Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA.We learn that Neanderthal genes offer a unique window into the lives of our hominin relatives and may hold the key to unlocking the mystery of why humans survived while Neanderthals went extinct. Drawing on genetic and fossil clues, Pääbo explores what is known about the origin of modern humans and their relationship to the Neanderthals and describes the fierce debate surrounding the nature of the two species’ interactions. His findings have not only redrawn our family tree, but recast the fundamentals of human history—the biological beginnings of fully modern Homo sapiens, the direct ancestors of all people alive today.A riveting story about a visionary researcher and the nature of scientific inquiry, Neanderthal Man offers rich insight into the fundamental question of who we are.

    In their new book, Stephen Hawking and Leonard Mlodinow present the most recent scientific thinking about the mysteries of the universe, in nontechnical language marked by both brilliance and simplicity. In The Grand Design they explain that according to quantum theory, the cosmos does not have just a single existence or history, but rather that every possible history of the universe exists simultaneously. When applied to the universe as a whole, this idea calls into question the very notion of cause and effect. But the “top-down” approach to cosmology that Hawking and Mlodinow describe would say that the fact that the past takes no definite form means that we create history by observing it, rather than that history creates us. The authors further explain that we ourselves are the product of quantum fluctuations in the very early universe, and show how quantum theory predicts the “multiverse”—the idea that ours is just one of many universes that appeared spontaneously out of nothing, each with different laws of nature.Along the way Hawking and Mlodinow question the conventional concept of reality, posing a “model-dependent” theory of reality as the best we can hope to find. And they conclude with a riveting assessment of M-theory, an explanation of the laws governing us and our universe that is currently the only viable candidate for a complete “theory of everything.” If confirmed, they write, it will be the unified theory that Einstein was looking for, and the ultimate triumph of human reason.A succinct, startling, and lavishly illustrated guide to discoveries that are altering our understanding and threatening some of our most cherished belief systems, The Grand Design is a book that will inform—and provoke—like no other.'

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    The book was based on a course of public lectures delivered by Schrödinger in February 1943 at Trinity College, Dublin. Schrödinger's lecture focused on one important question: "how can the events in space and time which take place within the spatial boundary of a living organism be accounted for by physics and chemistry?" In the book, Schrödinger introduced the idea of an "aperiodic crystal" that contained genetic information in its configuration of covalent chemical bonds. In the 1950s, this idea stimulated enthusiasm for discovering the genetic molecule and would give both Francis Crick and James Watson initial inspiration in their research.

    But what if science itself can’t be relied on?Medicine, education, psychology, health, parenting – wherever it really matters, we look to science for advice. Science Fictions reveals the disturbing flaws that undermine our understanding of all of these fields and more.While the scientific method will always be our best and only way of knowing about the world, in reality the current system of funding and publishing science not only fails to safeguard against scientists’ inescapable biases and foibles, it actively encourages them. From widely accepted theories about ‘priming’ and ‘growth mindset’ to claims about genetics, sleep, microbiotics, as well as a host of drugs, allergies and therapies, we can trace the effects of unreliable, overhyped and even fraudulent papers in austerity economics, the anti-vaccination movement and dozens of bestselling books – and occasionally count the cost in human lives.Stuart Ritchie was among the first people to help expose these problems. In this vital investigation, he gathers together the evidence of their full and shocking extent – and how a new reform movement within science is fighting back. Often witty yet deadly serious, Science Fictions is at the vanguard of the insurgency, proposing a host of remedies to save and protect this most valuable of human endeavours from itself.

