With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    As recently as 2013, Tim Berners-Lee, often credited as the inventor of the World Wide Web, declared that “piece by piece, website by website, China’s ‘great firewall’ would meet the same fate as the Berlin Wall.” Yet these predictions have been proved wrong. In We Have Been Harmonized, award-winning journalist Kai Strittmatter reveals how the internet and high tech have transformed the power of Chinese authoritarians, allowing them to create the most horrifying surveillance state in history.Advances in technology—facial recognition, GPS tracking, supercomputer databases, mobile phones, high-resolution security cameras—make it nearly impossible for a Chinese citizen to hide anything from authorities. Text messages and emails are instantly stripped of “problematic” words. The year 1989—when the world witnessed the student protests and tragic massacre at Tiananmen Square—has been banished from search results. Cameras scan for “appropriate” facial expressions as they track individuals’ movements. Each citizen is given a score for good behavior. Those who lose points can be banned from traveling, have their internet speed reduced, or even have their toilet paper limited. All of this has happened with the help of Chinese tech companies, as well as the complicity of Western governments and corporations eager to gain access to China’s huge market. While these companies export their technology to authoritarian states around the globe, they are also reshaping American lives via app, smart phones, and computing. Strittmatter’s book is a terrifying portrait of an Orwellian nightmare unlike anything we’ve ever witnessed, and a dire warning about what could happen anywhere.

    In this provocative analysis, leading legal scholar and social critic Dorothy Roberts argues that America is once again at the brink of a virulent outbreak of classifying population by race. By searching for differences at the molecular level, a new race-based science is obscuring racism in our society and legitimizing state brutality against communities of color at a time when America claims to be post-racial.Moving from an account of the evolution of race—proving that it has always been a mutable and socially defined political division supported by mainstream science—Roberts delves deep into the current debates, interrogating the newest science and biotechnology, interviewing its researchers, and exposing the political consequences obscured by the focus on genetic difference. Fatal Invention is a provocative call for us to affirm our common humanity.

    Now, in The Organ Thieves, Pulitzer Prize-nominated journalist Chip Jones exposes the horrifying inequality surrounding Tucker's death and how he was used as a human guinea pig without his family's permission or knowledge. The circumstances surrounding his death reflect the long legacy of mistreating African Americans that began more than a century before with cadaver harvesting and worse. It culminated in efforts to win the heart transplant race in the late 1960s.

    But just before sundown on Good Friday, the community was jolted by the most powerful earthquake in American history, a catastrophic 9.2 on the Richter Scale. For four and a half minutes, the ground lurched and rolled. Streets cracked open and swallowed buildings whole. And once the shaking stopped, night fell and Anchorage went dark. The city was in disarray and sealed off from the outside world.Slowly, people switched on their transistor radios and heard a familiar woman's voice explaining what had just happened and what to do next. Genie Chance was a part-time radio reporter and working mother who would play an unlikely role in the wake of the disaster, helping to put her fractured community back together. Her tireless broadcasts over the next three days would transform her into a legendary figure in Alaska and bring her fame worldwide--but only briefly. That Easter weekend in Anchorage, Genie and a cast of endearingly eccentric characters--from a mountaineering psychologist to the local community theater group staging Our Town--were thrown into a jumbled world they could not recognize. Together, they would make a home in it again.Drawing on thousands of pages of unpublished documents, interviews with survivors, and original broadcast recordings, This Is Chance! is the hopeful, gorgeously told story of a single catastrophic weekend and proof of our collective strength in a turbulent world.There are moments when reality instantly changes--when the life we assume is stable gets upended by pure chance. This Is Chance! is an electrifying and lavishly empathetic portrayal of one community rising above the randomness, a real-life fable of human connection withstanding chaos.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

