Her poignant and uplifting story touched the hearts of millions when it was first published and then made into a memorable television movie. A new introduction contains information on the latest cystic fibrosis research, and a touching postcript reveals how the Deford family came to terms with the loss of Alex.Whenever he speaks, sportswriter Frank Deford knows people will bring articles for him to sign. But what makes him happiest is when someone attends a sports-oriented lecture and brings a copy of Alex: The Life of a Child for him to sign. "Invariably, and happily, there's usually someone at each appearance who either brings that book or wants to talk about their connection to cystic fibrosis." Deford says. "It's tremendously gratifying to me. Rarely does a week go by that I don't get a letter about that book. People leave things at her grave. They really do. I have people tell me that she changed their lives. It's terribly dramatic, but they literally say that. I heard from a woman who became a pediatric nurse after reading the book. Hearing from people like that means more to me than anything."

    She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own--with very different results. Williams's experiences as a patient and a medical test subject reveal with stark honesty what it takes to weather disease, the extraordinary new developments that are rewriting the rules of science--and the healing power of human connection.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Michael Mosley'This book is marvellous: buy it, share it, recommend it.... We are fortunate to have dedicated, caring and humble folks such as Doc Morgan on the Critical Care front line. We are even better off when a writer can capture all that this exciting, mad, glorious and even exasperating job means. If you work in healthcare, know somebody that does, or simply inhabit a body then this book is for you: in fact it's critical.' Peter Brindley, Professor of Critical Care Medicine, Anesthesiology, Medical Ethics University of Alberta'Just wonderful. I love the exploration of what it means to survive, at what cost and so on. Such an important factor and it's a real problem with what we do. An old surgeon once told me ‘just because we can, doesn’t mean we should. Operating is the easiest thing in the world, not doing so is incredibly challenging’. A lovely book.' Dr Nikki Stamp FRACS Cardiothoracic and Transplant Surgeon and author of Can You Die of a Broken Heart?‘An illuminating, compassionate insight into the fascinating world of intensive care.’ Leah Hazzard, author of Hard PushedCritical is an intelligent, compelling and profoundly insightful journey into the world of intensive care medicine and the lives of people who have forever been changed by it. Being critically ill means one or more of your vital organs have failed – this could be your lungs, your heart, your kidneys, gut or even your brain. Starting with the first recognised case in which a little girl was saved by intensive care in 1952 in Copenhagen, Matt writes brilliantly about the fascinating history, practices and technology in this newest of all the major medical specialties. Matt guides us around the ICU by guiding us around the body and the different organs, and in this way, we learn not only the stories of many of the patients he’s treated over the years, but also about the various functions different parts of the body.   He draws on his time spent with real patients, on the brink of death, and explains how he and his colleagues fight against the odds to help them live. Happily many of his cases have happy endings, but Matt also writes movingly about those cases which will always remain with him – the cases where the mysteries of the body proved too hard to solve, or diagnoses came too late or made no difference to the outcome.

    Utilizing his background in medicine, he led the investigations of more than eight thousand individual deaths, becoming a key figure in some of New York’s most bizarre death cases and eventually taking charge of the largest forensic investigation ever attempted: identifying the dead in the aftermath of the September 11 tragedies.Now, in this mesmerizing book, Ribowsky pulls back the curtain on the New York City’s medical examiner’s office, giving an enthralling, never-before-seen glimpse into death and the city. Born and raised in New York City’s orthodox Jewish community, Ribowsky seems an unlikely candidate for this macabre profession. Nevertheless he has forsaken a promising career of medical work with the living, descending instead into the realm of the dead, enticed by the challenge of confronting death on a daily basis. Taking you through the vermin-infested Bowery flophouses and posh Upper East Side apartments of the city’s dead, Ribowsky explores in gruesome detail the skeletons that hang in the Big Apple’s closets. Combing through the autopsy room, he also exposes the grim secrets that only a scalpel and a dead body can tell and explains how forensic investigation does not merely solve crimes—it saves lives.But it is in the aftermath of September 11 that the ME’s office is handed its biggest challenge: to identify as many of the fallen as possible. With poignant descriptions, Ribowsky provides a dramatic account of the office’s diligent and unflappable work with the families of the victims, helping them emerge from the ashes of this tragedy while displaying the strength, grit, intelligence, and compassion that Americans expect from true New Yorkers.At once compelling and heartbreaking, Dead Center is a story of New York unlike any other, blending the haunting with the sublime, while painting a striking portrait of death (and life) in the city that never sleeps.

