Even before recorded history began, disease plagued human civilizations, claiming more lives than natural disasters and warfare combined. The ongoing battle with new and resurgent diseases has challenged physicians, scientists, and historians in their struggle to identify causes, antidotes, and preventative measures to combat these epidemics. Analyzing case studies including the Black Death, Spanish Flu, cholera, leprosy, syphilis, cancer, and Ebola, this book systematically maps the development of trends and the latest research on disease into a concise and enlightening timeline. Offering a fascinating and compelling insight into a popular area of social history, this easy-to-read introduction will tell you all you need to know about disease and the ongoing quest to protect human health.

    This trial serves as the backdrop for Superbugs, and the results will impact nothing less than the future of humanity.Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more.

    From the start, the drug's manufacturer aggressively marketed its patented time-release formula as a breakthrough in the effort to reduce prescription drug abuse. It wasn't long, however, before thrill-seeking teenagers shattered that illusion of safety; by simply crushing an "Oxy," they were able to tap into a high so seductive it would come to dominate their lives. Some patients, seeking relief from pain, also found themselves drawn to the drug's dark side. Pain Killer takes readers on a journey of discovery that begins with the true story of Lindsay, a high-school cheerleader in Virginia who gets hooked on Oxys, and expands outward to explore the critical issues of legitimate pain management, prescription drug abuse, and how the misuse of science by the drug industry threatens the public good. With the fast-rising abuse of prescription drugs by young people ringing alarm bells within government, the how and why behind the OxyContin disaster is a gripping read not only for parents, but also for medical professionals, community leaders, business executives, and all those concerned with this crisis. The dangers described in Pain Killer also reverberate far beyond the threat from a single drug at a particular moment in time. The focus of our government's war on drugs has clearly misled many of us into thinking that only illegal drugs smuggled from beyond our borders can be abused. As Meier tells the dramatic story, some of the most deadly substances are produced and sold legally right here at home.THE EXTRAORDINARY AND TRUE STORY OF OXYCONTIN EQUAL PARTS crime thriller, medical detective story, and business exposé, Pain Killer takes a hard-hitting look at how a powerful drug touted as the salvation for millions triggered a national tragedy. At its inception, the legal narcotic OxyContin was seen as a pharmaceutical dream, a "wonder" drug that would herald a sea change in medical care while reaping vast profits for its maker. It did do that; but it also unleashed a public health crisis that cut a swath of despair and crime through unsuspecting small towns, suburbs, and cities across the country. As reports of OxyContin overdoses made front-page and network news, doctors, narcotics agents, regulators, industry executives, and lawmakers raced in, scrambling to slow the damage. Behind it all stood one of America's wealthiest families, and a drug company whose relentless promotion helped fuel the problem Written by award-winning journalist Barry Meier, whose special report in the New York Times triggered national interest in OxyContin, Pain Killer chronicles the rise of the multibillion dollar pain management industry and lays bare its excesses and abuses.

    A “spirit photographer,” William Mumler took portrait photographs that featured the ghostly presence of a lost loved one alongside the living subject. Mumler was a sensation: The affluent and influential came calling, including Mary Todd Lincoln, who arrived at his studio in disguise amidst rumors of séances in the White House.Peter Manseau brilliantly captures a nation wracked with grief and hungry for proof of the existence of ghosts and for contact with their dead husbands and sons. It took a circus-like trial of Mumler on fraud charges, starring P. T. Barnum for the prosecution, to expose a fault line of doubt and manipulation. And even then, the judge sided with the defense — nobody ever solved the mystery of his spirit photography. This forgotten puzzle offers a vivid snapshot of America at a crossroads in its history, a nation in thrall to new technology while clinging desperately to belief.

    But American Overdose exposes the powerful forces they were up against, including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers--resulting in the resurgence of heroin cartels in the American heartland. McGreal tells the story, in terms both broad and intimate, of people hit by a catastrophe they never saw coming. Years in the making, its ruinous consequences will stretch years into the future.

    California’s gold drew fortune-seekers from the ends of the earth. It accelerated America’s imperial expansion and exacerbated the tensions that exploded in the Civil War. And, as H. W. Brands makes clear in this spellbinding book, the Gold Rush inspired a new American dream—the “dream of instant wealth, won by audacity and good luck.”Brands tells his epic story from multiple perspectives: of adventurers John and Jessie Fremont, entrepreneur Leland Stanford, and the wry observer Samuel Clemens—side by side with prospectors, soldiers, and scoundrels. He imparts a visceral sense of the distances they traveled, the suffering they endured, and the fortunes they made and lost. Impressive in its scholarship and overflowing with life, The Age of Gold is history in the grand traditions of Stephen Ambrose and David McCullough.