     NAMED ONE OF THE TEN BEST BOOKS OF THE YEAR BY CHICAGO TRIBUNE AND THE DALLAS MORNING NEWS - "A deft blend of nostalgia, humor and devastating insights."--PeopleRemember all those ingrained habits, cherished ideas, beloved objects, and stubborn preferences from the pre-Internet age? They're gone.To some of those things we can say good riddance. But many we miss terribly. Whatever our emotional response to this departed realm, we are faced with the fact that nearly every aspect of modern life now takes place in filtered, isolated corners of cyberspace--a space that has slowly subsumed our physical habitats, replacing or transforming the office, our local library, a favorite bar, the movie theater, and the coffee shop where people met one another's gaze from across the room. Even as we've gained the ability to gather without leaving our house, many of the fundamentally human experiences that have sustained us have disappeared.In one hundred glimpses of that pre-Internet world, Pamela Paul, editor of The New York Times Book Review, presents a captivating record, enlivened with illustrations, of the world before cyberspace--from voicemails to blind dates to punctuation to civility. There are the small losses: postcards, the blessings of an adolescence largely spared of documentation, the Rolodex, and the genuine surprises at high school reunions. But there are larger repercussions, too: weaker memories, the inability to entertain oneself, and the utter demolition of privacy.100 Things We've Lost to the Internet is at once an evocative swan song for a disappearing era and, perhaps, a guide to reclaiming just a little bit more of the world IRL.

    Mona Hanna-Attisha, alongside a team of researchers, parents, friends, and community leaders, discovered that the children of Flint, Michigan, were being exposed to lead in their tap water--and then battled her own government and a brutal backlash to expose that truth to the world. At the center of the story is Dr. Mona herself--an immigrant, doctor, scientist, and mother whose family's activist roots inspired her pursuit of justice.What the Eyes Don't See is a riveting account of a shameful disaster that became a tale of hope, the story of a city on the ropes that came together to fight for justice, self-determination, and the right to build a better world for their--and all of our--children.

    Chanda Prescod-Weinstein shares her love for physics, from the Standard Model of Particle Physics and what lies beyond it, to the physics of melanin in skin, to the latest theories of dark matter — all with a new spin informed by history, politics, and the wisdom of Star Trek.One of the leading physicists of her generation, Dr. Chanda Prescod-Weinstein is also one of fewer than one hundred Black American women to earn a PhD from a department of physics. Her vision of the cosmos is vibrant, buoyantly non-traditional, and grounded in Black feminist traditions.Prescod-Weinstein urges us to recognize how science, like most fields, is rife with racism, sexism, and other dehumanizing systems. She lays out a bold new approach to science and society that begins with the belief that we all have a fundamental right to know and love the night sky. The Disordered Cosmos dreams into existence a world that allows everyone to tap into humanity’s wealth of knowledge about the wonders of the universe.

    On the one hand, we struggle to survive on our own in the wild, often unable to solve basic problems, like obtaining food, building shelters, or avoiding predators. On the other hand, human groups have produced innovative technologies, sophisticated languages, and complex institutions that have permitted us to successfully expand into environments across the globe. What has enabled us to dominate such a vast range of environments, more than any other species? As this book shows, the secret of our success lies not in our innate intelligence, but in our collective brains--in the ability of human groups to socially interconnect and learn from one another.Drawing insights from lost European explorers, clever chimpanzees, hunter-gatherers, neuroscientists, ancient bones, and the human genome, Joseph Henrich demonstrates how our collective brains have propelled our species' genetic evolution and shaped our biology. Our early capacities for learning from others produced many innovations, such as fire, cooking, water containers, plant knowledge, and projectile weapons, which in turn drove the expansion of our brains and altered our physiology, anatomy, and psychology in crucial ways. Further on, some collective brains generated and recombined powerful concepts, such as the lever, wheel, screw, and writing. Henrich shows how our genetics and biology are inextricably interwoven with cultural evolution, and that this particular culture-gene interaction has propelled our species on an extraordinary evolutionary trajectory.Tracking clues from our ancient past to the present, "The Secret of Our Success" explores how our cultural and social natures produce a collective intelligence that explains both our species' immense success and our human uniqueness.

    A century after its founding, the ACLU remains the nation’s premier defender of the rights and freedoms guaranteed by the Constitution. In collaboration with the ACLU, prize-winning authors Michael Chabon and Ayelet Waldman have curated an anthology of essays about landmark cases in the ACLU’s 100-year history. In Fight of the Century, bestselling and award-winning authors present unique literary takes on historic decisions like Brown v. Board of Education, the Scopes trial, Roe v. Wade, and more. Contributors include Geraldine Brooks, Michael Cunningham, Jennifer Egan, Dave Eggers, Louise Erdrich, Neil Gaiman, Lauren Groff, Marlon James, Viet Thanh Nguyen, Morgan Parker, Ann Patchett, Salman Rushdie, George Saunders, Elizabeth Strout, Jesmyn Ward, Meg Wolitzer, and more. Fight of the Century shows how throughout American history, pivotal legal battles, fought primarily by underdogs and their lawyers, have advanced civil rights and social justice. The ACLU has been integral in this process. The essays range from personal memoir to narrative history, each shedding light on the work of one remarkable organization as it shaped a country. Chabon and Waldman are donating their advance to the ACLU and the contributors are forgoing payment.