    "One of today's best popularizers of science." —Kirkus Reviews.Loyal readers of the monthly "Universe" essays in Natural History magazine have long recognized Neil deGrasse Tyson's talent for guiding them through the mysteries of the cosmos with stunning clarity and almost childlike enthusiasm. Here, Tyson compiles his favorite essays across a myriad of cosmic topics. The title essay introduces readers to the physics of black holes by explaining the gory details of what would happen to your body if you fell into one. "Holy Wars" examines the needless friction between science and religion in the context of historical conflicts. "The Search for Life in the Universe" explores astral life from the frontiers of astrobiology. And "Hollywood Nights" assails the movie industry's feeble efforts to get its night skies right. Known for his ability to blend content, accessibility, and humor, Tyson is a natural teacher who simplifies some of the most complex concepts in astrophysics while simultaneously sharing his infectious excitement about our universe.

      In the past few years, a handful of scientists have been in a race to explain a disturbing aspect of our universe: only 4 percent of it consists of the matter that makes up you, me, our books, and every planet, star, and galaxy. The rest—96 percent of the universe—is completely unknown.   Richard Panek tells the dramatic story of how scientists reached this conclusion, and what they’re doing to find this "dark" matter and an even more bizarre substance called dark energy. Based on in-depth, on-site reporting and hundreds of interviews—with everyone from Berkeley’s feisty Saul Perlmutter and Johns Hopkins’s meticulous Adam Riess to the quietly revolutionary Vera Rubin—the book offers an intimate portrait of the bitter rivalries and fruitful collaborations, the eureka moments and blind alleys, that have fueled their search, redefined science, and reinvented the universe.

    Weaving together the cosmos' history and our own in an expanding intellectual adventure story, Dark Matter and the Dinosaurs takes us from the mysteries of dark matter and our cosmic environment to the conditions for life on Earth.Sixty-six million years ago, an object the size of a city descended from space to crash into Earth, creating a cataclysm that killed off the dinosaurs, along with three-quarters of the other species on the planet. What was its origin? Randall proposes it was a comet that was dislodged from its orbit as the Solar System passed through a disk of dark matter that is embedded in the plane of the Milky Way. Her research challenges the usual assumptions about the simple nature of dark matter and demonstrates how scientists formulate and establish new ideas. In a sense, it might have been dark matter that killed the dinosaurs.With her unique and wide-ranging perspective, Randall connects dark matter to the history of the world in the broadest terms. Bringing in pop culture and social and political viewpoints, she shares with us the latest findings—established and speculative—regarding dark matter, the cosmos, the galaxy, asteroids, comets, and impacts, as well as life's development and extinctions. Randall makes clear how connected the planet is to the makeup of the Universe, but also how fragile our place in the Universe, which evolved over billions of years, might be.In this brilliant and fresh exploration of our cosmic environment, Professor Randall explains the underlying science of our world in the breathtaking tale of a Universe in which the small and the large, the visible and the hidden are intimately related. Dark Matter and the Dinosaurs illuminates the deep relationships that are critical to our world as well as the astonishing beauty of the structures and connections that surround us. It's impossible to read this book and look at either Earth or sky again in the same way.

    Radiometric dating of nearby rocks indicated the skeleton, classified as Ardipithecus ramidus, was 4.4 million years old, more than a million years older than "Lucy," then the oldest known human ancestor. The findings challenged many assumptions about human evolution--how we started walking upright, how we evolved our nimble hands, and, most significantly, whether we were descended from an ancestor that resembled today's chimpanzee--and repudiated a half-century of paleoanthropological orthodoxy.Fossil Men is the first full-length exploration of Ardi, the fossil men who found her, and her impact on what we know about the origins of the human species. It is a scientific detective story played out in anatomy and the natural history of the human body. Kermit Pattison brings into focus a cast of eccentric, obsessive scientists, including one of the world's greatest fossil hunters, Tim White--an exacting and unforgiving fossil hunter whose virtuoso skills in the field were matched only by his propensity for making enemies; Gen Suwa, a Japanese savant who sometimes didn't bother going home at night to devote more hours to science; Owen Lovejoy, a onetime creationist-turned-paleoanthropologist; Berhane Asfaw, who survived imprisonment and torture to become Ethiopia's most senior paleoanthropologist and who fought for African scientists to gain equal footing in the study of human origins; and the Leakeys, for decades the most famous family in paloanthropology.An intriguing tale of scientific discovery, obsession and rivalry that moves from the sun-baked desert of Africa and a nation caught in a brutal civil war, to modern high-tech labs and academic lecture halls, Fossil Men is popular science at its best, and a must read for fans of Jared Diamond, Richard Dawkins, and Edward O. Wilson.