    Unable to stand, barely able to think, he waited for hours in an emergency room before being correctly diagnosed and rushed into surgery. Over the next few days, as he clung to life and the first light of a new year came through his window, he found himself reflecting on the fragility of health, not recognized in America as a human right but without which all rights and freedoms have no meaning.And that was before the pandemic. We have since watched American hospitals, long understaffed and undersupplied, buckling under waves of coronavirus patients. The federal government made matters worse through willful ignorance, misinformation, and profiteering. Our system of commercial medicine failed the ultimate test, and thousands of Americans died.In this eye-opening cri de coeur, Snyder traces the societal forces that led us here and outlines the lessons we must learn to survive. In examining some of the darkest moments of recent history and of his own life, Snyder finds glimmers of hope and principles that could lead us out of our current malaise. Only by enshrining healthcare as a human right, elevating the authority of doctors and medical knowledge, and planning for our children's future can we create an America where everyone is truly free.

    Many black residents were poor sharecroppers, but others owned their own farms and the land on which they’d founded the county’s thriving black churches.But then in September of 1912, three young black laborers were accused of raping and murdering a white girl. One man was dragged from a jail cell and lynched on the town square, two teenagers were hung after a one-day trial, and soon bands of white “night riders” launched a coordinated campaign of arson and terror, driving all 1,098 black citizens out of the county. In the wake of the expulsions, whites harvested the crops and took over the livestock of their former neighbors, and quietly laid claim to “abandoned” land. The charred ruins of homes and churches disappeared into the weeds, until the people and places of black Forsyth were forgotten.National Book Award finalist Patrick Phillips tells Forsyth’s tragic story in vivid detail and traces its long history of racial violence all the way back to antebellum Georgia. Recalling his own childhood in the 1970s and ’80s, Phillips sheds light on the communal crimes of his hometown and the violent means by which locals kept Forsyth “all white” well into the 1990s.Blood at the Root is a sweeping American tale that spans the Cherokee removals of the 1830s, the hope and promise of Reconstruction, and the crushing injustice of Forsyth’s racial cleansing. With bold storytelling and lyrical prose, Phillips breaks a century-long silence and uncovers a history of racial terrorism that continues to shape America in the twenty-first century.

    Seward, Salmon P. Chase, Edward Bates, and Abraham Lincoln waited in their hometowns for the results from the Republican National Convention in Chicago. When Lincoln emerged as the victor, his rivals were dismayed and angry.Throughout the turbulent 1850s, each had energetically sought the presidency as the conflict over slavery was leading inexorably to secession and civil war. That Lincoln succeeded, Goodwin demonstrates, was the result of a character that had been forged by experiences that raised him above his more privileged and accomplished rivals. He won because he possessed an extraordinary ability to put himself in the place of other men, to experience what they were feeling, to understand their motives and desires.It was this capacity that enabled Lincoln as president to bring his disgruntled opponents together, create the most unusual cabinet in history, and marshal their talents to the task of preserving the Union and winning the war.We view the long, horrifying struggle from the vantage of the White House as Lincoln copes with incompetent generals, hostile congressmen, and his raucous cabinet. He overcomes these obstacles by winning the respect of his former competitors, and in the case of Seward, finds a loyal and crucial friend to see him through.This brilliant multiple biography is centered on Lincoln's mastery of men and how it shaped the most significant presidency in the nation's history.

    Filled with vivid personalities, gossipy anecdotes, grand houses, and a wealth of period details--plus photographs, illustrations, quotes, and the finer points of Victorian and Edwardian etiquette--To Marry An English Lord is social history at its liveliest and most accessible.

    Outbreak! catalogs fifty of those incidents in gruesome detail, including:The Sweating Sickness that killed 15,000, including Henry VIII's older brotherSyphilis, the "French Disease," which spread throughout Europe in the late fifteenth centuryThe romantic disease: tuberculosis, featured in La Boheme, La Traviata, and Les MiserablesThe worldwide outbreak of influenza in 1918, which killed 3 percent of the populationThe mysterious appearance of HIV in the 1980sThe devastating spread of Ebola in West Africa in 2014From ancient outbreaks of smallpox and plague to modern epidemics such as SARS and Ebola, the stories capture the mystery and devastation brought on by these diseases. It's a sickeningly fun read that confirms the true definition of going viral.

    The American experiment rests on three ideas—“these truths,” Jefferson called them—political equality, natural rights, and the sovereignty of the people. But has the nation, and democracy itself, delivered on that promise?These Truths tells this uniquely American story, beginning in 1492, asking whether the course of events over more than five centuries has proven the nation’s truths, or belied them. To answer that question, Lepore wrestles with the state of American politics, the legacy of slavery, the persistence of inequality, and the nature of technological change. “A nation born in contradiction… will fight, forever, over the meaning of its history,” Lepore writes, but engaging in that struggle by studying the past is part of the work of citizenship. With These Truths, Lepore has produced a book that will shape our view of American history for decades to come.

    Here renowned historian Stephen Sears draws on a remarkable cache of diaries, dispatches, and letters to recreate the vivid drama of Antietam as experienced not only by its leaders but also by its soldiers, both Union and Confederate, to produce what the New York Times Book Review has called "the best account of the Battle of Antietam."

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.