    In 1828, when New York City purchased this narrow, two-mile-long island in the East River, it was called Blackwell’s Island. There, over the next hundred years, the city would send its insane, indigent, sick, and criminal. Told through the gripping voices of Blackwell’s inhabitants, as well as the period’s city officials, reformers, and journalists (including the famous Nellie Bly), Stacy Horn has crafted a compelling and chilling narrative.  Damnation Island recreates what daily life was like on the island, what politics shaped it, and what constituted charity and therapy in the nineteenth century. Throughout the book, we return to the extraordinary Blackwell’s missionary Reverend French, champion of the forgotten, as he ministers to these inmates, battles the bureaucratic mazes of the Corrections Department and a corrupt City Hall, testifies at salacious trials, and in his diary wonders about man’s inhumanity to man.   For history fans, and for anyone interested in the ways we care for the least fortunate among us, Damnation Island is an eye-opening look at a closed and secretive world. With a tale that is exceedingly relevant today, Horn shows us how far we’ve come—and how much work still remains.

    Our bodies are hardwired for sweets, so food giants have developed fifty-six types of sugar to add to their products, creating in us the expectation that everything should be cloying; we've evolved to prefer fast, convenient meals, hence our modern-day preference for ready-to-eat foods. Moss goes on to show how the processed food industry--including major companies like Nestlé, Mars, and Kellogg's--has tried not only to evade this troubling discovery about the addictiveness of food but to actually exploit it. For instance, in response to recent dieting trends, food manufacturers have simply turned junk food into junk diets, filling grocery stores with "diet" foods that are hardly distinguishable from the products that got us into trouble in the first place. As obesity rates continue to climb, manufacturers are now claiming to add ingredients that can effortlessly cure our compulsive eating habits. An account of the legal battles, insidious marketing campaigns, and cutting-edge food science that have brought us to our current public health crisis, Moss lays out all that the food industry is doing to exploit and deepen our addictions, and shows us why what we eat has never mattered more.From the #1 New York Times bestselling author of Salt Sugar Fat comes a powerful exposé of how the processed food industry exploits our evolutionary instincts, the emotions we associate with food, and legal loopholes in their pursuit of profit over public health.

    Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological.The Lady's Handbook for Her Mysterious Illness is a memoir with a mission, to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions.Ramey's pursuit of a diagnosis and cure for her own mysterious illness is a medical mystery that she says reveals a new understanding of today's chronic illnesses as ecological in nature, driven by modern changes to the basic foundations of health, from the quality of our sleep, diet, and social connection to the state of our microbiomes.

    But what happens when we take animal alteration a step further, engineering a cat that glows green under ultraviolet light or cloning the beloved family Labrador? Science has given us a whole new toolbox for tinkering with life. How are we using it?In Frankenstein's Cat, the journalist Emily Anthes takes us from petri dish to pet store as she explores how biotechnology is shaping the future of our furry and feathered friends. As she ventures from bucolic barnyards to a "frozen zoo" where scientists are storing DNA from the planet's most exotic creatures, she discovers how we can use cloning to protect endangered species, craft prosthetics to save injured animals, and employ genetic engineering to supply farms with disease-resistant livestock. Along the way, we meet some of the animals that are ushering in this astonishing age of enhancement, including sensor-wearing seals, cyborg beetles, a bionic bulldog, and the world's first cloned cat.Through her encounters with scientists, conservationists, ethicists, and entrepreneurs, Anthes reveals that while some of our interventions may be trivial (behold: the GloFish), others could improve the lives of many species-including our own. So what does biotechnology really mean for the world's wild things? And what do our brave new beasts tell us about ourselves?With keen insight and her trademark spunk, Anthes highlights both the peril and the promise of our scientific superpowers, taking us on an adventure into a world where our grandest science fiction fantasies are fast becoming reality.