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    Scientists around the world are currently monitoring the sixth extinction, predicted to be the most devastating extinction event since the asteroid impact that wiped out the dinosaurs. This time around, the cataclysm is us. In prose that is at once frank, entertaining, and deeply informed, The New Yorker writer Elizabeth Kolbert tells us why and how human beings have altered life on the planet in a way no species has before. Interweaving research in half a dozen disciplines, descriptions of the fascinating species that have already been lost, and the history of extinction as a concept, Kolbert provides a moving and comprehensive account of the disappearances occurring before our very eyes. She shows that the sixth extinction is likely to be mankind's most lasting legacy, compelling us to rethink the fundamental question of what it means to be human.

    In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation. Among the questions the obituary—and consequent outcry—prompted were, Who are the role models for today’s female scientists, and where can we find the stories that cast them in their true light?      Headstrong delivers a powerful, global, and engaging response. Covering Nobel Prize winners and major innovators, as well as lesser-known but hugely significant scientists who influence our every day, Rachel Swaby’s vibrant profiles span centuries of courageous thinkers and illustrate how each one’s ideas developed, from their first moment of scientific engagement through the research and discovery for which they’re best known. This fascinating tour reveals these 52 women at their best—while encouraging and inspiring a new generation of girls to put on their lab coats.

    But evolutionary biologists also point out many examples of contingency, cases where the tiniest change--a random mutation or an ancient butterfly sneeze--caused evolution to take a completely different course. What role does each force really play in the constantly changing natural world? Are the plants and animals that exist today, and we humans ourselves, inevitabilities or evolutionary freaks? And what does that say about life on other planets?Jonathan Losos reveals what the latest breakthroughs in evolutionary biology can tell us about one of the greatest ongoing debates in science. He takes us around the globe to meet the researchers who are solving the deepest mysteries of life on Earth through their work in experimental evolutionary science. Losos himself is one of the leaders in this exciting new field, and he illustrates how experiments with guppies, fruit flies, bacteria, foxes, and field mice, along with his own work with anole lizards on Caribbean islands, are rewinding the tape of life to reveal just how rapid and predictable evolution can be.Improbable Destinies will change the way we think and talk about evolution. Losos's insights into natural selection and evolutionary change have far-reaching applications for protecting ecosystems, securing our food supply, and fighting off harmful viruses and bacteria. This compelling narrative offers a new understanding of ourselves and our role in the natural world and the cosmos.

    And before there were fish in the sea, there were cephalopods - the ancestors of modern squid and Earth’s first truly substantial animals. Cephalopods became the first creatures to rise from the seafloor, essentially inventing the act of swimming. With dozens of tentacles and formidable shells, they presided over an undersea empire for millions of years. But when fish evolved jaws, the ocean’s former top predator became its most delicious snack. Cephalopods had to step up their game. Many species streamlined their shells and added defensive spines, but these enhancements only provided a brief advantage. Some cephalopods then abandoned the shell entirely, which opened the gates to a flood of evolutionary innovations: masterful camouflage, fin-supplemented jet propulsion, perhaps even dolphin-like intelligence. Squid Empire is an epic adventure spanning hundreds of millions of years, from the marine life of the primordial ocean to the calamari on tonight’s menu. Anyone who enjoys the undersea world—along with all those obsessed with things prehistoric—will be interested in the sometimes enormous, often bizarre creatures that ruled the seas long before the first dinosaurs.