    But behind her seemingly flawless façade lay a dangerous secret—for the better part of her life Cheney had been battling debilitating bipolar disorder and concealing a pharmacy's worth of prescriptions meant to stabilize her moods and make her "normal."In bursts of prose that mirror the devastating highs and extreme lows of her illness, Cheney describes her roller-coaster life with shocking honesty—from glamorous parties to a night in jail; from flying fourteen kites off the edge of a cliff in a thunderstorm to crying beneath her office desk; from electroshock therapy to a suicide attempt fueled by tequila and prescription painkillers.With Manic, Cheney gives voice to the unarticulated madness she endured. The clinical terms used to describe her illness were so inadequate that she chose to focus instead on her own experience, in her words, "on what bipolar disorder felt like inside my own body." Here the events unfold episodically, from mood to mood, the way she lived and remembers life. In this way the reader is able to viscerally experience the incredible speeding highs of mania and the crushing blows of depression, just as Cheney did. Manic does not simply explain bipolar disorder—it takes us in its grasp and does not let go.In the tradition of Darkness Visible and An Unquiet Mind, Manic is Girl, Interrupted with the girl all grown up. This harrowing yet hopeful book is more than just a searing insider's account of what it's really like to live with bipolar disorder. It is a testament to the sharp beauty of a life lived in extremes.

    Willie Parker grew up in the Deep South, lived in a Christian household, and converted to an even more fundamentalist form of Christianity as a young man. But upon reading an interpretation of the Good Samaritan in a sermon by Dr. Martin Luther King, Jr., he realized that in order to be a true Christian, he must show compassion for all women regardless of their needs. In 2009, he stopped practicing obstetrics to focus entirely on providing safe abortions for the women who need help the most—often women in poverty and women of color—and in the hot bed of the pro-choice debate: the South. He soon thereafter traded in his private practice and his penthouse apartment in Hawaii for the life of an itinerant abortion provider, focusing most recently on women in the Deep South. In Life’s Work, Dr. Willie Parker tells a deeply personal and thought-provoking narrative that illuminates the complex societal, political, religious, and personal realities of abortion in the United States from the unique perspective of someone who performs them and defends the right to do so every day. He also looks at how a new wave of anti-abortion activism, aimed at making incremental changes in laws and regulations state by state, are slowly chipping away at the rights of women to control their own lives. In revealing his daily battle against mandatory waiting periods and bogus rules governing the width of hallways, Dr. Parker uncovers the growing number of strings attached to the right to choose and makes a powerful Christian case for championing reproductive rights.

    Now, on the 150th anniversary of its publication, acclaimed science writer and master of narrative nonfiction Bill Hayes has written the fascinating, never-before-told true story of how this seminal volume came to be. A blend of history, science, culture, and Hayes’s own personal experiences, The Anatomist is this author’s most accomplished and affecting work to date.With passion and wit, Hayes explores the significance of Gray’s Anatomy and explains why it came to symbolize a turning point in medical history. But he does much, much more. Uncovering a treasure trove of forgotten letters and diaries, he illuminates the astonishing relationship between the fiercely gifted young anatomist Henry Gray and his younger collaborator H. V. Carter, whose exquisite anatomical illustrations are masterpieces of art and close observation. Tracing the triumphs and tragedies of these two extraordinary men, Hayes brings an equally extraordinary era–the mid 1800s–unforgettably to life.But the journey Hayes takes us on is not only outward but inward–through the blood and tissue and organs of the human body–for The Anatomist chronicles Hayes’s year as a student of classical gross anatomy, performing with his own hands the dissections and examinations detailed by Henry Gray 150 years ago. As Hayes’s acquaintance with death deepens, he finds his understanding and appreciation of life deepening in unexpected and profoundly moving ways. The Anatomist is more than just the story of a book. It is the story of the human body, a story whose beginning and end we all know and share but that, like all great stories, is infinitely rich in between.

    From the bestselling author of One Child comes the story of three of former special education teacher Torey Hayden’s most extraordinary challenges. Nine-year-old Cassandra, kidnapped by her father and found starving, dirty, and picking through garbage cans—is a child prone to long silences and erratic, violent behavior.Charming, charismatic four-year-old Drake will speak only in private to his mother—while his tough, unbending grandfather's demands for an immediate cure threatens to cause irreparable harm.And though she had never worked with adults, Hayden agrees to help fearful and silent eighty-two-year-old massive stroke victim Gerda—discovering in the process that a treatment's successes could prove nearly as heartbreaking as its limitations.

