug supply and manufacturing.Several decades ago, penicillin, vitamin C, and many other prescription and over-the-counter products were manufactured in the United States. But with the rise of globalization, antibiotics, antidepressants, birth control pills, blood pressure medicines, cancer drugs, among many others are made in China and sold in the United States. China's biggest impact on the US drug supply is making essential ingredients for thousands of medicines found in American homes and used in hospital intensive care units and operating rooms. The authors convincingly argue that there are at least two major problems with this scenario. First, it is inherently risky for the United States to become dependent on any one country as a source for vital medicines, especially given the uncertainties of geopolitics. For example, if an altercation in the South China Sea causes military personnel to be wounded, doctors may rely upon medicines with essential ingredients made by the adversary. Second, lapses in safety standards and quality control in Chinese manufacturing are a risk. Citing the concerns of FDA officials and insiders within the pharmaceutical industry, the authors document incidents of illness and death caused by contaminated medications that prompted reform. This probing book examines the implications of our reliance on China on the quality and availability of vital medicines.

    In One Renegade Cell, Weinberg presents a state-of-the-art account of how cancer begins and how, one day, it will be cured.

    Lewis Dartnell considers some of the fascinating questions facing researchers today. Could life exist anywhere else in the universe? What might aliens really look like? Dartnell explains why Earth is uniquely suited for life and reveals our profound connection to the cosmos.

    In this groundbreaking analysis, over thirty of the most popular treatments—acupuncture, homeopathy, aromatherapy, reflexology, chiropractic, and herbal medicines—are examined for their benefits and potential dangers. Questions answered include: What works and what doesn't? What are the secrets, and what are the lies? Who can you trust, and who is ripping you off? Can science decide what is best, or do the old wives' tales really tap into ancient, superior wisdom?In their scrutiny of alternative and complementary cures, authors Simon Singh and Edzard Ernst also strive to reassert the primacy of the scientific method as a means for determining public health practice and policy.

    We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise.So we've all heard of genes, but how do they actually work?According to legend, Ernest Hemingway was once given a six-toed cat by an old sea captain, and her distinctive descendants still roam the writer's Florida estate today. Scientists now know that the fault driving this profusion of digits lies in a tiny genetic control switch, miles away (in molecular terms) from the gene that 'makes' toes. And it's the same mistake that gives rise to multi-toed humans too.There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. And figuring out how it all works – how your genes make you, you – is a major challenge for researchers around the world.Drawing on stories ranging from six-toed cats and stickleback hips to wobbly worms and zombie genes, geneticist Kat Arney explores the how our genes work, creating a companion reader to the book of life itself.

    It combines the latest findings from the field of neuroscience with expert text and state-of-the-art illustrations and imaging techniques to provide an incomparable insight into every facet of the brain. Layer by layer, it reveals the fascinating details of this remarkable structure, covering all the key anatomy and delving into the inner workings of the mind, unlocking its many mysteries, and helping you to understand what's going on in those millions of little gray and white cells.Tricky concepts are illustrated and explained with clarity and precision, as The Human Brain Book looks at how the brain sends messages to the rest of the body, how we think and feel, how we perform unconscious actions (for example breathing), explores the nature of genius, asks why we behave the way we do, explains how we see and hear things, and how and why we dream. Physical and psychological disorders affecting the brain and nervous system are clearly illustrated and summarized in easy-to-understand terms.The unique DVD brings the subject to life with interactive elements. These include a clickable model of the brain's structure that allows the user to zoom in and discover deeper layers of detail, while complex processes, such as the journey of a nerve impulse, are broken down and simplified through intuitive animations.

    

    While some books explore our genetic inheritance and popular television shows celebrate ancestry, this is the first book to explore how everything from DNA to emotions to names and the stories that form our lives are all part of our human legacy. This book shows how trust is inherited in Africa, silence is passed down in Tasmania, and how the history of nations is written in our DNA. From fateful, ancient encounters to modern mass migrations and medical diagnoses, Kenneally explains how the forces that shaped the history of the world ultimately shape each human who inhabits it. The Invisible History of the Human Race is a deeply researched, carefully crafted, and provocative perspective on how our stories, psychology, and genetics affect our past and our future.

    His trademark combination of deep scientific understanding and entertaining writing style has thrilled his huge and devoted audience for years. Now, in Skeptic, seventy-five of these columns are available together for the first time; a welcome addition for his fans and a stimulating introduction for new readers.

    It is written to impart a sense of intellectual history of biochemistry, an understanding of the tools and approaches used to solve biochemical puzzles, and a hint of the excitement that accompanies new discoveries. This edition has been thoroughly updated to reflect the most recent advances in biochemistry, particularly in the areas of genomics and structural biology. A new chapter focuses on cytoskeletal and motor proteins, currently one of the most active areas of research in biochemistry.