    They were best friends, confidantes, and partners in the grand adventure of life. For three decades, nothing could separate them. Not college, not marriage, not miles. Then Suzy got sick. She was diagnosed with breast cancer in 1977; three agonizing years later, at thirty-six, she died.It wasn’t supposed to be this way. The Goodman girls were raised in postwar Peoria, Illinois, by parents who believed that small acts of charity could change the world. Suzy was the big sister—the homecoming queen with an infectious enthusiasm and a generous heart. Nancy was the little sister—the tomboy with an outsized sense of justice who wanted to right all wrongs. The sisters shared makeup tips, dating secrets, plans for glamorous fantasy careers. They spent one memorable summer in Europe discovering a big world far from Peoria. They imagined a long life together—one in which they’d grow old together surrounded by children and grandchildren. Suzy’s diagnosis shattered that dream.In 1977, breast cancer was still shrouded in stigma and shame. Nobody talked about early detection and mammograms. Nobody could even say the words “breast” and “cancer” together in polite company, let alone on television news broadcasts. With Nancy at her side, Suzy endured the many indignities of cancer treatment, from the grim, soul-killing waiting rooms to the mistakes of well-meaning but misinformed doctors. That’s when Suzy began to ask Nancy to promise. To promise to end the silence. To promise to raise money for scientific research. To promise to one day cure breast cancer for good. Big, shoot-for-the-moon promises that Nancy never dreamed she could fulfill. But she promised because this was her beloved sister. I promise, Suzy. . . . Even if it takes the rest of my life.Suzy’s death—both shocking and senseless—created a deep pain in Nancy that never fully went away. But she soon found a useful outlet for her grief and outrage. Armed only with a shoebox filled with the names of potential donors, Nancy put her formidable fund-raising talents to work and quickly discovered a groundswell of grassroots support. She was aided in her mission by the loving tutelage of her husband, restaurant magnate Norman Brinker, whose dynamic approach to entrepreneurship became Nancy’s model for running her foundation. Her account of how she and Norman met, fell in love, and managed to achieve the elusive “true marriage of equals” is one of the great grown-up love stories among recent memoirs. Nancy’s mission to change the way the world talked about and treated breast cancer took on added urgency when she was herself diagnosed with the disease in 1984, a terrifying chapter in her life that she had long feared. Unlike her sister, Nancy survived and went on to make Susan G. Komen for the Cure into the most influential health charity in the country and arguably the world. A pioneering force in cause-related marketing, SGK turned the pink ribbon into a symbol of hope everywhere. Each year, millions of people worldwide take part in SGK Race for the Cure events. And thanks to the more than $1.5 billion spent by SGK for cutting-edge research and community programs, a breast cancer diagnosis today is no longer a death sentence. In fact, in the time since Suzy’s death, the five-year survival rate for breast cancer has risen from 74 percent to 98 percent.Promise Me is a deeply moving story of family and sisterhood, the dramatic “30,000-foot view” of the democratization of a disease, and a soaring affirmative to the question: Can one person truly make a difference?From the Hardcover edition.

    With a slow chill that intensifies with each heart-pounding page, Rule describes her dawning awareness that Ted Bundy, her sensitive coworker on a crisis hotline, was one of the most prolific serial killers in America. He would confess to killing at least thirty-six young women from coast to coast, and was eventually executed for three of those cases. Drawing from their correspondence that endured until shortly before Bundy's death, and striking a seamless balance between her deeply personal perspective and her role as a crime reporter on the hunt for a savage serial killer -- the brilliant and charismatic Bundy, the man she thought she knew -- Rule changed the course of true-crime literature with this unforgettable chronicle.

    But the president insisted there was nothing to worry about.Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

    Elizabeth Ford went through medical school unsure of where she belonged. It wasn’t until she did her psychiatry rotation that she found her calling—to care for one of the most vulnerable populations of mentally ill people, the inmates of New York's jails, including Rikers Island, who are so sick that they are sent to the Bellevue Hospital Prison Ward for care.These men were broken, unloved, without resources or support, and very ill. They could be violent, unpredictable, but they could also be funny and tender and needy. Mostly, they were human and they awakened in Ford a boundless compassion. Her patients made her a great doctor and a better person and, as she treated these men, she learned about doctoring, about nurturing, about parenting, and about love. While Ford was a psychiatrist at Bellevue she becomes a wife and a mother. In her book she shares her struggles to balance her life and her work, to care for her children and her patients, and to maintain the empathy that is essential to her practice—all in the face of a jaded institution, an exhausting workload, and the deeply emotionally taxing nature of her work. Ford brings humor, grace, and humanity to the lives of the patients in her care and in beautifully rendered prose illuminates the inner workings (and failings) of our mental health system, our justice system, and the prison system.

    Mimi Guarneri reveals groundbreaking new research that the heart is a multilayered, complex organ, possessing intelligence, memory, and decision-making abilities independent from the mind—and that healing the heart can have more to do with healing the mind and soul than we ever knew. From childhood in a family riddled with heart disease to a medical career facing the pounding heartbeats of cardiac emergencies, Dr. Guarneri draws us into the intimate moments of life and death, and leads us on a riveting exploration of the heart's many mysteries. Through her compelling memoir we see that it is only by knowing the whole heart—its mental, emotional, spiritual, and universal aspects—that we can truly heal.

    At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions & bitter rivalries. With humility unspoiled by false modesty, Watson relates his & Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.